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2017 Journal Article DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathwayde Barros, Andrea C, Takeda, Agnes A S, Dreyer, Thiago R, Velazquez-Campoy, Adrian, Kobe, Boštjan and Fontes, Marcos R M (2017). DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 87-96. doi: 10.1016/j.biochi.2017.11.013 |
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2017 Journal Article Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein PZhang, Xiaoxiao, Farah, Nadya, Rolston, Laura, Ericsson, Daniel J., Catanzariti, Ann-Maree, Bernoux, Maud, Ve, Thomas, Bendak, Katerina, Chen, Chunhong, Mackay, Joel P., Lawrence, Gregory J., Hardham, Adrienne, Ellis, Jeffrey G., Williams, Simon J., Dodds, Peter N., Jones, David A. and Kobe, Bostjan (2017). Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P. Molecular Plant Pathology, 19 (5), 1196-1209. doi: 10.1111/mpp.12597 |
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2017 Journal Article Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signalingHughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114 |
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2017 Journal Article Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signalingVe, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444 |
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2017 Journal Article Emerging insights into the functions of pathogenesis-related protein 1Breen, Susan, Williams, Simon J., Outram, Megan, Kobe, Bostjan and Solomon, Peter S. (2017). Emerging insights into the functions of pathogenesis-related protein 1. Trends in Plant Science, 22 (10), 871-879. doi: 10.1016/j.tplants.2017.06.013 |
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2017 Journal Article Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug designChitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994 |
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2017 Journal Article The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathwaysVajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J. and Kobe, Bostjan (2017). The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways. Molecular Immunology, 86, 23-37. doi: 10.1016/j.molimm.2017.02.012 |
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2017 Journal Article Towards the structure of the TIR-domain signalosomeNimma, Surekha, Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2017). Towards the structure of the TIR-domain signalosome. Current Opinion In Structural Biology, 43, 122-130. doi: 10.1016/j.sbi.2016.12.014 |
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2017 Journal Article GMP synthase is required for virulence factor production and infection by cryptococcus neoformansChitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533 |
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2017 Journal Article PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylationPatrick, Ralph, Kobe, Bostjan, Lê Cao, Kim-Anh and Bodén, Mikael (2017). PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation. Bioinformatics, 33 (12), 1773-1781. doi: 10.1093/bioinformatics/btx072 |
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2017 Journal Article A non-uniform sampling approach enables studies of dilute and unstable proteinsMiljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z |
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2017 Journal Article Multiple functional self-association interfaces in plant TIR domainsZhang, Xiaoxiao, Bernoux, Maud, Bentham, Adam R., Newman, Toby E., Ve, Thomas, Casey, Lachlan W., Raaymakers, Tom M., Hu, Jian, Croll, Tristan I., Schreiber, Karl J., Staskawicz, Brian J., Anderson, Peter A., Sohn, Kee Hoon, Williams, Simon J., Dodds, Peter N. and Kobe, Bostjan (2017). Multiple functional self-association interfaces in plant TIR domains. Proceedings of the National Academy of Sciences, 114 (10), E2046-E2052. doi: 10.1073/pnas.1621248114 |
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2017 Journal Article Blood group antigen recognition via the group A Streptococcal M protein mediates host colonizationDe Oliveira, David M. P., Hartley-Tassell, Lauren, Everest-Dass, Arun, Day, Christopher J., Dabbs, Rebecca A., Ve, Thomas, Kobe, Bostjan, Nizet, Victor, Packer, Nicolle H., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2017). Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization. MBio, 8 (1) e02237-16, e02237-16. doi: 10.1128/mBio.02237-16 |
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2016 Journal Article Structure and function of the TIR domain from the grape NLR protein RPV1Williams, Simon J., Yin, Ling, Foley, Gabriel, Casey, Lachlan W., Outram, Megan A., Ericsson, Daniel J., Lu, Jiang, Boden, Mikael, Dry, Ian B. and Kobe, Bostjan (2016). Structure and function of the TIR domain from the grape NLR protein RPV1. Frontiers in Plant Science, 7 (DECEMBER2016) 1850, 1850. doi: 10.3389/fpls.2016.01850 |
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2016 Journal Article The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteinsCasey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113 |
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2016 Journal Article Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequencePatrick, Ralph, Horin, Coralie, Kobe, Bostjan, Cao, Kim-Anh Le and Bodén, Mikael (2016). Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence. Biochimica et Biophysica Acta, 1864 (11), 1599-1608. doi: 10.1016/j.bbapap.2016.08.001 |
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2016 Journal Article Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteinsBreen, Susan, Williams, Simon J., Winterberg, Britta, Kobe, Bostjan and Solomon, Peter S. (2016). Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins. Plant Journal, 88 (1), 13-25. doi: 10.1111/tpj.13228 |
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2016 Journal Article Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformansBlundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121 |
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2016 Journal Article Animal NLRs provide structural insights into plant NLR functionBentham, Adam, Burdett, Hayden, Anderson, Peter A., Williams, Simon J. and Kobe, Bostjan (2016). Animal NLRs provide structural insights into plant NLR function. Annals of Botany, 119 (5), 689-702. doi: 10.1093/aob/mcw171 |
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2016 Journal Article Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell deathSchreiber, Karl J., Bentham, Adam, Williams, Simon J., Kobe, Bostjan and Staskawicz, Brian J. (2016). Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell death. PLoS Pathogens, 12 (7) e1005769, e1005769. doi: 10.1371/journal.ppat.1005769 |
