Dr Lachlan Rash
Dr

Lachlan Rash

Email: 
Phone: 
+61 7 336 52745

Background

Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.

Availability

Dr Lachlan Rash is:
Available for supervision

Fields of research

Biological Sciences Pharmacology and pharmaceutical sciences Zoology

Qualifications

  • Bachelor of Science, Monash University
  • Doctor of Philosophy, Monash University

Search Professor Lachlan Rash’s works on UQ eSpace

78 works between 1998 and 2024
All (78) Journal Article (64) Book Chapter (5) Conference Publication (8) Other Outputs (1)

61 - 78 of 78 works

2012

Conference Publication

Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2

Blanchard, Maxime, Rash, Lachlan D. and Kellenberger, Stephan (2012). Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, United States, 12-16 November 2011. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2011.11.1780

Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2

2012

Conference Publication

Structure activity studies and therapeutic potential of venom peptides that target acid-sensing ion channels

Rash, Lachlan D. (2012). Structure activity studies and therapeutic potential of venom peptides that target acid-sensing ion channels. Joint ASCEPT-APSA 2012 Conference, Sydney, Australia, 2-5 December 2012.

Structure activity studies and therapeutic potential of venom peptides that target acid-sensing ion channels

2011

Journal Article

A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011). A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 (5), 796-808. doi: 10.1124/mol.111.072207

A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

2011

Journal Article

De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina)

Rash, Lachlan D., Morales, Rodrigo A.V., Vink, Simone and Alewood, Paul F. (2011). De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina). Toxicon, 57 (2), 208-216. doi: 10.1016/j.toxicon.2010.11.012

De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina)

2011

Journal Article

Venomics: A new paradigm for natural products-based drug discovery

Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4

Venomics: A new paradigm for natural products-based drug discovery

2011

Conference Publication

Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models

Mozar, C. A., Sun, T., Rash, L. D., King, G. F. and Christie, M. J. (2011). Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, United States, 12-16 November 2011.

Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models

2010

Journal Article

Spider-venom peptides as therapeutics

Seaz, Natalie J., Senff, Sebastian, Jensen, Jonas E., Er, Sing Yan, Herzig, Volker, Rash, Lachlan D. and King, Glenn F. (2010). Spider-venom peptides as therapeutics. Toxins, 2 (12), 2851-2871. doi: 10.3390/toxins2122851

Spider-venom peptides as therapeutics

2009

Journal Article

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

Jensen, J. E., Durek, T, Alewood, P. F., Adams, D. J., King, G. F. and Rash, L. D. (2009). Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. TOXICON, 54 (1), 56-61. doi: 10.1016/j.toxicon.2009.03.014

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

2006

Journal Article

Neurotoxicity and Other Pharmacological Activities of the Snake Venom Phospholipase A2 OS2: The N-Terminal Region Is More Important Than Enzymatic Activity

Rouault, Morgane, Rash, Lachlan D., Escoubas, Pierre, Boilard, Eric, Bollinger, James, Lomonte, Bruno, Maurin, Thomas, Guillaume, Carole, Canaan, Stéphane, Deregnaucourt, Christiane, Schrével, Joseph, Doglio, Alain, Gutiérrez, José María, Lazdunski, Michel, Gelb, Michael H. and Lambeau, Gérard (2006). Neurotoxicity and Other Pharmacological Activities of the Snake Venom Phospholipase A2 OS2: The N-Terminal Region Is More Important Than Enzymatic Activity. Biochemistry, 45 (18), 5800-5816. doi: 10.1021/bi060217r

Neurotoxicity and Other Pharmacological Activities of the Snake Venom Phospholipase A2 OS2: The N-Terminal Region Is More Important Than Enzymatic Activity

2006

Journal Article

Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes

Bosmans, Frank, Rash, Lachlan, Zhu, Shunyi, Diochot, Sylvie, Lazdunski, Michel, Escoubas, Pierre and Tytgat, Jan (2006). Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes. Molecular Pharmacology, 69 (2), 419-429. doi: 10.1124/mol.105.015941

Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes

2006

Journal Article

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

Salinas, Miguel, Rash, Lachlan D., Baron, Anne, Lambeau, Gerard, Escoubas, Pierre and Lazdunski, Michel (2006). The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. Journal of Physiology, 570 (2), 339-354. doi: 10.1113/jphysiol.2005.095810

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

2004

Journal Article

A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

Diochot, Sylvie, Baron, Anne, Rash, Lachlan D., Deval, Emmanuel, Escoubas, Pierre, Scarzello, Sabine, Salinas, Miguel and Lazdunsk, Michel (2004). A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. The EMBO journal, 23 (7), 1516-1525. doi: 10.1038/sj.emboj.7600177

A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

2004

Journal Article

Tarantulas: eight-legged pharmacists and combinatorial chemists

Escoubas, Pierre and Rash, Lachlan (2004). Tarantulas: eight-legged pharmacists and combinatorial chemists. Toxicon, 43 (5), 555-574. doi: 10.1016/j.toxicon.2004.02.007

Tarantulas: eight-legged pharmacists and combinatorial chemists

2002

Journal Article

Pharmacology and biochemistry of spider venoms

Rash, Lachlan D. and Hodgson, Wayne C. (2002). Pharmacology and biochemistry of spider venoms. Toxicon, 40 (3), 225-254. doi: 10.1016/S0041-0101(01)00199-4

Pharmacology and biochemistry of spider venoms

2002

Journal Article

Synthesis of Some Nefopam Analogues as Potential Analgesics

Rosamilla, Anthony E., Mayes, Penelope A., Papadopoulos, Roslyn, Campi, Eva M., Jackson, W. Roy, Rash, Lachlan and Jarrott, Bevyn (2002). Synthesis of Some Nefopam Analogues as Potential Analgesics. Australian Journal of Chemistry, 55 (9), 577-585. doi: 10.1071/CH02097

Synthesis of Some Nefopam Analogues as Potential Analgesics

2000

Journal Article

Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata)

Rash, LD, King, RG and Hodgson, WC (2000). Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata). Toxicon, 38 (8), 1111-1127. doi: 10.1016/S0041-0101(99)00226-3

Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata)

2000

Journal Article

Neurotoxic activity of venom from the Australian Eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating

Rash, LD, Birinyi-Strachan, LC, Nicholson, GM and Hodgson, WC (2000). Neurotoxic activity of venom from the Australian Eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating. British Journal of Pharmacology, 130 (8), 1817-1824. doi: 10.1038/sj.bjp.0703494

Neurotoxic activity of venom from the Australian Eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating

1998

Journal Article

Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi)

Rash, LD, King, RG and Hodgson, WC (1998). Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi). Toxicon, 36 (2), 367-375. doi: 10.1016/S0041-0101(97)00072-X

Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi)

Current funding

  • 2023 - 2026
    Target validation of acid-sensing ion channel inhibitors to stop disease progression and manage pain in MS
    National Multiple Sclerosis Society-US
    Open grant

Past funding

  • 2022 - 2024
    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis
    Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
    Open grant
  • 2020 - 2022
    Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
    Multiple Sclerosis Research Australia
    Open grant
  • 2020
    Electrophysiology Platform for Ion-channel Characterisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Accessing structurally elusive states of sodium channels as novel analgesic targets
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    Development of a first-in-class neuroprotective drug for protecting the brain after stroke
    NHMRC Development Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Developing subtype-selective blockers of acid-sensing ion channels for treating peripheral pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Development of potent and selective blockers of acid sensing ion channels for the treatment of pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Spider toxins as potential drug leads in breast cancer
    National Breast Cancer Foundation Novel Concept Award
    Open grant
  • 2008 - 2010
    Examining the role ASIC channels in pain through the development of subtype-specific ASIC channel modulators
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    INSERM FELLOWSHIP: Structural characterisation and pharmacology of ion channel toxins from spider venoms
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Availability

Dr Lachlan Rash is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    The ASIC thumb domain as a channel proxy for identification of drug leads for the treatment of ischemic conditions

    Associate Advisor

    Other advisors: Professor Mehdi Mobli

Completed supervision

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