Overview
Background
Dr Adam Walker received his BSc(Hons) in Biochemistry from the University of Tasmania, and PhD in Neuroscience from the Florey Institute of Neuroscience and Mental Health at the University of Melbourne, focused on understanding the molecular mechanisms of motor neuron disease (MND). He undertook a postdoctoral fellowship with Professor Virginia Lee at the Center for Neurodegenerative Disease Research, University of Pennsylvania (2011-2015), developing new transgenic TDP-43 mouse models of disease. Dr Walker was previously an NHMRC CJ Martin Overseas Biomedical Research Fellow and was awarded an NHMRC RD Wright Career Development Fellowship (2018-2022), to continue his research on neurodegenerative diseases.
He was Group Leader in the Clem Jones Centre for Ageing Dementia Research at the Queensland Brain Institute 2018-2025, and is now Honorary Professor.
Availability
- Professor Adam Walker is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, University of Melbourne
Research interests
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Motor neuron disease (MND)/amyotrophic lateral sclerosis (ALS)
Molecular mechanisms of disease and pre-clinical studies in model systems.
Works
Search Professor Adam Walker’s works on UQ eSpace
2023
Conference Publication
Moving Past the BBB - Screening for the Most Functional CNS-Tropic AAV
Merjane, Jessica, Brown-Wright, Heledd, Luu, Luan, Chung, Roger, Walker, Adam and Lisowski, Leszek (2023). Moving Past the BBB - Screening for the Most Functional CNS-Tropic AAV. 26th Annual Meeting of the American Society of Gene & Cell Therapy, Los Angeles, CA, United States, 16-20 May 2023. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.ymthe.2023.04.017
2023
Journal Article
Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain
Swanson, Molly E.V., Mrkela, Miran, Murray, Helen C., Cao, Maize C., Turner, Clinton, Curtis, Maurice A., Faull, Richard L.M., Walker, Adam K. and Scotter, Emma L. (2023). Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain. Acta Neuropathologica Communications, 11 (1) 69, 1-22. doi: 10.1186/s40478-023-01561-6
2023
Book Chapter
Application of WGCNA and PloGO2 in the analysis of complex proteomic data
Wu, Jemma X., Pascovici, Dana, Wu, Yunqi, Walker, Adam K. and Mirzaei, Mehdi (2023). Application of WGCNA and PloGO2 in the analysis of complex proteomic data. Statistical analysis of proteomic data: methods and tools. (pp. 375-390) edited by Thomas Burger. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1967-4_17
2022
Conference Publication
Inflammation Moderates Antidepressant Response to Ketamine in a Rodent Model of Treatment-Resistant Depression: Bioenergetic and Inflammatory Markers of Response
Tye, Susannah, Price, J. Blair, Walker, Adam, Kruse, Jennifer, Cullen, Kathryn, Frye, Mark, Schwieler, Lilly and Erhardt, Sophie (2022). Inflammation Moderates Antidepressant Response to Ketamine in a Rodent Model of Treatment-Resistant Depression: Bioenergetic and Inflammatory Markers of Response. 61st Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Phoenix Az, Dec 04-07, 2022. LONDON: SPRINGERNATURE.
