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2023 Journal Article Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse ModelChen, Min, Edwards, Stephen R., Maskey, Dhiraj, Woodruff, Trent M., Tomlinson, Stephen and Reutens, David (2023). Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model. Neurotrauma Reports, 4 (1), 663-681. doi: 10.1089/neur.2023.0024 |
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2023 Journal Article 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptorsAlbornoz, Eduardo and Woodruff, Trent (2023). 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptors. Immunobiology, 228 (5) 152650, 1-1. doi: 10.1016/j.imbio.2023.152650 |
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2023 Journal Article Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivoAlthobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964, e4964. doi: 10.1002/nbm.4964 |
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2023 Journal Article Complement peptide receptors in GtoPdb v.2023.1Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2023). Complement peptide receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f5/2023.1 |
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2023 Journal Article Neutrophil conversion to a tumor-killing phenotype underpins effective microbial therapyYam, Andrew O., Bailey, Jacqueline, Lin, Francis, Jakovija, Arnolda, Youlten, Scott E., Counoupas, Claudio, Gunzer, Matthias, Bald, Tobias, Woodruff, Trent M., Triccas, James A., Goldstein, Leonard D., Gallego-Ortega, David, Grey, Shane T. and Chtanova, Tatyana (2023). Neutrophil conversion to a tumor-killing phenotype underpins effective microbial therapy. Cancer Research, 83 (8), 1315-1328. doi: 10.1158/0008-5472.can-21-4025 |
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2023 Journal Article In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell modelGerogianni, Alexandra, Bal, Melissa, Mohlin, Camilla, Woodruff, Trent M., Lambris, John D., Mollnes, Tom E., Sjöström, Dick J. and Nilsson, Per H. (2023). In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model. Frontiers in Immunology, 14 1101387, 1101387. doi: 10.3389/fimmu.2023.1101387 |
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2023 Journal Article Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infectionSikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002 |
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2023 Journal Article TLQP-21 is a low potency partial C3aR activator on human primary macrophagesLi, Xaria X., Lee, John D., Lee, Han S., Clark, Richard J. and Woodruff, Trent M. (2023). TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Frontiers in Immunology, 14 1086673, 1-10. doi: 10.3389/fimmu.2023.1086673 |
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2022 Journal Article Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptorsCoughlan, Melinda T., Ziemann, Mark, Laskowski, Adrienne, Woodruff, Trent M. and Tan, Sih Min (2022). Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors. Scientific Reports, 12 (1) 20278, 1-10. doi: 10.1038/s41598-022-24851-w |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022)Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y. (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030 |
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2022 Journal Article Synthetic oligodeoxynucleotide CpG motifs activate human complement through their backbone structure and induce complement-dependent cytokine releasede Boer, Eline, Sokolova, Marina, Quach, Huy Q., McAdam, Karin E., Götz, Maximilian P., Chaban, Viktoriia, Vaage, Jarle, Fageräng, Beatrice, Woodruff, Trent M., Garred, Peter, Nilsson, Per H., Mollnes, Tom E. and Pischke, Søren E. (2022). Synthetic oligodeoxynucleotide CpG motifs activate human complement through their backbone structure and induce complement-dependent cytokine release. The Journal of Immunology, 209 (9), 1760-1767. doi: 10.4049/jimmunol.2101191 |
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2022 Journal Article Complement system inhibition modulates the inflammation induced by the venom of Premolis semirufa, an Amazon rainforest moth caterpillarGabrili, Joel J. M., Villas-Boas, Isadora Maria, Pidde, Giselle, Squaiella-Baptistão, Carla Cristina, Woodruff, Trent M. and Tambourgi, Denise V. (2022). Complement system inhibition modulates the inflammation induced by the venom of Premolis semirufa, an Amazon rainforest moth caterpillar. International Journal of Molecular Sciences, 23 (21) 13333, 1-20. doi: 10.3390/ijms232113333 |
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2022 Journal Article Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disordersMcDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061 |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacyXu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109 |
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2022 Journal Article Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variantsIsaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262 |
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2022 Journal Article Thrombin differentially modulates the acute inflammatory response to Escherichia coli and Staphylococcus aureus in human whole bloodJohnson, Christina, Quach, Huy Quang, Lau, Corinna, Ekholt, Karin, Espevik, Terje, Woodruff, Trent M., Pischke, Søren Erik, Mollnes, Tom Eirik and Nilsson, Per H. (2022). Thrombin differentially modulates the acute inflammatory response to Escherichia coli and Staphylococcus aureus in human whole blood. The Journal of Immunology, 208 (12), 2771-2778. doi: 10.4049/jimmunol.2101033 |
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2022 Journal Article Bothrops jararaca snake venom inflammation induced in human whole blood: role of the complement systemLeonel, Thyago Bispo, Gabrili, Joel José Megale, Squaiella-Baptistão, Carla Cristina, Woodruff, Trent M., Lambris, John D. and Tambourgi, Denise V. (2022). Bothrops jararaca snake venom inflammation induced in human whole blood: role of the complement system. Frontiers in Immunology, 13 885223, 1-16. doi: 10.3389/fimmu.2022.885223 |
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2022 Journal Article Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasisOrtiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos ... Pio, Ruben (2022). Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Letters, 529, 70-84. doi: 10.1016/j.canlet.2021.12.027 |
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2022 Journal Article Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant ProteinMurray, Margaret, Coughlan, Melinda T., Gibbon, Anne, Kumar, Vinod, Marques, Francine Z., Selby-Pham, Sophie, Snelson, Matthew, Tsyganov, Kirill, Williamson, Gary, Woodruff, Trent M., Wu, Tong and Bennett, Louise E. (2022). Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant Protein. Frontiers in Nutrition, 9 816749, 816749. doi: 10.3389/fnut.2022.816749 |
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2021 Journal Article Unexpected off-target activities for recombinant C5a in human macrophagesLi, Xaria X., Gorman, Declan M., Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2021). Unexpected off-target activities for recombinant C5a in human macrophages. Journal of Immunology, 208 (1), 133-142. doi: 10.4049/jimmunol.2100444 |
