Overview
Background
Dr Karan Gulati is a Research Group Leader and the Deputy Director of Research at the School of Dentistry, UQ. He is also the Deputy Director of Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3) at UQ Dentistry.
Dr Gulati is a pioneer in electrochemically nano-engineered dental implants with over 13 years of extensive research experience using nano-engineering towards various bioactive and therapeutic applications. Dr Gulati completed his PhD from the University of Adelaide (Australia) in 2015 and was awarded the Dean’s Commendation for Doctoral Thesis Excellence. His career has been supported by prestigious fellowships from NHMRC (National Health and Medical Research Council, Australia), JSPS (Japan Society for the Promotion of Science, Japan), Erasmus+ (Germany) and the University of Queensland. At 8 years post-PhD, Dr Gulati has edited 3 books, published 7 chapters and >72 publications (h-index 35), and presented >110 times in various reputed conferences.
Availability
- Dr Karan Gulati is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, University of Adelaide
Research impacts
The trans-mucosal nature of dental implants presents a unique challenge from a biomaterial perspective, requiring rapid establishment and maintenance of osseointegration in the alveolar bone of varying quantity and quality and the formation of resilient, soft tissue integration. Key challenges in achieving long-term dental implant success include sub-optimal osseointegration, soft-tissue integration, immunomodulation and onset of bacterial infection.
Dental implant surfaces have been enhanced via mechanical, chemical, and biological modifications to manage the complex therapeutic requirements of the dental microenvironment. Among these, nanotubes (NTs) or nanopores (NPs) engineered on implant surfaces (Ti, Zr, NiTi, Ti64 alloys, dental/orthopaedic/craniofacial implants) using electrochemical anodisation present considerable therapeutic potential due to several favourable properties, including enhanced integration, tailorable drug loading/release and mechano-transduction.
Dr. Gulati’s research group GATORs (Group for Anodized Therapies for Osseointegration, Regeneration and Stimulation) focus on the developments and challenges associated with nano-engineered implants, focusing on generating tailorable devices that can address the unique challenges related to biomedical implants.
Works
Search Professor Karan Gulati’s works on UQ eSpace
2018
Conference Publication
Quality by Design towards Standardization of 3D Printed Bone Implants and scaffolds for Industry Translation
Martinez-Marquez, Daniel, Gulati, Karan, Mirnajafizadeh, Ali, Carty, Christopher P., Stewart, Rodney and Ivanovski, Saso (2018). Quality by Design towards Standardization of 3D Printed Bone Implants and scaffolds for Industry Translation. 4th World Congress on Electrical Engineering and Computer Systems and Science, Madrid, Spain, August 21 – 23 2018. Avestia Publishing. doi: 10.11159/icbes18.124
2017
Journal Article
Anodized 3D-printed titanium implants with dual micro- and nano-scale topography promote interaction with human osteoblasts and osteocyte-like cells
Gulati, Karan, Prideaux, Matthew, Kogawa, Masakazu, Lima-Marques, Luis, Atkins, Gerald J., Findlay, David M. and Losic, Dusan (2017). Anodized 3D-printed titanium implants with dual micro- and nano-scale topography promote interaction with human osteoblasts and osteocyte-like cells. Journal of Tissue Engineering and Regenerative Medicine, 11 (12), 3313-3325. doi: 10.1002/term.2239
2017
Journal Article
Estimation of anisotropic permeability in trabecular bone based on microCT imaging and pore-scale fluid dynamics simulations
Daish, C., Blanchard, R., Gulati, K., Losic, D., Findlay, D., Harvie, D. J.E. and Pivonka, P. (2017). Estimation of anisotropic permeability in trabecular bone based on microCT imaging and pore-scale fluid dynamics simulations. Bone Reports, 6, 129-139. doi: 10.1016/j.bonr.2016.12.002