2022
Journal Article
Cryptic inclusions UNCover losses driving neurodegeneration
Bademosi, Adekunle T. and Walker, Adam K. (2022). Cryptic inclusions UNCover losses driving neurodegeneration. Trends in Genetics, 38 (9), 889-891. doi: 10.1016/j.tig.2022.06.004
2022
Journal Article
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis
Zamani, Akram, Walker, Adam K., Rollo, Ben, Ayers, Katie L., Farah, Raysha, O’Brien, Terence J. and Wright, David K. (2022). Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis. Translational Neurodegeneration, 11 (1) 17, 1-11. doi: 10.1186/s40035-022-00291-4
2022
Journal Article
miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy
Tsitkanou, Stavroula, Della Gatta, Paul A., Abbott, Gavin, Wallace, Marita A., Lindsay, Angus, Gerlinger-Romero, Frederico, Walker, Adam K., Foletta, Victoria C. and Russell, Aaron P. (2022). miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy. Neurobiology of Disease, 162 105559, 105559. doi: 10.1016/j.nbd.2021.105559
2022
Journal Article
Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS
Zamani, Akram, Walker, Adam K., Rollo, Ben, Ayers, Katie L., Farah, Raysha, O'Brien, Terence J. and Wright, David K. (2022). Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS. NeuroImage: Clinical, 34 103016, 103016. doi: 10.1016/j.nicl.2022.103016
2021
Journal Article
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex (vol 157, pg 1300, 2020)
Dyer, Marcus S., Reale, Laura A., Lewis, Katherine E., Walker, Adam K., Dickson, Tracey C., Woodhouse, Adele and Blizzard, Catherine A. (2021). Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex (vol 157, pg 1300, 2020). Journal of Neurochemistry, 159 (4), 789-790. doi: 10.1111/jnc.15494
2021
Conference Publication
PROVIDER VARIATION IN PAIN SCORES DURING FREEHAND TRANSPERINEAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA
Dupati, Ajith, Qi, Ji, Ferrante, Stephanie, DiBianco, John M., Walker, Adam, Wei, John T., Ellimoottil, Chandy, Herrel, Lindsey A., Wu, Richard C., George, Arvin K. and Stork, Brian R. (2021). PROVIDER VARIATION IN PAIN SCORES DURING FREEHAND TRANSPERINEAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
2021
Conference Publication
FREEHAND TRANSPERINEAL BIOPSY SAMPLING STRATEGIES: WHAT IS THE OPTIMAL TEMPLATE?
Dupati, Ajith, Qi, Ji, DiBianco, John M., Ferrante, Stephanie, Cole, Adam, Walker, Adam, Wei, John T., Ellimoottil, Chandy, Herrel, Lindsey A., Wu, Richard C., Stork, Brian R. and George, Arvin K. (2021). FREEHAND TRANSPERINEAL BIOPSY SAMPLING STRATEGIES: WHAT IS THE OPTIMAL TEMPLATE?. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
2021
Journal Article
Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis
Wright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco and Walker, Adam K. (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54 (6) ejn.15422, 6237-6255. doi: 10.1111/ejn.15422
2021
Journal Article
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex
Dyer, Marcus S., Reale, Laura A., Lewis, Katherine E., Walker, Adam K., Dickson, Tracey C., Woodhouse, Adele and Blizzard, Catherine A. (2021). Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex. Journal of Neurochemistry, 157 (4), 1300-1315. doi: 10.1111/jnc.15214
2021
Journal Article
Unbiased label-free quantitative proteomics of cells expressing Amyotrophic Lateral Sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway: a workflow to screen pathogenic gene mutations
Cheng, Flora, De Luca, Alana, Hogan, Alison L., Rayner, Stephanie L., Davidson, Jennilee M., Watchon, Maxinne, Stevens, Claire H., Muñoz, Sonia Sanz, Ooi, Lezanne, Yerbury, Justin J., Don, Emily K., Fifita, Jennifer A., Villalva, Maria D., Suddull, Hannah, Chapman, Tyler R., Hedl, Thomas J., Walker, Adam K., Yang, Shu, Morsch, Marco, Shi, Bingyang, Blair, Ian P., Laird, Angela S., Chung, Roger S. and Lee, Albert (2021). Unbiased label-free quantitative proteomics of cells expressing Amyotrophic Lateral Sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway: a workflow to screen pathogenic gene mutations. Frontiers in Molecular Neuroscience, 14 627740, 1-18. doi: 10.3389/fnmol.2021.627740
2020
Journal Article
