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Dr Run Zhang
Dr

Run Zhang

Email: 
Phone: 
+61 7 334 63806

Overview

Background

  • 2023-now Joint Senior Research Fellow, Centre for Nutrition and Food Sciences, The Queensland Alliance for Agriculture and Food Innovation (CNFS, QAAFI)
  • 2022-now Senior Research Fellow, AIBN, The University of Queensland
  • 2020-now NHMRC Emerging Leadership Fellow, AIBN, The University of Queensland
  • 2017-2019 ARC DECRA Fellow, AIBN, The University of Queensland
  • 2016-2017 Research Associate, AIBN, The University of Queensland
  • 2013-2015 Macquarie University Research Fellow (MQRF), Department of Chemistry and Biomolecular Science (CBMS), Macquarie University
  • 2012-2013 Postdoc Research Fellow, Department of Physics and Astronomy, Macquarie University
  • July 2012 PhD, Analytical Chemistry, Dalian University of Technology (DLUT), China

Research Team: Dr Zhang is now leading more than 15 researchers, working on the development of responsive molecules/nanomaterials for biosensing and imaging, early disease detection and treatment, food/agricultural/environmental applications. He has collaborations with scientist in Chemistry, Materials Science, Molecular Biology and Biotechnology, Food and Agriculture Science, and Biophotonics from Australia, US, UK, Sweden, India, Russia and China.

Research Support: Since 2011, Dr Zhang has attracted 12 research grants (> 4 million) as chief investigator (lead CI and/or co-CI). These grants include 3 Fellowship (NHMRC Emerging Leadership, ARC DECRA and MQRF to develop responsive probes for redox biomarkers detection within body), 1 NHMRC Project grant in redox quantification in liver cancer chemotherapy, 1 UQ ECR grant, 1 NSFC grant, and another 3 grants from universities.

Research Output: Dr Zhang has published more than 190 research papers since his first publication in 2010 (>100 papers published as first and/or corresponding author), and 1 patent. He frequently publishes in a number of premier journals, such as Nature Photonics, Nature Plants, Journal of the American Chemical Society (JACS), Angewandte Chemie, Analytical Chemistry, Chemical Society Reviews, and Accounts of Chemical Research. These publications have received ~10,000 citations with an H-index of 57. He has 8 Highly Cited Papers (7 in the ESI field of Chemistry-Analytical) and 3 Hot Articles.

Service: Dr Zhang is an Editor of TrAC Trends in Analytical Chemistry (Elsevier, 1/106 in Analytical Chemistry) and Methods (Elsevier, 7/85 in Biochemical Research), and Editorial Board Member of several international high impact journals, such as Chemistry-An Asian Journal (Wiley), Aggregate (Wiley), Journal of Pharmaceutical Analysis (Elsevier), Green Analytical Chemistry (Elsevier). He is a referee of ~80 international journals (2nd most contributions of all UQ researchers, with >20 awards from RSC and Elsevier journals), and grant assessor for more than 10 country and regions, such as Australia, UK, Europe, Netherland, New Zealand.

Award: Dr Zhang's national and international standing in the fields of chemistry (analytical and inorganic) and functional nanomaterials is evidenced by the awards of ACS Rising Star in Measurement Science, NJC Emerging Investigator, Biosensors Young Investigator Award, IAAM Scientist Medal, Vebleo Fellow, IAAM Fellow, ARC DECRA, NHMRC EL Fellow, MQRF, and more than 20 TOP Outstanding Reviewer awards from RSC and Elsevier. He has been a World's Top 2% Scientist in Chemistry (Analytical) and Nanoscience & Nanotechnology since 2022 by Stanford/Elsevier World’s Top 2% Scientist Ranking, and top 0.5% of all scholars worldwide for excellence in research productivity, impact and quality by ScholarGPS Ranking (ranked #183 Globally in Biomedical Engineering). He has delivered 40+ invited presentations and keynotes.

Teaching and Supervision: Dr Zhang has a strong commitment to training students. His students have received several awards, such as 4 "Dean’s Commendation for Outstanding Academic Performance", 1 "Dean’s Award for Excellence in Higher Degree Research", 1 "Dean's Award for Outstanding HDR Theses", ANFF-Q students award, 3MT Runner-UP and People's Choice. He has supervised 6 PhD and >20 Masters to completion. He is now co-coordinating and lecturing the MSE PP ENGY7112/7115/7114/7215 in School of Chem. Eng., EAIT. His teaching contributions in Faculty of Science, UQ are recognised by two nominations of "Dean’s Commendation for Excellent Teaching Awards" in semesters 1 and 2 in 2022.

