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Electrophysiology Platform for Ion-channel Characterisation (2020)

Abstract

Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.

Experts

Professor Glenn King

NHMRC Leadership Fellow and Group Leader
Institute for Molecular Bioscience
Affiliate of Centre for Innovation in Pain and Health Research (CIPHeR)
Centre for Innovation in Pain and Health Research
Faculty of Health, Medicine and Behavioural Sciences
Affiliate Professor of School of Chemistry and Molecular Biosciences
School of Chemistry and Molecular Biosciences
Faculty of Science
Affiliate of The Centre for Chemistry and Drug Discovery
Centre for Chemistry and Drug Discovery
Institute for Molecular Bioscience
Affiliate of ARC COE for Innovations in Peptide and Protein Science
ARC COE for Innovations in Peptide and Protein Science
Institute for Molecular Bioscience
Glenn King
Glenn King

Professor Irina Vetter

Affiliate of Centre for Innovation in Pain and Health Research (CIPHeR)
Centre for Innovation in Pain and Health Research
Faculty of Health, Medicine and Behavioural Sciences
Affiliate of The Centre for Chemistry and Drug Discovery
Centre for Chemistry and Drug Discovery
Institute for Molecular Bioscience
Affiliate of Centre for Marine Science
Centre for Marine Science
Faculty of Science
NHMRC Leadership Fellow - Group Leader
School of Pharmacy and Pharmaceutical Sciences
Faculty of Health, Medicine and Behavioural Sciences
NHMRC Leadership Fellow - Group Leader
Institute for Molecular Bioscience
Irina Vetter
Irina Vetter

Dr Lachlan Rash

Affiliate of Centre for Innovation in Pain and Health Research (CIPHeR)
Centre for Innovation in Pain and Health Research
Faculty of Health, Medicine and Behavioural Sciences
Associate Professor
School of Biomedical Sciences
Faculty of Health, Medicine and Behavioural Sciences
Lachlan Rash
Lachlan Rash

Professor Nathan Palpant

Affiliate Professor of School of Biomedical Sciences
School of Biomedical Sciences
Faculty of Health, Medicine and Behavioural Sciences
Affiliate of The Centre for Cell Biology of Chronic Disease
Centre for Cell Biology of Chronic Disease
Institute for Molecular Bioscience
National Heart Foundation of Australia Future Leader Fellow - Group Leader
Institute for Molecular Bioscience
Nathan Palpant
Nathan Palpant