Cellulose dissolution and regeneration using a non-aqueous, non-stoichiometric protic ionic liquid system
Berga, Laura, Bruce, Isobel, Nicol, Thomas W. J., Holding, Ashley J., Isobe, Noriyuki, Shimizu, Seishi, Walker, Adam J. and Reid, Joshua E. S. J. (2020). Cellulose dissolution and regeneration using a non-aqueous, non-stoichiometric protic ionic liquid system. Cellulose, 27 (16), 9593-9603. doi: 10.1007/s10570-020-03444-8
2020
Journal Article
Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
Konopka, Anna, Whelan, Donna R., Jamali, Md Shafi, Perri, Emma, Shahheydari, Hamideh, Toth, Reka P., Parakh, Sonam, Robinson, Tina, Cheong, Alison, Mehta, Prachi, Vidal, Marta, Ragagnin, Audrey M G, Khizhnyak, Ivan, Jagaraj, Cyril J., Galper, Jasmin, Grima, Natalie, Deva, Anand, Shadfar, Sina, Nicholson, Garth A., Yang, Shu, Cutts, Suzanne M., Horejsi, Zuzana, Bell, Toby D M, Walker, Adam K., Blair, Ian P. and Atkin, Julie D. (2020). Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations. Molecular neurodegeneration, 15 (1) 51, 51. doi: 10.1186/s13024-020-00386-4
2020
Journal Article
Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells
Gil, R. San, Cox, D., McAlary, L., Berg, T., Walker, A. K., Yerbury, J. J., Ooi, L. and Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133 (15) jcs243709, 1-15. doi: 10.1242/jcs.243709
2020
Journal Article
Workflow for rapidly extracting biological insights from complex, multicondition proteomics experiments with WGCNA and PloGO2
Wu, Jemma X., Pascovici, Dana, Wu, Yunqi, Walker, Adam K. and Mirzaei, Mehdi (2020). Workflow for rapidly extracting biological insights from complex, multicondition proteomics experiments with WGCNA and PloGO2. Journal of Proteome Research, 19 (7), 2898-2906. doi: 10.1021/acs.jproteome.0c00198
2020
Journal Article
Correction: The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis
Perri, Emma R., Parakh, Sonam, Vidal, Marta, Mehta, Prachi, Ma, Yi, Walker, Adam K. and Atkin, Julie D. (2020). Correction: The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis. Journal of Molecular Neuroscience, 70 (9), 1369-1369. doi: 10.1007/s12031-020-01617-5
2020
Conference Publication
PATIENT EXPERIENCE FOR TRANSPERINEAL BIOPSY UNDER LOCAL ANESTHESIA VERSUS TRANSRECTAL BIOPSY: RESULTS FROM THE MICHIGAN UROLOGICAL SURGERY IMPROVEMENT COLLABORATIVE
Ferrante, Stephanie, Hawken, Scott, Montie, James, Miller, David, Wu, Richard C., Ellimoottil, Chad, Herrel, Lindsey, Rogers, Craig, Patel, Amit, Frontera, J. Rene, Walker, Adam and George, Arvin (2020). PATIENT EXPERIENCE FOR TRANSPERINEAL BIOPSY UNDER LOCAL ANESTHESIA VERSUS TRANSRECTAL BIOPSY: RESULTS FROM THE MICHIGAN UROLOGICAL SURGERY IMPROVEMENT COLLABORATIVE. Annual Meeting of the American-Urological-Association (AUA), Washington Dc, May 15-18, 2020. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Adam Walker is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Mechanism underpinning TDP43 aggregation
Associate Advisor
Other advisors: Dr Rachel Gormal, Dr Adekunle Bademosi, Professor Frederic Meunier
Completed supervision
-
2026
Doctor Philosophy
The role and regulation of TDP-43 phosphorylation in the pathogenesis of ALS and FTD
Principal Advisor
Other advisors: Dr Adekunle Bademosi
-
2025
Doctor Philosophy
Investigating novel modulators of TDP-43 pathology within the context of ALS and FTD
Principal Advisor
Other advisors: Dr Rebecca San Gil
-
2025
Doctor Philosophy
Molecular elucidation of TDP-43 co-aggregators in models of ALS/FTD
Principal Advisor
Other advisors: Professor Massimo Hilliard
-
2025
Doctor Philosophy
TDP-43 and protein clearance in the pathogenesis and treatment of ALS and FTD
Principal Advisor
Other advisors: Dr Rebecca San Gil
-
2026
Doctor Philosophy
The effects of metabolic perturbations on the development of fatigue in Amyotrophic Lateral Sclerosis
Associate Advisor
Other advisors: Associate Professor Frederik Steyn, Associate Professor Shyuan Ngo
-
2025
Doctor Philosophy
From Shields to Scaffolds - Perineuronal Nets in Neuroprotection and Neuroplasticity
Associate Advisor
Other advisors: Associate Professor Mark Bellingham, Associate Professor Peter Noakes
Media
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