Professor Stefan Thor
Professor

Stefan Thor

Email: 
Phone: 
+61 7 336 52684

Background

BSc in Biology (1988) Umea University, Sweden

PhD in Molecular Biology (1994), Umea University, Sweden. Supervisor: Thomas Edlund

Postdoc, Molecular Neurobiology (1994-1999) Salk Institute, La Jolla, USA. Mentor: John B. Thomas

Assistant Professor (1999-2004), Harvard Medical School, Boston, USA

Professor of Developmental Biology (2004-2019), Linkoping University, Sweden

Professor of Developmental Biology (2019-), University of Queensland, Brisbane, Australia

Member of the Royal Swedish Academy of Sciences (2013-)

Availability

Professor Stefan Thor is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Institution to be confirmed

Search Professor Stefan Thor’s works on UQ eSpace

95 works between 1989 and 2024
All (95) Journal Article (86) Book Chapter (7) Conference Publication (2)

21 - 40 of 95 works

2019

Journal Article

PIP degron-stabilized Dacapo/p21Cip1 and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels

Bivik Stadler, Caroline, Arefin, Badrul, Ekman, Helen and Thor, Stefan (2019). PIP degron-stabilized Dacapo/p21Cip1 and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels. Development, 146 (13) dev175927, dev175927. doi: 10.1242/dev.175927

PIP degron-stabilized Dacapo/p21Cip1 and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels

2019

Journal Article

Anterior CNS expansion driven by brain transcription factors

Curt, Jesús Rodriguez, Salmani, Behzad Yaghmaeian and Thor, Stefan (2019). Anterior CNS expansion driven by brain transcription factors. eLife, 8 e45274, e45274. doi: 10.7554/elife.45274

Anterior CNS expansion driven by brain transcription factors

2019

Journal Article

A branching gene regulatory network dictating different aspects of a neuronal cell identity

Stratmann, Johannes, Ekman, Helen and Thor, Stefan (2019). A branching gene regulatory network dictating different aspects of a neuronal cell identity. Development, 146 (6) dev174300, dev174300. doi: 10.1242/dev.174300

A branching gene regulatory network dictating different aspects of a neuronal cell identity

2019

Journal Article

Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program

Bahrampour, Shahrzad, Jonsson, Carolin and Thor, Stefan (2019). Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program. PLoS biology, 17 (2) e3000163, e3000163. doi: 10.1371/journal.pbio.3000163

Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program

2018

Journal Article

Specification of Drosophila neuropeptidergic neurons by the splicing component brr2

Monedero Cobeta, Ignacio, Stadler, Caroline Bivik, Li, Jin, Yu, Peng, Thor, Stefan and Benito-Sipos, Jonathan (2018). Specification of Drosophila neuropeptidergic neurons by the splicing component brr2. PLoS Genetics, 14 (8) e1007496, e1007496. doi: 10.1371/journal.pgen.1007496

Specification of Drosophila neuropeptidergic neurons by the splicing component brr2

2018

Journal Article

Aggregated A beta 1-42 is selectively toxic for neurons, whereas glial cells produce mature fibrils with low toxicity in Drosophila

Jonson, Maria, Nystrom, Sofie, Sandberg, Alexander, Carlback, Marcus, Michno, Wojciech, Hanrieder, Jorg, Starkenberg, Annika, Nilsson, K. Peter R., Thor, Stefan and Hammarstrom, Per (2018). Aggregated A beta 1-42 is selectively toxic for neurons, whereas glial cells produce mature fibrils with low toxicity in Drosophila. Cell Chemical Biology, 25 (5), 595-610.e5. doi: 10.1016/j.chembiol.2018.03.006

Aggregated A beta 1-42 is selectively toxic for neurons, whereas glial cells produce mature fibrils with low toxicity in Drosophila

2018

Journal Article

Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program

Salmani, Behzad Yaghmaeian, Cobeta, Ignacio Monedero, Rakar, Jonathan, Bauer, Susanne, Curt, Jesus Rodriguez, Starkenberg, Annika and Thor, Stefan (2018). Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program. Development, 145 (7) dev160747, dev160747. doi: 10.1242/dev.160747

Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program

2017

Journal Article

Neural lineage progression controlled by a temporal proliferation program

Bahrampour, Shahrzad, Gunnar, Erika, Jonsson, Carolin, Ekman, Helen and Thor, Stefan (2017). Neural lineage progression controlled by a temporal proliferation program. Developmental Cell, 43 (3), 332-348.e4. doi: 10.1016/j.devcel.2017.10.004

Neural lineage progression controlled by a temporal proliferation program

2017

Journal Article

Bar-coding neurodegeneration: identifying subcellular effects of human neurodegenerative disease proteins using Drosophila leg neurons

Fernius, Josefin, Starkenberg, Annika and Thor, Stefan (2017). Bar-coding neurodegeneration: identifying subcellular effects of human neurodegenerative disease proteins using Drosophila leg neurons. Disease Models and Mechanisms, 10 (8), 1027-1038. doi: 10.1242/dmm.029637

Bar-coding neurodegeneration: identifying subcellular effects of human neurodegenerative disease proteins using Drosophila leg neurons

2017

Journal Article

Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau

Fernius, Josefin, Starkenberg, Annika, Pokrzywa, Malgorzata and Thor, Stefan (2017). Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau. Biology Open, 6 (7), 1013-1023. doi: 10.1242/bio.022749

Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau

2017

Journal Article

Nervous system development: temporal patterning of large neural lineages

Thor, Stefan (2017). Nervous system development: temporal patterning of large neural lineages. Current Biology, 27 (10), R392-R394. doi: 10.1016/j.cub.2017.03.070

Nervous system development: temporal patterning of large neural lineages

2017

Journal Article

Anterior-posterior gradient in neural stem and daughter cell proliferation governed by spatial and temporal Hox control

Cobeta, Ignacio Monedero, Salmani, Behzad Yaghmaeian and Thor, Stefan (2017). Anterior-posterior gradient in neural stem and daughter cell proliferation governed by spatial and temporal Hox control. Current Biology, 27 (8), 1161-1172. doi: 10.1016/j.cub.2017.03.023

Anterior-posterior gradient in neural stem and daughter cell proliferation governed by spatial and temporal Hox control

2017

Journal Article

Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene

Stratmann, Johannes and Thor, Stefan (2017). Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene. PLoS Genetics, 13 (4) e1006729, e1006729. doi: 10.1371/journal.pgen.1006729

Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene

2017

Book Chapter

From stem cell to unique neuron: combinatorial codes, feedforward loops and target-derived signals – an outlook from the Drosophila apterous neurons

Thor, S and Stratmann, J (2017). From stem cell to unique neuron: combinatorial codes, feedforward loops and target-derived signals – an outlook from the Drosophila apterous neurons. Reference module in neuroscience and biobehavioral psychology. (pp. 1-11) Amsterdam: Elsevier. doi: 10.1016/B978-0-12-809324-5.02415-9

From stem cell to unique neuron: combinatorial codes, feedforward loops and target-derived signals – an outlook from the Drosophila apterous neurons

2016

Journal Article

Neuronal cell fate diversification controlled by sub-temporal action of Kruppel

Stratmann, Johannes, Gabilondo, Hugo, Benito-Sipos, Jonathan and Thor, Stefan (2016). Neuronal cell fate diversification controlled by sub-temporal action of Kruppel. Elife, 5 e19311. doi: 10.7554/eLife.19311

Neuronal cell fate diversification controlled by sub-temporal action of Kruppel

2016

Journal Article

Ctr9, a key component of the Paf1 complex, affects proliferation and terminal differentiation in the developing Drosophila nervous system

Bahrampour, Shahrzad and Thor, Stefan (2016). Ctr9, a key component of the Paf1 complex, affects proliferation and terminal differentiation in the developing Drosophila nervous system. G3: Genes, Genomes, Genetics, 6 (10), 3229-3239. doi: 10.1534/g3.116.034231

