Overview
Background
Dr. Andrew Lai is a leading biotechnologist and translational researcher, specialising in the role of extracellular vesicles (EVs) in gynaecological cancers and reproductive diseases. His research focuses on developing innovative EV isolation methods and characterising EV cargo to discover biomarkers with potential clinical applications.
His work has directly influenced the development of an early-detection test for ovarian cancer, OCRF-7, which is currently being validated for clinical use. His expertise in mass spectrometry-based proteomics has been instrumental in advancing the understanding of EV roles in cancer progression and treatment resistance.
Availability
- Dr Andrew Lai is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Science, University of New South Wales
- Masters (Coursework) of Biotechnology, Queensland University of Technology
- Bachelor (Honours) of Life Science, Queensland University of Technology
- Doctor of Philosophy, Queensland University of Technology
Works
Search Professor Andrew Lai’s works on UQ eSpace
2021
Journal Article
Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer
Robinson, Harley, Ruelcke, Jayde E., Lewis, Amanda, Bond, Charles S., Fox, Archa H., Bharti, Vandhana, Wani, Shivangi, Cloonan, Nicole, Lai, Andrew, Margolin, David, Li, Li, Salomon, Carlos, Richards, Renée S., Farrell, Aine, Gardiner, Robert A., Parton, Robert G., Cristino, Alexandre S. and Hill, Michelle M. (2021). Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer. Clinical and Translational Medicine, 11 (4) e381, e381. doi: 10.1002/ctm2.381
2021
Book Chapter
Extracellular vesicles and preeclampsia: current knowledge and future research directions
Palma, Carlos, Jellins, Jessica, Lai, Andrew, Salas, Alexis, Campos, America, Sharma, Shayna, Duncombe, Gregory, Hyett, Jon and Salomon, Carlos (2021). Extracellular vesicles and preeclampsia: current knowledge and future research directions. New Frontiers: Extracellular Vesicles. (pp. 455-482) edited by Suresh Mathivanan, Pamali Fonseka, Christina Nedeva and Ishara Atukorala. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-67171-6_18
2020
Journal Article
Anti-inflammatory effects of gallic acid in human gestational tissues in vitro
Nguyen-Ngo, Caitlyn, Salomon, Carlos, Lai, Andrew, Willcox, Jane C. and Lappas, Martha (2020). Anti-inflammatory effects of gallic acid in human gestational tissues in vitro. Reproduction, 160 (4), 561-578. doi: 10.1530/rep-20-0249
2020
Journal Article
miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer
Alharbi, Mona, Sharma, Shayna, Guanzon, Dominic, Lai, Andrew, Zuñiga, Felipe, Shiddiky, Muhammad J.A., Yamauchi, Yusuke, Salas-Burgos, Alexis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2020). miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 28 102207, 102207. doi: 10.1016/j.nano.2020.102207
2020
Journal Article
Detection of Salivary Small Extracellular Vesicles Associated Inflammatory Cytokines Gene Methylation in Gingivitis
Han, Pingping, Lai, Andrew, Salomon, Carlos and Ivanovski, Sašo (2020). Detection of Salivary Small Extracellular Vesicles Associated Inflammatory Cytokines Gene Methylation in Gingivitis. International Journal of Molecular Sciences, 21 (15) 5273, 5273-17. doi: 10.3390/ijms21155273
2020
Journal Article
Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study
Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Kshetrapal, Pallavi, Sheller-Miller, Samantha, Salomon, Carlos and The Garbh-Ini Study team (2020). Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study. Endocrinology, 161 (4) bqaa009. doi: 10.1210/endocr/bqaa009
2020
Journal Article
Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats
Dutta, Suchismita, Lai, Andrew, Scholz-Romero, Katherin, Shiddiky, Muhammad J. A., Yamauchi, Yusuke, Mishra, Jay S., Rice, Gregory E., Hyett, Jon, Kumar, Sathish and Salomon, Carlos (2020). Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats. Clinical Science, 134 (6), 593-607. doi: 10.1042/cs20191155
2020
Journal Article
Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes
Nguyen-Ngo, Caitlyn, Salomon, Carlos, Quak, Stephanie, Lai, Andrew, Willcox, Jane C and Lappas, Martha (2020). Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes. Clinical Science, 134 (6), 571-592. doi: 10.1042/cs20191099
2020
Journal Article
Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes
James-Allan, Laura B., Rosario, Frederick J., Barner, Kelsey, Lai, Andrew, Guanzon, Dominic, McIntyre, H. David, Lappas, Martha, Powell, Theresa L., Salomon, Carlos and Jansson, Thomas (2020). Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB Journal, 34 (4) fj.201902522RR, 5724-5739. doi: 10.1096/fj.201902522RR
2019
Journal Article
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess
Tapia-Castillo, Alejandra, Guanzon, Dominic, Palma, Carlos, Lai, Andrew, Barros, Eric, Allende, Fidel, Vecchiola, Andrea, Fardella, Carlos E., Salomón, Carlos and Carvajal, Cristian A. (2019). Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess. Journal of Translational Medicine, 17 (1) 392, 392. doi: 10.1186/s12967-019-02143-8
2019
Journal Article
Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells
Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D and Salomon, Carlos (2019). Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells. Clinical Science, 133 (13), CS20190082-1419. doi: 10.1042/cs20190082
2019
Journal Article
Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth
Menon, Ramkumar, Dixon, Christopher Luke, Sheller-Miller, Samantha, Fortunato, Stephen J., Saade, George R., Palma, Carlos, Lai, Andrew, Guanzon, Dominic and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth. Endocrinology, 160 (3), 639-650. doi: 10.1210/en.2018-00820
2019
Conference Publication
Exosomal protein and miRNA analysis in cervico-vaginal fluid at early gestation from term and preterm pregnancies
Tribe, Rachel M., Jenkins, Holly, Palma, Carlos, Lai, Andrew, Guanzon, Dominic, Hezelgrave, Natasha L., Shennan, Andrew H. and Salomon, Carlos (2019). Exosomal protein and miRNA analysis in cervico-vaginal fluid at early gestation from term and preterm pregnancies. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12 - 16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression
Sharma, Shayna, Lai, Andrew, Guanzon, Dominic, Morgan, Terry, Perrin, Lewis C., Hooper, John D. and Salomon, Carlos (2019). Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Cytokines profile in different populations of extracellular vesicles during the first trimester of pregnancy
Scholz-Romero, Katherin, Lai, Andrew, Duncombe, Gregory, Rice, Gregory and Salomon, Carlos (2019). Cytokines profile in different populations of extracellular vesicles during the first trimester of pregnancy. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, Japan, 21-24 September 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.079
2019
Conference Publication
Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy
Nair, Soumyalekshmi S., Lai, Andrew, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo
Alharbi, Mona G., Lai, Andrew, Zuniga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D. and Salomon, Carlos (2019). Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy
Nair, Soumyalekshmi, Ormazabal, Valeska, Ramirez, Macarena, Lai, Andrew, Scholz Romero, Katherin, McIntyre, David, Diaz, Emilio, Zuniga, Felipe, Lappas, Martha and Salomon, Carlos (2019). Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.307
2019
Conference Publication
Low dose aspirin modulates the proteomic content of placental trophoblast derived exosomes at different oxygen tensions
Dutta, Suchismita, Palma, Carlos, Lai, Andrew, Kumar, Sathish, Hyett, Jonathan, Nakahara, Angela, Longo, Sherri and Salomon, Carlos (2019). Low dose aspirin modulates the proteomic content of placental trophoblast derived exosomes at different oxygen tensions. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Journal Article
Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus
Jayabalan, Nanthini, Lai, Andrew, Nair, Soumyalekshmi, Guanzon, Dominic, Scholz-Romero, Katherin, Palma, Carlos, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus. Proteomics, 19 (1-2) 1800164, e1800164. doi: 10.1002/pmic.201800164
Supervision
Availability
- Dr Andrew Lai is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Characterisation of EV-associated lipids in the progression of ovarian cancer
Associate Advisor
Other advisors: Dr Dominic Guanzon, Professor Carlos Salomon Gallo
-
Doctor Philosophy
Gene editing of ovarian cancer by CRISPR/Cas9 and miRNAs-loaded extracellular vesicles
Associate Advisor
Other advisors: Dr Marianne Gillard, Professor Carlos Salomon Gallo
Media
Enquiries
Contact Dr Andrew Lai directly for media enquiries about:
- Extracellular Vesicles
- Proteomics
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