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2016 Journal Article α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptorsCastro, Joel, Harrington, Andrea M., Garcia-Caraballo, Sonia, Maddern, Jessica, Grundy, Luke, Zhang, Jingming, Page, Guy, Miller, Paul E., Craik, David J., Adams, David J. and Brierley, Stuart M. (2016). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66 (6), 1083-1094. doi: 10.1136/gutjnl-2015-310971 |
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2016 Journal Article Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffoldWang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016). Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109, 342-349. doi: 10.1016/j.ejmech.2016.01.006 |
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2016 Journal Article Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gatingDeplazes, Evelyne, Troeira Henriques, Sonia, Smith, Jennifer J., King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta - Biomembranes, 1858 (4), 872-882. doi: 10.1016/j.bbamem.2016.02.002 |
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2016 Journal Article Chlorotoxin: structure, activity, and potential uses in cancer therapyOjeda, Paola G., Wang, Conan K. and Craik, David J. (2016). Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 (1), 25-36. doi: 10.1002/bip.22748 |
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2016 Journal Article Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclizationConibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767 |
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2016 Journal Article Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancerD'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016). Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 (2), 396-405. doi: 10.1021/acs.biochem.5b00529 |
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2016 Journal Article Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactionsPhilippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016). Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 (6), 853-863. doi: 10.1002/bip.22893 |
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2016 Journal Article Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional MotifCarstens, Bodil B., Berecki, Geza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie - International Edition, 55 (15), 4692-4696. doi: 10.1002/anie.201600297 |
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2016 Journal Article The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilmsVriens, Kim, Cools, Tanne L., Harvey, Peta J., Craik, David J., Braem, Annabel, Vleugels, Jozef, Coninck, Barbara De, Cammue, Bruno P. A. and Thevissen, Karin (2016). The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms. Peptides, 75, 71-79. doi: 10.1016/j.peptides.2015.11.001 |
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2016 Journal Article Natural structural diversity within a conserved cyclic peptide scaffoldElliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016). Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 (1), 1-14. doi: 10.1007/s00726-016-2333-x |
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2015 Journal Article Effects of Cyclization on Peptide Backbone DynamicsWang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015). Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 (52), 15821-15830. doi: 10.1021/acs.jpcb.5b11085 |
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2015 Journal Article Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxinsAkcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699 |
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2015 Journal Article Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migrationChan, Lai Yue, Craik, David J. and Daly, Norelle L. (2015). Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Bioscience Reports, 35 (6) e00270, e00270-e00270. doi: 10.1042/BSR20150210 |
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2015 Journal Article PrefaceCraik, David J. (2015). Preface. Plant Cyclotides, 76, XI-XIII. doi: 10.1016/S0065-2296(15)00118-4 |
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2015 Journal Article Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceaeRavipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015). Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 (11), 2491-2500. doi: 10.1021/acschembio.5b00454 |
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2015 Journal Article Distribution of circular proteins in plants: large-scale mapping of cyclotides in the ViolaceaeBurman, Robert, Yeshak, Mariamawit Y., Larsson, Sonny, Craik, David J., Rosengren, K. Johan and Goeransson, Ulf (2015). Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science, 6 (855) 855, 1-13. doi: 10.3389/fpls.2015.00855 |
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2015 Journal Article Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonistsSwedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015). Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103, 175-184. doi: 10.1016/j.ejmech.2015.08.046 |
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2015 Journal Article Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide libraryde Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148 |
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2015 Journal Article Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1Yu, Rilei, Seymour, Victoria A. L., Berecki, Geza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin and Craik, David J. (2015). Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports, 5 (Art No.: 13264) 13264, 13264. doi: 10.1038/srep13264 |
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2015 Journal Article The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering CellsHenriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Stephanie, Sani, Marc-Antoine, Poth, Aaron G., Separovic, Frances and Craik, David J. (2015). The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chemistry and Biology, 22 (8) 3107, 1087-1097. doi: 10.1016/j.chembiol.2015.07.012 |
