
Overview
Background
After completing neurology training at the Royal Brisbane & Women’s Hospital(RBWH) in 1995, A/Prof O’Sullivan completed Fellowships in Movement Disorders at the Austin & Repatriation Medical Centre, Melbourne then the National Hospital for Neurology and Neurosurgery, and Middlesex Hospital in London, UK. He was awarded a doctorate in Medicine from Melbourne University in 2000 for studies into surgery for Parkinson’s disease. He returned to the RBWH in 2001 and set up the Movement Disorders Clinical Service including botulinum toxin and later Friedreich's ataxia clinics, and co-ordinating the Huntington's disease multidisciplinary clinic. Through these clinics he has established collaborations with local, interstate and international researchers in the fields of Parkinson's disease, and other movement disorders and neurodegenerative diseases. He is currently Associate Professor of Medicine and Principal Research Fellow at UQ Centre for Clinical Research, previously Royal Brisbane and Uniting Care Health Clinical Units in UQ School of Clinical Medicine. A/Prof O'Sullivan past President of the Movement Disorders Society of Australia and New Zealand (MDSANZ), having previously served as Chair of the MDSANZ Clinical Trials and Research Group. He is on the Council of the Australian and New Zealand Association of Neurolgists (ANZAN) and previously chaired the ANZAN Scientific Program Committee
Availability
- Associate Professor John O'Sullivan is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Non-motor features of Parkinson's disease
This research involves studies into depression, anxiety and cognitive function in Parkinson's disease in collaboration with Dr Nadeeka Dissanayaka, Dr Robert Adam, Prof Gerard Byrne, Dr Nancy Pachana & Dr Rodney Marsh
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Novel compounds and clinical trials in neurodegenerative diseases
Research involves novel compounds and repurposed drugs for treatment and disease-modification in Parkinson's, Huntington's disease, Friedreich's Ataxia, Progressive Supranuclear Palsy and motor neurone diseases in collaboration with Dr Richard Gordon, A/Prof Trent Woodruff, A/Prof Rob Henderson, Prof Pam McCombe, Dr Robert Adam and Wesley Medical Research.
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Exercise in Parkinson's disease
In collaboration with Prof Sandy Brauer, Dr Robyn Lamont, and Wesley Medical Research, studies exploring maintenance of exercise, gait and boxing in Parkinson's disease.
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Sleep in neurodegenerative diseases
These studies in collaboration with Dr Simon Smith, Dr Jane Nikles and Wesley Medical Research explore novel aspects involving sleep in Parkinson's, Huntington's and motor neurone diseases and Friedreich's ataxia
Research impacts
A/Prof O’Sullivan’s novel investigator-initiated clinical trial in Parkinson’s disease (PD) (Mov Dis 2007; 22:1543-9) is cited in the American Academy of Neurology Practice Parameters and MDS Evidence Based Medicine Review of Management of Non-motor symptoms in PD. The initial description of syndrome of Dopamine Dysregulation in PD (JNNP 2000; 68:423-428) complicating dopamine replacement therapy in some patients with Parkinson’s disease has led to widespread recognition of the syndrome, and this paper has had more than 400 citations. The Movement Disorders Society revision of the Unified Parkinson’s Disease Rating Scale (MDS–UPDRS) includes a section to address features of the dopamine dysregulation syndrome as a result of this. This research has also contributed to debate about addiction in general (Addiction. 2012;107(2):253).
Works
Search Professor John O'Sullivan’s works on UQ eSpace
2001
Conference Publication
Drooling in Parkinson's disease: A novel speech and language therapy intervention
Marks, L., Turner, K., O'Sullivan, J., Deighton, B. and Lees, A. (2001). Drooling in Parkinson's disease: A novel speech and language therapy intervention.
2001
Journal Article
Prospective study of selective peripheral denervation for botulinum-toxin resistant patients with cervical dystonia
Munchau, A, Palmer, JD, Dressler, D, O'Sullivan, JD, Tsang, KL, Jahanshahi, M, Quinn, NP, Lees, AJ and Bhatia, KP (2001). Prospective study of selective peripheral denervation for botulinum-toxin resistant patients with cervical dystonia. Brain, 124 (4), 769-783. doi: 10.1093/brain/124.4.769
2001
Journal Article
SPECT imaging of the dopamine transporter in juvenile-onset dystonia
O'Sullivan, JD, Costa, DC, Gacinovic, S and Lees, AJ (2001). SPECT imaging of the dopamine transporter in juvenile-onset dystonia. Neurology, 56 (2), 266-267. doi: 10.1212/WNL.56.2.266
2001
Journal Article
Unusual tremor associated with a posterolateral thalamic lesion in a drummer
O'Sullivan, JD, Brown, P and Lees, AJ (2001). Unusual tremor associated with a posterolateral thalamic lesion in a drummer. Movement Disorders, 16 (1), 174-176. doi: 10.1002/1531-8257(200101)16:13.0.CO;2-I
2001
Journal Article
Motor imagery in Parkinson's disease: A PET study
Cunnington, R, Egan, GF, OSullivan, JD, Hughes, AJ, Bradshaw, JL and Colebatch, JG (2001). Motor imagery in Parkinson's disease: A PET study. Movement Disorders, 16 (5), 849-857. doi: 10.1002/mds.1181
2000
Journal Article
Nonparkinsonian tremors
O'Sullivan, John D. and Lees, Andrew J. (2000). Nonparkinsonian tremors. Clinical Neuropharmacology, 23 (5), 233-238. doi: 10.1097/00002826-200009000-00001
2000
Journal Article
L-dopa-resistant parkinsonism syndrome following cerebral radiation therapy for neoplasm
Wick, W, Hochberg, F, O'Sullivan, J, Goessling, A, Hughes, A and Cher, L (2000). L-dopa-resistant parkinsonism syndrome following cerebral radiation therapy for neoplasm. Oncology Reports, 7 (6), 1367-1370.