2017
Journal Article
Dental implants modified with drug releasing titania nanotubes: therapeutic potential and developmental challenges
Gulati, Karan and Ivanovski, Saso (2017). Dental implants modified with drug releasing titania nanotubes: therapeutic potential and developmental challenges. Expert Opinion On Drug Delivery, 14 (8), 1009-1024. doi: 10.1080/17425247.2017.1266332
2016
Journal Article
Drug-releasing nano-engineered titanium implants: therapeutic efficacy in 3D cell culture model, controlled release and stability
Gulati, Karan, Kogawa, Masakazu, Prideaux, Matthew, Findlay, David M., Atkins, Gerald J. and Losic, Dusan (2016). Drug-releasing nano-engineered titanium implants: therapeutic efficacy in 3D cell culture model, controlled release and stability. Materials Science and Engineering C: Materials for Biological Applications, 69, 831-840. doi: 10.1016/j.msec.2016.07.047
2016
Journal Article
Titanium wire implants with nanotube arrays: A study model for localized cancer treatment
Kaur, Gagandeep, Willsmore, Tamsyn, Gulati, Karan, Zinonos, Irene, Wang, Ye, Kurian, Mima, Hay, Shelley, Losic, Dusan and Evdokiou, Andreas (2016). Titanium wire implants with nanotube arrays: A study model for localized cancer treatment. Biomaterials, 101, 176-188. doi: 10.1016/j.biomaterials.2016.05.048
2016
Journal Article
Titania nanotubes for orchestrating osteogenesis at the bone-implant interface
Gulati, Karan, Maher, Shaheer, Findlay, David M. and Losic, Dusan (2016). Titania nanotubes for orchestrating osteogenesis at the bone-implant interface. Nanomedicine, 11 (14), 1847-1864. doi: 10.2217/nnm-2016-0169
2016
Journal Article
In situ transformation of chitosan films into microtubular structures on the surface of nanoengineered titanium implants
Gulati, Karan, Johnson, Lucas, Karunagaran, Ramesh, Findlay, David and Losic, Dusan (2016). In situ transformation of chitosan films into microtubular structures on the surface of nanoengineered titanium implants. Biomacromolecules, 17 (4), 1261-1271. doi: 10.1021/acs.biomac.5b01037
2016
Journal Article
Drug diffusion, integration, and stability of nanoengineered drug-releasing implants in bone ex-vivo
Rahman, Shafiur, Gulati, Karan, Kogawa, Masakazu, Atkins, Gerald J., Pivonka, Peter, Findlay, David M. and Losic, Dusan (2016). Drug diffusion, integration, and stability of nanoengineered drug-releasing implants in bone ex-vivo. Journal of Biomedical Materials Research Part A, 104 (3), 714-725. doi: 10.1002/jbm.a.35595
2016
Journal Article
Conversion of titania (TiO2) into conductive titanium (Ti) nanotube arrays for combined drug-delivery and electrical stimulation therapy
Gulati, Karan, Maher, Shaheer, Chandrasekaran, Soundarrajan, Findlay, David M. and Losic, Dusan (2016). Conversion of titania (TiO2) into conductive titanium (Ti) nanotube arrays for combined drug-delivery and electrical stimulation therapy. Journal of Materials Chemistry B, 4 (3), 371-375. doi: 10.1039/c5tb02108a
2015
Journal Article
Synthesis of Carbon Nanotube-Nanotubular Titania Composites by Catalyst-Free CVD Process: Insights into the Formation Mechanism and Photocatalytic Properties
Alsawat, Mohammed, Altalhi, Tariq, Gulati, Karan, Santos, Abel and Losic, Dusan (2015). Synthesis of Carbon Nanotube-Nanotubular Titania Composites by Catalyst-Free CVD Process: Insights into the Formation Mechanism and Photocatalytic Properties. ACS Applied Materials and Interfaces, 7 (51), 28361-28368. doi: 10.1021/acsami.5b08956
2015
Journal Article
Localized drug delivery of selenium (Se) using nanoporous anodic aluminium oxide for bone implants
Saji, Viswanathan S., Kumeria, Tushar, Gulati, Karan, Prideaux, Matthew, Rahman, Shafiur, Alsawat, Mohammed, Santos, Abel, Atkins, Gerald J. and Losic, Dusan (2015). Localized drug delivery of selenium (Se) using nanoporous anodic aluminium oxide for bone implants. Journal of Materials Chemistry B, 3 (35), 7090-7098. doi: 10.1039/c5tb00125k
2015
Journal Article