Availability

Dr Run Zhang is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy of Engineering, Dalian University of Technology

Research interests

  • Responsive probes to detect and visualise highly reactive biomolecules

    design and synthesis of organic/organometallic complexes (including Ru(II) and Ir(III) complexes and lanthanide chelate) for sensing of bioactive ions, reactive oxygen species (ROS), reactive nitrogen species (RNS), redox biomolecules, gasotransmitters, amino acid, and proteins in various diseases, such as cancer, cardiovascular, and inflammatory diseases.

  • Functional nanomaterial for early diseases diagnosis and treatment

    engineering of functional nanomaterials for disease detection and treatment through monitoring and regulation of redox state, including photodynamic therapy (PDT), photothermal therapy (PTT), and sonodynamic therapy (SDT) for diseases deeply seated in body.

  • Sensors for the detection of food quality & safety and environmental pollutants

    development of ultra-sensitive sensors for the detection of food additives, antibiotics, pesticides, spoilage, heavy metals, toxic anions and gases (greenhouse gases and VOCs), etc.

  • Bionanoprobes for deep tissue sensing and imaging

    fabrication of responsive nanomaterials for sensing and imaging of biomarkers located deeply inside the body. The probes allow the monitoring of specific disease-related biomarkers through optical, acoustic, and magnetic resonance spectroscopy.

  • Redox monitoring and regulation for diagnosis and treatment

    development of novel luminescent probes with long emission lifetime to eliminate autofluorescence, allowing background-free quantification and bioimaging of redox species in situ development of responsive nanomaterials for treatment through quantitative redox regulation

Works

Search Professor Run Zhang’s works on UQ eSpace

198 works between 2010 and 2025

61 - 80 of 198 works

2022

Journal Article

Clay nanoparticles efficiently deliver small interfering RNA to intact plant leaf cells

Yong, Jiaxi, Wu, Miaomiao, Zhang, Run, Bi, Shengnan, Mann, Christopher W. G., Mitter, Neena, Carroll, Bernard J. and Xu, Zhi Ping (2022). Clay nanoparticles efficiently deliver small interfering RNA to intact plant leaf cells. Plant Physiology, 190 (4), 2187-2202. doi: 10.1093/plphys/kiac430

Clay nanoparticles efficiently deliver small interfering RNA to intact plant leaf cells

2022

Journal Article

Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy

Wu, Miaomiao, Niu, Xueming, Zhang, Run and Xu, Zhi Ping (2022). Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy. Advanced Drug Delivery Reviews, 187 114360, 1. doi: 10.1016/j.addr.2022.114360

Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy

2022

Journal Article

Biological sensing of nitric oxide in macrophages and atherosclerosis using a ruthenium-based sensor

Vidanapathirana, Achini K., Goyne, Jarrad M., Williamson, Anna E., Pullen, Benjamin J., Chhay, Pich, Sandeman, Lauren, Bensalem, Julien, Sargeant, Timothy J., Grose, Randall, Crabtree, Mark J., Zhang, Run, Nicholls, Stephen J., Psaltis, Peter J. and Bursill, Christina A. (2022). Biological sensing of nitric oxide in macrophages and atherosclerosis using a ruthenium-based sensor. Biomedicines, 10 (8) 1807, 1-19. doi: 10.3390/biomedicines10081807

Biological sensing of nitric oxide in macrophages and atherosclerosis using a ruthenium-based sensor

2022

Book Chapter

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

Wu, Miaomiao, Zhang, Zexi, Yong, Jiaxi, Schenk, Peer M., Tian, Dihua, Xu, Zhi Ping and Zhang, Run (2022). Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors. Metal Ligand Chromophores for Bioassays. (pp. 199-243) Cham, Switzerland: Springer. doi: 10.1007/978-3-031-19863-2_6

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

2022

Journal Article

Determination and imaging of small biomolecules and ions using Ruthenium(II) complex-based chemosensors

Wu, Miaomiao, Zhang, Zexi, Yong, Jiaxi, Schenk, Peer M., Tian, Dihua, Xu, Zhi Ping and Zhang, Run (2022). Determination and imaging of small biomolecules and ions using Ruthenium(II) complex-based chemosensors. Topics in Current Chemistry, 380 (5) 29, 29. doi: 10.1007/s41061-022-00392-8

