Overview
Background
After completing neurology training at the Royal Brisbane & Women’s Hospital(RBWH) in 1995, A/Prof O’Sullivan completed Fellowships in Movement Disorders at the Austin & Repatriation Medical Centre, Melbourne then the National Hospital for Neurology and Neurosurgery, and Middlesex Hospital in London, UK. He was awarded a doctorate in Medicine from Melbourne University in 2000 for studies into surgery for Parkinson’s disease. He returned to the RBWH in 2001 and set up the Movement Disorders Clinical Service which he directs including botulinum toxin and later Friedreich's ataxia clinics, and co-ordinating the Huntington's disease multidisciplinary clinic. Through these clinics he has established collaborations with local, interstate and international researchers in the fields of Parkinson's disease, and other movement disorders and neurodegenerative diseases. He is currently Associate Professor of Medicine at UQ Centre for Clinical Research, currently co-director of the Neurodegenertion Clinical Research Group. A/Prof O'Sullivan past President of the Movement Disorders Society of Australia and New Zealand (MDSANZ), having previously served as Chair of the MDSANZ Clinical Trials and Research Group. He has been is on the Council of the Australian and New Zealand Association of Neurolgists (ANZAN) and previously chaired the ANZAN Scientific Program Committee.
Availability
- Associate Professor John O'Sullivan is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Non-motor features of Parkinson's disease
This research involves studies into depression, anxiety and cognitive function in Parkinson's disease in collaboration with Dr Nadeeka Dissanayaka, Dr Robert Adam, Prof Gerard Byrne, Dr Nancy Pachana & Dr Rodney Marsh
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Novel compounds and clinical trials in neurodegenerative diseases
Research involves novel compounds and repurposed drugs for treatment and disease-modification in Parkinson's, Huntington's disease, Friedreich's Ataxia, Progressive Supranuclear Palsy and motor neurone diseases in collaboration with Dr Richard Gordon, A/Prof Trent Woodruff, A/Prof Rob Henderson, Prof Pam McCombe, Dr Robert Adam and Wesley Medical Research.
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Exercise in Parkinson's disease
In collaboration with Prof Sandy Brauer, Dr Robyn Lamont, and Wesley Medical Research, studies exploring maintenance of exercise, gait and boxing in Parkinson's disease.
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Sleep in neurodegenerative diseases
These studies in collaboration with Dr Simon Smith, Dr Jane Nikles and Wesley Medical Research explore novel aspects involving sleep in Parkinson's, Huntington's and motor neurone diseases and Friedreich's ataxia
Research impacts
A/Prof O’Sullivan’s novel investigator-initiated clinical trial in Parkinson’s disease (PD) (Mov Dis 2007; 22:1543-9) is cited in the American Academy of Neurology Practice Parameters and MDS Evidence Based Medicine Review of Management of Non-motor symptoms in PD. The initial description of syndrome of Dopamine Dysregulation in PD (JNNP 2000; 68:423-428) complicating dopamine replacement therapy in some patients with Parkinson’s disease has led to widespread recognition of the syndrome, and this paper has had more than 400 citations. The Movement Disorders Society revision of the Unified Parkinson’s Disease Rating Scale (MDS–UPDRS) includes a section to address features of the dopamine dysregulation syndrome as a result of this. This research has also contributed to debate about addiction in general (Addiction. 2012;107(2):253).
Works
Search Professor John O'Sullivan’s works on UQ eSpace
2005
Conference Publication
Circadian blood pressure variation after acute stroke
Pandian, J., Wong, A., Lincoln, D., Davis, J., Henderson, R., O'Sullivan, J. and Read, S. (2005). Circadian blood pressure variation after acute stroke. 18th World Congress of Neurology, Sydney, Australia, 5-11 November 2005. Amsterdam, Netherlands: Elsevier .
