Overview
Background
Dr. Steyn began his career as a Biomedical Researcher, conducting detailed investigations into the hypothalamic regulation of energy homeostasis, growth, and reproduction. He was instrumental in the creation of robust methodologies that are now considered the industry standard for the evaluation of patterned hormone release in murine models. In 2015, Dr. Steyn broadened his research scope to focus on studies on neurodegenerative diseases. He created methods for a more precise assessment of energy expenditure in Motor Neurone Disease (MND) patients and set up a research platform at the University of Queensland for the better analysis of hypermetabolism's role in the progression of neurodegenerative diseases. This platform has since evolved to support studies aimed at improving our understanding of the heterogeneity of disease, and specifically MND.
Dr. Steyn currently manages a dual pre-clinical and clinical research program aimed at enhancing our knowledge of the diversity of neurodegenerative diseases. As part of this research, Dr. Steyn's team is working to further our understanding of the physiological response to disease, particularly in neurodegenerative diseases marked by the loss of upper and lower motor neurons. In this program, he leads studies on the impact of metabolism on neurodegenerative disease progression (MEND-MND), the consequences of appetite loss and impaired body weight regulation (EATT4MND) on disease progression, and the impact of the burden of disease on patient outcomes and disease progression. In conjunction with these studies, he collaborates with industry to develop new treatment approaches for MND and is working on refining digital health technologies for improved monitoring of disease progression and the effectiveness of therapy on disease outcomes.
Availability
- Associate Professor Frederik Steyn is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma, University of Otago
Research impacts
I have developed a translational research focus where I am assessing the role of altered growth and metabolism on the rate of progression of neurodegenerative disease, and in particular Motor Neurone Disease (MND). Through patient and animal directed studies I seek to repurpose endocrine and metabolic-directed treatment strategies to slow disease progression and improve quality of life for those currently living with MND.
Works
Search Professor Frederik Steyn’s works on UQ eSpace
2024
Journal Article
Generation of human induced pluripotent stem cell lines from sporadic, sporadic frontotemporal dementia, familial SOD1, and familial C9orf72 amyotrophic lateral sclerosis (ALS) patients
Jiang, Leanne, Tracey, Timothy J., Gill, Melinder K., Howe, Stephanie L., Power, Dominique T., Bharti, Vanda, McCombe, Pamela A., Henderson, Robert D., Steyn, Frederik J. and Ngo, Shyuan T. (2024). Generation of human induced pluripotent stem cell lines from sporadic, sporadic frontotemporal dementia, familial SOD1, and familial C9orf72 amyotrophic lateral sclerosis (ALS) patients. Stem Cell Research, 78 103447, 103447. doi: 10.1016/j.scr.2024.103447
2024
Journal Article
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis
Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 4528. doi: 10.1038/s41467-024-48317-x
2024
Journal Article
Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosis
Wong, Julian P. H., Blazev, Ronnie, Ng, Yaan‐Kit, Goodman, Craig A., Montgomery, Magdalene K., Watt, Kevin I., Carl, Christian S., Watt, Matthew J., Voldstedlund, Christian T., Richter, Erik A., Crouch, Peter J., Steyn, Frederik J., Ngo, Shyuan T. and Parker, Benjamin L. (2024). Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosis. The FASEB Journal, 38 (10) e23647, e23647. doi: 10.1096/fj.202400045r
2024
Journal Article
Variation in resting metabolic rate affects identification of metabolic change in geographically distinct cohorts of patients with ALS
Holdom, Cory J., Janse van Mantgem, Mark R., He, Ji, Howe, Stephanie L., McCombe, Pamela A., Fan, Dongsheng, van den Berg, Leonard H., Henderson, Robert D., van Eijk, Ruben, Steyn, Frederik J. and Ngo, Shyuan T. (2024). Variation in resting metabolic rate affects identification of metabolic change in geographically distinct cohorts of patients with ALS. Neurology, 102 (5) e208117, 1-11. doi: 10.1212/wnl.0000000000208117
2024
Journal Article
Associations of postprandial ghrelin, liver‐expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosis
Howe, Stephanie L., Holdom, Cory J., McCombe, Pamela A., Henderson, Robert D., Zigman, Jeffrey M., Ngo, Shyuan T. and Steyn, Frederik J. (2024). Associations of postprandial ghrelin, liver‐expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosis. European Journal of Neurology, 31 (1) e16052, e16052. doi: 10.1111/ene.16052
2024
Journal Article
TSH pulses finely tune thyroid hormone release and TSH receptor transduction
Guillou, Anne, Kemkem, Yasmine, Lafont, Chrystel, Fontanaud, Pierre, Calebiro, Davide, Campos, Pauline, Bonnefont, Xavier, Fiordelisio-Coll, Tatiana, Wang, Ying, Brûlé, Emilie, Bernard, Daniel J, Le Tissier, Paul, Steyn, Frederik and Mollard, Patrice (2024). TSH pulses finely tune thyroid hormone release and TSH receptor transduction. Endocrinology, 165 (1) 1, 1-9. doi: 10.1210/endocr/bqad164
2023
Journal Article
The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunction
Choudhury, Chandra, Gill, Melinder K., McAleese, Courtney E., Butcher, Neville J., Ngo, Shyuan T., Steyn, Frederik J. and Minchin, Rodney F. (2023). The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunction. Pharmacological Reviews, 76 (2), 300-320. doi: 10.1124/pharmrev.123.000835
2023
Journal Article
Skeletal muscle in amyotrophic lateral sclerosis
Shefner, Jeremy M., Musaro, Antonio, Ngo, Shyuan T., Lunetta, Christian, Steyn, Frederik J., Robitaille, Richard, De Carvalho, Mamede, Rutkove, Seward, Ludolph, Albert C. and Dupuis, Luc (2023). Skeletal muscle in amyotrophic lateral sclerosis. Brain, 146 (11), 4425-4436. doi: 10.1093/brain/awad202
2023
Journal Article
The complexity of multidisciplinary respiratory care in amyotrophic lateral sclerosis
Berlowitz, David J., Mathers, Susan, Hutchinson, Karen, Hogden, Anne, Carey, Kate A., Graco, Marnie, Whelan, Brooke-Mai, Charania, Salma, Steyn, Frederik, Allcroft, Peter, Crook, Ashley and Sheers, Nicole L. (2023). The complexity of multidisciplinary respiratory care in amyotrophic lateral sclerosis. Breathe, 19 (3) 220269, 220269. doi: 10.1183/20734735.0269-2022
2023
Journal Article
Nutritional and metabolic factors in amyotrophic lateral sclerosis
Ludolph, Albert, Dupuis, Luc, Kasarskis, Edward, Steyn, Frederik, Ngo, Shyuan and McDermott, Christopher (2023). Nutritional and metabolic factors in amyotrophic lateral sclerosis. Nature Reviews Neurology, 19 (9), 511-524. doi: 10.1038/s41582-023-00845-8
2023
Journal Article
Use of hip- versus wrist-based actigraphy for assessing functional decline and disease progression in patients with motor neuron disease
Holdom, Cory J., van Unnik, Jordi W. J., van Eijk, Ruben P. A., van den Berg, Leonard H., Henderson, Robert D., Ngo, Shyuan T. and Steyn, Frederik J. (2023). Use of hip- versus wrist-based actigraphy for assessing functional decline and disease progression in patients with motor neuron disease. Journal of Neurology, 270 (5), 2597-2605. doi: 10.1007/s00415-023-11584-7
2023
Journal Article
Muscle and its neuromuscular synapse – players in the pathogenesis of motor neuron disease
Noakes, Peter G., Phillips, William D., Jeffree, Rosalind L., Steyn, Frederik J., Wolvetang, Ernst J., Henderson, Rob D., McCombe, Pamela A. and Ngo, Shyuan T. (2023). Muscle and its neuromuscular synapse – players in the pathogenesis of motor neuron disease. Journal of Experimental Neurology, 4 (1), 1-5. doi: 10.33696/neurol.4.067
2023
Book Chapter
Diet, disease severity, and energy expenditure in amyotrophic lateral sclerosis (ALS)
Castles, Zoe, Buckett, Lauren, Jiang, Leanne, Steyn, Frederik J. and Ngo, Shyuan T. (2023). Diet, disease severity, and energy expenditure in amyotrophic lateral sclerosis (ALS). Diet and nutrition in neurological disorders. (pp. 123-140) edited by Colin R. Martin, Vinood B. Patel and Victor R. Preedy. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-323-89834-8.00007-6
2023
Other Outputs
Skeletal muscle and blood RNA-seq counts in motor neurone disease cases and controls
Anna Freydenzon, Allan F. McRaee, Shyuan Ngo, Naomi R. Wray, Leanne Wallace, Anjali K. Henders, Pamela A. McCombe, Robert D. Henderson and Frederik J. Steyn (2023). Skeletal muscle and blood RNA-seq counts in motor neurone disease cases and controls. The University of Queensland. (Dataset) doi: 10.48610/b722f1f
2023
Conference Publication
Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T
Chang, Jeryn, Steyn, Frederik, Ngo, Shyuan, Henderson, Robert, Guo, Christine, Bollmann, Steffen, Fripp, Jurgen, Barth, Markus and Shaw, Thomas (2023). Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T. Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, London, United Kingdom, 7-12 May 2022. Concord, CA United States: International Society for Magnetic Resonance in Medicine. doi: 10.58530/2022/3808
