Overview
Background
Dr. Andrew Lai is a leading biotechnologist and translational researcher, specialising in the role of extracellular vesicles (EVs) in gynaecological cancers and reproductive diseases. His research focuses on developing innovative EV isolation methods and characterising EV cargo to discover biomarkers with potential clinical applications.
His work has directly influenced the development of an early-detection test for ovarian cancer, OCRF-7, which is currently being validated for clinical use. His expertise in mass spectrometry-based proteomics has been instrumental in advancing the understanding of EV roles in cancer progression and treatment resistance.
Availability
- Dr Andrew Lai is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Science, University of New South Wales
- Masters (Coursework) of Biotechnology, Queensland University of Technology
- Bachelor (Honours) of Life Science, Queensland University of Technology
- Doctor of Philosophy, Queensland University of Technology
Works
Search Professor Andrew Lai’s works on UQ eSpace
2019
Conference Publication
Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo
Alharbi, Mona G., Lai, Andrew, Zuniga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D. and Salomon, Carlos (2019). Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy
Nair, Soumyalekshmi, Ormazabal, Valeska, Ramirez, Macarena, Lai, Andrew, Scholz Romero, Katherin, McIntyre, David, Diaz, Emilio, Zuniga, Felipe, Lappas, Martha and Salomon, Carlos (2019). Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.307
2019
Conference Publication
Low dose aspirin modulates the proteomic content of placental trophoblast derived exosomes at different oxygen tensions
Dutta, Suchismita, Palma, Carlos, Lai, Andrew, Kumar, Sathish, Hyett, Jonathan, Nakahara, Angela, Longo, Sherri and Salomon, Carlos (2019). Low dose aspirin modulates the proteomic content of placental trophoblast derived exosomes at different oxygen tensions. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2018
Journal Article
Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus
Jayabalan, Nanthini, Lai, Andrew, Ormazabal, Valeska, Adam, Stefanie, Guanzon, Dominic, Palma, Carlos, Scholz-Romero, Katherin, Lim, Ratana, Jansson, Thomas, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2018). Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 104 (5) jcem-201801599, 1735-1752. doi: 10.1210/jc.2018-01599
2018
Journal Article
The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer
Alharbi, Mona, Zuñiga, Felipe, Elfeky, Omar, Guanzon, Dominic, Lai, Andrew, Rice, Gregory E., Perrin, Lewis, Hooper, John and Salomon, Carlos (2018). The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer. Endocrine-Related Cancer, 25 (12), R663-R685. doi: 10.1530/erc-18-0019
2018
Journal Article
Circulating exosomal miRNA profile during term and preterm birth pregnancies - a longitudinal study
Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Pallavi, S. K., Sheller-Miller, Samantha, The Garbhini Study team and Salomon, Carlos (2018). Circulating exosomal miRNA profile during term and preterm birth pregnancies - a longitudinal study. Endocrinology, 160 (2), 249-275. doi: 10.1210/en.2018-00836
2018
Journal Article
Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration
Sharma, Shayna, Alharbi, Mona, Kobayashi, Miharu, Lai, Andrew, Guanzon, Dominic, Zuñiga, Felipe, Ormazabal, Valeska, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E., Hooper, John D. and Salomon, Carlos (2018). Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration. Clinical Science, 132 (18), 2029-2044. doi: 10.1042/CS20180425
2018
Journal Article
Amniotic fluid exosome proteomic profile exhibits unique pathways of term and preterm labor
Dixon, C. Luke, Sheller-Miller, Samantha, Saade, George R., Fortunato, Stephen J., Lai, Andrew, Palma, Carlos, Guazon, Dominic, Salomon, Carlos and Menon, Ramkumar (2018). Amniotic fluid exosome proteomic profile exhibits unique pathways of term and preterm labor. Endocrinology, 159 (5), 2229-2240. doi: 10.1210/en.2018-00073
2018
Journal Article
Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth
Miranda, Jezid, Paules, Cristina, Nair, Soumyalekshmi, Lai, Andrew, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E., Gratacos, Eduard, Crispi, Fatima and Salomon, Carlos (2018). Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth. Placenta, 64, 34-43. doi: 10.1016/j.placenta.2018.02.006
2018
Conference Publication
Proteomic profile of amniotic fluid exosomes in spontaneous preterm birth
Dixon, Christopher L., Lai, Andrew, Palma, Carlos, Salomon, Carlos and Menon, Ramkumar (2018). Proteomic profile of amniotic fluid exosomes in spontaneous preterm birth. 38th Annual Meeting and Pregnancy Meeting of the Society for Maternal Fetal Medicine, Dallas, TX, United States, 29 January - 3 February 2018. Philadelphia, PA, United States: Mosby. doi: 10.1016/j.ajog.2017.11.132
2018
Conference Publication
Interactions between placental exosomes and skeletal muscle implication in cell metabolism in gestational diabetes mellitus
Nair, Soumyalekshmi, Jayabalan, Nanthini, Guanzon, Dominic, Lai, Andrew, Scholz-Romero, Katherin, Elfeky, Omar, Zuniga, Felipe, Diaz, Emilio, McIntyre, David, Rice, Gregory E., Lappas, Martha and Salomon, Carlos (2018). Interactions between placental exosomes and skeletal muscle implication in cell metabolism in gestational diabetes mellitus. 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego, CA, United States, 6-10 March 2018. Thousand Oaks, CA, United States: Sage. doi: 10.1177/1933719118759999
2018
Conference Publication
Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer
Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Sharma, Shayna, Palma, Carlos, Zuniga, Felipe, Rice, Gregory E., Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2018). Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer. 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego Ca United States, 6-10 March 2018. Thousand Oaks, CA United States: Sage.
