Professor

Adam Walker

Email: 

Background

Dr Adam Walker received his BSc(Hons) in Biochemistry from the University of Tasmania, and PhD in Neuroscience from the Florey Institute of Neuroscience and Mental Health at the University of Melbourne, focused on understanding the molecular mechanisms of motor neuron disease (MND). He undertook a postdoctoral fellowship with Professor Virginia Lee at the Center for Neurodegenerative Disease Research, University of Pennsylvania (2011-2015), developing new transgenic TDP-43 mouse models of disease. Dr Walker was previously an NHMRC CJ Martin Overseas Biomedical Research Fellow and was awarded an NHMRC RD Wright Career Development Fellowship (2018-2022), to continue his research on neurodegenerative diseases.

He was Group Leader in the Clem Jones Centre for Ageing Dementia Research at the Queensland Brain Institute 2018-2025, and is now Honorary Professor.

Availability

Professor Adam Walker is:
Not available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cell neurochemistry Neurosciences

Qualifications

  • Doctor of Philosophy, University of Melbourne

Research interests

  • Motor neuron disease (MND)/amyotrophic lateral sclerosis (ALS)

    Molecular mechanisms of disease and pre-clinical studies in model systems.

Search Professor Adam Walker’s works on UQ eSpace

88 works between 2007 and 2026
All (88) Journal Article (69) Conference Publication (17) Book Chapter (2)

41 - 60 of 88 works

2020

Journal Article

The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis

Perri, Emma R., Parakh, Sonam, Vidal, Marta, Mehta, Prachi, Ma, Yi, Walker, Adam K. and Atkin, Julie D. (2020). The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis. Journal of Molecular Neuroscience, 70 (9), 1357-1368. doi: 10.1007/s12031-020-01551-6

The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis

2019

Journal Article

Proteomics approaches for biomarker and drug target discovery in ALS and FTD

Hedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K. and Lee, Albert (2019). Proteomics approaches for biomarker and drug target discovery in ALS and FTD. Frontiers in Neuroscience, 13 (JUN) 548, 548. doi: 10.3389/fnins.2019.00548

Proteomics approaches for biomarker and drug target discovery in ALS and FTD

2019

Journal Article

Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery

Wang, Guoying, Fu, Libing, Walker, Adam, Chen, Xianfeng, Lovejoy, David B., Hao, Mingcong, Lee, Albert, Chung, Roger, Rizos, Helen, Irvine, Mal, Zheng, Meng, Liu, Xiuhua, Lu, Yiqing and Shi, Bingyang (2019). Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery. Biomacromolecules, 20 (5), 2148-2158. doi: 10.1021/acs.biomac.9b00494

Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery

2019

Journal Article

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD

Berning, Britt A. and Walker, Adam K. (2019). The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD. Frontiers in Neuroscience, 13 (APR) 335, 335. doi: 10.3389/fnins.2019.00335

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD

2019

Conference Publication

MI TREXIT: PILOT EVALUATIONOFA STATE-WIDE INITIATIVE FOR IN-OFFICE TRANSPERINEAL VERSUS TRANSRECTAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA

Cole, Adam, Lee, Matthew, Raisky, Jeremy, Qi, Ji, Linsell, Susan, Martin, Rabia, Ellimoottil, Chandy, Walker, Adam, Stork, Brian, Herrel, Lindsey, Wei, John, Miller, David, Montie, Jim and George, Arvin (2019). MI TREXIT: PILOT EVALUATIONOFA STATE-WIDE INITIATIVE FOR IN-OFFICE TRANSPERINEAL VERSUS TRANSRECTAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA. 114th Annual Meeting of the American-Urological-Association (AUA), Chicago Il, May 03-06, 2019. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

MI TREXIT: PILOT EVALUATIONOFA STATE-WIDE INITIATIVE FOR IN-OFFICE TRANSPERINEAL VERSUS TRANSRECTAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA

2019

Journal Article

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

McCann, Emily P., Fifita, Jennifer A., Grima, Natalie, Galper, Jasmin, Mehta, Prachi, Freckleton, Sarah E., Zhang, Katharine Y., Henden, Lyndal, Hogan, Alison L., Chan Moi Fat, Sandrine, Wu, Sharlynn S.L., Jagaraj, Cyril J., Berning, Britt A., Williams, Kelly Louise, Twine, Natalie A., Bauer, Denis, Piguet, Olivier, Hodges, John, Kwok, John B.J., Halliday, Glenda M., Kiernan, Matthew C., Atkin, Julie, Rowe, Dominic B., Nicholson, Garth A., Walker, Adam K., Blair, Ian P. and Yang, Shu (2019). Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice. Journal of Neurology, Neurosurgery and Psychiatry, 91 (2), 162-2019. doi: 10.1136/jnnp-2019-321790

