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2024

Conference Publication

Peptide-drug conjugates as a novel approach to antimalarial therapeutics

Gare, Caitlin, Palombi, Isabella, White, Andrew, Lawrence, Nicole, Craik, David, McMorran, Brendan and Malins, Lara (2024). Peptide-drug conjugates as a novel approach to antimalarial therapeutics. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25–29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Peptide-drug conjugates as a novel approach to antimalarial therapeutics

2024

Conference Publication

A chemo-enzymatic approach to produce a cyclic analogues of peptide drug leads

Zhou, Yan, Harvey, Peta, Durek, Tom and Craik, David (2024). A chemo-enzymatic approach to produce a cyclic analogues of peptide drug leads. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

A chemo-enzymatic approach to produce a cyclic analogues of peptide drug leads

2024

Conference Publication

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

Zhang, Yuhui, Wang, Li, Tombling, Benjamin, Lammi, Carmen, Huang, Yen-Hua, Yue, Li, Bartolomei, Martina, Hong, Bin, Craik, David and Wang, Conan (2024). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

2024

Conference Publication

Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1

Huang, Yen-Hua, Jiang, Zhihao, Yap, Kuok, Bigot, Aurelien, Kaas, Quentin, Wang, Conan and Craik, David (2024). Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1

2022

Conference Publication

Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake

Philippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445

Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake

2021

Conference Publication

An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

Silva Cardoso, Marlon Henrique E., Chan, Lai Yue, Candido, Elizabete De Souza, Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Itala C., Goncalves, S., Buccini, Danieli Fernanda, Lu, Timothy K., Santos, Nuno C., De la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octavio L. (2021). An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. 20th IUPAB International Congress, 45th SBBf Congress and 50th Annual Meeting of SBBq, Online, 4-8 October 2021. London, United Kingdom: Springer.

An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

2020

Conference Publication

The insecticidal wasp toxin Γ–Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels

Peigneur, Steve, Tsarev, Andrey V., Paramonov, Alexander S., Schroeder, Christina I., Ikonomopoulou, Maria P., Inagaki, Hidetoshi, Craik, David J., Konno, Katsuhiro, Shenkarev, Zakhar O. and Tytgat, Jan (2020). The insecticidal wasp toxin Γ–Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier.

The insecticidal wasp toxin Γ–Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels

2020

Conference Publication

Challenging the chirality paradigm in peptide-lipid interactions

Henriques, Sonia Troeira, Peacock, Hayden, Benfield, Aurelie H., Wang, Conan K. and Craik, David (2020). Challenging the chirality paradigm in peptide-lipid interactions. 64th Annual Meeting of the Biophysical Society, San Diego, CA, United States, 15-19 February 2020. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2019.11.1983

Challenging the chirality paradigm in peptide-lipid interactions

2019

Conference Publication

Spider toxins as novel allosteric modulators of insect nicotinic receptors

Earley, Fergus, Chambers, Chris, Cutler, Penny, Huang, Yen-Hua and Craik, David (2019). Spider toxins as novel allosteric modulators of insect nicotinic receptors. ACS Fall National Meeting and Exposition, San Diego, CA, United States, 25-29 August, 2019. Washington, DC United States: American Chemical Society.

Spider toxins as novel allosteric modulators of insect nicotinic receptors

2018

Conference Publication

Topologically complex peptides from plants as tools for the development of eco-friendly drugs and agrichemicals

Craik, David (2018). Topologically complex peptides from plants as tools for the development of eco-friendly drugs and agrichemicals. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans La, Mar 18-22, 2018. WASHINGTON: AMER CHEMICAL SOC.

