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Dr Lachlan Rash
Dr

Lachlan Rash

Email: 
Phone: 
+61 7 336 52745

Overview

Background

Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.

Availability

Dr Lachlan Rash is:
Available for supervision

Qualifications

  • Bachelor of Science, Monash University
  • Doctor of Philosophy, Monash University

Works

Search Professor Lachlan Rash’s works on UQ eSpace

73 works between 1998 and 2024

1 - 20 of 73 works

2024

Journal Article

Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede

Schendel, Vanessa, Hamilton, Brett R., Robinson, Samuel D., Green, Kathryn, Sayre, Marcel E., Brown, Darren, Stow, Jennifer L., Øyen, Jan Philip, Voje, Kjetil L., Millard, S. Sean, Vetter, Irina, Rash, Lachlan D. and Undheim, Eivind A. B. (2024). Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede. Nature Ecology & Evolution, 1-14. doi: 10.1038/s41559-024-02556-9

Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in a giant centipede

2024

Journal Article

The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation

Budusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology, 228 116175, 1-12. doi: 10.1016/j.bcp.2024.116175

The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation

2024

Journal Article

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants

Cristofori-Armstrong, Ben, Budusan, Elena, Smith, Jennifer J., Reynaud, Steve, Voll, Kerstin, Chassagnon, Irène R., Durek, Thomas and Rash, Lachlan D. (2024). Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants. Cellular and Molecular Life Sciences, 81 (1) 266, 266. doi: 10.1007/s00018-024-05276-2

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants

2024

Journal Article

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

2024

Journal Article

Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice

Knezic, Adriana, Budusan, Elena, Saez, Natalie J., Broughton, Brad R. S., Rash, Lachlan D., King, Glenn F., Widdop, Robert E. and McCarthy, Claudia A. (2024). Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice. ACS Pharmacology and Translational Science, 7 (4), 1043-1054. doi: 10.1021/acsptsci.3c00328

Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice

2024

Book Chapter

Targeting acid-sensing ion channels in disease

Senescall, Victor, Budusan, Elena, Knezic, Adriana, Waqar, Maleeha, Butcher, Neville, Khan, Nemat, McCarthy, Claudia, Widopp, Robert, Karatt-Vellat, Aneesh and Rash, Lachlan D. (2024). Targeting acid-sensing ion channels in disease. Ion channels as targets in drug discovery. (pp. 303-355) edited by Gary Stephens and Edward Stevens. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-031-52197-3_10

Targeting acid-sensing ion channels in disease

2023

Journal Article

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Alexander, Stephen P. H., Mathie, Alistair A., Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M., Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Caceres, Ana I., Catterall, William A., Conner, Alex C., Davies, Paul, De Clerq, Katrien, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta, Fenske, Stefanie, Fortuny‐Gomez, Anna, Fountain, Samuel, George, Chandy, Goldstein, Steve A. N. ... Zhu, Michael (2023). The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal of Pharmacology, 180 (S2), S145-S222. doi: 10.1111/bph.16178

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

2023

Journal Article

Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a

Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346

Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a

2023

Journal Article

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

2023

Journal Article

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1

Kellenberger, Stephan and Rash, Lachlan D. (2023). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f118/2023.1

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1

2022

Journal Article

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider

Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider

2021

Journal Article

Total synthesis of the spider-venom peptide Hi1a

Duggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112

Total synthesis of the spider-venom peptide Hi1a

2021

Journal Article

The concise guide to pharmacology 2021/22: ion channels

Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M, Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, Fenske, Stefanie, George, Chandy, Goldstein, Steve A. N., Grissmer, Stephan, Ha, Kotdaji ... Zhu, Michael (2021). The concise guide to pharmacology 2021/22: ion channels. British Journal of Pharmacology, 178 (S1), S157-S245. doi: 10.1111/bph.15539

The concise guide to pharmacology 2021/22: ion channels

2021

Journal Article

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

Foster, Victoria S., Rash, Lachlan D., King, Glenn F. and Rank, Michelle M. (2021). Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System. Frontiers in cellular neuroscience, 15 738043, 1-16. doi: 10.3389/fncel.2021.738043

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

2021

Journal Article

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3

Kellenberger, Stephan and Rash, Lachlan D. (2021). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021 (3). doi: 10.2218/gtopdb/f118/2021.3

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3

2021

Journal Article

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead

Cristofori-Armstrong, Ben, Budusan, Elena and Rash, Lachlan D. (2021). Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead. Proceedings of the National Academy of Sciences, 118 (8) e2021581118, 1-3. doi: 10.1073/pnas.2021581118

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead

2021

Other Outputs

Neuroprotective agents derived from spider venom peptides

King, Glenn , Rash, Lachlan Douglas, Chassagnon, Irene, Pineda Gonzalez, Sandy Steffany, Widdop, Robert Edward and Ireland, Claudia Ann (2021). Neuroprotective agents derived from spider venom peptides. 10881712.

Neuroprotective agents derived from spider venom peptides

2020

Journal Article

Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Kellenberger, Stephan and Rash, Lachlan D. (2020). Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). doi: 10.2218/gtopdb/f118/2020.5

Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

2019

Journal Article

The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution

Schendel, Vanessa, Rash, Lachlan D., Jenner, Ronald A. and Undheim, Eivind A. B. (2019). The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11 (11) 666, 666. doi: 10.3390/toxins11110666

The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution

2019

Journal Article

The Concise Guide to Pharmacology 2019/20: Ion channels

Alexander, Stephen P.H., Mathie, Alistair, Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Aldrich, Richard W., Becirovic, Elvir, Biel, Martin, Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, George, Chandy, Goldstein, Steve A.N., Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike ... Zhu, Michael (2019). The Concise Guide to Pharmacology 2019/20: Ion channels. British Journal of Pharmacology, 176 (S1), S142-S228. doi: 10.1111/bph.14749

The Concise Guide to Pharmacology 2019/20: Ion channels

Funding

Current funding

  • 2023 - 2026
    Target validation of acid-sensing ion channel inhibitors to stop disease progression and manage pain in MS
    National Multiple Sclerosis Society-US
    Open grant
  • 2022 - 2024
    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis
    Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
    Open grant

Past funding

  • 2020 - 2022
    Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
    Multiple Sclerosis Research Australia
    Open grant
  • 2020
    Electrophysiology Platform for Ion-channel Characterisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Accessing structurally elusive states of sodium channels as novel analgesic targets
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    Development of a first-in-class neuroprotective drug for protecting the brain after stroke
    NHMRC Development Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Developing subtype-selective blockers of acid-sensing ion channels for treating peripheral pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Development of potent and selective blockers of acid sensing ion channels for the treatment of pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Spider toxins as potential drug leads in breast cancer
    National Breast Cancer Foundation Novel Concept Award
    Open grant
  • 2008 - 2010
    Examining the role ASIC channels in pain through the development of subtype-specific ASIC channel modulators
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    INSERM FELLOWSHIP: Structural characterisation and pharmacology of ion channel toxins from spider venoms
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Dr Lachlan Rash is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.

    Principal Advisor

    Other advisors: Dr Neville Butcher, Dr Nemat Khan

  • Doctor Philosophy

    The ASIC thumb domain as a channel proxy for identification of drug leads for the treatment of ischemic conditions

    Associate Advisor

    Other advisors: Professor Mehdi Mobli

Completed supervision

Media

Enquiries

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