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

2018

Journal Article

Stilbenes from Veratrum maackii Regel protect against ethanol-induced DNA damage in mouse cerebellum and cerebral cortex

Wu, Yantong, Li, Shasha, Liu, Jinjin, Liu, Xiping, Ruan, Weimin, Lu, Jengwei, Liu, Yong, Lawson, Tom, Shimoni, Olga, Lovejoy, David B., Walker, Adam K., Cong, Yue and Shi, Bingyang (2018). Stilbenes from Veratrum maackii Regel protect against ethanol-induced DNA damage in mouse cerebellum and cerebral cortex. ACS Chemical Neuroscience, 9 (7), 1616-1624. doi: 10.1021/acschemneuro.8b00006

Stilbenes from Veratrum maackii Regel protect against ethanol-induced DNA damage in mouse cerebellum and cerebral cortex

2018

Journal Article

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, Sonam, Jagaraj, Cyril J., Vidal, Marta, Ragagnin, Audrey M. G., Perri, Emma R., Konopka, Anna, Toth, Reka P., Galper, Jasmin, Blair, Ian P., Thomas, Colleen J., Walker, Adam K., Yang, Shu, Spencer, Damian M. and Atkin, Julie D. (2018). ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis. Human Molecular Genetics, 27 (8), 1311-1331. doi: 10.1093/hmg/ddy041

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

2017

Journal Article

Note in reference to “Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase” [Neurobiol. Aging 33(12) (2012) 2855-2868]

Farg, Manal A., Soo, Kai Y., Walker, Adam K., Pham, Hong, Orian, Jacqueline, Horne, Malcolm K., Warraich, Sadaf T., Williams, Kelly L., Blair, Ian P. and Atkin, Julie D. (2017). Note in reference to “Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase” [Neurobiol. Aging 33(12) (2012) 2855-2868]. Neurobiology of Aging, 60, 205-205. doi: 10.1016/j.neurobiolaging.2017.10.001

Note in reference to “Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase” [Neurobiol. Aging 33(12) (2012) 2855-2868]

2017

Journal Article

Structure-property relationships in protic ionic liquids: a study of solvent-solvent and solvent-solute interactions

Reid, Joshua E. S. J., Bernardes, Carlos E. S., Agapito, Filipe, Martins, Filomena, Shimizu, Seishi, Minas da Piedade, Manuel E. and Walker, Adam J. (2017). Structure-property relationships in protic ionic liquids: a study of solvent-solvent and solvent-solute interactions. Physical Chemistry Chemical Physics, 19 (41), 28133-28138. doi: 10.1039/c7cp05076c

Structure-property relationships in protic ionic liquids: a study of solvent-solvent and solvent-solute interactions

2017

Journal Article

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Lee, Albert, Rayner, Stephanie L., De Luca, Alana, Gwee, Serene S. L., Morsch, Marco, Sundaramoorthy, Vinod, Shahheydari, Hamideh, Ragagnin, Audrey, Shi, Bingyang, Yang, Shu, Williams, Kelly L., Don, Emily K., Walker, Adam K., Zhang, Katharine Y., Yerbury, Justin J., Cole, Nicholas J., Atkin, Julie D., Blair, Ian P., Molloy, Mark P. and Chung, Roger S. (2017). Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biology, 7 (10) 170058, 170058. doi: 10.1098/rsob.170058

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

2017

Journal Article

Erratum: Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis (Human molecular genetics (2015) 24 13 (3830-3846))

Sundaramoorthy, Vinod, Walker, Adam K., Tan, Vanessa, Fifita, Jennifer A., Mccann, Emily P., Williams, Kelly L., Blair, Ian P., Guillemin, Gilles J., Farg, Manal A. and Atkin, Julie D. (2017). Erratum: Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis (Human molecular genetics (2015) 24 13 (3830-3846)). Human Molecular Genetics, 26 (17), 3452-3452. doi: 10.1093/hmg/ddx268

Erratum: Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis (Human molecular genetics (2015) 24 13 (3830-3846))

2017

Journal Article

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, Albert, Rayner, Stephanie L., Gwee, Serene S. L., De Luca, Alana, Shahheydari, Hamideh, Sundaramoorthy, Vinod, Ragagnin, Audrey, Morsch, Marco, Radford, Rowan, Galper, Jasmin, Freckleton, Sarah, Shi, Bingyang, Walker, Adam K., Don, Emily K., Cole, Nicholas J., Yang, Shu, Williams, Kelly L., Yerbury, Justin J., Blair, Ian P., Atkin, Julie D., Molloy, Mark P. and Chung, Roger S. (2017). Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences, 75 (2), 335-354. doi: 10.1007/s00018-017-2632-8