Optimizing anodization conditions for the growth of titania nanotubes on curved surfaces
Gulati, Karan, Santos, Abel, Findlay, David and Losic, Dusan (2015). Optimizing anodization conditions for the growth of titania nanotubes on curved surfaces. Journal of Physical Chemistry C, 119 (28), 16033-16045. doi: 10.1021/acs.jpcc.5b03383
2015
Journal Article
Advanced biopolymer-coated drug-releasing titania nanotubes (TNTs) implants with simultaneously enhanced osteoblast adhesion and antibacterial properties
Kumeria, Tushar, Mon, Htwe, Aw, Moom Sinn, Gulati, Karan, Santos, Abel, Griesser, Hans J. and Losic, Dusan (2015). Advanced biopolymer-coated drug-releasing titania nanotubes (TNTs) implants with simultaneously enhanced osteoblast adhesion and antibacterial properties. Colloids and Surfaces B: Biointerfaces, 130, 255-263. doi: 10.1016/j.colsurfb.2015.04.021
2015
Journal Article
Titania nanotube arrays for local drug delivery: recent advances and perspectives
Losic, Dusan, Aw, Moom Sinn, Santos, Abel, Gulati, Karan and Bariana, Manpreet (2015). Titania nanotube arrays for local drug delivery: recent advances and perspectives. Expert Opinion on Drug Delivery, 12 (1), 103-127. doi: 10.1517/17425247.2014.945418
2015
Book Chapter
Titania nanotubes for local drug delivery from implant surfaces
Gulati, Karan, Kogawa, Masakazu, Maher, Shaheer, Atkins, Gerald, Findlay, David and Losic, Dusan (2015). Titania nanotubes for local drug delivery from implant surfaces. Electrochemically engineered nanoporous materials: methods, properties and applications. (pp. 307-355) edited by Dusan Losic and Abel Santos. Berlin, Germany: Springer. doi: 10.1007/978-3-319-20346-1_10
2015
Journal Article
Periodically tailored titania nanotubes for enhanced drug loading and releasing performances
Gulati, Karan, Kant, Krishna, Findlay, David and Losic, Dusan (2015). Periodically tailored titania nanotubes for enhanced drug loading and releasing performances. Journal of Materials Chemistry B, 3 (12), 2553-2559. doi: 10.1039/c4tb01882f
2014
Conference Publication
Computational and experimental model of nano-engineered drug delivery system for trabecular bone
Mokhtarzadeh, Hossein, Aw, Moom S., Khalid, Kamarul A., Gulati, Karan, Atkins, Gerald J., Findlay, David M., Losic, Dusan and Pivonka, Peter (2014). Computational and experimental model of nano-engineered drug delivery system for trabecular bone. 11th World Congress on Computational Mechanics (WCCM XI), Barcelona, Spain, 20-25 July 2014. Barcelona, Spain: International Center for Numerical Methods in Engineering.
2013
Journal Article
Real-time and in situ drug release monitoring from nanoporous implants under dynamic flow conditions by reflectometric interference spectroscopy
Kumeria, Tushar, Gulati, Karan, Santos, Abel and Losic, Dusan (2013). Real-time and in situ drug release monitoring from nanoporous implants under dynamic flow conditions by reflectometric interference spectroscopy. ACS Applied Materials and Interfaces, 5 (12), 5436-5442. doi: 10.1021/am4013984
2013
Conference Publication
Nano-engineered titanium for enhanced bone therapy
Gulati, Karan, Atkins, Gerald J., Findlay, David M. and Losic, Dusan (2013). Nano-engineered titanium for enhanced bone therapy. Conference on Biosensing and Nanomedicine VI, San Diego CA, United States, 25-28 August 2013. Bellingham, WA United States: SPIE - International Society for Optical Engineering. doi: 10.1117/12.2027151
Funding
Supervision
Availability
- Dr Karan Gulati is:
- Available for supervision
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Supervision history
Completed supervision
-
2023
Doctor Philosophy
Nano-Engineered Titanium Dental Implants for Tailored Therapy and Bioactivity
Principal Advisor
Other advisors: Professor Saso Ivanovski
-
2023
Doctor Philosophy
Fabrication Optimization of Bioactive Nano-Engineered Titanium Dental Implants
Principal Advisor
Other advisors: Professor Saso Ivanovski, Dr Pingping Han
Media
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