![Professor Elizabeth Krenske](/sites/default/files/profiles/1018.jpeg)
Overview
Background
Professor Elizabeth Krenske leads a computational chemistry laboratory that specialises in understanding molecular behaviour. Her laboratory has a particular focus on the study of chemical reaction mechanisms, including the computational prediction of reaction outcomes. Prof. Krenske obtained her PhD in synthetic main-group chemistry at The Australian National University's Research School of Chemistry, where she worked with Professor Bruce Wild. After two years of postdoctoral research at the ANU she was awarded a Fulbright Postdoctoral Scholarship and spent two years at the University of California, Los Angeles, working in the field of theoretical and computational chemistry with Professor Kendall Houk. She returned to Australia in 2009 as an ARC Australian Postdoctoral Fellow at the University of Melbourne, and moved to The University of Queensland in 2012 as an ARC Future Fellow. She is currently a Professor in the UQ School of Chemistry and Molecular Biosciences.
Prof. Krenske is a Fellow of the Royal Australian Chemical Institute, Fellow of the Royal Society of Chemistry, Fellow of the Higher Education Academy and former Associate Editor of the RSC journal Organic & Biomolecular Chemistry.
Availability
- Professor Elizabeth Krenske is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, Australian National University
Works
Search Professor Elizabeth Krenske’s works on UQ eSpace
2017
Journal Article
Synthesis of spirocyclic orthoesters by 'anomalous' rhodium(ii)-catalysed intramolecular C-H insertions
Lombard, Fanny J, Lepage, Romain J, Schwartz, Brett D, Johnston, Ryne C, Healy, Peter C, Krenske, Elizabeth H and Coster, Mark J (2017). Synthesis of spirocyclic orthoesters by 'anomalous' rhodium(ii)-catalysed intramolecular C-H insertions. Organic & biomolecular chemistry, 16 (2), 256-261. doi: 10.1039/c7ob02123b
2017
Journal Article
(4+3) Cycloaddition reactions of N-alkyl oxidopyridinium ions
Fu, Chencheng, Lora, Nestor, Kirchhoefer, Patrick L., Lee, Dong Reyoul, Altenhofer, Erich, Barnes, Charles L., Hungerford, Natasha L., Krenske, Elizabeth H. and Harmata, Michael (2017). (4+3) Cycloaddition reactions of N-alkyl oxidopyridinium ions. Angewandte Chemie (International Edition), 56 (46), 14682-14687. doi: 10.1002/anie.201708320
2017
Journal Article
Claisen rearrangements of benzyl vinyl ethers: theoretical investigation of mechanism, substituent effects, and regioselectivity
Krenske, Elizabeth H., Burns, Jed M. and McGeary, Ross P. (2017). Claisen rearrangements of benzyl vinyl ethers: theoretical investigation of mechanism, substituent effects, and regioselectivity. Organic and Biomolecular Chemistry, 15 (37), 7887-7893. doi: 10.1039/c7ob01666b
2017
Journal Article
Multistereocenter-containing cyclopentanoids from Ynamides via oxazolidinone-controlled nazarov cyclization
Manchala, Narasimhulu, Law, Hanson Y. L., Kerr, Daniel J., Volpe, Rohan, Lepage, Romain J., White, Jonathan M., Krenske, Elizabeth H. and Flynn, Bernard L. (2017). Multistereocenter-containing cyclopentanoids from Ynamides via oxazolidinone-controlled nazarov cyclization. Journal of Organic Chemistry, 82 (13), 6511-6527. doi: 10.1021/acs.joc.7b00082
2017
Journal Article
An unprecedented stereoselective base-induced trimerization of an α-bromovinylsulfone
Fisher, Brendan, Lepage, Romain J., White, Jonathan M., Ye, Young, Krenske, Elizabeth H. and Rizzacasa, Mark A. (2017). An unprecedented stereoselective base-induced trimerization of an α-bromovinylsulfone. Organic & Biomolecular Chemistry, 15 (26), 5529-5534. doi: 10.1039/c7ob01121k
2017
Journal Article
Ionic and neutral mechanisms for C-H bond silylation of aromatic heterocycles catalyzed by potassium tert-butoxide
Banerjee, Shibdas, Yang, Yun-Fang, Jenkins, Ian D., Liang, Yong, Toutov, Anton A., Liu, Wen-Bo, Schuman, David P., Grubbs, Robert H., Stoltz, Brian M., Krenske, Elizabeth H., Houk, Kendall N. and Zare, Richard N. (2017). Ionic and neutral mechanisms for C-H bond silylation of aromatic heterocycles catalyzed by potassium tert-butoxide. Journal of the American Chemical Society, 139 (20), 6880-6887. doi: 10.1021/jacs.6b13032
