Overview
Background
Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.
Availability
- Dr Lachlan Rash is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, Monash University
- Doctor of Philosophy, Monash University
Works
Search Professor Lachlan Rash’s works on UQ eSpace
2024
Journal Article
Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede
Schendel, Vanessa, Hamilton, Brett R., Robinson, Samuel D., Green, Kathryn, Sayre, Marcel E., Brown, Darren, Stow, Jennifer L., Øyen, Jan Philip, Voje, Kjetil L., Millard, S. Sean, Vetter, Irina, Rash, Lachlan D. and Undheim, Eivind A. B. (2024). Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede. Nature Ecology & Evolution, 1-14. doi: 10.1038/s41559-024-02556-9
2024
Journal Article
The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation
Budusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology, 228 116175, 1-12. doi: 10.1016/j.bcp.2024.116175
2024
Journal Article
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Cristofori-Armstrong, Ben, Budusan, Elena, Smith, Jennifer J., Reynaud, Steve, Voll, Kerstin, Chassagnon, Irène R., Durek, Thomas and Rash, Lachlan D. (2024). Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants. Cellular and Molecular Life Sciences, 81 (1) 266, 266. doi: 10.1007/s00018-024-05276-2
2024
Journal Article
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793
2024
Journal Article
Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice
Knezic, Adriana, Budusan, Elena, Saez, Natalie J., Broughton, Brad R. S., Rash, Lachlan D., King, Glenn F., Widdop, Robert E. and McCarthy, Claudia A. (2024). Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice. ACS Pharmacology and Translational Science, 7 (4), 1043-1054. doi: 10.1021/acsptsci.3c00328
2024
Book Chapter
Targeting acid-sensing ion channels in disease
Senescall, Victor, Budusan, Elena, Knezic, Adriana, Waqar, Maleeha, Butcher, Neville, Khan, Nemat, McCarthy, Claudia, Widopp, Robert, Karatt-Vellat, Aneesh and Rash, Lachlan D. (2024). Targeting acid-sensing ion channels in disease. Ion channels as targets in drug discovery. (pp. 303-355) edited by Gary Stephens and Edward Stevens. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-031-52197-3_10
2023
Journal Article
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
Alexander, Stephen P. H., Mathie, Alistair A., Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M., Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Caceres, Ana I., Catterall, William A., Conner, Alex C., Davies, Paul, De Clerq, Katrien, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta, Fenske, Stefanie, Fortuny‐Gomez, Anna, Fountain, Samuel, George, Chandy, Goldstein, Steve A. N. ... Zhu, Michael (2023). The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal of Pharmacology, 180 (S2), S145-S222. doi: 10.1111/bph.16178
2023
Journal Article
Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a
Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346
2023
Journal Article
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
2023
Journal Article
Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1
Kellenberger, Stephan and Rash, Lachlan D. (2023). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f118/2023.1
2022
Journal Article
Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider
Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119
2021
Journal Article
Total synthesis of the spider-venom peptide Hi1a
Duggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112
2021
Journal Article
The concise guide to pharmacology 2021/22: ion channels
Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M, Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, Fenske, Stefanie, George, Chandy, Goldstein, Steve A. N., Grissmer, Stephan, Ha, Kotdaji ... Zhu, Michael (2021). The concise guide to pharmacology 2021/22: ion channels. British Journal of Pharmacology, 178 (S1), S157-S245. doi: 10.1111/bph.15539
2021
Journal Article
Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System
Foster, Victoria S., Rash, Lachlan D., King, Glenn F. and Rank, Michelle M. (2021). Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System. Frontiers in cellular neuroscience, 15 738043, 1-16. doi: 10.3389/fncel.2021.738043
2021
Journal Article
Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3
Kellenberger, Stephan and Rash, Lachlan D. (2021). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021 (3). doi: 10.2218/gtopdb/f118/2021.3
2021
Journal Article
Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead
Cristofori-Armstrong, Ben, Budusan, Elena and Rash, Lachlan D. (2021). Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead. Proceedings of the National Academy of Sciences, 118 (8) e2021581118, 1-3. doi: 10.1073/pnas.2021581118
2021
Other Outputs
Neuroprotective agents derived from spider venom peptides
King, Glenn , Rash, Lachlan Douglas, Chassagnon, Irene, Pineda Gonzalez, Sandy Steffany, Widdop, Robert Edward and Ireland, Claudia Ann (2021). Neuroprotective agents derived from spider venom peptides. 10881712.
