Overview
Background
Dr Adam Walker received his BSc(Hons) in Biochemistry from the University of Tasmania, and PhD in Neuroscience from the Florey Institute of Neuroscience and Mental Health at the University of Melbourne, focused on understanding the molecular mechanisms of motor neuron disease (MND). He undertook a postdoctoral fellowship with Professor Virginia Lee at the Center for Neurodegenerative Disease Research, University of Pennsylvania (2011-2015), developing new transgenic TDP-43 mouse models of disease. Dr Walker was previously an NHMRC CJ Martin Overseas Biomedical Research Fellow and was awarded an NHMRC RD Wright Career Development Fellowship (2018-2022), to continue his research on neurodegenerative diseases. His research has been supported by fellowships and project grants from the Australian National Health and Medical Research Council, the Australian National Foundation for Medical Research and Innovation, Dementia Australia, Motor Neuron Disease Research Institute of Australia, MonSTaR Foundation and the Cure for MND Foundation.
Availability
- Associate Professor Adam Walker is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Melbourne
Research interests
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Motor neuron disease (MND)/amyotrophic lateral sclerosis (ALS)
Molecular mechanisms of disease and pre-clinical studies in model systems.
Works
Search Professor Adam Walker’s works on UQ eSpace
2013
Journal Article
N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2)
Walker, Adam K., Soo, Kai Ying, Levina, Vita, Talbo, Gert H. and Atkin, Julie D. (2013). N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2). FEBS Journal, 280 (1), 233-243. doi: 10.1111/febs.12063
2012
Journal Article
Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase
Farg, Manal A., Soo, Kai Y., Walker, Adam K., Pham, Hong, Orian, Jacqueline, Horne, Malcolm K., Warraich, Sadaf T., Williams, Kelly L., Blair, Ian P. and Atkin, Julie D. (2012). Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase. Neurobiology of Aging, 33 (12), 2855-2868. doi: 10.1016/j.neurobiolaging.2012.02.009
2012
Journal Article
Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis
Soo, Kai Y., Atkin, Julie D., Farg, Manal, Walker, Adam K., Horne, Malcolm K. and Nagley, Phillip (2012). Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis. PLoS One, 7 (4) e35413, e35413. doi: 10.1371/journal.pone.0035413
2011
Journal Article
Stress signaling from the endoplasmic reticulum: a central player in the pathogenesis of amyotrophic lateral sclerosis
Walker, Adam K. and Atkin, Julie D. (2011). Stress signaling from the endoplasmic reticulum: a central player in the pathogenesis of amyotrophic lateral sclerosis. IUBMB Life, 63 (9), 754-763. doi: 10.1002/iub.520
2011
Journal Article
Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis
Walker, Adam K. and Atkin, Julie D. (2011). Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis. Neurology Research International, 2011 317340. doi: 10.1155/2011/317340
2010
Journal Article
Protein disulfide isomerase and the endoplasmic reticulum in amyotrophic lateral sclerosis
Walker, Adam K. (2010). Protein disulfide isomerase and the endoplasmic reticulum in amyotrophic lateral sclerosis. Journal of Neuroscience, 30 (11), 3865-3867. doi: 10.1523/JNEUROSCI.0408-10.2010
2010
Journal Article
Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
Walker, Adam K., Farg, Manal A., Bye, Chris R., McLean, Catriona A., Horne, Malcolm K. and Atkin, Julie D. (2010). Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis. Brain, 133 (1), 105-116. doi: 10.1093/brain/awp267
2009
Book Chapter
Endoplasmic reticulum stress and protein misfolding in amyotrophic lateral sclerosis
Walker, A. K., Turner, B. J. and Atkin, J. D. (2009). Endoplasmic reticulum stress and protein misfolding in amyotrophic lateral sclerosis. Protein Misfolding Disorders: A Trip into the ER. (pp. 56-76) edited by K. Walker, A., J. Turner, B. and D. Atkin, J.. Bentham Science Publishers Ltd.. doi: 10.2174/978160805013010901010056
2008
Journal Article
Redefining the role of metallothionein within the injured brain: Extracellular metallothioneins play an important role in the astrocyte-neuron response to injury
Chung, Roger S., Penkowa, Milena, Dittmann, Justin, King, Carolyn E., Bartlett, Carole, Asmussen, Johanne W., Hidalgo, Juan, Carrasco, Javier, Leung, Yee Kee J., Walker, Adam K., Fung, Samantha J., Dunlop, Sarah A., Fitzgerald, Melinda, Beazley, Lyn D., Chuah, Meng I., Vickers, James C. and West, Adrian K. (2008). Redefining the role of metallothionein within the injured brain: Extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. Journal of Biological Chemistry, 283 (22), 15349-15358. doi: 10.1074/jbc.M708446200
2007
Journal Article
Metallothionein expression by NG2 glial cells following CNS injury
Chung, R. S., Fung, S. J., Leung, Y. K., Walker, A. K., McCormack, G. H., Chuah, M. I., Vickers, J. C. and West, A. K. (2007). Metallothionein expression by NG2 glial cells following CNS injury. Cellular and Molecular Life Sciences, 64 (19-20), 2716-2722. doi: 10.1007/s00018-007-7267-8
Funding
Current funding
Supervision
Availability
- Associate Professor Adam Walker is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
TDP-43 and protein clearance in the pathogenesis and treatment of ALS and FTD
Principal Advisor
Other advisors: Dr Rebecca San Gil
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Doctor Philosophy
The role of post-translational modification of TDP-43 in disease pathology
Principal Advisor
Other advisors: Dr Adekunle Bademosi
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Doctor Philosophy
Molecular elucidation of TDP-43 co-aggregators in models of ALS/FTD
Principal Advisor
Other advisors: Professor Massimo Hilliard
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Doctor Philosophy
Molecular pathway elucidation of TDP-43 pathology
Principal Advisor
Other advisors: Professor Massimo Hilliard
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Doctor Philosophy
TDP-43 and protein clearance in the pathogenesis and treatment of ALS and FTD
Principal Advisor
Other advisors: Dr Rebecca San Gil
-
Doctor Philosophy
The Role of NFI Genes in Maintaining Astrocyte Differentiation
Principal Advisor
Other advisors: Dr Rebecca San Gil
-
Doctor Philosophy
Mechanism underpinning TDP43 aggregation
Associate Advisor
Other advisors: Dr Rachel Gormal, Dr Adekunle Bademosi, Professor Frederic Meunier
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Doctor Philosophy
The role of perineuronal nets in motor neuron disease: matrix barriers to local inflammation.
Associate Advisor
Other advisors: Associate Professor Mark Bellingham, Associate Professor Peter Noakes
-
Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for amyotrophic lateral sclerosis (METALS)
Associate Advisor
Other advisors: Associate Professor Frederik Steyn, Associate Professor Shyuan Ngo
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Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for amyotrophic lateral sclerosis (METALS)
Associate Advisor
Other advisors: Associate Professor Frederik Steyn, Associate Professor Shyuan Ngo
Media
Enquiries
Contact Associate Professor Adam Walker directly for media enquiries about:
- Frontotemporal dementia
- Motor Neuron Disease
- Neurodegenerative disease mechanisms
- Pre-clinical disease research
- TDP-43
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