
Overview
Background
- 2023-now Joint Senior Research Fellow, Centre for Nutrition and Food Sciences, The Queensland Alliance for Agriculture and Food Innovation (CNFS, QAAFI)
- 2022-now Senior Research Fellow, AIBN, The University of Queensland
- 2020-now NHMRC Emerging Leadership Fellow, AIBN, The University of Queensland
- 2017-2019 ARC DECRA Fellow, AIBN, The University of Queensland
- 2016-2017 Research Associate, AIBN, The University of Queensland
- 2013-2015 Macquarie University Research Fellow (MQRF), Department of Chemistry and Biomolecular Science (CBMS), Macquarie University
- 2012-2013 Postdoc Research Fellow, Department of Physics and Astronomy, Macquarie University
- July 2012 PhD, Analytical Chemistry, Dalian University of Technology (DLUT), China
Research Team: Dr Zhang is now leading more than 15 researchers, working on the development of responsive molecules/nanomaterials for biosensing and imaging, early disease detection and treatment, food/agricultural/environmental applications. He has collaborations with scientist in Chemistry, Materials Science, Molecular Biology and Biotechnology, Food and Agriculture Science, and Biophotonics from Australia, US, UK, Sweden, India, Russia and China.
Research Support: Since 2011, Dr Zhang has attracted 11 research grants (> 3 million) as chief investigator (lead CI and/or co-CI). These grants include 3 Fellowship (NHMRC Emerging Leadership, ARC DECRA and MQRF to develop responsive probes for redox biomarkers detection within body), 1 NHMRC Project grant in redox quantification in liver cancer chemotherapy, 1 UQ ECR grant, 1 NSFC grant, and another 3 grants from universities.
Research Output: Dr Zhang has published more than 180 research papers since his first publication in 2010 (>95 papers published as first and/or corresponding author), and 1 patent. He frequently publishes in a number of premier journals, such as Nature Photonics, Nature Plants, Journal of the American Chemical Society (JACS), Angewandte Chemie, Analytical Chemistry, Chemical Society Reviews, and Accounts of Chemical Research. These publications have received >9,000 citations with an H-index of 55. He has 8 Highly Cited Papers (7 in the ESI field of Chemistry-Analytical) and 3 Hot Articles.
Service: Dr Zhang is an Editor of TrAC Trends in Analytical Chemistry (Elsevier, 1/106 in Analytical Chemistry) and Methods (Elsevier), and Editorial Board Member of several international high impact journals, such as Chemistry-An Asian Journal (Wiley), Aggregate (Wiley), Journal of Pharmaceutical Analysis (Elsevier), Green Analytical Chemistry (Elsevier). He is a referee of ~80 international journals (2nd most contributions of all UQ researchers, with >20 awards from RSC and Elsevier journals), and grant assessor for more than 10 country and regions, such as Australia, UK, Europe, Netherland, New Zealand.
Award: Dr Zhang's national and international standing in the fields of chemistry (analytical and inorganic) and functional nanomaterials is evidenced by the awards of ACS Rising Star in Measurement Science, NJC Emerging Investigator, Biosensors Young Investigator Award, IAAM Scientist Medal, Vebleo Fellow, IAAM Fellow, ARC DECRA, NHMRC EL Fellow, MQRF, and more than 20 TOP Outstanding Reviewer awards from RSC and Elsevier. He has been a World's Top 2% Scientist in Chemistry (Analytical) and Nanoscience & Nanotechnology since 2022. He has delivered about 40 invited presentations and keynotes.
Teaching and Supervision: Dr Zhang has a strong commitment to training students. His students have received several awards, such as 4 "Dean’s Commendation for Outstanding Academic Performance", 1 "Dean’s Award for Excellence in Higher Degree Research", 1 "Dean's Award for Outstanding HDR Theses", ANFF-Q students award, 3MT Runner-UP and People's Choice. He has supervised 6 PhD and >20 Masters to completion. He is now co-coordinating and lecturing the MSE PP ENGY7112/7115/7114/7215 in School of Chem. Eng., EAIT. His teaching contributions in Faculty of Science, UQ are recognised by two nominations of "Dean’s Commendation for Excellent Teaching Awards" in semesters 1 and 2 in 2022.