2020
Journal Article
Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Kellenberger, Stephan and Rash, Lachlan D. (2020). Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). doi: 10.2218/gtopdb/f118/2020.5
2019
Journal Article
The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution
Schendel, Vanessa, Rash, Lachlan D., Jenner, Ronald A. and Undheim, Eivind A. B. (2019). The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11 (11) 666, 666. doi: 10.3390/toxins11110666
2019
Journal Article
The Concise Guide to Pharmacology 2019/20: Ion channels
Alexander, Stephen P.H., Mathie, Alistair, Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Aldrich, Richard W., Becirovic, Elvir, Biel, Martin, Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, George, Chandy, Goldstein, Steve A.N., Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike ... Zhu, Michael (2019). The Concise Guide to Pharmacology 2019/20: Ion channels. British Journal of Pharmacology, 176 (S1), S142-S228. doi: 10.1111/bph.14749
Funding
Current funding
Supervision
Availability
- Dr Lachlan Rash is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Principal Advisor
Other advisors: Dr Neville Butcher, Dr Nemat Khan
-
Doctor Philosophy
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Principal Advisor
Other advisors: Dr Neville Butcher, Dr Nemat Khan
-
Doctor Philosophy
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Nemat Khan
-
Doctor Philosophy
Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.
Principal Advisor
Other advisors: Dr Neville Butcher, Dr Nemat Khan
-
Doctor Philosophy
The ASIC thumb domain as a channel proxy for identification of drug leads for the treatment of ischemic conditions
Associate Advisor
Other advisors: Professor Mehdi Mobli
Completed supervision
-
2023
Doctor Philosophy
Characterisation of venom-derived peptides that target acid-sensing ion channels
Principal Advisor
Other advisors: Professor Irina Vetter, Professor Mehdi Mobli
-
2019
Doctor Philosophy
Discovery and modulation of acid-sensing ion channel modulating venom peptides
Principal Advisor
Other advisors: Professor Glenn King
-
2023
Doctor Philosophy
Structural study of the ASIC thumb domain (ATD) in isolation by solution-state NMR spectroscopy
Associate Advisor
Other advisors: Professor Mehdi Mobli
-
2022
Doctor Philosophy
Centipede venom: Modulation, functional neuro-anatomy and evolutionary origin of the venom gland
Associate Advisor
-
2017
Doctor Philosophy
Peptide modulators of ASIC1a: a putative drug target for the treatment of stroke
Associate Advisor
Other advisors: Professor Glenn King
-
2017
Doctor Philosophy
Biotechnological applications of spider venom peptides
Associate Advisor
Other advisors: Professor Glenn King
-
2014
Doctor Philosophy
Discovery and characterization of NaV modulatory venom peptides
Associate Advisor
Other advisors: Professor Richard Lewis, Professor Irina Vetter
-
2013
Doctor Philosophy
Characterising the molecular basis of the interaction between the putative drug target ASIC1a and pi-TRTX-Pc1a
Associate Advisor
Other advisors: Professor Glenn King
-
2013
Doctor Philosophy
Dissecting the interaction between the sea anemone toxin APETx2 and its analgesic target, acid-sensing ion channel 3
Associate Advisor
Other advisors: Professor Glenn King
Media
Enquiries
For media enquiries about Dr Lachlan Rash's areas of expertise, story ideas and help finding experts, contact our Media team: