Dr Rebecca San Gil
Dr

Rebecca San Gil

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Background

Rebecca completed her PhD at the Illawarra Health and Medical Research Institute at the University of Wollongong in June 2018. Her PhD research investigated the role of the heat shock response and inflammation in neurodegenerative diseases with a focus on motor neuron disease (MND). During her PhD, Rebecca undertook an Endeavour Research Fellowship to conduct research at the Institute of Neurology, University College London under the supervision of Prof Linda Greensmith. She has since been recruited to the Neurodegeneration Pathobiology Lab at the Queensland Brain Institute by Dr Adam Walker as a Postdoctoral Research Fellow. Rebecca is a motivated and passionate MND researcher whose main objective is to find new therapeutics to treat or cure people living with MND.

Availability

Dr Rebecca San Gil is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Wollongong

Research interests

  • Motor Neuron Disease (MND)

  • Proteostasis

Search Professor Rebecca San Gil’s works on UQ eSpace

15 works between 2016 and 2024
All (15) Journal Article (15)

1 - 15 of 15 works

2024

Journal Article

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

2023

Journal Article

UndERACting ion channels in neurodegeneration

Jacobs, Matisse T., San Gil, Rebecca and Walker, Adam K. (2023). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47 (2), 87-89. doi: 10.1016/j.tins.2023.11.002

UndERACting ion channels in neurodegeneration

2023

Journal Article

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

2023

Journal Article

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43

Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca and Walker, Adam K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80 (4) 95, 1-23. doi: 10.1007/s00018-023-04739-2

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43

2022

Journal Article

TDP-43 pathology: from noxious assembly to therapeutic removal

Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L. and Walker, Adam K. (2022). TDP-43 pathology: from noxious assembly to therapeutic removal. Progress in Neurobiology, 211 102229, 102229. doi: 10.1016/j.pneurobio.2022.102229

TDP-43 pathology: from noxious assembly to therapeutic removal

2021

Journal Article

Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis

Wright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco and Walker, Adam K. (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54 (6) ejn.15422, 6237-6255. doi: 10.1111/ejn.15422

Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis

2021

Journal Article

Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A mice

San Gil, Rebecca, Clarke, Benjamin E., Ecroyd, Heath, Kalmar, Bernadett and Greensmith, Linda (2021). Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A mice. Cells, 10 (5) 1257, 1-18. doi: 10.3390/cells10051257

Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A mice

2020

Journal Article

First person - Rebecca San Gil

San Gil, Rebecca (2020). First person - Rebecca San Gil. Journal of Cell Science, 133 (15) jcs251918, 1-2. doi: 10.1242/jcs.251918

First person - Rebecca San Gil

2020

Journal Article

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

Gil, R. San, Cox, D., McAlary, L., Berg, T., Walker, A. K., Yerbury, J. J., Ooi, L. and Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133 (15), 1-15. doi: 10.1242/jcs.243709

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

2019

Journal Article

Proteomics approaches for biomarker and drug target discovery in ALS and FTD

Hedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K. and Lee, Albert (2019). Proteomics approaches for biomarker and drug target discovery in ALS and FTD. Frontiers in Neuroscience, 13 (JUN) 548, 548. doi: 10.3389/fnins.2019.00548

Proteomics approaches for biomarker and drug target discovery in ALS and FTD

2019

Journal Article

Regional differences in the inflammatory and heat shock response in glia: implications for ALS

Clarke, Benjamin E., Gil, Rebecca San, Yip, Jing, Kalmar, Bernadett and Greensmith, Linda (2019). Regional differences in the inflammatory and heat shock response in glia: implications for ALS. Cell Stress and Chaperones, 24 (5), 857-870. doi: 10.1007/s12192-019-01005-y

Regional differences in the inflammatory and heat shock response in glia: implications for ALS

2018

Journal Article

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

Cox, Dezerae, Whiten, Daniel R., Brown, James W. P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M. and Ecroyd, Heath (2018). The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. Journal of Biological Chemistry, 293 (12), 4486-4497. doi: 10.1074/jbc.m117.813865

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

2017

Journal Article

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

San Gil, Rebecca, Ooi, Lezanne, Yerbury, Justin J. and Ecroyd, Heath (2017). The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Molecular Neurodegeneration, 12 (1) 65. doi: 10.1186/s13024-017-0208-6

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

2017

Journal Article

Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells

San Gil, Rebecca, Berg, Tracey and Ecroyd, Heath (2017). Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Scientific Reports, 7 (1) 2387. doi: 10.1038/s41598-017-02459-9

Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells

2016

Journal Article

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

Whiten, D. R., San Gil, R., McAlary, L., Yerbury, J. J., Ecroyd, H. and Wilson, M. R. (2016). Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Scientific Reports, 6 (1) 31138. doi: 10.1038/srep31138

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

Current funding

  • 2024 - 2025
    Exploring the therapeutic potential of a key chaperone against TDP-43 proteinopathy in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2024 - 2027
    Oligodendrocytes and TDP-43 pathology in MND
    Cure for MND Foundation - Discovery Research Grants
    Open grant
  • 2024 - 2025
    Synaptic mechanisms of non-motor dysfunction in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant

Past funding

  • 2021 - 2022
    Defining the involvement of ubiquilin-2 in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020 - 2023
    Genome-wide CRISPR screen to reveal regulators of TDP-43 aggregation and toxicity in MND
    Cure for MND Foundation - Post Doctoral Research Fellowships
    Open grant
  • 2019 - 2020
    Genome-wide CRISPR screens to reveal regulators of TDP-43 aggregation and toxicity in motor neuron disease and frontotemporal dementia
    Brain Foundation Research Gift
    Open grant

Availability

Dr Rebecca San Gil is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    TDP-43 and protein clearance in the pathogenesis and treatment of ALS and FTD

    Associate Advisor

    Other advisors: Associate Professor Adam Walker

  • Doctor Philosophy

    The Role of NFI Genes in Maintaining Astrocyte Differentiation

    Associate Advisor

    Other advisors: Associate Professor Adam Walker

Enquiries

Contact Dr Rebecca San Gil directly for media enquiries about:

  • Cell and Molecular Biology
  • Motor Neuron Disease
  • Neurodegeneration

Need help?

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communications@uq.edu.au