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Dr Run Zhang
Dr

Run Zhang

Email: 
Phone: 
+61 7 334 63806

Overview

Background

  • 2023-now Joint Senior Research Fellow, Centre for Nutrition and Food Sciences, The Queensland Alliance for Agriculture and Food Innovation (CNFS, QAAFI)
  • 2022-now Senior Research Fellow, AIBN, The University of Queensland
  • 2020-now NHMRC Emerging Leadership Fellow, AIBN, The University of Queensland
  • 2017-2019 ARC DECRA Fellow, AIBN, The University of Queensland
  • 2016-2017 Research Associate, AIBN, The University of Queensland
  • 2013-2015 Macquarie University Research Fellow (MQRF), Department of Chemistry and Biomolecular Science (CBMS), Macquarie University
  • 2012-2013 Postdoc Research Fellow, Department of Physics and Astronomy, Macquarie University
  • July 2012 PhD, Analytical Chemistry, Dalian University of Technology (DLUT), China

Research Team: Dr Zhang is now leading more than 15 researchers, working on the development of responsive molecules/nanomaterials for biosensing and imaging, early disease detection and treatment, food/agricultural/environmental applications. He has collaborations with scientist in Chemistry, Materials Science, Molecular Biology and Biotechnology, Food and Agriculture Science, and Biophotonics from Australia, US, UK, Sweden, India, Russia and China.

Research Support: Since 2011, Dr Zhang has attracted 11 research grants (> 3 million) as chief investigator (lead CI and/or co-CI). These grants include 3 Fellowship (NHMRC Emerging Leadership, ARC DECRA and MQRF to develop responsive probes for redox biomarkers detection within body), 1 NHMRC Project grant in redox quantification in liver cancer chemotherapy, 1 UQ ECR grant, 1 NSFC grant, and another 3 grants from universities.

Research Output: Dr Zhang has published more than 180 research papers since his first publication in 2010 (>95 papers published as first and/or corresponding author), and 1 patent. He frequently publishes in a number of premier journals, such as Nature Photonics, Nature Plants, Journal of the American Chemical Society (JACS), Angewandte Chemie, Analytical Chemistry, Chemical Society Reviews, and Accounts of Chemical Research. These publications have received >9,000 citations with an H-index of 55. He has 8 Highly Cited Papers (7 in the ESI field of Chemistry-Analytical) and 3 Hot Articles.

Service: Dr Zhang is an Editor of TrAC Trends in Analytical Chemistry (Elsevier, 1/106 in Analytical Chemistry) and Methods (Elsevier), and Editorial Board Member of several international high impact journals, such as Chemistry-An Asian Journal (Wiley), Aggregate (Wiley), Journal of Pharmaceutical Analysis (Elsevier), Green Analytical Chemistry (Elsevier). He is a referee of ~80 international journals (2nd most contributions of all UQ researchers, with >20 awards from RSC and Elsevier journals), and grant assessor for more than 10 country and regions, such as Australia, UK, Europe, Netherland, New Zealand.

Award: Dr Zhang's national and international standing in the fields of chemistry (analytical and inorganic) and functional nanomaterials is evidenced by the awards of ACS Rising Star in Measurement Science, NJC Emerging Investigator, Biosensors Young Investigator Award, IAAM Scientist Medal, Vebleo Fellow, IAAM Fellow, ARC DECRA, NHMRC EL Fellow, MQRF, and more than 20 TOP Outstanding Reviewer awards from RSC and Elsevier. He has been a World's Top 2% Scientist in Chemistry (Analytical) and Nanoscience & Nanotechnology since 2022. He has delivered about 40 invited presentations and keynotes.

Teaching and Supervision: Dr Zhang has a strong commitment to training students. His students have received several awards, such as 4 "Dean’s Commendation for Outstanding Academic Performance", 1 "Dean’s Award for Excellence in Higher Degree Research", 1 "Dean's Award for Outstanding HDR Theses", ANFF-Q students award, 3MT Runner-UP and People's Choice. He has supervised 6 PhD and >20 Masters to completion. He is now co-coordinating and lecturing the MSE PP ENGY7112/7115/7114/7215 in School of Chem. Eng., EAIT. His teaching contributions in Faculty of Science, UQ are recognised by two nominations of "Dean’s Commendation for Excellent Teaching Awards" in semesters 1 and 2 in 2022.

