Dr Lachlan Rash
Dr

Lachlan Rash

Email: 
Phone: 
+61 7 336 52745

Background

Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.

Availability

Dr Lachlan Rash is:
Available for supervision

Fields of research

Biological Sciences Pharmacology and pharmaceutical sciences Zoology

Qualifications

  • Bachelor of Science, Monash University
  • Doctor of Philosophy, Monash University

Search Professor Lachlan Rash’s works on UQ eSpace

78 works between 1998 and 2024
All (78) Journal Article (64) Book Chapter (5) Conference Publication (8) Other Outputs (1)

41 - 60 of 78 works

2016

Journal Article

NaV1.7 as a pain target – from gene to pharmacology

Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015

NaV1.7 as a pain target – from gene to pharmacology

2016

Journal Article

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]

Koehn, Liam M., Dong, Qing, Er, Sing-Yan, Rash, Lachlan D., King, Glenn F., Dziegielewska, Katarzyna M., Saunders, Norman R. and Habgood, Mark D. (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]. F1000Research, 5 1822, 1822. doi: 10.12688/F1000RESEARCH.9094.1

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]

2016

Journal Article

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

Koehn, Liam M, Noor, Natassya M, Dong, Qing, Er, Sing-Yan, Rash, Lachlan D, King, Glenn F, Dziegielewska, Katarzyna M, Saunders, Norman R and Habgood, Mark D (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury. F1000Research, 5 1822, 1822. doi: 10.12688/f1000research.9094.2

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

2015

Journal Article

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, Claudia A., Rash, Lachlan D., Chassagnon, Irene R., King, Glenn F. and Widdop, Robert E. (2015). PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology, 99 5986, 650-657. doi: 10.1016/j.neuropharm.2015.08.040

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

2015

Journal Article

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

Cristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W. and Rash, Lachlan D. (2015). Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports, 5 (1) 14763, 14763.1-14763.12. doi: 10.1038/srep14763

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

2015

Journal Article

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015). Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 (20), 4985-4995. doi: 10.1111/bph.13267

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

2015

Journal Article

Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula

Chow, Chun Yuen, Cristofori-Armstrong, Ben, Undheim, Eivind A. B., King, Glenn F. and Rash, Lachlan D. (2015). Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula. Toxins, 7 (7), 2494-2513. doi: 10.3390/toxins7072494

Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula

2015

Journal Article

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015)

Simons, Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, Franois-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Goezde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015). Nature Genetics, 47 (3), 304-304. doi: 10.1038/ng0315-304b

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015)

2015

Journal Article

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Simons Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, François-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Gözde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. Nature Genetics, 47 (1), 73-77. doi: 10.1038/ng.3153

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

2015

Book Chapter

Research methods

Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.

Research methods

2015

Book Chapter

Therapeutic applications of spider-venom peptides

Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. (pp. 221-244) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry.. doi: 10.1039/9781849737876-00221

Therapeutic applications of spider-venom peptides

2014

Journal Article

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

Klint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

2014

Journal Article

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

2014

Journal Article

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

2014

Journal Article

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

2013

Journal Article

ASIC3: first the heartache, now a migraine!

Rash, Lachlan D. (2013). ASIC3: first the heartache, now a migraine!. Headache, 53 (8), 1204-1206. doi: 10.1111/head.12170

ASIC3: first the heartache, now a migraine!

2013

Journal Article

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli

Klint, Julie K., Senff, Sebastian, Saez, Natalie J., Seshadri, Radha, Lau, Ho Yee, Bende, Nira J., Undheim, Eivind A. B., Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2013). Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS One, 8 (5) e63865, e63865.1-e63865.12. doi: 10.1371/journal.pone.0063865

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli

2012

Journal Article

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3

Anangi, Raveendra, Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2012). Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Marine Drugs, 10 (7), 1605-1618. doi: 10.3390/md10071605

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3

2012

Journal Article

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Jensen, Jonas E., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2012). Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs, 10 (7), 1511-1527. doi: 10.3390/md10071511

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

2012

Journal Article

Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2

Blanchard, Maxime G., Rash, Lachlan D. and Kellenberger, Stephan (2012). Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2. British Journal of Pharmacology, 165 (7), 2167-2177. doi: 10.1111/j.1476-5381.2011.01674.x

Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2

Current funding

  • 2023 - 2026
    Target validation of acid-sensing ion channel inhibitors to stop disease progression and manage pain in MS
    National Multiple Sclerosis Society-US
    Open grant

Past funding

  • 2022 - 2024
    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis
    Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
    Open grant
  • 2020 - 2022
    Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
    Multiple Sclerosis Research Australia
    Open grant
  • 2020
    Electrophysiology Platform for Ion-channel Characterisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Accessing structurally elusive states of sodium channels as novel analgesic targets
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    Development of a first-in-class neuroprotective drug for protecting the brain after stroke
    NHMRC Development Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Developing subtype-selective blockers of acid-sensing ion channels for treating peripheral pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Development of potent and selective blockers of acid sensing ion channels for the treatment of pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Spider toxins as potential drug leads in breast cancer
    National Breast Cancer Foundation Novel Concept Award
    Open grant
  • 2008 - 2010
    Examining the role ASIC channels in pain through the development of subtype-specific ASIC channel modulators
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    INSERM FELLOWSHIP: Structural characterisation and pharmacology of ion channel toxins from spider venoms
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Availability

Dr Lachlan Rash is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    The ASIC thumb domain as a channel proxy for identification of drug leads for the treatment of ischemic conditions

    Associate Advisor

    Other advisors: Professor Mehdi Mobli

Completed supervision

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