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2024 Journal Article Profiling reduced expression of contractile and mitochondrial mRNAs in the human sinoatrial node vs. right atrium and predicting their suppressed expression by transcription factors and/or microRNAsChen, Weixuan, Aminu, Abimbola J., Yin, Zeyuan, Karaesmen, Irem, Atkinson, Andrew J., Kuniewicz, Marcin, Holda, Mateusz, Walocha, Jerzy, Perde, Filip, Molenaar, Peter and Dobrzynski, Halina (2024). Profiling reduced expression of contractile and mitochondrial mRNAs in the human sinoatrial node vs. right atrium and predicting their suppressed expression by transcription factors and/or microRNAs. International Journal of Molecular Sciences, 25 (19) 10402, 1-24. doi: 10.3390/ijms251910402 |
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2024 Journal Article The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitisTalamonti, Emanuela, Davegardh, Jelena, Kalinovich, Anastasia, van Beek, Sten M. M., Dehvari, Nodi, Halleskog, Carina, Bokhari, Hamza M., Hutchinson, Dana S., Ham, Seungmin, Humphrys, Laura J., Dijon, Nicola C., Motso, Aikaterini, Sandstrom, Anna, Zacharewicz, Evelyn, Mutule, Ilga, Suna, Edgars, Spura, Jana, Ditrychova, Karolina, Stoddart, Leigh A., Holliday, Nicholas D., Wright, Shane C., Lauschke, Volker M., Nielsen, Soren, Scheele, Camilla, Cheesman, Elizabeth, Hoeks, Joris, Molenaar, Peter, Summers, Roger J., Pelcman, Benjamin ... Bengtsson, Tore (2024). The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis. Molecular Metabolism, 85 101931, 101931. doi: 10.1016/j.molmet.2024.101931 |
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2023 Journal Article Potential of β2AR for added benefit in treating heart failure through a better understanding of signalingWalweel, Kafa, Cheesman, Elizabeth and Molenaar, Peter (2023). Potential of β2AR for added benefit in treating heart failure through a better understanding of signaling. Current Opinion in Physiology, 36 100719, 100719. doi: 10.1016/j.cophys.2023.100719 |
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2023 Journal Article Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheepSee Hoe, Louise E., Bassi, Gianluigi Li, Wildi, Karin, Passmore, Margaret R., Bouquet, Mahe, Sato, Kei, Heinsar, Silver, Ainola, Carmen, Bartnikowski, Nicole, Wilson, Emily S., Hyslop, Kieran, Skeggs, Kris, Obonyo, Nchafatso G., Shuker, Tristan, Bradbury, Lucy, Palmieri, Chiara, Pedersen, Sanne-Engkilde, McDonald, Charles, Colombo, Sebastiano M., Wells, Matthew A., Reid, Janice D., O'Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Haymet, Andrew, Jung, Jae-Seung, Sato, Noriko, James, Lynnette, He, Ting ... Fraser, John F. (2023). Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep. The Journal of Heart and Lung Transplantation, 42 (8), 1015-1029. doi: 10.1016/j.healun.2023.03.020 |
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2022 Journal Article Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals: Iodine and graphene oxide – visualising human conduction system in normal, aged, and obese heartsAminu, Abimbola J., Chen, Weixuan, Yin, Zeyuan, Kuniewicz, Marcin, Walocha, Jerzy, Perde, Filip, Molenaar, Peter, Iaizzo, Paul A., Dobrzynski, Halina and Atkinson, Andrew J. (2022). Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals: Iodine and graphene oxide – visualising human conduction system in normal, aged, and obese hearts. Translational Research in Anatomy, 27 100175, 1-17. doi: 10.1016/j.tria.2022.100175 |
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2021 Journal Article A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem deathSee Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4 |
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2021 Journal Article Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAsAminu, Abimbola J., Petkova, Maria, Atkinson, Andrew J., Yanni, Joseph, Morris, Alex D., Simms, Robert T., Chen, Weixuan, Yin, Zeyuan, Kuniewicz, Marcin, Holda, Mateusz K., Kuzmin, Vladislav S., Perde, Filip, Molenaar, Peter and Dobrzynski, Halina (2021). Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs. Progress in Biophysics and Molecular Biology, 166, 86-104. doi: 10.1016/j.pbiomolbio.2021.04.008 |
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2021 Journal Article Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem deathWells, Matthew A., See Hoe, Louise E., Molenaar, Peter, Pedersen, Sanne, Obonyo, Nchafatso G., McDonald, Charles I., Mo, Weilan, Bouquet, Mahè, Hyslop, Kieran, Passmore, Margaret R., Bartnikowski, Nicole, Suen, Jacky Y., Peart, Jason N., McGiffin, David C., Fraser, John F. and on behalf of the Dead Heart Project (2021). Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death. Pharmacological Research, 169 105631, 1-12. doi: 10.1016/j.phrs.2021.105631 |
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2021 Journal Article Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenalineDashwood, Alexander, Cheesman, Elizabeth, Wong, Yee Weng, Haqqani, Haris, Beard, Nicole, Hay, Karen, Spratt, Melanie, Chan, Wandy and Molenaar, Peter (2021). Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline. Pharmacology Research and Perspectives, 9 (3) e00760, e00760. doi: 10.1002/prp2.760 |