Availability

Dr Run Zhang is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy of Engineering, Dalian University of Technology

Research interests

  • Responsive probes to detect and visualise highly reactive biomolecules

    design and synthesis of organic/organometallic complexes (including Ru(II) and Ir(III) complexes and lanthanide chelate) for sensing of bioactive ions, reactive oxygen species (ROS), reactive nitrogen species (RNS), redox biomolecules, gasotransmitters, amino acid, and proteins in various diseases, such as cancer, cardiovascular, and inflammatory diseases.

  • Functional nanomaterial for early diseases diagnosis and treatment

    engineering of functional nanomaterials for disease detection and treatment through monitoring and regulation of redox state, including photodynamic therapy (PDT), photothermal therapy (PTT), and sonodynamic therapy (SDT) for diseases deeply seated in body.

  • Sensors for the detection of food quality & safety and environmental pollutants

    development of ultra-sensitive sensors for the detection of food additives, antibiotics, pesticides, spoilage, heavy metals, toxic anions and gases (greenhouse gases and VOCs), etc.

  • Bionanoprobes for deep tissue sensing and imaging

    fabrication of responsive nanomaterials for sensing and imaging of biomarkers located deeply inside the body. The probes allow the monitoring of specific disease-related biomarkers through optical, acoustic, and magnetic resonance spectroscopy.

  • Redox monitoring and regulation for diagnosis and treatment

    development of novel luminescent probes with long emission lifetime to eliminate autofluorescence, allowing background-free quantification and bioimaging of redox species in situ development of responsive nanomaterials for treatment through quantitative redox regulation

Works

Search Professor Run Zhang’s works on UQ eSpace

190 works between 2010 and 2025

81 - 100 of 190 works

2021

Journal Article

Synergistic cancer photochemotherapy via layered double hydroxide-based trimodal nanomedicine at very low therapeutic doses

Liu, Jianping, Sun, Luyao, Li, Li, Zhang, Run and Xu, Zhi Ping (2021). Synergistic cancer photochemotherapy via layered double hydroxide-based trimodal nanomedicine at very low therapeutic doses. ACS Applied Materials and Interfaces, 13 (6) acsami.0c23143, 7115-7126. doi: 10.1021/acsami.0c23143

Synergistic cancer photochemotherapy via layered double hydroxide-based trimodal nanomedicine at very low therapeutic doses

2021

Journal Article

Enhancing tumor accumulation and cellular uptake of layered double hydroxide nanoparticles by coating/detaching pH-triggered charge-convertible polymers

Xu, Tiefeng, Liu, Jianping, Sun, Luyao, Zhang, Run, Xu, Zhi Ping and Sun, Qing (2021). Enhancing tumor accumulation and cellular uptake of layered double hydroxide nanoparticles by coating/detaching pH-triggered charge-convertible polymers. ACS Omega, 6 (5), 3822-3830. doi: 10.1021/acsomega.0c05520

Enhancing tumor accumulation and cellular uptake of layered double hydroxide nanoparticles by coating/detaching pH-triggered charge-convertible polymers

2021

Journal Article

Lipid-encapsulated upconversion nanoparticle for near-infrared light-mediated carbon monoxide release for cancer gas therapy

Opoku-Damoah, Yaw, Zhang, Run, Ta, Hang T., Amilan Jose, D., Sakla, Rahul and Xu, Zhi Ping (2021). Lipid-encapsulated upconversion nanoparticle for near-infrared light-mediated carbon monoxide release for cancer gas therapy. European Journal of Pharmaceutics and Biopharmaceutics, 158, 211-221. doi: 10.1016/j.ejpb.2020.11.014

Lipid-encapsulated upconversion nanoparticle for near-infrared light-mediated carbon monoxide release for cancer gas therapy

2021

Journal Article

Resorufin-based responsive probes for fluorescent and colorimetric analysis

Tian, Lu, Feng, Huan, Dai, Zhichao and Zhang, Run (2021). Resorufin-based responsive probes for fluorescent and colorimetric analysis. Journal of Materials Chemistry B, 9 (1), 53-79. doi: 10.1039/d0tb01628d

Resorufin-based responsive probes for fluorescent and colorimetric analysis

2021

Journal Article

Recent advances in the development of theranostic nanoparticles for cardiovascular diseases

Wu, Yuao, Vazquez-Prada, Karla X., Liu, Yajun, Whittaker, Andrew K., Zhang, Run and Ta, Hang T. (2021). Recent advances in the development of theranostic nanoparticles for cardiovascular diseases. Nanotheranostics, 5 (4), 499-514. doi: 10.7150/NTNO.62730