Determination and imaging of small biomolecules and ions using Ruthenium(II) complex-based chemosensors

2022

Journal Article

Development of a fluorescein modified ruthenium(II) complex probe for lysosome-targeted ratiometric luminescence detection and imaging of peroxynitrite in living cells

Ren, Junyu, Du, Zhongbo, Zhang, Wenzhu, Zhang, Run, Song, Bo and Yuan, Jingli (2022). Development of a fluorescein modified ruthenium(II) complex probe for lysosome-targeted ratiometric luminescence detection and imaging of peroxynitrite in living cells. Analytica Chimica Acta, 1205 339784, 1-8. doi: 10.1016/j.aca.2022.339784

Development of a fluorescein modified ruthenium(II) complex probe for lysosome-targeted ratiometric luminescence detection and imaging of peroxynitrite in living cells

2022

Journal Article

Responsive gadolinium(III) complex-based small molecule magnetic resonance imaging probes: design, mechanism and application

Meng, Qingtao, Wu, Miaomiao, Shang, Zhuye, Zhang, Zhiqiang and Zhang, Run (2022). Responsive gadolinium(III) complex-based small molecule magnetic resonance imaging probes: design, mechanism and application. Coordination Chemistry Reviews, 457 214398, 214398. doi: 10.1016/j.ccr.2021.214398

Responsive gadolinium(III) complex-based small molecule magnetic resonance imaging probes: design, mechanism and application

2022

Journal Article

Ruthenium(II) complex-based long-lived two-photon luminescence probe for dynamic monitoring of glutathione S-transferases in mouse models of drug-induced liver injury

Liu, Chaolong, Zhang, Wenzhu, Zhang, Run, Gao, Xiaona, Song, Bo and Yuan, Jingli (2022). Ruthenium(II) complex-based long-lived two-photon luminescence probe for dynamic monitoring of glutathione S-transferases in mouse models of drug-induced liver injury. Sensors and Actuators B: Chemical, 357 131440, 131440. doi: 10.1016/j.snb.2022.131440

Ruthenium(II) complex-based long-lived two-photon luminescence probe for dynamic monitoring of glutathione S-transferases in mouse models of drug-induced liver injury

2022

Journal Article

Fluorescence detection and imaging of intracellular sulphite using a remote light activatable photochromic nanoprobe

Fu, Youxin, Zhang, Xing, Liu, Jianping, Qian, Guangren, Xu, Zhi Ping and Zhang, Run (2022). Fluorescence detection and imaging of intracellular sulphite using a remote light activatable photochromic nanoprobe. Journal of Materials Chemistry B, 10 (17), 3366-3374. doi: 10.1039/d2tb00021k

Fluorescence detection and imaging of intracellular sulphite using a remote light activatable photochromic nanoprobe

2022

Journal Article

A red-emission fluorescence probe based on 1,4-addition reaction mechanism for the detection of biothiols in vitro and in vivo

Hu, Yaoyun, Shang, Zhuye, Gu, Pengli, He, Guangjie, Zhang, Run, Meng, Qingtao and Zhang, Zhiqiang (2022). A red-emission fluorescence probe based on 1,4-addition reaction mechanism for the detection of biothiols in vitro and in vivo. Analytical Sciences, 38 (3), 505-514. doi: 10.2116/analsci.21P177

A red-emission fluorescence probe based on 1,4-addition reaction mechanism for the detection of biothiols in vitro and in vivo

2022

Journal Article

A near-infrared fluorescence probe for the detection of bisulfite in vivo and food samples

Shang, Zhuye, Liu, Jianhua, Hu, Zhizhi, Meng, Qingtao, Wang, Yue, Zhang, Run and Zhang, Zhiqiang (2022). A near-infrared fluorescence probe for the detection of bisulfite in vivo and food samples. Dyes and Pigments, 200 110119, 110119. doi: 10.1016/j.dyepig.2022.110119

A near-infrared fluorescence probe for the detection of bisulfite in vivo and food samples

2022

Journal Article

Sequential detection of hypochlorous acid and sulfur dioxide derivatives by a red-emitting fluorescent probe and bioimaging applications in vitro and in vivo

Liu, Jianhua, Yin, Haoyuan, Shang, Zhuye, Gu, Pengli, He, Guangjie, Meng, Qingtao, Zhang, Run and Zhang, Zhiqiang (2022). Sequential detection of hypochlorous acid and sulfur dioxide derivatives by a red-emitting fluorescent probe and bioimaging applications in vitro and in vivo. RSC Advances, 12 (25), 15861-15869. doi: 10.1039/d2ra01048h

