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Honorary Professor

Peter Molenaar

Email: 
Phone: 
+61 7 3139 4052

Overview

Availability

Honorary Professor Peter Molenaar is:
Available for supervision

Qualifications

  • Bachelor of Pharmacy, Victoria University
  • Masters (Coursework), Victoria University
  • Doctor of Philosophy, University of Melbourne

Works

Search Professor Peter Molenaar’s works on UQ eSpace

102 works between 1997 and 2024

21 - 40 of 102 works

2017

Journal Article

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts

Walweel, K., Molenaar, P., Imtiaz, M. S., Denniss, A., dos Remedios, C., van Helden, D. F., Dulhunty, A. F., Laver, D. R. and Beard, N. A. (2017). Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts. Journal of Molecular and Cellular Cardiology, 104, 53-62. doi: 10.1016/j.yjmcc.2017.01.016

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts

2015

Journal Article

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation

Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, Dos Remedios, Cristobal G., Thomas, Walter G. and Ramialison, Mirana (2015). Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (10) 1118, 1009-1027. doi: 10.1007/s00210-015-1118-1

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation

2015

Journal Article

G protein-coupled receptors in cardiac biology: old and new receptors

Foster, Simon R, Roura, Eugeni, Molenaar, Peter and Thomas, Walter G. (2015). G protein-coupled receptors in cardiac biology: old and new receptors. Biophysical Reviews, 7 (1), 77-89. doi: 10.1007/s12551-014-0154-2

G protein-coupled receptors in cardiac biology: old and new receptors

2015

Conference Publication

Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses

Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, dos Remedios, Cris G., Thomas, Walter G. and Ramialison, Mirana (2015). Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses. 15th Scientific Meeting of the Australasian Association for ChemoSensory Science (AACSS), Brisbane, QLD Australia, 03-05 December 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv008

Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses

2014

Journal Article

Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Walweel, Kafa, Li, Jiao, Molenaar, Peter, Imtiaz, Mohammad S., Quail, Anthony, dos Remedios, Cris G., Beard, Nicole A., Dulhunty, Angela F., van Helden, Dirk F. and Laver, Derek R. (2014). Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum. Journal of General Physiology, 144 (3), 263-271. doi: 10.1085/jgp.201311157

Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

2014

Journal Article

Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

Molenaar, Peter, Christ, Torsten, Berk, Emanuel, Engel, Andreas, Gillette, Katherine T., Galindo-Tovar, Alejandro, Ravens, Ursula and Kaumann, Alberto J. (2014). Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology, 387 (7), 629-640. doi: 10.1007/s00210-014-0974-4

Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

2013

Journal Article

Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling

Kiriazis, Helen, Tugiono, Niquita, Xu, Qi, Gao, Xiao-Ming, Jennings, Nicole L., Ming, Ziqui, Su, Yidan, Klenowski, Paul, Summers, Roger J., Kaumann, Alberto, Molenaar, Peter and Du, Xiao-Jun (2013). Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling. British Journal of Pharmacology, 170 (2), 352-365. doi: 10.1111/bph.12272

Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling

2013

Journal Article

PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

Molenaar, Peter, Christ, Torsten, Hussain, Rizwan I., Engel, Andreas, Berk, Emanuel, Gillette, Katherine T., Chen, Lu, Galindo-Tovar, Alejandro, Krobert, Kurt A., Ravens, Ursula, Levy, Finn Olav and Kaumann, Alberto J. (2013). PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. British Journal of Pharmacology, 169 (3), 528-538. doi: 10.1111/bph.12167

PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

2013

Journal Article

Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

Foster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579

Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

2013

Conference Publication

The role of beta1 adrenoceptors in the development of alcohol dependence

Klenowski, P. M., Holgate, J., Bellingham, M., Molenaar, P. and Bartlett, S. (2013). The role of beta1 adrenoceptors in the development of alcohol dependence. Neuroscience 2013: 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA, USA, 9-13 November, 2013.