Recent advances in the development of theranostic nanoparticles for cardiovascular diseases

2021

Journal Article

A phenothiazine-based turn-on fluorescent probe for the selective detection of hydrogen sulfide in food, live cells and animals

Hu, Yaoyun, Shang, Zhuye, Wang, Juan, Hong, Min, Zhang, Run, Meng, Qingtao and Zhang, Zhiqiang (2021). A phenothiazine-based turn-on fluorescent probe for the selective detection of hydrogen sulfide in food, live cells and animals. Analyst, 146 (24), 7528-7536. doi: 10.1039/d1an01762d

A phenothiazine-based turn-on fluorescent probe for the selective detection of hydrogen sulfide in food, live cells and animals

2021

Journal Article

Sweetsop-like α-Fe2O3@CoNi catalyst with superior peroxidase-like activity for sensitive and selective detection of hydroquinone

Feng, Min, Wen, Shaohua, Chen, Xiaofang, Deng, Die, Yang, Xiupei and Zhang, Run (2021). Sweetsop-like α-Fe2O3@CoNi catalyst with superior peroxidase-like activity for sensitive and selective detection of hydroquinone. RSC Advances, 11 (39), 24065-24071. doi: 10.1039/d1ra03456a

Sweetsop-like α-Fe2O3@CoNi catalyst with superior peroxidase-like activity for sensitive and selective detection of hydroquinone

2020

Journal Article

Advances in the development of fluorescence probes for cell plasma membrane imaging

Liu, Chaolong, Gao, Xiaona, Yuan, Jingli and Zhang, Run (2020). Advances in the development of fluorescence probes for cell plasma membrane imaging. Trends in Analytical Chemistry, 133 116092, 116092. doi: 10.1016/j.trac.2020.116092

Advances in the development of fluorescence probes for cell plasma membrane imaging

2020

Journal Article

J-aggregate-based FRET monitoring of drug release from polymer nanoparticles with high drug loading

Liu, Yun, Yang, Guangze, Jin, Song, Zhang, Run, Chen, Peng, Jisi, Teng, Wang, Lianzhou, Chen, Dong, Weitz, David and Zhao, Chun-Xia (2020). J-aggregate-based FRET monitoring of drug release from polymer nanoparticles with high drug loading. Angewandte Chemie, 132 (45) anie.202008018, 20240-20249. doi: 10.1002/anie.202008018

J-aggregate-based FRET monitoring of drug release from polymer nanoparticles with high drug loading

2020

Journal Article

Different approaches to develop nanosensors for diagnosis of diseases

Arndt, Nina, Tran, Huong D. N., Zhang, Run, Xu, Zhi Ping and Ta, Hang T. (2020). Different approaches to develop nanosensors for diagnosis of diseases. Advanced Science, 7 (24) 2001476, 1-31. doi: 10.1002/advs.202001476

Different approaches to develop nanosensors for diagnosis of diseases

2020

Journal Article

Luminescent thermochromic silver iodides as wavelength-dependent thermometers

Song, Dan-Na, Zhang, Dao-Jun, Wang, Yong-Lei, Wang, Jun-Jie, Xing, Xiu-Shuang, Lv, Zhi-Ying, Liu, Fan, Han, Jiang-Xia, Zhang, Ren-Chun, Liao, Shui-Jiao and Zhang, Run (2020). Luminescent thermochromic silver iodides as wavelength-dependent thermometers. Inorganic Chemistry, 59 (18) acs.inorgchem.0c00606, 13067-13077. doi: 10.1021/acs.inorgchem.0c00606

Luminescent thermochromic silver iodides as wavelength-dependent thermometers

2020

Journal Article

Development of “dual-key-and-lock” responsive probes for biosensing and imaging

Feng, Huan, Meng, Qingtao, Ta, Hang T. and Zhang, Run (2020). Development of “dual-key-and-lock” responsive probes for biosensing and imaging. New Journal of Chemistry, 44 (30), 12890-12896. doi: 10.1039/d0nj02762f

Development of “dual-key-and-lock” responsive probes for biosensing and imaging

2020

Journal Article

Charge reversion simultaneously enhances tumor accumulation and cell uptake of layered double hydroxide nanohybrids for effective imaging and therapy

Liu, Jianping, Wu, Yilun, Fu, Changkui, Li, Bei, Li, Li, Zhang, Run, Xu, Tiefeng and Xu, Zhi Ping (2020). Charge reversion simultaneously enhances tumor accumulation and cell uptake of layered double hydroxide nanohybrids for effective imaging and therapy. Small, 16 (31) 2002115, e2002115. doi: 10.1002/smll.202002115