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

2017

Journal Article

The first reactive synthesis competition (SYNTCOMP 2014)

Jacobs, Swen, Bloem, Roderick, Brenguier, Romain, Ehlers, Ruediger, Hell, Timotheus, Koenighofer, Robert, Perez, Guillermo A., Raskin, Jean-Francois, Ryzhyk, Leonid, Sankur, Ocan, Seidl, Martina, Tentrup, Leander and Walker, Adam (2017). The first reactive synthesis competition (SYNTCOMP 2014). International Journal On Software Tools for Technology Transfer, 19 (3), 367-390. doi: 10.1007/s10009-016-0416-3

The first reactive synthesis competition (SYNTCOMP 2014)

2017

Journal Article

Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum

Shahheydari, Hamideh, Ragagnin, Audrey, Walker, Adam K., Toth, Reka P., Vidal, Marta, Jagaraj, Cyril J., Perri, Emma R., Konopka, Anna, Sultana, Jessica M. and Atkin, Julie D. (2017). Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum. Frontiers in Molecular Neuroscience, 10 119, 1-25. doi: 10.3389/fnmol.2017.00119

Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum

2017

Conference Publication

EARLY AMBULATION DECREASES HOSPITAL LENGTH OF STAY IN RENAL TRAUMA: A RANDOMIZED, PROSPECTIVE STUDY

Aleksic, Ilija, Sorokin, Igor, Aggarwal, Himanshu, Walker, Adam, Feustel, Paul and Kaufman, Ronald (2017). EARLY AMBULATION DECREASES HOSPITAL LENGTH OF STAY IN RENAL TRAUMA: A RANDOMIZED, PROSPECTIVE STUDY. Annual Meeting of the American-Urological-Association (AUA), Boston Ma, May 12-16, 2017. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.juro.2017.02.3314

EARLY AMBULATION DECREASES HOSPITAL LENGTH OF STAY IN RENAL TRAUMA: A RANDOMIZED, PROSPECTIVE STUDY

2016

Conference Publication

The Second Reactive Synthesis Competition (SYNTCOMP 2015)

Jacobs, Swen, Bloem, Roderick, Brenguier, Romain, Koenighofer, Robert, Perez, Guillermo A., Raskin, Jean-Francois, Ryzhyk, Leonid, Sankur, Ocan, Seidl, Martina, Tentrup, Leander and Walker, Adam (2016). The Second Reactive Synthesis Competition (SYNTCOMP 2015). 4th Workshop on Synthesis, San Francisco Ca, Jul 18, 2015. SYDNEY: OPEN PUBL ASSOC. doi: 10.4204/EPTCS.202.4

The Second Reactive Synthesis Competition (SYNTCOMP 2015)

2016

Conference Publication

The 3rd Reactive Synthesis Competition (SYNTCOMP 2016): Benchmarks, Participants & Results

Jacobs, Swen, Bloem, Roderick, Brenguier, Romain, Khalimov, Ayrat, Klein, Felix, Koenighofer, Robert, Kreber, Jens, Legg, Alexander, Narodytska, Nina, Perez, Guillermo A., Raskin, Jean-Francois, Ryzhyk, Leonid, Sankur, Ocan, Seidl, Martina, Tentrup, Leander and Walker, Adam (2016). The 3rd Reactive Synthesis Competition (SYNTCOMP 2016): Benchmarks, Participants & Results. 5th Workshop on Synthesis (SYNT), Toronto Canada, Jul 17-18, 2016. SYDNEY: OPEN PUBL ASSOC. doi: 10.4204/EPTCS.229.12

The 3rd Reactive Synthesis Competition (SYNTCOMP 2016): Benchmarks, Participants & Results

2016

Conference Publication

Developing a Practical Reactive Synthesis Tool: Experience and Lessons Learned

Ryzhyk, Leonid and Walker, Adam (2016). Developing a Practical Reactive Synthesis Tool: Experience and Lessons Learned. 5th Workshop on Synthesis (SYNT), Toronto Canada, Jul 17-18, 2016. SYDNEY: OPEN PUBL ASSOC. doi: 10.4204/EPTCS.229.8

Developing a Practical Reactive Synthesis Tool: Experience and Lessons Learned

2015

Journal Article

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice

Walker, Adam K., Tripathy, Kalyan, Restrepo, Clark R., Ge, Guanghui, Xu, Yan, Kwong, Linda K., Trojanowski, John Q. and Lee, Virginia M. -Y. (2015). An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human Molecular Genetics, 24 (25), 7241-7254. doi: 10.1093/hmg/ddv424