Availability
- Dr Run Zhang is:
- Available for supervision
- Media expert
Qualifications
- Doctor of Philosophy of Engineering, Dalian University of Technology
Research interests
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Responsive probes to detect and visualise highly reactive biomolecules
design and synthesis of organic/organometallic complexes (including Ru(II) and Ir(III) complexes and lanthanide chelate) for sensing of bioactive ions, reactive oxygen species (ROS), reactive nitrogen species (RNS), redox biomolecules, gasotransmitters, amino acid, and proteins in various diseases, such as cancer, cardiovascular, and inflammatory diseases.
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Functional nanomaterial for early diseases diagnosis and treatment
engineering of functional nanomaterials for disease detection and treatment through monitoring and regulation of redox state, including photodynamic therapy (PDT), photothermal therapy (PTT), and sonodynamic therapy (SDT) for diseases deeply seated in body.
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Sensors for the detection of food quality & safety and environmental pollutants
development of ultra-sensitive sensors for the detection of food additives, antibiotics, pesticides, spoilage, heavy metals, toxic anions and gases (greenhouse gases and VOCs), etc.
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Bionanoprobes for deep tissue sensing and imaging
fabrication of responsive nanomaterials for sensing and imaging of biomarkers located deeply inside the body. The probes allow the monitoring of specific disease-related biomarkers through optical, acoustic, and magnetic resonance spectroscopy.
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Redox monitoring and regulation for diagnosis and treatment
development of novel luminescent probes with long emission lifetime to eliminate autofluorescence, allowing background-free quantification and bioimaging of redox species in situ development of responsive nanomaterials for treatment through quantitative redox regulation
Works
Search Professor Run Zhang’s works on UQ eSpace
2020
Journal Article
A hydrogen peroxide activatable nanoprobe for light-controlled “double-check” multi-colour fluorescence imaging
Zhang, Xing, Fu, Youxin, Liu, Jianping, Qian, Guangren, Zhang, Junji, Zhang, Run and Xu, Zhi Ping (2020). A hydrogen peroxide activatable nanoprobe for light-controlled “double-check” multi-colour fluorescence imaging. Nanoscale, 12 (44), 22527-22533. doi: 10.1039/d0nr04881j
2020
Conference Publication
Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes
Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058
2020
Journal Article
Responsive ruthenium complex probe for phosphorescence and time-gated luminescence detection of bisulfite
Zhang, Wenzhu, Xi, Xiuyan, Wang, Yong-Lei, Du, Zhongbo, Liu, Chaolong, Liu, Jianping, Song, Bo, Yuan, Jingli and Zhang, Run (2020). Responsive ruthenium complex probe for phosphorescence and time-gated luminescence detection of bisulfite. Dalton Transactions, 49 (17), 5531-5538. doi: 10.1039/c9dt04614c
2019
Journal Article
Insight into synergistic effect of adsorption-photocatalysis for the removal of organic dye pollutants by Cr doped ZnO
Chen, Jie, Xiong, Yan, Duan, Ming, Li, Xiang, Li, Jun, Fang, Shenwen, Qin, Sha and Zhang, Run (2019). Insight into synergistic effect of adsorption-photocatalysis for the removal of organic dye pollutants by Cr doped ZnO. Langmuir, 36 (2) acs.langmuir.9b02879, 520-533. doi: 10.1021/acs.langmuir.9b02879
2019
Journal Article
Responsive nanosensor for ratiometric luminescence detection of hydrogen sulfide in inflammatory cancer cells
Liu, Jianping, Duan, Chengchen, Zhang, Wenzhu, Ta, Hang Thu, Yuan, Jingli, Zhang, Run and Xu, Zhi Ping (2019). Responsive nanosensor for ratiometric luminescence detection of hydrogen sulfide in inflammatory cancer cells. Analytica Chimica Acta, 1103, 156-163. doi: 10.1016/j.aca.2019.12.056
2019