Charge reversion simultaneously enhances tumor accumulation and cell uptake of layered double hydroxide nanohybrids for effective imaging and therapy

2020

Journal Article

“Two Birds with One Stone” Ruthenium(II) Complex Probe for Biothiols Discrimination and Detection In Vitro and In Vivo

Liu, Chaolong, Liu, Jianping, Zhang, Wenzhu, Wang, Yong‐Lei, Liu, Qi, Song, Bo, Yuan, Jingli and Zhang, Run (2020). “Two Birds with One Stone” Ruthenium(II) Complex Probe for Biothiols Discrimination and Detection In Vitro and In Vivo. Advanced Science, 7 (14) 2000458, 2000458. doi: 10.1002/advs.202000458

“Two Birds with One Stone” Ruthenium(II) Complex Probe for Biothiols Discrimination and Detection In Vitro and In Vivo

2020

Journal Article

Time-gated luminescence probe for ratiometric and luminescence lifetime detection of Hypochorous acid in lysosomes of live cells

Tian, Lu, Ma, Hua, Song, Bo, Dai, Zhichao, Zheng, Xiuwen, Zhang, Run, Chen, Kuiyong and Yuan, Jingli (2020). Time-gated luminescence probe for ratiometric and luminescence lifetime detection of Hypochorous acid in lysosomes of live cells. Talanta, 212 120760, 120760. doi: 10.1016/j.talanta.2020.120760

Time-gated luminescence probe for ratiometric and luminescence lifetime detection of Hypochorous acid in lysosomes of live cells

2020

Journal Article

Recent advances in the development of responsive probes for selective detection of cysteine

Zhang, Run, Yong, Jiaxi, Yuan, Jingli and Xu, Zhi Ping (2020). Recent advances in the development of responsive probes for selective detection of cysteine. Coordination Chemistry Reviews, 408 213182, 1-41. doi: 10.1016/j.ccr.2020.213182

Recent advances in the development of responsive probes for selective detection of cysteine

2020

Journal Article

Investigation on the adsorption-interaction mechanism of Pb(II) at surface of silk fibroin protein-derived hybrid nanoflower adsorbent

Li, Xiang, Xiong, Yan, Duan, Ming, Wan, Haiqin, Li, Jun, Zhang, Can, Qin, Sha, Fang, Shenwen and Zhang, Run (2020). Investigation on the adsorption-interaction mechanism of Pb(II) at surface of silk fibroin protein-derived hybrid nanoflower adsorbent. Materials, 13 (5) 1241, 1241. doi: 10.3390/ma13051241

Investigation on the adsorption-interaction mechanism of Pb(II) at surface of silk fibroin protein-derived hybrid nanoflower adsorbent

2020

Journal Article

Red-emission probe for ratiometric fluorescent detection of bisulfite and its application in live animals and food samples

Zhou, Fang, Feng, Huan, Li, Haibo, Wang, Yue, Zhang, Zhiqiang, Kang, Wenjun, Jia, Hongmin, Yang, Xinyi, Meng, Qingtao and Zhang, Run (2020). Red-emission probe for ratiometric fluorescent detection of bisulfite and its application in live animals and food samples. ACS Omega, 5 (10) acsomega.0c00063, 5452-5459. doi: 10.1021/acsomega.0c00063

Red-emission probe for ratiometric fluorescent detection of bisulfite and its application in live animals and food samples

2020

Journal Article

A copper (II) ensemble-based fluorescence chemosensor and its application in the ‘Naked–Eye’ detection of biothiols in human urine

Wang, Yue, Feng, Huan, Li, Haibo, Yang, Xinyi, Jia, Hongmin, Kang, Wenjun, Meng, Qingtao, Zhang, Zhiqiang and Zhang, Run (2020). A copper (II) ensemble-based fluorescence chemosensor and its application in the ‘Naked–Eye’ detection of biothiols in human urine. Sensors, 20 (5) 1331, 1331. doi: 10.3390/s20051331

A copper (II) ensemble-based fluorescence chemosensor and its application in the ‘Naked–Eye’ detection of biothiols in human urine

2020

Journal Article

An artificial protein-probe hybrid as a responsive probe for ratiometric detection and imaging of hydrogen peroxide in cells

Zhang, Xing, Fu, Youxin, Qian, Guangren, Zhang, Run and Xu, Zhi Ping (2020). An artificial protein-probe hybrid as a responsive probe for ratiometric detection and imaging of hydrogen peroxide in cells. Journal of Materials Chemistry B, 8 (25), 5420-5424. doi: 10.1039/d0tb00856g