2005
Journal Article
First case report of X linked dystonia parkinsonism (XDP) or 'lubag' in Australia
Plummer, C., Bradfield, J., Singleton, A. B., Hernandez, D., Singleton, A. A. and O'Sullivan, J. (2005). First case report of X linked dystonia parkinsonism (XDP) or 'lubag' in Australia. Journal of Clinical Neuroscience, 12 (8), 946-947. doi: 10.1016/j.jocn.2004.10.015
2005
Journal Article
Teaching people with Parkinson's disease about their medication
O'Maley, Karen, O'Sullivan, John, Wollin, Judy, Barras, Michael and Brammer, Jillian (2005). Teaching people with Parkinson's disease about their medication. Nursing Older People, 17 (1) doi: 10.7748/nop2005.03.17.1.14.c2357
2005
Journal Article
Cerebeller vermis hyperdensity on CT scan
Wolski, P., Read, S. J., O'Sullivan, J. D. and Henderson, R. D. (2005). Cerebeller vermis hyperdensity on CT scan. Journal of Clinical Neuroscience, 12 (6), 676-676. doi: 10.1016/j.jocn.2005.03.011
2005
Conference Publication
Impact of depression on quality of life in people with Parkinson’s disease
Dissanayaka, N. N. W., Sellbach, A., O’Sullivan, J. D., Silburn, P. A. and Mellick, G. D. (2005). Impact of depression on quality of life in people with Parkinson’s disease. 4th National Conference of Emerging Researchers in Aging, Brisbane, 2005.
2005
Conference Publication
Risk factors and assessment methods for depression associated with Parkinson's disease
Dissanayaka, N. N. W., Deng, Y., Marsh, R., O’Sullivan, J. D., Silburn, P. A., Roberts, M. and Mellick, G. D. (2005). Risk factors and assessment methods for depression associated with Parkinson's disease. ASMR Queensland Postgraduate Medical Research Student Conference, Brisbane, QLD, Australia, 10 June, 2005.
2005
Journal Article
Guidelines for filming digital camera video clips for the assessment of gait and movement disorders by teleneurology
Schoffer, Kerrie L., Patterson, Victor, Read, Stephen J., Henderson, Robert D., Pandian, Jeyaraj D. and O'Sullivan, John D. (2005). Guidelines for filming digital camera video clips for the assessment of gait and movement disorders by teleneurology. Journal of Telemedicine and Telecare, 11 (7), 368-371. doi: 10.1258/135763305774472042
2005
Journal Article
The effect of admission physiological variables on 30 day outcome after stroke
Wong, Andrew A., Davis, James P., Schluter, Philip J., Henderson, Robert D., O'Sullivan, John D. and Read, Stephen J. (2005). The effect of admission physiological variables on 30 day outcome after stroke. Journal of Clinical Neuroscience, 12 (8), 905-910. doi: 10.1016/j.jocn.2004.11.012
2005
Journal Article
Ring enhancement after hemorrhagic stroke
Wong, A.A., Henderson, R. D., O'Sullivan, J. D., Read, S. J. and Rajah, R.T. (2005). Ring enhancement after hemorrhagic stroke. Archives of Neurology, 61 (11), 1790-1790. doi: 10.1001/archneur.61.11.1790
2005
Conference Publication
The impact of depression and motor disability on quality of life in patients suffering from Parkinson's disease
Dissanayaka, N. N. W., Sellbach, A., O’Sullivan, J. D., Silburn, P. A. and Mellick, G. D. (2005). The impact of depression and motor disability on quality of life in patients suffering from Parkinson's disease. The University of Queensland School of Medicine Southern Clinical Division Post Graduate Student Conference, Brisbane, QLD, Australia, 2005.
