Overview
Background
Dr Andrew Lai is the current proteomic leader in Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group.
Availability
- Dr Andrew Lai is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Science, University of New South Wales
- Masters (Coursework) of Biotechnology, Queensland University of Technology
- Bachelor (Honours) of Life Science, Queensland University of Technology
- Doctor of Philosophy, Queensland University of Technology
Works
Search Professor Andrew Lai’s works on UQ eSpace
2024
Journal Article
Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering
Alharbi, Mona, Lai, Andrew, Godbole, Nihar, Guanzon, Dominic, Nair, Soumyalekshmi, Zuñiga, Felipe, Quinn, Alexander, Yang, Mengliu, Wu, Sherry Y. and Salomon, Carlos (2024). Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering. International Journal of Cancer, 155 (8), 1510-1523. doi: 10.1002/ijc.35055
Featured
2022
Journal Article
Targeted mass spectrometry-based proteomics method to quantify placental extracellular vesicles
Lai, Andrew, Palma, Carlos, Salas, Alexis, Carrion, Flavio and Salomon, Carlos (2022). Targeted mass spectrometry-based proteomics method to quantify placental extracellular vesicles. Methods in Molecular Biology, 2504, 79-89. doi: 10.1007/978-1-0716-2341-1_6
2021
Journal Article
Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence
Alharbi, Mona, Lai, Andrew, Sharma, Shayna, Kalita-De Croft, Priyakshi, Godbole, Nihar, Campos, America, Guanzon, Dominic, Salas-Burgos, Alexis, Carrion, Flavio, Zuñiga, Felipe A., Perrin, Lewis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Hooper, John D., Rice, Gregory E. and Salomon, Carlos (2021). Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence. Cancers, 13 (14) 3388, 1-26. doi: 10.3390/cancers13143388
2024
Journal Article
High throughput Surface Epitope Immunoaffinity Isolation of Extracellular Vesicles and Downstream Analysis
Khanabdali, Ramin, Mandrekar, Michelle, Grygiel, Rick, Vo, Phuoc-an, Palma, Carlos, Nikseresht, Sara, Barton, Siena, Shojaee, Mozhgan, Bhuiyan, Sadman, Asari, Kartini, Belzer, Susan, Ansari, Khairul, Coward, Jermaine I, Perrin, Lewis, Hooper, John, Guanzon, Dominic, Lai, Andrew, Salomon, Carlos, Kershner, Kevin, Newton, Christine, Horejsh, Douglas and Rice, Gregory (2024). High throughput Surface Epitope Immunoaffinity Isolation of Extracellular Vesicles and Downstream Analysis. Biology Methods and Protocols, 9 (1) ARTN bpae032, bpae032. doi: 10.1093/biomethods/bpae032
2024
Conference Publication
Changes in extracellular vesicle miRNAs from three-dimensional ovarian cancer cell models reflect physiological changes and cancer survival
Godbole, Nihar, Ravichandran, Akhilandeshwari, Guanzon, Dominic, Lai, Andrew, Carrion, Flavio, de Croft, Priyakshi Kalita, Perrin, Lewis, Hooper, John, Bray, Laura and Salomon, Carlos (2024). Changes in extracellular vesicle miRNAs from three-dimensional ovarian cancer cell models reflect physiological changes and cancer survival. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-3386
2024
Journal Article
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches: Position paper
Welsh, Joshua A., Goberdhan, Deborah C. I., O'Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrugger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, My G., Mohanty, Sujata, Moller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco ... Allenby, Mark (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches: Position paper. Journal of Extracellular Vesicles, 13 (2) e12404. doi: 10.1002/jev2.12404
2024
Journal Article
Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A
Palma, Carlos, Lai, Andrew, Scholz‐Romero, Katherin, Chittoory, Haarika, Van Haeringen, Benjamin, Carrion, Flavio, Handberg, Aase, Lappas, Martha, Lakhani, Sunil R., McCart Reed, Amy E, McIntyre, H. David, Nair, Soumyalekshmi and Salomon, Carlos (2024). Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A. Journal of Extracellular Biology, 3 (1) e135, e135. doi: 10.1002/jex2.135
2023
Journal Article
Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification
Iannotta, Dalila, Amruta A., Lai, Andrew, Nair, Soumyalekshmi, Koifman, Na'ama, Lappas, Martha, Salomon, Carlos and Wolfram, Joy (2023). Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification. Small, 20 (18) 2307240, 1-14. doi: 10.1002/smll.202307240
2023
Journal Article
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus
Rani, Shikha, Lai, Andrew, Nair, Soumya, Sharma, Shayna, Handberg, Aase, Carrion, Flavio, Möller, Andreas and Salomon, Carlos (2023). Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus. Cytokine and Growth Factor Reviews, 73, 52-68. doi: 10.1016/j.cytogfr.2023.06.004
2023
Other Outputs
Mass spectrometry raw data and ion library
Lai, Andrew and Mass Spectrometry Facility, UQCCR (2023). Mass spectrometry raw data and ion library. The University of Queensland. (Dataset) doi: 10.48610/1958974