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2021 Journal Article Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia RiskPineda, Santiago, Nikolova-Krstevski, Vesna, Leimena, Christiana, Atkinson, Andrew J., Altekoester, Ann-Kristin, Cox, Charles D., Jacoby, Arie, Huttner, Inken G., Ju, Yue-Kun, Soka, Magdalena, Ohanian, Monique, Trivedi, Gunjan, Kalvakuri, Sreehari, Birker, Katja, Johnson, Renee, Molenaar, Peter, Kuchar, Dennis, Allen, David G., Van Helden, Dirk F., Harvey, Richard P., Hill, Adam P., Bodmer, Rolf, Vogler, Georg, Dobrzynski, Halina, Ocorr, Karen and Fatkin, Diane (2021). Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk. Circulation: Genomic and Precision Medicine, 14 (2) 003144, 230-242. doi: 10.1161/CIRCGEN.120.003144 |
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2020 Journal Article Correction to “Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure”Dashwood, Alexander, Beard, Nicole, Wong, Yee Weng, Haqqani, Haris, Cheesman, Elizabeth and Molenaar, Peter (2020). Correction to “Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure”. ACS Pharmacology and Translational Science, 3 (6), 1422-1422. doi: 10.1021/acsptsci.0c00148 |
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2020 Journal Article Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?Denniss, Amanda L., Dashwood, Alexander M., Molenaar, Peter and Beard, Nicole A. (2020). Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?. Biophysical Reviews, 12 (4), 865-878. doi: 10.1007/s12551-020-00736-y |
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2020 Journal Article Understanding how phosphorylation and redox modifications regulate cardiac ryanodine receptor type 2 activity to produce an arrhythmogenic phenotype in advanced heart failureDashwood, Alexander, Cheesman, Elizabeth, Beard, Nicole, Haqqani, Haris, Wong, Yee Weng and Molenaar, Peter (2020). Understanding how phosphorylation and redox modifications regulate cardiac ryanodine receptor type 2 activity to produce an arrhythmogenic phenotype in advanced heart failure. ACS Pharmacology and Translational Science, 3 (4) acsptsci.0c00003, 563-582. doi: 10.1021/acsptsci.0c00003 |
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2020 Journal Article Phenytoin reduces activity of cardiac ryanodine receptor 2; a potential mechanism for its cardioprotective actionAshna, A., van Heiden, D. F., dos Remedios, C., Molenaar, P. and Laver, D. R. (2020). Phenytoin reduces activity of cardiac ryanodine receptor 2; a potential mechanism for its cardioprotective action. Molecular Pharmacology, 97 (4), 250-258. doi: 10.1124/mol.119.117721 |
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2019 Journal Article Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814Walweel, Kafa, Gomez-Hurtado, Nieves, Rebbeck, Robyn T., Oo, Ye Wint, Beard, Nicole A., Molenaar, Peter, dos Remedios, Cris, van Helden, Dirk F., Cornea, Razvan L., Knollmann, Björn C. and Laver, Derek R. (2019). Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814. Journal of Molecular and Cellular Cardiology, 130, 96-106. doi: 10.1016/j.yjmcc.2019.03.018 |
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2017 Journal Article The β3-adrenoceptor agonist mirabegron increases human atrial force through β1-adrenoceptors: an indirect mechanism?Mo, Weilan, Michel, Martin C., Lee, Xiang Wen, Kaumann, Alberto J. and Molenaar, Peter (2017). The β3-adrenoceptor agonist mirabegron increases human atrial force through β1-adrenoceptors: an indirect mechanism?. British Journal of Pharmacology, 174 (16), 2706-2715. doi: 10.1111/bph.13897 |
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2017 Journal Article Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human heartsWalweel, K., Molenaar, P., Imtiaz, M. S., Denniss, A., dos Remedios, C., van Helden, D. F., Dulhunty, A. F., Laver, D. R. and Beard, N. A. (2017). Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts. Journal of Molecular and Cellular Cardiology, 104, 53-62. doi: 10.1016/j.yjmcc.2017.01.016 |
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2015 Journal Article Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulationFoster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, Dos Remedios, Cristobal G., Thomas, Walter G. and Ramialison, Mirana (2015). Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (10) 1118, 1009-1027. doi: 10.1007/s00210-015-1118-1 |
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2015 Journal Article G protein-coupled receptors in cardiac biology: old and new receptorsFoster, Simon R, Roura, Eugeni, Molenaar, Peter and Thomas, Walter G. (2015). G protein-coupled receptors in cardiac biology: old and new receptors. Biophysical Reviews, 7 (1), 77-89. doi: 10.1007/s12551-014-0154-2 |
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2014 Journal Article Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulumWalweel, Kafa, Li, Jiao, Molenaar, Peter, Imtiaz, Mohammad S., Quail, Anthony, dos Remedios, Cris G., Beard, Nicole A., Dulhunty, Angela F., van Helden, Dirk F. and Laver, Derek R. (2014). Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum. Journal of General Physiology, 144 (3), 263-271. doi: 10.1085/jgp.201311157 |
