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2020 Journal Article Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosisMcGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013 |
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2020 Journal Article The complement C5a-C5aR1 GPCR axis in COVID-19 therapeuticsWoodruff, Trent M. and Shukla, Arun K. (2020). The complement C5a-C5aR1 GPCR axis in COVID-19 therapeutics. Trends in Immunology, 41 (11), 965-967. doi: 10.1016/j.it.2020.09.008 |
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2018 Journal Article Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceGordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066 |
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2018 Journal Article Complement: the emerging architect of the developing brainCoulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). Complement: the emerging architect of the developing brain. Trends in Neurosciences, 41 (6), 373-384. doi: 10.1016/j.tins.2018.03.009 |
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2017 Journal Article Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζCoulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017 |
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2017 Journal Article Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2024 Journal Article Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitmentSnelson, Matthew, Deliyanti, Devy, Tan, Sih Min, Drake, Anna M., de Pasquale, Cassandra, Kumar, Vinod, Woodruff, Trent M., Wilkinson-Berka, Jennifer L. and Coughlan, Melinda T. (2024). Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment. Nutrition and Diabetes, 14 (1) 46, 1-9. doi: 10.1038/s41387-024-00305-2 |
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2024 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2024). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 134 (16). doi: 10.1172/jci185067 |
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2024 Journal Article Sex differences in Huntington's disease from a neuroinflammation perspectiveRisby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480 |
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2024 Journal Article Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposureChen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306 |
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2024 Journal Article C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosisPerrino, Melissa R., Ahmari, Niousha, Hall, Ashley, Jackson, Mark, Na, Youjin, Pundavela, Jay, Szabo, Sara, Woodruff, Trent M., Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. Life Science Alliance, 7 (5) e202302229, 1-16. doi: 10.26508/lsa.202302229 |
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2024 Journal Article A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral SclerosisVassileff, Natasha, Spiers, Jereme G., Lee, John D., Woodruff, Trent M., Ebrahimie, Esmaeil, Mohammadi Dehcheshmeh, Manijeh, Hill, Andrew F. and Cheng, Lesley (2024). A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 61 (8), 1-15. doi: 10.1007/s12035-023-03857-z |
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2023 Journal Article The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptorsAlexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180 (S2), S23-S144. doi: 10.1111/bph.16177 |
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2023 Journal Article Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse ModelChen, Min, Edwards, Stephen R., Maskey, Dhiraj, Woodruff, Trent M., Tomlinson, Stephen and Reutens, David (2023). Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model. Neurotrauma Reports, 4 (1), 663-681. doi: 10.1089/neur.2023.0024 |
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2023 Journal Article The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptorsAlexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al-hosaini, Khaled, Back, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean-Martin, Beck-Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180, S23-S144. doi: 10.1111/bph.16177 |
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2023 Journal Article 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptorsAlbornoz, Eduardo and Woodruff, Trent (2023). 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptors. Immunobiology, 228 (5) 152650, 1-1. doi: 10.1016/j.imbio.2023.152650 |
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2023 Journal Article Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivoAlthobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964, e4964. doi: 10.1002/nbm.4964 |