The role of beta1 adrenoceptors in the development of alcohol dependence

2011

Journal Article

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

Chandler, Natalie, Aslanidi, Oleg, Buckley, David, Inada, Shin, Birchall, Steven, Atkinson, Andrew, Kirk, Danielle, Monfredi, Oliver, Molenaar, Peter, Anderson, Robert, Sharma, Vinod, Sigg, Daniel, Zhang, Henggui, Boyett, Mark and Dobrzynski, Halina (2011). Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area. Anatomical Record, 294 (6), 970-979. doi: 10.1002/ar.21379

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

2011

Journal Article

Molecular architecture of the human specialised atrioventricular conduction axis

Greener, I. D., Monfredi, O., Inada, S., Chandler, N. J, Tellez, J.O., Atkinson, A., Taube, M. A., Billeter, R., Anderson, R. H., Efimov, I. R., Molenaar, P., Sigg, D. C., Sharma, V., Boyett, M. R. and Dobrzynski, H. (2011). Molecular architecture of the human specialised atrioventricular conduction axis. Journal of Molecular and Cellular Cardiology, 50 (4), 642-651. doi: 10.1016/j.yjmcc.2010.12.017

Molecular architecture of the human specialised atrioventricular conduction axis

2011

Journal Article

Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperature

Christ, Torsten, Molenaar, Peter, Klenowski, Paul M., Ravens, Ursula and Kaumann, Alberto J. (2011). Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperature. British Journal of Pharmacology, 162 (4), 823-839. doi: 10.1111/j.1476-5381.2010.00996.x

Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperature

2009

Journal Article

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

Musa, Hanny, Tellez, James O., Chandler, Natalie J., Greener, Ian D., Maczewski, Michał, Mackiewicz, Urszula, Beresewicz, Andrzej, Molenaar, Peter, Boyett, Mark R. and Dobrzynski, Halina (2009). P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions. Naunyn-Schmiedeberg's Archives of Pharmacology, 379 (6), 541-549. doi: 10.1007/s00210-009-0403-2

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

2009

Journal Article

Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac Pacemaker

Chandler, Natalie J., Greener, Ian D., Tellez, James O., Inada, Shin, Musa, Hanny, Molenaar, Peter, DiFrancesco, Dario, Baruscotti, Mirko, Longhi, Renato, Anderson, Robert H., Billeter, Rudolf, Sharma, Vinod, Sigg, Daniel C., Boyett, Mark R. and Dobrzynski, Halina (2009). Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac Pacemaker. Circulation, 119 (12), 1562-1575. doi: 10.1161/CIRCULATIONAHA.108.804369

Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac Pacemaker

2008

Journal Article

The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology

Kaumann, Alberto J. and Molenaar, Peter (2008). The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology. Pharmacology and Therapeutics, 118 (3), 303-336. doi: 10.1016/j.pharmthera.2008.03.009

The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology

2007

Journal Article

Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol

Cheng lu, Meyers, Deborah, Javorsky, George, Bursto, Darryl, Lolekha, Pakorn, Lucas, Margaret, Semmler, Annalese B. T., Savarimuthu, Santiyagu M., Fong, Kwun M., Yang, Ian A., Atherton, John, Galbraith, Andrew J., Parsonage, William A. and Molenaar, Peter (2007). Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. Pharmacogenetics And Genomics, 17 (11), 941-949. doi: 10.1097/FPC.0b013e3282ef7354

Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol

2007

Journal Article

beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design

Yang, Ian A., Ng, Taria, Molenaar, Peter and Fong, Kwun M. (2007). beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design. Clinical And Experimental Pharmacology and Physiology, 34 (10), 1029-1036. doi: 10.1111/j.1440-1681.2007.04731.x

beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design

2007

Journal Article

Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphism

Molenaar, P., Chen, L., Semmler, A. B. T., Parsonage, W. A. and Kaumann, A. J. (2007). Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphism. Clinical And Experimental Pharmacology And Physiology, 34 (10), 1020-1028. doi: 10.1111/j.1440-1681.2007.04730.x

Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphism

2007

Journal Article

The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells

Kaumann, Alberto, Semmler, Annalese B. T. and Molenaar, Peter (2007). The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. Naunyn-schmiedebergs Archives of Pharmacology, 375 (2), 123-131. doi: 10.1007/s00210-007-0140-3

The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells

Funding

Current funding

  • 2024 - 2025
    Discovering new therapeutic targets for cardiac fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2023 - 2028
    Human Heart Research
    Research Donation Generic
    Open grant
  • 2023 - 2026
    Keeping Failing Hearts Beating - Research Towards the Prevention of Sudden Cardiac Death (Perpetual Impact Philanthropy Grant administered by TPCHF)
    Prince Charles Hospital Foundation
    Open grant