2017
Journal Article
Optimized Specific Isolation of Placenta-Derived Exosomes from Maternal Circulation
Lai, Andrew, Elfeky, Omar, Rice, Gregory E. and Salomon, Carlos (2017). Optimized Specific Isolation of Placenta-Derived Exosomes from Maternal Circulation. Methods in Molecular Biology , 1710, 131-138. doi: 10.1007/978-1-4939-7498-6_10
2017
Journal Article
Proteomics Method to Identification of Protein Profiles in Exosomes
Lai, Andrew, Kinhal, Vyjayanthi, Nuzhat, Zarin, Menon, Ramkumar, Rice, Gregory E. and Salomon, Carlos (2017). Proteomics Method to Identification of Protein Profiles in Exosomes. Methods in Molecular Biology, 1710, 139-153. doi: 10.1007/978-1-4939-7498-6_11
2017
Journal Article
Fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies
Adam, Stefanie, Elfeky, Omar, Kinhal, Vyjayanthi, Dutta, Suchismita, Lai, Andrew, Jayabalan, Nanthini, Nuzhat, Zarin, Palma, Carlos, Rice, Gregory E. and Salomon, Carlos (2017). Fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies. Placenta, 54, 83-88. doi: 10.1016/j.placenta.2016.12.001
2017
Journal Article
Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells-liquid biopsies for monitoring complications of pregnancy
Truong, Grace, Guanzon, Dominic, Kinhal, Vyjayanthi, Elfeky, Omar, Lai, Andrew, Longo, Sherri, Nuzhat, Zarin, Palma, Carlos, Scholz-Romero, Katherin, Menon, Ramkumar, Mol, Ben W., Rice, Gregory E. and Salomon, Carlos (2017). Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells-liquid biopsies for monitoring complications of pregnancy. PLoS ONE, 12 (3) e0174514, e0174514. doi: 10.1371/journal.pone.0174514
2017
Conference Publication
Maternal BMI regulates the exosomal bioactivity on cytokine release from endothelial cells
Elfeky, Omar, Longo, Sherri, Lai, Andrew, Duncombe, Gregory, Rice, Gregory E. and Salomon, Carlos (2017). Maternal BMI regulates the exosomal bioactivity on cytokine release from endothelial cells. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL United States, 15-18 March 2017. Thousand Oaks, CA United States: Sage Publications. doi: 10.1177/1933719117699773
2017
Conference Publication
Exosomal content in the plasma of patients with ovarian cancer reflect tumor state and induce the epithelial to mesenchymal transition in target cells
Sharma, Shayna, Scholz-Romero, Katherin, Kline, Richard, Wade, Katrina, Estes, Jacob, Palma, Carlos, Guanzon, Dominic, Lai, Andrew, Hooper, John, Rice, Gregory E. and Salomon, Carlos (2017). Exosomal content in the plasma of patients with ovarian cancer reflect tumor state and induce the epithelial to mesenchymal transition in target cells. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719117699773
2017
Book Chapter
Cross‐talk between hypoxia and the tumour via exosomes
Sharma, Shayna, Alharbi, Mona, Lai, Andrew, Kobayashi, Miharu, Kline, Richard, Wade, Katrina, Rice, Gregory E. and Salomon, Carlos (2017). Cross‐talk between hypoxia and the tumour via exosomes. Hypoxia and human diseases. (pp. 365-381) edited by Jing Zheng and Chi Zhou. Rijeka, Croatia: Intech. doi: 10.5772/65688
2017
Journal Article
Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation
Elfeky, Omar, Longo, Sherri, Lai, Andrew, Rice, Gregory E. and Salomon, Carlos (2017). Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation. Placenta, 50, 60-69. doi: 10.1016/j.placenta.2016.12.020
Supervision
Availability
- Dr Andrew Lai is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Characterisation of EV-associated lipids in the progression of ovarian cancer
Associate Advisor
Other advisors: Honorary Professor John Hooper, Dr Dominic Guanzon, Professor Carlos Salomon Gallo
-
Doctor Philosophy
Scalable Production of Ligand-Directed Extracellular Vesicles for Targeted Ovarian Cancer Therapy and Identification of Novel Therapeutic Targets
Associate Advisor
Other advisors: Dr Marianne Gillard, Professor Carlos Salomon Gallo
Media
Enquiries
Contact Dr Andrew Lai directly for media enquiries about:
- Extracellular Vesicles
- Proteomics
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