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Honorary Professor

Peter Molenaar

Email: 
Phone: 
+61 7 3139 4052

Overview

Availability

Honorary Professor Peter Molenaar is:
Available for supervision

Qualifications

  • Bachelor of Pharmacy, Victoria University
  • Masters (Coursework), Victoria University
  • Doctor of Philosophy, University of Melbourne

Works

Search Professor Peter Molenaar’s works on UQ eSpace

102 works between 1997 and 2024

41 - 60 of 102 works

2007

Journal Article

(-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.

Molenaar, P., Savarimuthu, S. M., Sarsero, D., Chen, L., Semmler, A. B. T., Carle, A., Yang, I., Bartel, S., Vetter, D., Beyerdorfer, I., Krause,E-G. and Kaumann, A. J. (2007). (-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.. Naunyn-Schmiedeberg's Archives of Pharmocolgy, 375 (1), 11-28. doi: 10.1007/s00210-007-0138-x

(-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.

2006

Conference Publication

Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptors

Molenaar, P., Chen, Lu, Meyers, E., Javorsky, G., Burstow, M., Lucas, P., Lolekha, J., Atherton, A., Semmler, A. B., Savarimuthu, S., Fong, K. M., Yang, I. A., Galbraith, A. and Parsonage, W. A. (2006). Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptors. The Australian Health and Medical Research Congress, Melbourn, Australia, 26th November - 1st December, 2006. Australia: Australian Govenment NHMRC.

Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptors

2006

Journal Article

Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting

Molenaar, Peter, Chen, Lu and Parsonage, William A. (2006). Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting. British Journal of Pharmacology, 147 (6), 583-586. doi: 10.1038/sj.bjp.0706670

Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting

2006

Conference Publication

Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium

Christ, T., Molenaar, P., Galindo-Tovar, A., Ravens, U. and Kaumann, A. J. (2006). Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium. Compartmentalization of cyclic AMP signalling, Cambridge, U.K., 29-30 March, 2006.

Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium

2006

Conference Publication

Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathy

Chen, L., Meyers, D., Semmler, A.B., Yang, I., Pakorn, L., Lucas, M., Jovarsky, G., Savarimuthu, S., Galbraith, A., Parsonage, W. and Molenaar, P. (2006). Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathy. 15th World Congress of Pharmacology, Beijing, China, 2nd - 7th July, 2006. China: Chinese Pharmacological Society.

Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathy

2006

Journal Article

Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart

Molenaar, Peter, Christ, Torsten, Ravens, Ursula and Kaumann, Alberto (2006). Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart. Cardiovascular Research, 69 (1), 128-139. doi: 10.1016/j.cardiores.2005.08.024

Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart

2006

Conference Publication

Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism

Molenaar, P., Chen, Lu, Semmler, A. B., Parsonage, W. A. and Kaumann, A. (2006). Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism. The Australian Health & Medical Research Congress, Melbourne, Australia, 26 November - 1 December, 2006. Australia: Australian Govenment NHMRC.

Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism

2006

Conference Publication

Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism

Molenaar, P., Chen, L., Semmler, A. B., Parsonage, W. A. and Kaumann, A. (2006). Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism. 15th World Congress of Pharmacology, Beijing, China, 7 - 9 July, 2006. China: Institute of Vascular Medicine.

Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism

2005

Journal Article

Fundamental considerations of beta-adrenoceptor subtypes in human heart failure

Molenaar, P and Parsonage, WA (2005). Fundamental considerations of beta-adrenoceptor subtypes in human heart failure. Trends In Pharmacological Sciences, 26 (7), 368-375. doi: 10.1016/j.tips.2005.05.005

Fundamental considerations of beta-adrenoceptor subtypes in human heart failure

2005

Conference Publication

Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium

Kaumann, A. J., Christ, T., Ravens, U. and Molenaar, P. (2005). Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium. BPS Summer Meeting 2005, Cambridge, U.K., July, 2005.

Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium

2005

Journal Article

Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo

Winkel, KD, Tibballs, J, Molenaar, P, Lambert, G, Coles, P, Ross-Smith, M, Wiltshire, C, Fenner, PJ, Gershwin, LA, Hawdon, GM, Wright, CE and Angus, JA (2005). Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo. Clinical And Experimental Pharmacology And Physiology, 32 (9), 777-788. doi: 10.1111/j.1440-1681.2005.04258.x

Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo

2005

Conference Publication

Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure

Qvigstad, E., Brattelid, T., Sjaastad, I., Molenaar, P., Birkeland, J. A., Andressen, K. W., Krobert, K. A., Sejersted, O. M., Skomedal, T., Osnes, J-B., Kaumann, A. J. and Levy, F. O. (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure. International Soc for Heart Research, European Section Mtg, Norway, 21-25 Jun, 2005. Italy: Medimond International.

Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure

2005

Journal Article

Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II

Li, J., Wang, J. C., Russell, F. D. and Molenaar, P. (2005). Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. British Journal of Pharmacology, 145 (4), 432-440. doi: 10.1038/sj.bjp.0706217

Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II

2005

Conference Publication

Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium

Kaumann, A. J. and Molenaar, P. (2005). Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium. BPS Summer Meeting 2005, Cambridge, U.K., July, 2005.

Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium

2005

Conference Publication

Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart

Molenaar, P., Christ, T., Ravens, U., Chen, L. and Kaumann, A. (2005). Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart. Joint Meeting of ASCEPT & APSA, Melbourne, Australia, 4 - 7 Dec, 2005. Australia: ASCEPT.

Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart

2004

Conference Publication

Investigation of urotensin-II converting enzyme activity in human cells and blood

Kearns, P., Russell, F. D., Toth, I. and Molenaar, P. (2004). Investigation of urotensin-II converting enzyme activity in human cells and blood. 8th Annual Scientific Sessions of the Latin American Section of the International-Society for Heart Research, Brisbane, Qld, Australia, 7th - 11th August, 2004. United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003

Investigation of urotensin-II converting enzyme activity in human cells and blood

2004

Journal Article

Cardiovascular actions of human urotensin II - considerations for hypertension

Russell, F. D. and Molenaar, P. (2004). Cardiovascular actions of human urotensin II - considerations for hypertension. Naunyn-Schmiedebergs Archives of Pharmacology, 369 (3), 271-273. doi: 10.1007/s00210-004-0876-y

Cardiovascular actions of human urotensin II - considerations for hypertension

2004

Conference Publication

Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium

Russell, F. D. and Molenaar, P. (2004). Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium. 2004 ISHR World Congress Meeting, Brisbane, Qld, Australia, 7 - 11 August, 2004. London, England: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003

Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium

2004

Journal Article

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

Brattelid, T, Qvigstad, E, Lynham, JA, Molenaar, P, Aass, H, Geiran, O, Skomedal, T, Osnes, JB, Levy, FO and Kaumann, AJ (2004). Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's Arch Pharmacol, 370 (3), 157-166. doi: 10.1007/s00210-004-0963-0

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

2004

Journal Article

Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart

Russell, FD and Molenaar, P (2004). Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart. Cardiovascular Research, 63 (4), 673-681. doi: 10.1016/j.cardiores.2004.05.009

Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart

Funding

Current funding

  • 2024 - 2025
    Discovering new therapeutic targets for cardiac fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2023 - 2028
    Human Heart Research
    Research Donation Generic
    Open grant
  • 2023 - 2026
    Keeping Failing Hearts Beating - Research Towards the Prevention of Sudden Cardiac Death (Perpetual Impact Philanthropy Grant administered by TPCHF)
    Prince Charles Hospital Foundation
    Open grant