Topologically complex peptides from plants as tools for the development of eco-friendly drugs and agrichemicals

2018

Conference Publication

A journey alongside cyclosporin on the road to peptide oral bioavailability

Wang, Conan and Craik, David (2018). A journey alongside cyclosporin on the road to peptide oral bioavailability. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

A journey alongside cyclosporin on the road to peptide oral bioavailability

2018

Conference Publication

Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons

Huang, Yen-Hua, Passioura, Toby, Peacock, Hayden, Henriques, Sonia Troeira, Wang, Conan, Kaas, Quentin, Suga, Hiroaki and Craik, David (2018). Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons

2018

Conference Publication

The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors

Schroeder, Christina, Agwa, Akello, Mueller, Alexander, Chow, Chun Yuen, Peigneur, Steve, Lawrence, Nicole, Deplazes, Evelyne, Mark, Alan, Craik, David, Tytgat, Jan, King, Glenn, Vetter, Irina and Henriques, Sonia Troeira (2018). The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors

2018

Conference Publication

Mechanisms of bacterial membrane permeabilization of snake venom-derived peptides crotalicidin (Ctn) and Ctn[15-34]

Perez-Peinado, Clara, Almeida Dias, Susana, Domingues, Marco M., Benfield, Aurelie H., Miguel Freire, Jodo, Radis-Baptista, Gandhi, Gaspar, Diana, Castanho, Miguel, Craik, David, Henriques, Sonia Troeira, Salome Veiga, Ana and Andreu, David (2018). Mechanisms of bacterial membrane permeabilization of snake venom-derived peptides crotalicidin (Ctn) and Ctn[15-34]. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons .

Mechanisms of bacterial membrane permeabilization of snake venom-derived peptides crotalicidin (Ctn) and Ctn[15-34]

2018

Conference Publication

Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1

Henriques, Sonia Troeira, Peacock, Hayden, Benfield, Aurelie H., Wang, Conan and Craik, David (2018). Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1

2018

Conference Publication

Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1

White, Andrew, Deveer, Simon, Swedberg, Joakim, Durek, Thomas and Craik, David (2018). Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3127

Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1

2018

Conference Publication

Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins

Kaas, Quentin, Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J. and Craik, David (2018). Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins

2017

Conference Publication

Small molecule and peptidic ligands as PCSK9-LDLR inhibitors

Bhattacharya, Samit, Ammirati, Mark, Borzilleri, Kris, Cheneval, Olivier, Chrunyk, Boris, Craik, David, Daly, Norelle, Dullea, Robert, Griffor, Matthew, Kamlet, Adam, Limberakis, Chris, Sahasrabudhe, Parag, Liu, Shenping, Loria, Paula, Mc Clure, Kim, Menhaji-Klotz, Elnaz, Petersen, Donna, Piotrowski, David, Popovska-Gorevski, Marina, Price, David, Reyes, Allan, Ruggeri, Roger, Schroeder, Christina, Song, Kun, Swedberg, Joakim, Stock, Ingrid, Tu, Meihua and Withka, Jane (2017). Small molecule and peptidic ligands as PCSK9-LDLR inhibitors. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC, 20-24 August 2017 . Washington, DC, United States: American Chemical Society.

Small molecule and peptidic ligands as PCSK9-LDLR inhibitors

2016

Conference Publication

Miniaturised Alpha-Conotoxins for the Treatment of Pain

Carstens, B., Berecki, G., Daniel, J., Lee, H. S., Jackson, K., Tae, H-S., Sadeghi, M., Castro, J., O'Donnell, T., Deiteren, A., Brierley, S., Craik, D., Adams, D. and Clark, R. (2016). Miniaturised Alpha-Conotoxins for the Treatment of Pain. 247th National Spring Meeting of the American-Chemical-Society (ACS), Dallas Tx, Mar 16-20, 2014. HOBOKEN: WILEY.

Miniaturised Alpha-Conotoxins for the Treatment of Pain

2016

Conference Publication

Towards An Understanding of A- Conotoxin Receptor Specificity

Kaas, Q. and Craik, D. J. (2016). Towards An Understanding of A- Conotoxin Receptor Specificity. HOBOKEN: Wiley.

Towards An Understanding of A- Conotoxin Receptor Specificity