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2024 Journal Article Correction to: The JAK-STAT pathway: from structural biology to cytokine engineering (Signal Transduction and Targeted Therapy, (2024), 9, 1, (221), 10.1038/s41392-024-01934-w)Lv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). Correction to: The JAK-STAT pathway: from structural biology to cytokine engineering (Signal Transduction and Targeted Therapy, (2024), 9, 1, (221), 10.1038/s41392-024-01934-w). Signal Transduction and Targeted Therapy, 9 (1) 290, 290. doi: 10.1038/s41392-024-01975-1 |
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2024 Journal Article Structural characterization of TIR-domain signalosomes through a combination of structural biology approachesBhatt, Akansha, Mishra, Biswa P., Gu, Weixi, Sorbello, Mitchell, Xu, Hongyi, Ve, Thomas and Kobe, Bostjan (2024). Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches. IUCrJ, 11 (5), 695-707. doi: 10.1107/s2052252524007693 |
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2024 Journal Article Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assemblyLi, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210 |
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2024 Journal Article Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptorsTeng, Linhong, Sun, Yuhuan, Chen, Jiayi, Wang, Chenghui, Urbach, Jonathan M., Kobe, Bostjan, Ye, Naihao and Zeng, Qiangcheng (2024). Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptors. Frontiers in Plant Science, 15 1445022. doi: 10.3389/fpls.2024.1445022 |
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2024 Journal Article The JAK-STAT pathway: from structural biology to cytokine engineeringLv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). The JAK-STAT pathway: from structural biology to cytokine engineering. Signal Transduction and Targeted Therapy, 9 (1) 221, 221. doi: 10.1038/s41392-024-01934-w |
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2024 Journal Article SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunitiesMcGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2024). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 30 (4), 473-492. doi: 10.1177/10738584231162508 |
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2024 Journal Article Structural characterization of macro domain–containing Thoeris antiphage defense systemsShi, Yun, Masic, Veronika, Mosaiab, Tamim, Rajaratman, Premraj, Hartley-Tassell, Lauren, Sorbello, Mitchell, Goulart, Cassia C., Vasquez, Eduardo, Mishra, Biswa P., Holt, Stephanie, Gu, Weixi, Kobe, Bostjan and Ve, Thomas (2024). Structural characterization of macro domain–containing Thoeris antiphage defense systems. Science Advances, 10 (26) eadn3310, eadn3310. doi: 10.1126/sciadv.adn3310 |
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2024 Journal Article Small molecule drug discovery targeting the JAK-STAT pathwayLv, You, Mi, Pengbing, Babon, Jeffrey J., Fan, Guohuang, Qi, Jianxun, Cao, Longxing, Lang, Jiajia, Zhang, Jin, Wang, Faming and Kobe, Bostjan (2024). Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research, 204 107217, 107217. doi: 10.1016/j.phrs.2024.107217 |
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2024 Journal Article o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055 |
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2024 Journal Article Mixed-organism enzyme in plant defenseThynne, Elisha and Kobe, Bostjan (2024). Mixed-organism enzyme in plant defense. Science, 383 (6684), 707-708. doi: 10.1126/science.adn8306 |
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2024 Journal Article Hfe permease and Haemophilus influenzae manganese homeostasisGanio, Katherine, Nasreen, Marufa, Yang, Zihao, Maunders, Eve A., Luo, Zhenyao, Hossain, Sheikh Imamul, Ngu, Dalton H. Y., Ellis, Daniel, Gu, Jin, Neville, Stephanie L., Wilksch, Jonathan, Gunn, Adam P., Whittall, Jonathan J., Kobe, Boštjan, Deplazes, Evelyne, Kappler, Ulrike and McDevitt, Christopher A. (2024). Hfe permease and Haemophilus influenzae manganese homeostasis. ACS Infectious Diseases, 10 (2), 436-452. doi: 10.1021/acsinfecdis.3c00407 |