2017
Journal Article
Mechanisms of carbonyl activation by BINOL N-triflylphosphoramides: enantioselective nazarov cyclizations
Lovie-Toon, Joseph P., Tram, Camilla Mia, Flynn, Bernard L. and Krenske, Elizabeth H. (2017). Mechanisms of carbonyl activation by BINOL N-triflylphosphoramides: enantioselective nazarov cyclizations. Acs Catalysis, 7 (5), 3466-3476. doi: 10.1021/acscatal.7b00292
2017
Journal Article
Aromatic claisen rearrangements of benzyl ketene acetals: conversion of benzylic alcohols to (ortho-tolyl)acetates
Burns, Jed M., Krenske, Elizabeth H. and McGeary, Ross P. (2017). Aromatic claisen rearrangements of benzyl ketene acetals: conversion of benzylic alcohols to (ortho-tolyl)acetates. European Journal of Organic Chemistry, 2017 (2), 252-256. doi: 10.1002/ejoc.201601354
2017
Journal Article
Hydroxyl radicals via collision-induced dissociation of trimethylammonium benzyl alcohols
Moore, Peter W., Hooker, Jordan P., Zavra, Athanasios, Khairallah, George N., Krenske, Elizabeth H., Bernhardt, Paul V., Quach, Gina, Moore, Evan G., O’Hair, Richard A. J. and William, Craig M. (2017). Hydroxyl radicals via collision-induced dissociation of trimethylammonium benzyl alcohols. Australian Journal of Chemistry, 70 (4), 397-406. doi: 10.1071/CH16602
2016
Journal Article
Kinetics and thermodynamics of reversible thiol additions to mono- and diactivated Michael acceptors: implications for the design of drugs that bind covalently to cysteines
Krenske, Elizabeth H., Petter, Russell C. and Houk, K. N. (2016). Kinetics and thermodynamics of reversible thiol additions to mono- and diactivated Michael acceptors: implications for the design of drugs that bind covalently to cysteines. Journal of Organic Chemistry, 81 (23), 11726-11733. doi: 10.1021/acs.joc.6b02188
2016
Journal Article
The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-D-glucuronides to L-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations
Mohamed, Shifaza, Krenske, Elizabeth H. and Ferro, Vito (2016). The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-D-glucuronides to L-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations. Organic and Biomolecular Chemistry, 14 (10), 2950-2960. doi: 10.1039/C6OB00283H
2016
Journal Article
Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation
Stok, Jeanette E., Chow, Sharon, Krenske, Elizabeth H., Farfan Soto, Clementina, Matyas, Csongor, Poirier, Raymond A., Williams, Craig M. and De Voss, James J. (2016). Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation. Chemistry: A European Journal, 22 (13), 4408-4412. doi: 10.1002/chem.201600246
2016
Journal Article
Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases
Brown, Joshua J., Gahan, Lawrence R., Schöffler, Anne, Krenske, Elizabeth H. and Schenk, Gerhard (2016). Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases. Journal of Inorganic Biochemistry, 162, 356-365. doi: 10.1016/j.jinorgbio.2016.02.008
2016
Other Outputs
Olefin strain energy as a predictor of isolability
Krenske, Elizabeth H. and Williams, Craig M. (2016). Olefin strain energy as a predictor of isolability. The University of Queensland. (Dataset) doi: 10.14264/uql.2016.208
2015
Journal Article
Towards the synthesis of dihydrooxepino[4,3-b]pyrrole-containing natural products via cope rearrangement of vinyl pyrrole epoxides
Cameron, Alex, Fisher, Brendan, Fisk, Nicholas, Hummel, Jessica, White, Jonathan M., Krenske, Elizabeth H. and Rizzacasa, Mark A. (2015). Towards the synthesis of dihydrooxepino[4,3-b]pyrrole-containing natural products via cope rearrangement of vinyl pyrrole epoxides. Organic Letters, 17 (24), 5998-6001. doi: 10.1021/acs.orglett.5b02965
2015
Journal Article
Do anti-Bredt natural products exist? Olefin strain energy as a predictor of isolability
Krenske, Elizabeth H. and Williams, Craig M. (2015). Do anti-Bredt natural products exist? Olefin strain energy as a predictor of isolability. Angewandte Chemie International Edition, 54 (36), 10608-10612. doi: 10.1002/anie.201503822