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice

Current funding

  • 2024 - 2027
    Preclinical development of complement C5a receptor 2 modulators for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2024 - 2027
    Oligodendrocytes and TDP-43 pathology in MND
    Cure for MND Foundation - Discovery Research Grants
    Open grant
  • 2023 - 2027
    Australian Preclinical Research ALS (APRALS) Network: a roadmap for effective translation of therapeutics for sporadic MND (MNDRA and FightMND grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2021 - 2026
    Understanding the dynamics of TDP-43 aggregation in FTE using advanced imaging tools
    Dementia Australia Research Foundation
    Open grant

Past funding

  • 2024 - 2025
    Upstream Protein Clearance Pathway Activators for MND Treatment
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2024 - 2026
    Elucidating the role of UNC13A risk variants in sporadic frontotemporal dementia
    Dementia Australia Research Foundation
    Open grant
  • 2024 - 2025
    Exploring the therapeutic potential of a key chaperone against TDP-43 proteinopathy in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2024 - 2025
    Synaptic mechanisms of non-motor dysfunction in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2026
    A Collaborative Multivariable Approach to Prevent Network Dysfunction in ALS (University of Tasmania administered MNDRA grant)
    University of Tasmania
    Open grant
  • 2023 - 2024
    Identifying proteins controlling post-translational modification of TDP-43
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023
    High-resolution imaging of protein clumps in frontotemporal dementia and motor neuron disease
    Brain Foundation Research Grant
    Open grant
  • 2022 - 2025
    Clearing TDP-43 pathology for MND therapy
    Cure for MND Foundation - Bill Guest Mid-Career Fellowship
    Open grant
  • 2022 - 2025
    New viral-mediated TDP-43 mouse models of MND
    Cure for MND Foundation - Impact Grants
    Open grant
  • 2022 - 2024
    The Glymphatic System: Novel Biomarker of Disease Severity and Therapeutic Target (FightMND Impact Grant administered by Monash University)
    Monash University
    Open grant
  • 2022 - 2025
    Exploiting the neuroprotective effects of the gut microbiome for the treatment of spinocerebellar ataxia-3 and related neurodegenerative diseases (NHMRC Ideas Grant administered by Macquarie Uni).
    Macquarie University
    Open grant
  • 2022 - 2025
    NIBR Global Scholars Program Scholars Agreement
    UniQuest Pty Ltd
    Open grant
  • 2021 - 2022
    Defining the involvement of ubiquilin-2 in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2021
    Is the brain's waste clearance system impaired in Motor Neurone Disease (Bethlehem Griffiths Research Foundation Grant led by Monash University)
    Monash University
    Open grant
  • 2020 - 2024
    Preclinical development of centrally active complement C3a receptor modulators as disease-modifying drugs for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2020 - 2023
    Development of a TDP43-targeting gene therapy (FightMND Drug Development Grant administered by Macquarie University)
    Macquarie University
    Open grant
  • 2020 - 2021
    New mouse models of TDP-43 pathology
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020 - 2025
    From the nucleus to the powerhouse: investigating how TDP-43-mitochondrial interactions wreak havoc in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020
    Using viruses to target TDP-43 pathology for pre-clinical studies of neurodegenerative disease
    UQ Early Career Researcher
    Open grant
  • 2019 - 2020
    Genome-wide CRISPR screens to reveal regulators of TDP-43 aggregation and toxicity in motor neuron disease and frontotemporal dementia
    Brain Foundation Research Gift
    Open grant
  • 2019 - 2022
    Rapid flow cytometry screen for identifying novel ALS drug leads (CDMRP Grant administered by University of Wollongong)
    University of Wollongong
    Open grant
  • 2019 - 2021
    Targeting the nucleo-cytoplasmic transport machinery in sporadic and familial ALS (MNDRIA Grant led by Macquarie University)
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2020
    Pre-Clinical evaluation of novel therapies for clearance of TDP-43 in amyotrophic lateral sclerosis (NFMRI grant administered by Macquarie University)
    Macquarie University
    Open grant
  • 2018 - 2022
    Neurodegenerative disease pathology, mechanisms, models and treatments
    NHMRC Career Development Fellowship
    Open grant
  • 2018 - 2020
    Understanding the early disease mechanisms of motor neuron disease and frontotemporal dementia
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Calpeptin, and related candidates, for the treatment of Machado Joseph Disease (NHMRC Project Grant led by Macquarie University)
    Macquarie University
    Open grant

Availability

Professor Adam Walker is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

For media enquiries about Professor Adam Walker's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au