Journal Article
Investigating the use of layered double hydroxide nanoparticles as carriers of metal oxides for theranostics of ROS-related diseases
Liu, Yajun, Wu, Yuao, Zhang, Run, Lam, Jacinta, Ng, Jack C., Xu, Zhi Ping, Li, Li and Ta, Hang T. (2019). Investigating the use of layered double hydroxide nanoparticles as carriers of metal oxides for theranostics of ROS-related diseases. ACS Applied Bio Materials, 2 (12) acsabm.9b00852, 5930-5940. doi: 10.1021/acsabm.9b00852
2019
Journal Article
Insight into adsorption-interaction mechanism of Cr(VI) at silica adsorbent surface by evanescent wave measurement
Xiong, Yan, Chen, Jie, Duan, Ming, Li, Xiang, Li, Jun, Zhang, Can, Fang, Shenwen, Liu, Rui and Zhang, Run (2019). Insight into adsorption-interaction mechanism of Cr(VI) at silica adsorbent surface by evanescent wave measurement. Langmuir, 35 (45) acs.langmuir.9b01556, 14414-14427. doi: 10.1021/acs.langmuir.9b01556
2019
Journal Article
Remote light-responsive nanocarriers for controlled drug delivery: advances and perspectives
Zhao, Wei, Zhao, Yongmei, Wang, Qingfu, Liu, Tianqing, Sun, Jingjiang and Zhang, Run (2019). Remote light-responsive nanocarriers for controlled drug delivery: advances and perspectives. Small, 15 (45) 1903060, e1903060. doi: 10.1002/smll.201903060
2019
Journal Article
Nanoparticle‐based nanomedicines to promote cancer immunotherapy: recent advances and future directions
Liu, Jianping, Zhang, Run and Xu, Zhi Ping (2019). Nanoparticle‐based nanomedicines to promote cancer immunotherapy: recent advances and future directions. Small, 15 (32) 1900262, 1900262. doi: 10.1002/smll.201900262
2019
Journal Article
A folic acid-functionalized dual-emissive nanoprobe for “double-check” luminescence imaging of cancer cells
Liu, Chaolong, Liu, Jianping, Ma, Hua, Zhang, Wenzhu, Song, Bo, Guo, Lianying, Zhang, Run and Yuan, Jingli (2019). A folic acid-functionalized dual-emissive nanoprobe for “double-check” luminescence imaging of cancer cells. Methods, 168, 102-108. doi: 10.1016/j.ymeth.2019.07.001
2019
Journal Article
A redox-switchable colorimetric probe for “naked-eye” detection of hypochlorous acid and glutathione
Han, Qian, Zhou, Fang, Wang, Yue, Feng, Huan, Meng, Qingtao, Zhang, Zhiqiang and Zhang, Run (2019). A redox-switchable colorimetric probe for “naked-eye” detection of hypochlorous acid and glutathione. Molecules, 24 (13) 2455, 2455. doi: 10.3390/molecules24132455
2019
Journal Article
A highly specific fluorescent probe for rapid detection of hypochlorous acid in vivo and in water samples
Feng, Huan, Wang, Yue, Liu, Jianping, Zhang, Zhiqiang, Yang, Xinyi, Chen, Rong, Meng, Qingtao and Zhang, Run (2019). A highly specific fluorescent probe for rapid detection of hypochlorous acid in vivo and in water samples. Journal of Materials Chemistry B, 7 (24), 3909-3916. doi: 10.1039/c9tb00551j
2019
Journal Article
A new red-emitting fluorescence probe for rapid and effective visualization of bisulfite in food samples and live animals
Zhou, Fang, Sultanbawa, Yasmina, Feng, Huan, Wang, Yong-Lei, Meng, Qingtao, Wang, Yue, Zhang, Zhiqiang and Zhang, Run (2019). A new red-emitting fluorescence probe for rapid and effective visualization of bisulfite in food samples and live animals. Journal of Agricultural and Food Chemistry, 67 (15), 4375-4383. doi: 10.1021/acs.jafc.8b07110
2019
Journal Article
“Dual-key-and-lock” ruthenium complex probe for lysosomal formaldehyde in cancer cells and tumors
Liu, Chaolong, Zhang, Run, Zhang, Wenzhu, Liu, Jianping, Wang, Yong-Lei, Du, Zhongbo, Song, Bo, Xu, Zhi Ping and Yuan, Jingli (2019). “Dual-key-and-lock” ruthenium complex probe for lysosomal formaldehyde in cancer cells and tumors. Journal of the American Chemical Society, 141 (21) jacs.8b13898, 8462-8472. doi: 10.1021/jacs.8b13898
2019
Journal Article
A novel ruthenium-based molecular sensor to detect endothelial nitric oxide