Past funding

  • 2022 - 2023
    Determination of effects of Atrogi compounds in human heart
    Atrogi AB
    Open grant
  • 2021 - 2023
    Anti-arrhythmic medicines: a new prototype targeting the ryanodine channel (RyR2) to reduce sudden death in heart failure patients
    Prince Charles Hospital Foundation
    Open grant
  • 2020 - 2021
    Assessment of effects of Atrogi future medicines in human heart
    Atrogi AB
    Open grant
  • 2020 - 2021
    Development and testing of new medicines in a human model of ventricular arrhythmias to keep heart failure patients alive.
    National Heart Foundation Vanguard Grant
    Open grant
  • 2019 - 2024
    New Medicines to Keep Heart Failure Patients Alive
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Cardio-Vascular Molecular & Translational Research Group
    Prince Charles Hospital Foundation
    Open grant
  • 2016 - 2020
    Identifying cyclic AMP limiting phosphodiesterases for heart failure treatment
    Prince Charles Hospital Foundation
    Open grant
  • 2015 - 2018
    Beta-blocker control of human ventricular arrhythmias in patients with heart failure through phosphodiesterases
    Prince Charles Hospital Foundation
    Open grant
  • 2014 - 2017
    Phosphodiesterase 2, 3 and 4 control of arrhythmias in the human heart
    Prince Charles Hospital Foundation
    Open grant
  • 2013
    Phosphodiesterase enzyme control of arrhythmias in human heart
    Prince Charles Hospital Foundation
    Open grant
  • 2012 - 2014
    Defining role of B2-adrenoceptors and human ventricular arrhythmias
    Prince Charles Hospital Foundation
    Open grant
  • 2011 - 2013
    To determine the effects of (-)- and (±)-ASL-8052 in the human heart (in vitro)
    UniQuest Pty Ltd
    Open grant
  • 2008 - 2010
    Molecular attributes and physiological significance of beta1L-adrenoceptors
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The genetic basis of B-blockers in heart failure
    Prince Charles Hospital Foundation
    Open grant
  • 2005 - 2007
    Elucidation of the molecular requirements of the low affinity 'state' of the beta1-adrenoceptor
    NHMRC Project Grant
    Open grant
  • 2004 - 2005
    NHMRC Senior Research Fellowship -- Grant In Aid for Year 7
    NHMRC Fellowship Grant
    Open grant
  • 2003 - 2004
    Adrenergic receptor regulation of calcineurin in the infant human heart
    Prince Charles Hospital Foundation
    Open grant
  • 2002 - 2004
    Contractile and relaxant effects of b2-and b1-adrenoceptors in human heart: blockade by a third generation b-blocker
    NHMRC Project Grant
    Open grant
  • 2000 - 2001
    Polymorphisms of B1 and B2 adrenoceptors in human heart
    National Heart Foundation of Australia
    Open grant
  • 1999 - 2000
    Effects of chronic administration of B-blockers in contractile function in human heart
    Prince Charles Hospital Foundation
    Open grant
  • 1999
    Chronic administration of B-adrenoceptor blockers in end-stage heart failure: Mechanism of benefit
    UQ New Staff Research Start-Up Fund
    Open grant
  • 1999
    Localization and quantitation of novel receptors in human heart
    Ramaciotti Foundation
    Open grant
  • 1998 - 2002
    Modulation of human cardiac function by B-adrenoceptor and endothelin receptor systems
    NHMRC Project Grant - 5 Yr Extended with Fellow
    Open grant
  • 1998 - 2004
    NHMRC RESEARCH FELLOWSHIP (Senior Research Fellow)
    NHMRC Fellowship Grant
    Open grant

Supervision

Availability

Honorary Professor Peter Molenaar is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Understanding How Phosphorylative and Oxidative Stress Regulate Cardiac Ryanodine Receptor-Type 2 Gating Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure

    Principal Advisor

    Other advisors: Dr Yee Weng Wong

  • Doctor Philosophy

    Cause and prevention of stress induced arrhythmias in human heart

    Principal Advisor

    Other advisors: Dr Yee Weng Wong

Completed supervision

Media

Enquiries

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