Sequential detection of hypochlorous acid and sulfur dioxide derivatives by a red-emitting fluorescent probe and bioimaging applications in vitro and in vivo

2021

Journal Article

Engineering chitosan nano-cocktail containing iron oxide and ceria: a two-in-one approach for treatment of inflammatory diseases and tracking of material delivery

Wu, Yuao, Cowin, Gary, Moonshi, Shehzahdi S., Tran, Huong D. N., Fithri, Najma Annuria, Whittaker, Andrew K., Zhang, Run and Ta, Hang T. (2021). Engineering chitosan nano-cocktail containing iron oxide and ceria: a two-in-one approach for treatment of inflammatory diseases and tracking of material delivery. Materials Science and Engineering C, 131 112477, 1-15. doi: 10.1016/j.msec.2021.112477

Engineering chitosan nano-cocktail containing iron oxide and ceria: a two-in-one approach for treatment of inflammatory diseases and tracking of material delivery

2021

Journal Article

A novel fluorescence probe for the reversible detection of bisulfite and hydrogen peroxide pair in vitro and in vivo

Wang, Yue, Zhou, Fang, Meng, Qingtao, Zhang, Songhe, Jia, Hongmin, Wang, Cuiping, Zhang, Run and Zhang, Zhiqiang (2021). A novel fluorescence probe for the reversible detection of bisulfite and hydrogen peroxide pair in vitro and in vivo. Chemistry: An Asian Journal, 16 (21), 3419-3426. doi: 10.1002/asia.202100926

A novel fluorescence probe for the reversible detection of bisulfite and hydrogen peroxide pair in vitro and in vivo

2021

Journal Article

Quinoline-based fluorescent probe for the detection and monitoring of hypochlorous acid in a rheumatoid arthritis model

Yang, Xinyi, Wang, Yue, Shang, Zhuye, Zhang, Zexi, Chi, Haijun, Zhang, Zhiqiang, Zhang, Run and Meng, Qingtao (2021). Quinoline-based fluorescent probe for the detection and monitoring of hypochlorous acid in a rheumatoid arthritis model. RSC Advances, 11 (50), 31656-31662. doi: 10.1039/d1ra06224g

Quinoline-based fluorescent probe for the detection and monitoring of hypochlorous acid in a rheumatoid arthritis model

2021

Journal Article

A reversible near-infrared fluorescence probe for the monitoring of HSO3−/H2O2-regulated cycles in vivo

Song, Qiuying, Zhou, Bo, Zhang, Dongyu, Chi, Haijun, Jia, Hongmin, Zhu, Peixun, Zhang, Zhiqiang, Meng, Qingtao and Zhang, Run (2021). A reversible near-infrared fluorescence probe for the monitoring of HSO3−/H2O2-regulated cycles in vivo. New Journal of Chemistry, 45 (40), 19011-19018. doi: 10.1039/d1nj03507j

A reversible near-infrared fluorescence probe for the monitoring of HSO3−/H2O2-regulated cycles in vivo

2021

Journal Article

Facile synthesis of nitrogen-defective g-C3N4 for superior photocatalytic degradation of rhodamine B

Yang, Xiupei, Zhang, Lin, Wang, Dan, Zhang, Qian, Zeng, Jie and Zhang, Run (2021). Facile synthesis of nitrogen-defective g-C3N4 for superior photocatalytic degradation of rhodamine B. RSC Advances, 11 (49), 30503-30509. doi: 10.1039/d1ra05535f

Facile synthesis of nitrogen-defective g-C3N4 for superior photocatalytic degradation of rhodamine B

2021

Journal Article

Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy

Opoku-Damoah, Yaw, Zhang, Run, Ta, Hang T. and Xu, Zhi Ping (2021). Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy. Biomaterials Science, 9 (18), 6086-6097. doi: 10.1039/d1bm00941a

Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy

2021

Journal Article

Heat/pH-boosted release of 5-fluorouracil and albumin-bound paclitaxel from Cu-doped layered double hydroxide nanomedicine for synergistical chemo-photo-therapy of breast cancer