2004
Journal Article
L-Dopa-responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings
Evans, AH, Costa, DC, Gacinovic, S, Katzenschlager, R, O'Sullivan, JD, Heales, S, Lee, P and Lees, AJ (2004). L-Dopa-responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings. Movement Disorders, 19 (10), 1232-1236. doi: 10.1002/mds.20146
2004
Journal Article
Impact of premorbid undernutrition on outcome in stroke patients
Davis, James P., Wong, Andrew A., Schluter, Philip J., Henderson, Robert D., OSullivan, John D. and Read, Stephen J. (2004). Impact of premorbid undernutrition on outcome in stroke patients. Stroke, 35 (8), 1930-1934. doi: 10.1161/01.STR.0000135227.10451.c9
2004
Journal Article
Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome
Evans, Andrew H., Katzenschlager, Regina, Paviour, Dominic, O'Sullivan, John D., Appel, Silke, Lawrence, Andrew D. and Lees, Andrew J. (2004). Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome. Movement Disorders, 19 (4), 397-405. doi: 10.1002/mds.20045
2003
Journal Article
Erratum: [12I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor (Annals of Neurology (2003) 53 (489-496))
Katzenschlager, R., Costa, D., Gerschlager, W., O'Sullivan, J., Zijlmans, J., Gacinovic, S., Pirker, W., Wills, A., Bhatia, K., Lees, A. J. and Brown, P. (2003). Erratum: [12I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor (Annals of Neurology (2003) 53 (489-496)). Annals of Neurology, 54 (2) doi: 10.1002/ana.10704
2003
Journal Article
[123I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor
Katzenschlager, Regina, Costa, Durval, Gerschlager, Willibald, O'Sullivan, John, Zijlmans, Jan, Gacinovic, Svetoslav, Pirker, Walter, Wills, Adrian, Bhatia, Kailash, Lees, Andrew J. and Brown, Peter (2003). [123I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor. Annals of Neurology, 53 (4), 489-496. doi: 10.1002/ana.10475
2003
Journal Article
Unilateral pallidotomy for Parkinson's disease disrupts ocular fixation
O'Sullivan, JD, Maruff, P, Tyler, P, Peppard, RF, McNeill, P and Currie, J (2003). Unilateral pallidotomy for Parkinson's disease disrupts ocular fixation. Journal of Clinical Neuroscience, 10 (2), 181-185. doi: 10.1016/S0967-5868(02)00125-X
2002
Journal Article
Apomorphine as an alternative to sildenafil in Parkinson's disease
O'Sullivan, JD (2002). Apomorphine as an alternative to sildenafil in Parkinson's disease. Journal of Neurology Neurosurgery and Psychiatry, 72 (5), 681-681. doi: 10.1136/jnnp.72.5.681
2002
Journal Article
Bilaterally coherent tremor resembling enhanced physiological tremor: Report of three cases
O'Sullivan, JD, Rothwell, J, Lees, AJ and Brown, P (2002). Bilaterally coherent tremor resembling enhanced physiological tremor: Report of three cases. Movement Disorders, 17 (2), 387-391. doi: 10.1002/mds.10097
2002
Conference Publication
Controlled trial of speech therapy and intra-parotid botulinum toxin for the treatment of salivary drooling in Parkinson's disease
O'Sullivan, JD, Turner, K, Marks, L and Lees, AJ (2002). Controlled trial of speech therapy and intra-parotid botulinum toxin for the treatment of salivary drooling in Parkinson's disease. 7th International Congress of Parkinsons Disease and Movement Disorders, Miami Florida, Nov 10-14, 2002. NEW YORK: WILEY-LISS.
2002
Conference Publication
Dopamine transporter imaging with I-123-FP-CIT SPECT demonstrates marked presynaptic nigrostriatal dopaminergic deficit in orthostatic tremor
Katzenschlager, R, Costa, D, Gerschlager, W, O'Sullivan, JD, Lees, AJ and Brown, P (2002). Dopamine transporter imaging with I-123-FP-CIT SPECT demonstrates marked presynaptic nigrostriatal dopaminergic deficit in orthostatic tremor. 7th International Congress of Parkinsons Disease and Movement Disorders, Miami Florida, Nov 10-14, 2002. NEW YORK: WILEY-LISS.
Funding
Current funding
Supervision
Availability
- Associate Professor John O'Sullivan is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Digital symptom tracking - using digital tools for measuring and tracking motor, cognitive, and speech changes
Associate Advisor
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Doctor Philosophy
The evolution of cognitive deficits in Lewy body disorders and related degenerative diseases.
Associate Advisor
Other advisors: Professor Peter Nestor
Completed supervision
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2023
Doctor Philosophy
Cognitive subtypes in Parkinson's disease: exploring phenotypes, neuroimaging targets, and therapeutics
Associate Advisor
Other advisors: Professor Gerard Byrne, Dr Ji Hyun Julia Yang, Professor Nadeeka Dissanayaka
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2008
Doctor Philosophy
Depression in Parkinson's disease: assessment methods and risk factors
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts
Media
Enquiries
Contact Associate Professor John O'Sullivan directly for media enquiries about:
- Botulinum toxin
- Dystonia
- Huntington's disease
- Movement disorders
- Parkinson's disease
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