2000
Journal Article
Parkinsonism in HIV encephalopathy
O'Sullivan, John D., Hanagasi, Hasmet A., Daniel, Susan E., Tidswell, Phillip, Davies, Stephen W. and Lees, Andrew J. (2000). Parkinsonism in HIV encephalopathy. Movement Disorders, 15 (5), 1032-1033. doi: 10.1002/1531-8257(200009)15:53.0.CO;2-X
2000
Journal Article
Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies
Giovannoni, G, O'Sullivan, JD, Turner, K, Manson, AJ and Lees, AJL (2000). Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies. Journal of Neurology Neurosurgery and Psychiatry, 68 (4), 423-428. doi: 10.1136/jnnp.68.4.423
2000
Journal Article
An ambulatory dyskinesia monitor
Manson, AJ, Brown, P, O'Sullivan, JD, Asselman, P, Buckwell, D and Lees, AJ (2000). An ambulatory dyskinesia monitor. Journal of Neurology Neurosurgery and Psychiatry, 68 (2), 196-201. doi: 10.1136/jnnp.68.2.196
2000
Journal Article
Botulinum toxin A as treatment for drooling saliva in PD [7] (multiple letters)
O'Sullivan, John D., Bhatia, Kailash P. and Lees, Andrew J. (2000). Botulinum toxin A as treatment for drooling saliva in PD [7] (multiple letters). Neurology, 55 (4), 606-607. doi: 10.1212/WNL.55.4.606-a
1999
Journal Article
Use of apomorphine in Parkinson's disease
O'Sullivan, JD and Lees, AJ (1999). Use of apomorphine in Parkinson's disease. Hospital Medicine, 60 (11), 816-820. doi: 10.12968/hosp.1999.60.11.1236
1999
Journal Article
Oral dopamine agonists adverse drug reaction profile
O'Sullivan, J. and Lees, A. (1999). Oral dopamine agonists adverse drug reaction profile. Prescribers' Journal, 39 (3), 166-172.
1999
Journal Article
Yawning in Parkinson's disease [1] (multiple letters)
Colosimo, C., Pontieri, F. E., Evidente, V. G.H., Hardy, K. G., O'Sullivan, J. D., Lees, A. J., Hughes, A. J., Friedman, J. H. and Goren, J. (1999). Yawning in Parkinson's disease [1] (multiple letters). Neurology, 52 (2), 428-428. doi: 10.1212/WNL.52.2.428
1999
Journal Article
Yawning in Parkinson's disease
O'Sullivan, JD, Lees, AJ and Hughes, AJ (1999). Yawning in Parkinson's disease. Neurology, 52 (2), 428-428.
1998
Journal Article
Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function
O'Sullivan, JD, Said, CM, Dillon, LC, Hoffman, M and Hughes, AJ (1998). Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function. Movement Disorders, 13 (6), 900-906. doi: 10.1002/mds.870130607
1998
Journal Article
The effect of unilateral posteroventral pallidotomy on the kinematics of the reach to grasp movement
Bennett, KMB, O'Sullivan, JD, Peppard, RF, McNeill, PM and Castiello, U (1998). The effect of unilateral posteroventral pallidotomy on the kinematics of the reach to grasp movement. Journal of Neurology Neurosurgery and Psychiatry, 65 (4), 479-487. doi: 10.1136/jnnp.65.4.479
1998
Journal Article
Apomorphine-induced penile erections in Parkinson's disease
O'Sullivan, JD and Hughes, AJ (1998). Apomorphine-induced penile erections in Parkinson's disease. Movement Disorders, 13 (3), 536-539. doi: 10.1002/mds.870130326
1998
Journal Article
Left posteroventral pallidotomy results in a deficit in verbal memory
Crowe, SF, O'Sullivan, JD, Peppard, RE, McNeill, PM, Bardenhagen, F and Bowden, S. (1998). Left posteroventral pallidotomy results in a deficit in verbal memory. Behavioural Neurology, 11 (2), 79-84. doi: 10.1155/1998/174740
1997
Journal Article
Fatal encephalitis due to novel paramyxovirus transmitted from horses
Osullivan, JD, Allworth, AM, Paterson, DL, Snow, TM, Boots, R, Gleeson, LJ, Gould, AR, Hyatt, AD and Bradfield, J (1997). Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet, 349 (9045), 93-95. doi: 10.1016/S0140-6736(96)06162-4
Funding
Current funding
Supervision
Availability
- Associate Professor John O'Sullivan is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Digital symptom tracking - using digital tools for measuring and tracking motor, cognitive, and speech changes
Associate Advisor
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Doctor Philosophy
The evolution of cognitive deficits in Lewy body disorders and related degenerative diseases.
Associate Advisor
Other advisors: Professor Peter Nestor
Completed supervision
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2023
Doctor Philosophy
Cognitive subtypes in Parkinson's disease: exploring phenotypes, neuroimaging targets, and therapeutics
Associate Advisor
Other advisors: Professor Gerard Byrne, Dr Ji Hyun Julia Yang, Professor Nadeeka Dissanayaka
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2008
Doctor Philosophy
Depression in Parkinson's disease: assessment methods and risk factors
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts
Media
Enquiries
Contact Associate Professor John O'Sullivan directly for media enquiries about:
- Botulinum toxin
- Dystonia
- Huntington's disease
- Movement disorders
- Parkinson's disease
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