Vidanapathirana, Achini K., Pullen, Benjamin J., Zhang, Run, Duong, MyNgan, Goyne, Jarrad M., Zhang, Xiaozhou, Bonder, Claudine S., Abell, Andrew D., Bursill, Christina A., Nicholls, Stephen J. and Psaltis, Peter J. (2019). A novel ruthenium-based molecular sensor to detect endothelial nitric oxide. Scientific Reports, 9 (1) 1720, 1720. doi: 10.1038/s41598-019-39123-3
2019
Journal Article
Methods for biosensing and imaging
Zhang, Run and Tan, Mingqian (2019). Methods for biosensing and imaging. Methods, 168, 1-2. doi: 10.1016/j.ymeth.2019.09.010
2018
Journal Article
Responsive upconversion nanoprobe for background‐free hypochlorous acid detection and bioimaging
Zhang, Run, Liang, Liuen, Meng, Qingtao, Zhao, Jiangbo, Ta, Hang T., Li, Li, Zhang, Zhiqiang, Sultanbawa, Yasmina and Xu, Zhi Ping (2018). Responsive upconversion nanoprobe for background‐free hypochlorous acid detection and bioimaging. Small, 15 (2) 1803712, e1803712. doi: 10.1002/smll.201803712
2018
Journal Article
Iridium(III) complex-based activatable probe for phosphorescent/time-gated luminescent sensing and imaging of cysteine in mitochondria of live cells and animals
Du, Zhongbo, Zhang, Run, Song, Bo, Zhang, Wenzhu, Wang, Yong-Lei, Liu, Jianping, Liu, Chaolong, Xu, Zhi Ping and Yuan, Jingli (2018). Iridium(III) complex-based activatable probe for phosphorescent/time-gated luminescent sensing and imaging of cysteine in mitochondria of live cells and animals. Chemistry: A European Journal, 25 (6), 1365-1365. doi: 10.1002/chem.201805079
2018
Journal Article
Turn-on fluorescence probe for nitric oxide detection and bioimaging in live cells and zebrafish
Han, Qian, Liu, Jianping, Meng, Qingtao, Wang, Yong-Lei, Feng, Huan, Zhang, Zhiqiang, Xu, Zhi Ping and Zhang, Run (2018). Turn-on fluorescence probe for nitric oxide detection and bioimaging in live cells and zebrafish. ACS Sensors, 4 (2) acssensors.8b00776, 309-316. doi: 10.1021/acssensors.8b00776
2018
Journal Article
Bio-distribution and interaction with dopamine of fluorescent nanodots from roasted chicken
Song, Xunyu, Wang, Haitao, Zhang, Run, Yu, Chenxu and Tan, Mingqian (2018). Bio-distribution and interaction with dopamine of fluorescent nanodots from roasted chicken. Food and Function, 9 (12), 6227-6235. doi: 10.1039/c8fo01159a
Supervision
Availability
- Dr Run Zhang is:
- Available for supervision
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Available projects
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Responsive molecules and nanomaterials for bisoensing and bioimaging
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Sensors for environmental pollutants and food quality & safety
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Theranostic nanomaterials: especially the optical nanomaterials for diagnosis and therapy
Supervision history
Current supervision
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Doctor Philosophy
Activatable nanomaterials for cancer treatment
Principal Advisor
Other advisors: Dr Ruirui Qiao
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Doctor Philosophy
Development of responsive nanoprobe for enzyme analysis in inflammation
Principal Advisor
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Doctor Philosophy
In-situ growth of layered two-dimensional nano-sonosensitisers for enhanced sonodynamic therapy
Principal Advisor
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Doctor Philosophy
Sensitive Detection of Antibiotics with Nanoprobes
Principal Advisor
Other advisors: Professor Yasmina Sultanbawa
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Doctor Philosophy
Monitoring inflammation through quantitation of redox-mediated macrophage polarisation
Principal Advisor
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Doctor Philosophy
Functional piezoelectric scaffolds for bone tissue regeneration
Principal Advisor
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Doctor Philosophy
Responsive nanoprobe for redox biomolecules quantification
Principal Advisor
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Doctor Philosophy