An artificial protein-probe hybrid as a responsive probe for ratiometric detection and imaging of hydrogen peroxide in cells

Funding

Current funding

  • 2020 - 2025
    Monitoring inflammation through quantitation of redox-mediated macrophage polarisation
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2018
    Paper-based sensing devices for quick and effective monitoring of red meat quality
    UQ Early Career Researcher
    Open grant
  • 2017 - 2019
    X-ray Induced Photoacoustic Nanoprobe: Break Depth Dependency of Bioimaging
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2017 - 2019
    Visualisation and early prediction of ROS-mediated treatment response in liver cancer by a novel nanoplatform
    NHMRC Project Grant
    Open grant

Supervision

Availability

Dr Run Zhang is:
Available for supervision

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Available projects

  • Responsive molecules and nanomaterials for bisoensing and bioimaging

  • Sensors for environmental pollutants and food quality & safety

  • Theranostic nanomaterials: especially the optical nanomaterials for diagnosis and therapy

Supervision history

Current supervision

  • Doctor Philosophy

    Activatable nanomaterials for cancer treatment

    Principal Advisor

    Other advisors: Dr Ruirui Qiao

  • Doctor Philosophy

    Development of responsive nanoprobe for enzyme analysis in inflammation

    Principal Advisor

  • Doctor Philosophy

    In-situ growth of layered two-dimensional nano-sonosensitisers for enhanced sonodynamic therapy

    Principal Advisor

  • Doctor Philosophy

    Sensitive Detection of Antibiotics with Nanoprobes

    Principal Advisor

    Other advisors: Professor Yasmina Sultanbawa

  • Doctor Philosophy

    Monitoring inflammation through quantitation of redox-mediated macrophage polarisation

    Principal Advisor

  • Doctor Philosophy

    Functional piezoelectric scaffolds for bone tissue regeneration

    Principal Advisor

  • Doctor Philosophy

    Responsive nanoprobe for redox biomolecules quantification

    Principal Advisor

  • Doctor Philosophy

    Sensitive Detection of Antibiotics with Nanoprobes

    Principal Advisor

    Other advisors: Professor Yasmina Sultanbawa

  • Doctor Philosophy

    Responsive probe for time-gated luminescence bioassay and imaging

    Principal Advisor

  • Doctor Philosophy

    The efficacy of nanoencapsulation as a delivery system of Terminalia ferdinandiana extract for periodontal disease therapy

    Associate Advisor

    Other advisors: Professor Yasmina Sultanbawa

  • Doctor Philosophy

    Precision Engineering Lipid Nanoparticles for Drug Delivery

    Associate Advisor

  • Doctor Philosophy

    Precision Engineering Lipid Nanoparticles for Drug Delivery

    Associate Advisor

  • Master Philosophy

    Development of cerium-containing layered double hydroxide nanoparticles as antioxidant for disease treatment

    Associate Advisor

  • Doctor Philosophy

    Thermo-triggered Release of Drug/Gene Carrier System by Lipid-Encapsulated Gold Nanoparticles for Tumour Therapy

    Associate Advisor

  • Doctor Philosophy

    Precision-engineered hybrid core-shell materials

    Associate Advisor

  • Doctor Philosophy

    Improving the Shelf-life of Salmon Fillets Using an Advanced Nanoencapsulation Technology

    Associate Advisor

    Other advisors: Dr Dharini Sivakumar, Professor Yasmina Sultanbawa

  • Doctor Philosophy

    Thermo-triggered Release of Drug/Gene Carrier System by Lipid-Encapsulated Gold Nanoparticles for Tumour Therapy

    Associate Advisor

  • Master Philosophy

    Bioinspired Piezoelectric Scaffolds for Bone Tissue Engineering

    Associate Advisor

  • Doctor Philosophy

    Upconversion-encoded microspheres for glucocorticoids detection as food hazards or health markers

    Associate Advisor

    Other advisors: Dr Kayvan Etebari, Dr Zeinab Khalil, Professor Yasmina Sultanbawa

Completed supervision

Media

Enquiries

Contact Dr Run Zhang directly for media enquiries about:

  • Biosensing and imaging
  • Cancer
  • Environmental pollution
  • Food safety
  • Inflammation
  • Optical probe
  • Redox biomolecules
  • Sensor
  • Stress resilience
  • Theranostic nanomaterials

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