2015
Journal Article
Biosynthetic insights provided by unusual sesterterpenes from the medicinal herb Aletris farinosa
Challinor, Victoria L., Johnston, Ryne C., Bernhardt, Paul V., Lehmann, Reginald P., Krenske, Elizabeth H. and De Voss, James J. (2015). Biosynthetic insights provided by unusual sesterterpenes from the medicinal herb Aletris farinosa. Chemical Science, 6 (10), 5740-5745. doi: 10.1039/c5sc02056e
2015
Journal Article
Antimalarial isocyano and isothiocyanato sesquiterpenes with tri- and bicyclic skeletons from the nudibranch Phyllidia ocellata
White, Andrew M., Pierens, Gregory K., Skinner-Adams, Tina, Andrews, Katherine T., Bernhardt, Paul V., Krenske, Elizabeth H., Mollo, Ernesto and Garson, Mary J. (2015). Antimalarial isocyano and isothiocyanato sesquiterpenes with tri- and bicyclic skeletons from the nudibranch Phyllidia ocellata. Journal of Natural Products, 78 (6), 1422-1427. doi: 10.1021/acs.jnatprod.5b00354
2015
Journal Article
Concerted ring opening and cycloaddition of chiral epoxy enolsilanes with dienes
Krenske, Elizabeth H., Lam, Sarah, Ng, Jerome P. L., Lo, Brian, Lam, Sze Kui, Chiu, Pauline and Houk, Kendall N. (2015). Concerted ring opening and cycloaddition of chiral epoxy enolsilanes with dienes. Angewandte Chemie (International Edition), 54 (25), 7422-7425. doi: 10.1002/anie.201503003
2015
Journal Article
Mapping the Interactions of I2, I., I−, and I+ with Alkynes and Their Roles in Iodocyclizations
Volpe, Rohan, Aurelio, Luigi, Gillin, Murray G., Krenske, Elizabeth H. and Flynn, Bernard L. (2015). Mapping the Interactions of I2, I., I−, and I+ with Alkynes and Their Roles in Iodocyclizations. Chemistry - A European Journal, 21 (28), 10191-10199. doi: 10.1002/chem.201500384
Funding
Current funding
Past funding
Supervision
Availability
- Professor Elizabeth Krenske is:
- Available for supervision
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Available projects
-
Molecular modelling. Chemical Reactivity. Catalysis. Drug Design.
Supervision history
Current supervision
-
Doctor Philosophy
New technology for computational prediction of chemical reaction outcomes
Principal Advisor
Other advisors: Professor Debra Bernhardt
-
Doctor Philosophy
Development of new computational techniques for carbohydrate and agricultural chemistry
Principal Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Synthesis of L-sugars via radical chemistry
Associate Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Insight into Nonequilibrium Behaviour from Molecular Simulations
Associate Advisor
Other advisors: Professor Debra Bernhardt
Completed supervision
-
2024
Doctor Philosophy
Theoretical and experimental investigations into the mechanisms of Cytochromes P450
Principal Advisor
Other advisors: Professor James De Voss
-
2022
Doctor Philosophy
Application of Molecular Modelling Techniques to Guide the Design of New Molecules in Material Science and Drug Discovery
Principal Advisor
Other advisors: Associate Professor Shih-Chun Lo, Associate Professor Ebinazar Namdas
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2021
Doctor Philosophy
Computational studies of asymmetric catalytic reactions
Principal Advisor
Other advisors: Professor Debra Bernhardt
-
2023
Doctor Philosophy
A Synergistic Approach to L-Hexose Synthesis
Associate Advisor
Other advisors: Professor Vito Ferro
-
2017
Doctor Philosophy
Explorations in Novel Caged Hydrocarbon Chemistry
Associate Advisor
Other advisors: Professor Craig Williams
-
2017
Doctor Philosophy
Cubane in Drug Discovery and Development
Associate Advisor
Other advisors: Professor Craig Williams
-
2017
Doctor Philosophy
Kinetic, mechanistic, structural and spectroscopic investigations of Bimetallic Metallohydrolases.
Associate Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Experimental and Computational Investigations into the Benzyl-Claisen Rearrangement
Associate Advisor
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