Sensitive Detection of Antibiotics with Nanoprobes
Principal Advisor
Other advisors: Professor Yasmina Sultanbawa
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Doctor Philosophy
Responsive probe for time-gated luminescence bioassay and imaging
Principal Advisor
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Doctor Philosophy
The efficacy of nanoencapsulation as a delivery system of Terminalia ferdinandiana extract for periodontal disease therapy
Associate Advisor
Other advisors: Professor Yasmina Sultanbawa
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Doctor Philosophy
Precision Engineering Lipid Nanoparticles for Drug Delivery
Associate Advisor
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Doctor Philosophy
Precision Engineering Lipid Nanoparticles for Drug Delivery
Associate Advisor
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Master Philosophy
Development of cerium-containing layered double hydroxide nanoparticles as antioxidant for disease treatment
Associate Advisor
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Doctor Philosophy
Thermo-triggered Release of Drug/Gene Carrier System by Lipid-Encapsulated Gold Nanoparticles for Tumour Therapy
Associate Advisor
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Doctor Philosophy
Precision-engineered hybrid core-shell materials
Associate Advisor
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Doctor Philosophy
Improving the Shelf-life of Salmon Fillets Using an Advanced Nanoencapsulation Technology
Associate Advisor
Other advisors: Dr Dharini Sivakumar, Professor Yasmina Sultanbawa
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Doctor Philosophy
Thermo-triggered Release of Drug/Gene Carrier System by Lipid-Encapsulated Gold Nanoparticles for Tumour Therapy
Associate Advisor
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Master Philosophy
Bioinspired Piezoelectric Scaffolds for Bone Tissue Engineering
Associate Advisor
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Doctor Philosophy
Upconversion-encoded microspheres for glucocorticoids detection as food hazards or health markers
Associate Advisor
Other advisors: Dr Kayvan Etebari, Dr Zeinab Khalil, Professor Yasmina Sultanbawa
Completed supervision
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2025
Doctor Philosophy
Precision Engineering Lipid Nanoparticles for Drug Delivery
Associate Advisor
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2024
Master Philosophy
Development of cerium-containing layered double hydroxide nanoparticles as antioxidants for disease treatment
Associate Advisor
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2023
Doctor Philosophy
Developing efficient nanoparticle-based platform to deliver biomolecules for plant modification
Associate Advisor
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2022
Doctor Philosophy
Development of Lipid-Coated Upconversion Nanoparticle as a Responsive Therapeutic Gas Release Nanoplatform for Cancer Therapy
Associate Advisor
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2022
Doctor Philosophy
Layered double hydroxide nanoparticles tailored to target tumor microenvironment as multifunctional nanoplatforms for synergistic cancer therapy
Associate Advisor
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2021
Doctor Philosophy
Development of theranostic nanomaterials based on iron oxide and cerium oxide for ROS-related and inflammatory diseases
Associate Advisor
Other advisors: Professor Andrew Whittaker
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2021
Doctor Philosophy
Novel Cu-LDH-based nanomedicine for combination cancer therapy
Associate Advisor
Media
Enquiries
Contact Dr Run Zhang directly for media enquiries about:
- Biosensing and imaging
- Cancer
- Environmental pollution
- Food safety
- Inflammation
- Optical probe
- Redox biomolecules
- Sensor
- Stress resilience
- Theranostic nanomaterials
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