2022
Journal Article
Lower hypothalamic volume with lower BMI is associated with shorter survival in patients with ALS
Chang, Jeryn, Shaw, Thomas B., Holdom, Cory J., McCombe, Pamela A., Henderson, Robert D., Fripp, Jurgen, Barth, Markus, Guo, Christine C., Ngo, Shyuan T. and Steyn, Frederik J. (2022). Lower hypothalamic volume with lower BMI is associated with shorter survival in patients with ALS. European Journal of Neurology, 30 (1), 57-68. doi: 10.1111/ene.15589
2022
Journal Article
Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T
Chang, Jeryn, Steyn, Frederik, Ngo, Shyuan, Henderson, Robert, Guo, Christine, Bollmann, Steffen, Fripp, Jurgen, Barth, Markus and Shaw, Thomas (2022). Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T. Journal of Open Source Software, 7 (76), 4368. doi: 10.21105/joss.04368
2022
Journal Article
Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey
Helleman, Jochem, Johnson, Barbara, Holdom, Cory, Hobson, Esther, Murray, Deirdre, Steyn, Frederik J., Ngo, Shyuan T., Henders, Anjali, Lokeshappa, Madhura B., Visser-Meily, Johanna M. A., van den Berg, Leonard H., Hardiman, Orla, Beelen, Anita, McDermott, Chris and van Eijk, Ruben P. A. (2022). Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey. Journal of Neurology, 269 (11), 1-11. doi: 10.1007/s00415-022-11273-x
2022
Journal Article
A longitudinal descriptive assessment of US college COVID-19 dashboards
Jones, Katerina A., Steyn, Frank D. and Wallace, Lorraine S (2022). A longitudinal descriptive assessment of US college COVID-19 dashboards. Journal of American College Health, 72 (3), 1-7. doi: 10.1080/07448481.2022.2061861
2022
Journal Article
Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Frederik Steyn is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
NAT1 as a regulator of the metabolic response to disease
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo
-
Doctor Philosophy
Use of bioinformatics to decode disease heterogeneity in motor neuron disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo, Dr Thomas Shaw
-
Doctor Philosophy
Redefining digital technology to provide patient centric platform to meet the need of patients with Motor Neuron Disease
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo, Dr Rebecca Packer, Dr Taylor Dick
-
Doctor Philosophy
MINDE: A patient-centred study on Metabolism, Individualised Nutrition & Daily Eating
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo
-
Doctor Philosophy
Transforming growth factors to alter metabolic and functional physiology in health and disease.
Associate Advisor
Other advisors: Dr Adam Hagg, Dr Kelly Walton
-
Doctor Philosophy
Fine tuning metabolic flux: Modulating substrate oxidation as a therapeutic strategy in motor neuron disease (MND)
Associate Advisor
Other advisors: Associate Professor Peter Noakes, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Deciphering the spatio-temporal landscape of cell-autonomous and non-cell-autonomous drivers of motor neuron death in MND
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for amyotrophic lateral sclerosis (METALS)
Associate Advisor
Other advisors: Associate Professor Adam Walker, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for ALS (METALS)
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo
Completed supervision
-
2022
Master Philosophy
Validating a candidate ALS gene in Drosophila
Associate Advisor
Other advisors: Associate Professor Sean Millard
-
2018
Doctor Philosophy
Effects of adiposity, age and deletion of ghrelin o-acyltransferase on pulsatile growth hormone secretion in male mice
Associate Advisor
-
2017
Doctor Philosophy
The role of the Growth Hormone/Insulin-like Growth Factor-1 axis in Neuromuscular Degeneration in a mouse model of Amyotrophic Lateral Sclerosis
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo
-
2017
Master Philosophy
Energy metabolism in amyotrophic lateral sclerosis: Assessment of body composition and energy expenditure
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo, Professor Pamela McCombe
-
2014
Doctor Philosophy
Modulation of Pulsatile Growth Hormone (GH) Secretion in Positive and Negative Energy Balance in the Mouse
Associate Advisor
-
2014
Doctor Philosophy
Investigating the Role of Melanocortin System in Regulating Linear Growth and Growth Hormone Secretion
Associate Advisor
Media
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