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2024 Journal Article The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compoundsChen, Rachel M., Emming, Stefan, Cinnamon, Roseanna, Cameron, Jacob P., Schroder, Kate, Kobe, Bostjan and Robertson, Avril A. B. (2024). The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds. Organic & Biomolecular Chemistry. doi: 10.1039/d4ob01453g |
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2023 Journal Article Mildew RALPHs up in arms with cerealsMaruta, Natsumi, Outram, Megan A. and Kobe, Bostjan (2023). Mildew RALPHs up in arms with cereals. Proceedings of the National Academy of Sciences, 120 (36) e2311817120, 1-3. doi: 10.1073/pnas.2311817120 |
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2023 Journal Article Toll/interleukin-1 receptor domains in bacterial and plant immunityLi, Sulin, Manik, Mohammad K., Shi, Yun, Kobe, Bostjan and Ve, Thomas (2023). Toll/interleukin-1 receptor domains in bacterial and plant immunity. Current Opinion in Microbiology, 74 102316, 1-10. doi: 10.1016/j.mib.2023.102316 |
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2023 Journal Article A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathwaysMcCombe, Carl L., Catanzariti, Ann‐Maree, Greenwood, Julian R., Desai, Anna M., Outram, Megan A., Yu, Daniel S., Ericsson, Daniel J., Brenner, Steven E., Dodds, Peter N., Kobe, Bostjan, Jones, David A. and Williams, Simon J. (2023). A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways. New Phytologist, 239 (1), 222-239. doi: 10.1111/nph.18727 |
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2023 Journal Article TIR domain-associated nucleotides with functions in plant immunity and beyondMaruta, Natsumi, Sorbello, Mitchell, Lim, Bryan Y. J., McGuinness, Helen Y., Shi, Yun, Ve, Thomas and Kobe, Bostjan (2023). TIR domain-associated nucleotides with functions in plant immunity and beyond. Current Opinion in Plant Biology, 73 102364, 102364. doi: 10.1016/j.pbi.2023.102364 |
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2023 Journal Article Discovery of C-5 pyrazole-substituted pyrrolopyridine derivatives as potent and selective inhibitors for janus kinase 1Lang, Jia-Jia, Lv, You, Kobe, Bostjan, Chen, Hongfei, Tan, Yan, Chen, Limei, Wang, Xuechuan, Mi, Pengbing, Zheng, Xing and Lin, Ying-Wu (2023). Discovery of C-5 pyrazole-substituted pyrrolopyridine derivatives as potent and selective inhibitors for janus kinase 1. Journal of Medicinal Chemistry, 66 (10), 6725-6742. doi: 10.1021/acs.jmedchem.3c00050 |
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2023 Journal Article Exon shuffling potentiates a diverse repertoire of brown algal NB‐ARC‐TPR candidate immune receptor proteins via alternative splicingTeng, Linhong, Liang, Miao, Wang, Chenghui, Li, Yan, Urbach, Jonathan M., Kobe, Bostjan, Xing, Qikun, Han, Wentao and Ye, Naihao (2023). Exon shuffling potentiates a diverse repertoire of brown algal NB‐ARC‐TPR candidate immune receptor proteins via alternative splicing. The Plant Journal, 114 (2), 246-261. doi: 10.1111/tpj.16131 |
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2023 Journal Article Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1Tao, Le, Yang, Guangyue, Sun, Tiantian, Tao, Jie, Zhu, Chan, Yu, Huimin, Cheng, Yalan, Yang, Zongguo, Xu, Mingyi, Jiang, Yuefeng, Zhang, Wei, Wang, Zhiyi, Ma, Wenting, Wu, Liu, Xue, Dongying, Wang, Dongxue, Yang, Wentao, Zhao, Yongjuan, Horsefield, Shane, Kobe, Bostjan, Zhang, Zhe, Tang, Zongxiang, Li, Qigen, Zhai, Qiwei, Dooley, Steven, Seki, Ekihiro, Liu, Ping, Xu, Jianrong, Chen, Hongzhuan and Liu, Cheng (2023). Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. Journal of Hepatology, 78 (4), 805-819. doi: 10.1016/j.jhep.2022.12.031 |
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2023 Journal Article Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase productsBayless, Adam M., Chen, Sisi, Ogden, Sam C., Xu, Xiaoyan, Sidda, John D., Manik, Mohammad K., Li, Sulin, Kobe, Bostjan, Ve, Thomas, Song, Lijiang, Grant, Murray, Wan, Li and Nishimura, Marc T. (2023). Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products. Science Advances, 9 (11) eade8487, 1-15. doi: 10.1126/sciadv.ade8487 |