Liu, Jianping, Liu, Kai, Zhang, Liming, Zhong, Ming, Hong, Tingliang, Zhang, Run, Gao, Yufan, Li, Rui, Xu, Tiefeng and Xu, Zhi Ping (2021). Heat/pH-boosted release of 5-fluorouracil and albumin-bound paclitaxel from Cu-doped layered double hydroxide nanomedicine for synergistical chemo-photo-therapy of breast cancer. Journal of Controlled Release, 335, 49-58. doi: 10.1016/j.jconrel.2021.05.011

Heat/pH-boosted release of 5-fluorouracil and albumin-bound paclitaxel from Cu-doped layered double hydroxide nanomedicine for synergistical chemo-photo-therapy of breast cancer

2021

Journal Article

Sheet-like clay nanoparticles deliver RNA into developing pollen to efficiently silence a target gene

Yong, Jiaxi, Zhang, Run, Bi, Shengnan, Li, Peng, Sun, Luyao, Mitter, Neena, Carroll, Bernard J and Xu, Zhi Ping (2021). Sheet-like clay nanoparticles deliver RNA into developing pollen to efficiently silence a target gene. Plant Physiology, 187 (2), 1-14. doi: 10.1093/plphys/kiab303

Sheet-like clay nanoparticles deliver RNA into developing pollen to efficiently silence a target gene

Funding

Current funding

  • 2020 - 2025
    Monitoring inflammation through quantitation of redox-mediated macrophage polarisation
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2018
    Paper-based sensing devices for quick and effective monitoring of red meat quality
    UQ Early Career Researcher
    Open grant
  • 2017 - 2019
    X-ray Induced Photoacoustic Nanoprobe: Break Depth Dependency of Bioimaging
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2017 - 2019
    Visualisation and early prediction of ROS-mediated treatment response in liver cancer by a novel nanoplatform
    NHMRC Project Grant
    Open grant

Supervision

Availability

Dr Run Zhang is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Responsive molecules and nanomaterials for bisoensing and bioimaging

  • Sensors for environmental pollutants and food quality & safety

  • Theranostic nanomaterials: especially the optical nanomaterials for diagnosis and therapy

Supervision history

Current supervision

  • Doctor Philosophy

    Activatable nanomaterials for cancer treatment

    Principal Advisor

    Other advisors: Dr Ruirui Qiao

  • Doctor Philosophy

    Sensitive Detection of Antibiotics with Nanoprobes

    Principal Advisor

    Other advisors: Professor Yasmina Sultanbawa

  • Doctor Philosophy

    Development of responsive nanoprobe for enzyme analysis in inflammation

    Principal Advisor

  • Doctor Philosophy

    Responsive nanoprobe for redox biomolecules quantification

    Principal Advisor

  • Doctor Philosophy

    Responsive probe for time-gated luminescence bioassay and imaging

    Principal Advisor

    Other advisors: Dr Jiaxi Yong

  • Doctor Philosophy

    Functional piezoelectric scaffolds for bone tissue regeneration

    Principal Advisor

    Other advisors: Dr Li Li

  • Doctor Philosophy

    New Strategies in Targeted Proteolysis with Nanoparticle-Mediated mRNA Delivery

    Associate Advisor

    Other advisors: Dr Li Li

  • Doctor Philosophy

    Improving the Shelf-life of Salmon Fillets Using an Advanced Nanoencapsulation Technology

    Associate Advisor

    Other advisors: Dr Dharini Sivakumar, Professor Yasmina Sultanbawa

  • Doctor Philosophy

    The efficacy of nanoencapsulation as a delivery system of Terminalia ferdinandiana extract for periodontal disease therapy

    Associate Advisor

    Other advisors: Professor Yasmina Sultanbawa

  • Doctor Philosophy

    Optimization and Characterization of Seaweed Bioactive Materials for Encapsulation and Valorization of Seaweed based products

    Associate Advisor

    Other advisors: Professor Yasmina Sultanbawa, Dr Dharini Sivakumar

  • Doctor Philosophy

    Upconversion-encoded microspheres for glucocorticoids detection as food hazards or health markers

    Associate Advisor

    Other advisors: Dr Kayvan Etebari, Dr Zeinab Khalil, Professor Yasmina Sultanbawa

Completed supervision

Media

Enquiries

Contact Dr Run Zhang directly for media enquiries about:

  • Biosensing and imaging
  • Cancer
  • Environmental pollution
  • Food safety
  • Inflammation
  • Optical probe
  • Redox biomolecules
  • Sensor
  • Stress resilience
  • Theranostic nanomaterials

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