Ctr9, a key component of the Paf1 complex, affects proliferation and terminal differentiation in the developing Drosophila nervous system

2016

Journal Article

Neuronal cell fate specification by the convergence of different spatiotemporal cues on a common terminal selector cascade

Gabilondo, Hugo, Stratmann, Johannes, Rubio-Ferrera, Irene, Millan-Crespo, Irene, Contero-Garcia, Patricia, Bahrampour, Shahrzad, Thor, Stefan and Benito-Sipos, Jonathan (2016). Neuronal cell fate specification by the convergence of different spatiotemporal cues on a common terminal selector cascade. PLoS Biology, 14 (5) e1002450, e1002450. doi: 10.1371/journal.pbio.1002450

Neuronal cell fate specification by the convergence of different spatiotemporal cues on a common terminal selector cascade

2016

Journal Article

Control of neural daughter cell proliferation by multi-level notch/Su(H)/E(spl)-HLH signaling

Bivik, Caroline, MacDonald, Ryan B., Gunnar, Erika, Mazouni, Khalil, Schweisguth, Francois and Thor, Stefan (2016). Control of neural daughter cell proliferation by multi-level notch/Su(H)/E(spl)-HLH signaling. Plos Genetics, 12 (4) e1005984, e1005984. doi: 10.1371/journal.pgen.1005984

Control of neural daughter cell proliferation by multi-level notch/Su(H)/E(spl)-HLH signaling

2016

Journal Article

Sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous systems

Gunnar, Erika, Bivik, Caroline, Starkenberg, Annika and Thor, Stefan (2016). Sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous systems. Journal of Cell Science, 143 (20), 3774-3784. doi: 10.1242/dev.139998

Sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous systems

2016

Book Chapter

Advances in understanding the generation and specification of unique neuronal sub-types from Drosophila neuropeptidergic neurons

Thor, Stefan and Allan, Douglas W. (2016). Advances in understanding the generation and specification of unique neuronal sub-types from Drosophila neuropeptidergic neurons. Organogenetic gene networks: genetic control of organ formation. (pp. 57-93) edited by James Castelli-Gair Hombría and Paola Bovolenta. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-42767-6_3

Advances in understanding the generation and specification of unique neuronal sub-types from Drosophila neuropeptidergic neurons

Current funding

  • 2023 - 2026
    What drives the Anterior Expansion of the Central Nervous System?
    ARC Discovery Projects
    Open grant
  • 2023 - 2025
    Developing an in vitro human sleep system
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2023 - 2024
    What is the common factor driving brain overgrowth in ASD? Investigating the relationship between epigenetic marks neural stem cell proliferation.
    Simons Foundation Autism Research Initiative - Pilot Award
    Open grant
  • 2022 - 2025
    Understanding the generation of hypothalamic sleep neurons
    ARC Discovery Projects
    Open grant
  • 2019
    Vevo 3100 Imaging System for ultrahigh resolution and frame rate echocardiographic assessment of small animals.
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Stefan Thor is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • The role of the hypothalamic neuropeptide Npvf in mouse fertility and sleep-wake behaviours

    The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours, in several different mammalian species, as well as in the zebrafish. But these studies have been based upon correlative experiments, RNAi and peptide injections, and the Npvf gene has hitherto not beek knocked out. we have geneerated a condititional null allele of Npvf. This project aims to address the effect of a null mutation in Npvf upon a set of mouse behaviours.

  • The role of the mouse Tead1/Vgll2 transcription factors in dictating hypothalamic cell fate

    The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours. Using single cell transcriptional profiling, we and others have identified the transcription factors Tead1 and Vgll2 as selectively expressed in Npvf neurons in the mouse hypothalamus. The Tead and Vgll families typically interact and form a complex. We have generated a mouse Tead1 knock-out, and found that the Npvf neurons are missing. The project aims to address the underlying reason for the phenotype. We are also in the process of obtaining the mouse Vgll2 knockout, to be able to compare the effects of this knock-out with that of Tead1.

Supervision history

Current supervision

Completed supervision

Enquiries

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