Past funding

  • 2022 - 2023
    Determination of effects of Atrogi compounds in human heart
    Atrogi AB
    Open grant
  • 2021 - 2023
    Anti-arrhythmic medicines: a new prototype targeting the ryanodine channel (RyR2) to reduce sudden death in heart failure patients
    Prince Charles Hospital Foundation
    Open grant
  • 2020 - 2021
    Assessment of effects of Atrogi future medicines in human heart
    Atrogi AB
    Open grant
  • 2020 - 2021
    Development and testing of new medicines in a human model of ventricular arrhythmias to keep heart failure patients alive.
    National Heart Foundation Vanguard Grant
    Open grant
  • 2019 - 2024
    New Medicines to Keep Heart Failure Patients Alive
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Cardio-Vascular Molecular & Translational Research Group
    Prince Charles Hospital Foundation
    Open grant
  • 2016 - 2020
    Identifying cyclic AMP limiting phosphodiesterases for heart failure treatment
    Prince Charles Hospital Foundation
    Open grant
  • 2015 - 2018
    Beta-blocker control of human ventricular arrhythmias in patients with heart failure through phosphodiesterases
    Prince Charles Hospital Foundation
    Open grant
  • 2014 - 2017
    Phosphodiesterase 2, 3 and 4 control of arrhythmias in the human heart
    Prince Charles Hospital Foundation
    Open grant
  • 2013
    Phosphodiesterase enzyme control of arrhythmias in human heart
    Prince Charles Hospital Foundation
    Open grant
  • 2012 - 2014
    Defining role of B2-adrenoceptors and human ventricular arrhythmias
    Prince Charles Hospital Foundation
    Open grant
  • 2011 - 2013
    To determine the effects of (-)- and (±)-ASL-8052 in the human heart (in vitro)
    UniQuest Pty Ltd
    Open grant
  • 2008 - 2010
    Molecular attributes and physiological significance of beta1L-adrenoceptors
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The genetic basis of B-blockers in heart failure
    Prince Charles Hospital Foundation
    Open grant
  • 2005 - 2007
    Elucidation of the molecular requirements of the low affinity 'state' of the beta1-adrenoceptor
    NHMRC Project Grant
    Open grant
  • 2004 - 2005
    NHMRC Senior Research Fellowship -- Grant In Aid for Year 7
    NHMRC Fellowship Grant
    Open grant
  • 2003 - 2004
    Adrenergic receptor regulation of calcineurin in the infant human heart
    Prince Charles Hospital Foundation
    Open grant
  • 2002 - 2004
    Contractile and relaxant effects of b2-and b1-adrenoceptors in human heart: blockade by a third generation b-blocker
    NHMRC Project Grant
    Open grant
  • 2000 - 2001
    Polymorphisms of B1 and B2 adrenoceptors in human heart
    National Heart Foundation of Australia
    Open grant
  • 1999 - 2000
    Effects of chronic administration of B-blockers in contractile function in human heart
    Prince Charles Hospital Foundation
    Open grant
  • 1999
    Chronic administration of B-adrenoceptor blockers in end-stage heart failure: Mechanism of benefit
    UQ New Staff Research Start-Up Fund
    Open grant
  • 1999
    Localization and quantitation of novel receptors in human heart
    Ramaciotti Foundation
    Open grant
  • 1998 - 2002
    Modulation of human cardiac function by B-adrenoceptor and endothelin receptor systems
    NHMRC Project Grant - 5 Yr Extended with Fellow
    Open grant
  • 1998 - 2004
    NHMRC RESEARCH FELLOWSHIP (Senior Research Fellow)
    NHMRC Fellowship Grant
    Open grant

Supervision

Availability

Honorary Professor Peter Molenaar is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Cause and prevention of stress induced arrhythmias in human heart

    Principal Advisor

    Other advisors: Dr Yee Weng Wong

  • Doctor Philosophy

    Understanding How Phosphorylative and Oxidative Stress Regulate Cardiac Ryanodine Receptor-Type 2 Gating Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure

    Principal Advisor

    Other advisors: Dr Yee Weng Wong

Completed supervision

Media

Enquiries

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