2023
Conference Publication
Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes
Nair, Soumyalekshmi S., Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Carrion, Flavio, Lappas, Martha and Salomon, Carlos (2023). Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2023
Conference Publication
Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia
D'Crus, Angel Nilesh, Jellins, Jessica, Lai, Andrew, Guanzon, Dominic, Carrion, Flavio, Nair, Soumyalekshmi, Hyett, Jon and Salomon, Carlos (2023). Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2022
Journal Article
Sucrose-based cryoprotective storage of extracellular vesicles
Walker, Sierra A., Davidovich, Irina, Yang, Yubo, Lai, Andrew, Goncalves, Jenifer Pendiuk, Deliwala, Vatsal, Busatto, Sara, Shapiro, Shane, Koifman, Na’ama, Salomon, Carlos, Talmon, Yeshayahu and Wolfram, Joy (2022). Sucrose-based cryoprotective storage of extracellular vesicles. Extracellular Vesicle, 1 100016, 1-7. doi: 10.1016/j.vesic.2022.100016
2022
Journal Article
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation
Nadal-Bufí, Ferran, Chan, Lai Y., Mohammad, Hadi H., Mason, Jody M., Salomon, Carlos, Lai, Andrew, Thompson, Erik W., Craik, David J., Kaas, Quentin and Henriques, Sónia T. (2022). Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation. Cellular and Molecular Life Sciences, 79 (12) 606, 606. doi: 10.1007/s00018-022-04633-3
2022
Journal Article
A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice
James-Allan, Laura B, Rosario, Frederick J, Madi, Lana, Barner, Kelsey, Nair, Soumyalekshmi, Lai, Andrew, Carrion, Flavio, Powell, Theresa L, Salomon, Carlos and Jansson, Thomas (2022). A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice. Clinical Science, 136 (21), 1535-1549. doi: 10.1042/cs20220484
2022
Journal Article
The impact of obesity and uncontrolled asthma during pregnancy on metabolic and inflammatory pathways
Bhaumik, Sreeparna, Lockett, Jack, Saif, Zarqa, Lai, Andrew, Salomon, Carlos, Whitehead, Jonathan P. and Clifton, Vicki L. (2022). The impact of obesity and uncontrolled asthma during pregnancy on metabolic and inflammatory pathways. Journal of Asthma, 60 (6), 1-12. doi: 10.1080/02770903.2022.2134794
2021
Journal Article
Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus
Nair, Soumyalekshmi, Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Kalita de Croft, Priyakshi, Ormazabal, Valeska, Palma, Carlos, Diaz, Emilio, McCarthy, Elizabeth A., Shub, Alexis, Miranda, Jezid, Gratacós, Eduard, Crispi, Fátima, Duncombe, Gregory, Lappas, Martha, McIntyre, H. David, Rice, Gregory and Salomon, Carlos (2021). Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus. Journal of Translational Medicine, 19 (1) 360, 1-17. doi: 10.1186/s12967-021-02999-9
2021
Journal Article
Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer
Robinson, Harley, Ruelcke, Jayde E., Lewis, Amanda, Bond, Charles S., Fox, Archa H., Bharti, Vandhana, Wani, Shivangi, Cloonan, Nicole, Lai, Andrew, Margolin, David, Li, Li, Salomon, Carlos, Richards, Renée S., Farrell, Aine, Gardiner, Robert A., Parton, Robert G., Cristino, Alexandre S. and Hill, Michelle M. (2021). Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer. Clinical and Translational Medicine, 11 (4) e381, e381. doi: 10.1002/ctm2.381
2021
Book Chapter
Extracellular vesicles and preeclampsia: current knowledge and future research directions
Palma, Carlos, Jellins, Jessica, Lai, Andrew, Salas, Alexis, Campos, America, Sharma, Shayna, Duncombe, Gregory, Hyett, Jon and Salomon, Carlos (2021). Extracellular vesicles and preeclampsia: current knowledge and future research directions. New frontiers: extracellular vesicles. (pp. 455-482) edited by Suresh Mathivanan, Pamali Fonseka, Christina Nedeva and Ishara Atukorala. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-67171-6_18
2020
Journal Article
Anti-inflammatory effects of gallic acid in human gestational tissues in vitro
Nguyen-Ngo, Caitlyn, Salomon, Carlos, Lai, Andrew, Willcox, Jane C. and Lappas, Martha (2020). Anti-inflammatory effects of gallic acid in human gestational tissues in vitro. Reproduction, 160 (4), 561-578. doi: 10.1530/rep-20-0249
Supervision
Availability
- Dr Andrew Lai is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Gene editing of ovarian cancer by CRISPR/Cas9 and miRNAs-loaded extracellular vesicles
Associate Advisor
Other advisors: Professor Carlos Salomon Gallo
-
Doctor Philosophy
Characterisation of EV-associated lipids in the progression of ovarian cancer
Associate Advisor
Other advisors: Honorary Professor John Hooper, Dr Dominic Guanzon, Professor Carlos Salomon Gallo
Media
Enquiries
Contact Dr Andrew Lai directly for media enquiries about:
- Extracellular Vesicles
- Proteomics
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