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2016 Journal Article Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor regionCouñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G. and Kobe, Bostjan (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44 (14), 6981-6993. doi: 10.1093/nar/gkw543 |
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2016 Journal Article Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequencede Barros, Andrea C., Takeda, Agnes A.S., Dreyer, Thiago R., Velazquez-Campoy, Adrian, Kobe, Bostjan and Fontes, Marcos R.M. (2016). Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequence. Journal of Molecular Biology, 428 (10), 2120-2131. doi: 10.1016/j.jmb.2016.01.019 |
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2016 Journal Article Structural biology and regulation of protein import into the nucleusChristie, Mary, Chang, Chiung-Wen, Róna, Gergely, Smith, Kate M., Stewart, Alastair G, Takeda, Agnes A. S., Fontes, Marcos R. M., Stewart, Murray, Vértessy, Beáta G., Forwood, Jade K. and Kobe, Bostjan (2016). Structural biology and regulation of protein import into the nucleus. Journal of Molecular Biology, 428 (10), 2060-2090. doi: 10.1016/j.jmb.2015.10.023 |
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2016 Journal Article Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013)Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2016). Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013). Traffic, 17 (6), 704-704. doi: 10.1111/tra.12395 |
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2016 Journal Article TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic targetUllah, M. Obayed, Sweet, Matthew J., Mansell, Ashley, Kellie, Stuart and Kobe, Bostjan (2016). TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. Journal of Leukocyte Biology, 100 (1), 27-45. doi: 10.1189/jlb.2RI1115-531R |
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2016 Journal Article Protein crystal screening and characterization for serial femtosecond nanocrystallographyDarmanin, Connie, Strachan, Jamie, Adda, Christopher G., Ve, Thomas, Kobe, Bostjan and Abbey, Brian (2016). Protein crystal screening and characterization for serial femtosecond nanocrystallography. Scientific Reports, 6 (1) 25345, 25345.1-25345.8. doi: 10.1038/srep25345 |
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2016 Journal Article Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studiesZhang, Xiaoxiao, Nguyen, Neal, Breen, Susan, Outram, Megan A., Dodds, Peter N., Kobe, Bostjan, Solomon, Peter S. and Williams, Simon J. (2016). Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies. Molecular Plant Pathology, 18 (1), 141-151. doi: 10.1111/mpp.12385 |
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2016 Journal Article Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discoveryYou, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672 |
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2016 Journal Article Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and productionOyarzun, Patricio and Kobe, Bostjan (2016). Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production. Human Vaccines and Immunotherapeutics, 12 (3), 763-767. doi: 10.1080/21645515.2015.1094595 |
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2016 Journal Article Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation modelBernoux, Maud, Burdett, Hayden, Williams, Simon J., Zhang, Xiaoxiao, Chen, Chunhong, Newell, Kim, Lawrence, Gregory J., Kobe, Bostjan, Ellis, Jeffrey G., Anderson, Peter A. and Dodds, Peter N. (2016). Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model. Plant Cell, 28 (1), 146-159. doi: 10.1105/tpc.15.00303 |
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2015 Journal Article Characterizing the conformational dynamics of metal-free PsaA usingmolecular dynamics simulations and electron paramagnetic resonance spectroscopyDeplazes, Evelyne, Begg, Stephanie L., van Wonderen, Jessica H., Campbell, Rebecca, Kobe, Bostjan, Paton, James C., MacMillan, Fraser, McDevitt, Christopher A. and O'Mara, Megan L. (2015). Characterizing the conformational dynamics of metal-free PsaA usingmolecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60. doi: 10.1016/j.bpc.2015.08.004 |
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2015 Journal Article Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcALuo, Zhenyao, Morey, Jacqueline R., McDevitt, Christopher A. and Kobe, Bostjan (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica: Section F Structural Biology Communications, 71 (12), 1459-1464. doi: 10.1107/S2053230X15021330 |
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2015 Journal Article Computer-aided design of T-cell epitope-based vaccines: addressing population coverageOyarzun, P. and Kobe, B. (2015). Computer-aided design of T-cell epitope-based vaccines: addressing population coverage. International Journal of Immunogenetics, 42 (5), 313-321. doi: 10.1111/iji.12214 |
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2015 Journal Article Structural and biochemical analysis of a single amino-acid mutant of WzzBSF that alters Lipopolysaccharide O-antigen chain length in Shigella flexneriChang, Chiung-Wen, Tran, Elizabeth N. H., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Benning, Friederike, Morona, Renato and Kobe, Bostjan (2015). Structural and biochemical analysis of a single amino-acid mutant of WzzBSF that alters Lipopolysaccharide O-antigen chain length in Shigella flexneri. PLoS One, 10 (9) e0138266, e0138266. doi: 10.1371/journal.pone.0138266 |
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2015 Journal Article Fusion-protein-assisted protein crystallizationKobe, Bostjan, Ve, Thomas and Williams, Simon J. (2015). Fusion-protein-assisted protein crystallization. Acta Crystallographica. Section F Structural Biology Communications, 71 (7), 861-869. doi: 10.1107/S2053230X15011061 |
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2015 Journal Article Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolaseCork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764 |
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2015 Journal Article Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniaeBegg, Stephanie L., Eijkelkamp, Bart A., Luo, Zhenyao, Couñago, Rafael M., Morey, Jacqueline R., Maher, Megan J., Ong, Cheryl-lynn Y., McEwan, Alastair G., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6 (6418) 6418, 1-11. doi: 10.1038/ncomms7418 |
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2015 Journal Article Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approachBajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x |
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2015 Journal Article A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexesWilliams, Simon J., Ve, Thomas and Kobe, Bostjan (2015). A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes. Protein Engineering, Design and Selection, 28 (5), 137-145. doi: 10.1093/protein/gzv013 |
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2015 Journal Article TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290 |
