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2025 Journal Article Segmentation of the human tongue musculature using MRI: Field guide and validation in motor neuron diseaseShaw, Thomas B., Ribeiro, Fernanda L., Zhu, Xiangyun, Aiken, Patrick, Bollmann, Saskia, Bollmann, Steffen, Chang, Jeryn, Chidley, Kali, Dempsey-Jones, Harriet, Eftekhari, Zeinab, Gillespie, Jennifer, Henderson, Robert D., Kiernan, Matthew C., Ktena, Ira, McCombe, Pamela A., Ngo, Shyuan T., Taubert, Shana T., Whelan, Brooke-Mai, Ye, Xincheng, Steyn, Frederik J., Tu, Sicong and Barth, Markus (2025). Segmentation of the human tongue musculature using MRI: Field guide and validation in motor neuron disease. Computers in Biology and Medicine, 196 110824, 110824. doi: 10.1016/j.compbiomed.2025.110824 |
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2025 Journal Article Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progressionChang, Jeryn, Teo, Annissa H., Shaw, Thomas B., Dupuis, Luc, Ngo, Shyuan T. and Steyn, Frederik J. (2025). Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression. eBioMedicine, 118 105845, 105845-118. doi: 10.1016/j.ebiom.2025.105845 |
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2025 Journal Article Lower-limb biomechanics in motor neuron disease: a joint-level perspective of gait disruptionHoldom, Cory J., Williamson, James L., O’Reilly, Georgia, Henderson, Robert D., Neville, Sally, Ngo, Shyuan T., Dick, Taylor J. M. and Steyn, Frederik J. (2025). Lower-limb biomechanics in motor neuron disease: a joint-level perspective of gait disruption. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-11. doi: 10.1080/21678421.2025.2523945 |
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2025 Journal Article Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron diseaseHoldom, Cory J., Pilkar, Rakesh, Guo, Christine C., Eijk, Ruben P.A van, Sethi, Nadia, Henderson, Robert D., Ngo, Shyuan T. and Steyn, Frederik J. (2025). Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron disease. eBioMedicine, 117 105779, 105779-117. doi: 10.1016/j.ebiom.2025.105779 |
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2025 Journal Article Assessment of the “MND-Prism” smartphone application as a tool for self-managementNeville, Sally, Ziser, Laura, Henders, Anjali, Milne, Jane, Ngo, Shyuan T., Packer, Rebecca and Steyn, Frederik J. (2025). Assessment of the “MND-Prism” smartphone application as a tool for self-management. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ahead-of-print (ahead-of-print), 1-10. doi: 10.1080/21678421.2025.2511119 |
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2025 Journal Article Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALSBlazev, Ronnie, Zee, Barry M., Peckham, Hayley, Ng, Yaan-Kit, Lewis, Christopher T. A., Zhang, Chengxin, McNamara, James W., Goodman, Craig A., Gregorevic, Paul, Ochala, Julien, Steyn, Frederik J., Ngo, Shyuan T., Stokes, Matthew P. and Parker, Benjamin L. (2025). Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS. Cell Reports Methods, 5 (5) 101048. doi: 10.1016/j.crmeth.2025.101048 |
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2025 Journal Article An annotated multi-site and multi-contrast magnetic resonance imaging dataset for the study of the human tongue musculatureRibeiro, Fernanda L., Zhu, Xiangyun, Ye, Xincheng, Tu, Sicong, Ngo, Shyuan T., Henderson, Robert D., Steyn, Frederik J., Kiernan, Matthew C., Barth, Markus, Bollmann, Steffen and Shaw, Thomas B. (2025). An annotated multi-site and multi-contrast magnetic resonance imaging dataset for the study of the human tongue musculature. Scientific Data, 12 (1) 790, 790. doi: 10.1038/s41597-025-05092-8 |
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2025 Journal Article An fMRI dataset for appetite neural correlates in people living with Motor Neuron DiseaseChang, Jeryn, Lv, JingLei, Guo, Christine C., Lucia, Diana, Bollmann, Saskia, Garner, Kelly, McCombe, Pamela A., Henderson, Robert D., Shaw, Thomas B., Steyn, Frederik J. and Ngo, Shyuan T. (2025). An fMRI dataset for appetite neural correlates in people living with Motor Neuron Disease. Scientific Data, 12 (1) 466, 466. doi: 10.1038/s41597-025-04828-w |
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2025 Journal Article Appetite loss in patients with motor neuron disease: impact on weight loss and neural correlates of visual food cuesChang, Jeryn, Shaw, Thomas B., McCombe, Pamela A., Henderson, Robert D., Lucia, Diana, Guo, Christine C., Lv, Jinglei, Garner, Kelly, Bollmann, Saskia, Ngo, Shyuan T. and Steyn, Frederik J. (2025). Appetite loss in patients with motor neuron disease: impact on weight loss and neural correlates of visual food cues. Brain Communications, 7 (2) fcaf111, 1-14. doi: 10.1093/braincomms/fcaf111 |
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2025 Journal Article Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosisBuckett, Lauren E., Holdom, Cory J., Howe, Stephanie L., McCombe, Pamela A., Henderson, Robert D., Al-Chalabi, Ammar, Steyn, Frederik J. and Ngo, Shyuan T. (2025). Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ahead-of-print (ahead-of-print), 1-10. doi: 10.1080/21678421.2025.2471429 |
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2025 Journal Article An open-label phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosisvan Eijk, Ruben P. A., Steyn, Frederik J., Janse van Mantgem, Mark R., Schmidt, Angela, Meyjes, Myrte, Allen, Sally, Daygon, Dara V., Loeffler, Jean-Philippe, Al-Chalabi, Ammar, van den Berg, Leonard H., Henderson, Robert D. and Ngo, Shyuan T. (2025). An open-label phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosis. Brain Communications, 7 (1) fcaf063, fcaf063-1. doi: 10.1093/braincomms/fcaf063 |
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2024 Journal Article The use of digital devices to monitor physical behaviour in motor neuron disease: a systematic review Musson, Lucy Samantha, Mitic, Nina, Leigh-Valero, Victoria, Onambele-Pearson, Gladys, Knox, Liam, Steyn, Frederik J., Holdom, Cory J., Dick, Taylor J. M., van Eijk, Ruben P. A., van Unnik, Jordi W. J., Botman, Lianne C. M., Beswick, Emily, Murray, Deirdre, Griffiths, Alys, McDermott, Christopher, Hobson, Esther, Chaouch, Amina and Hodson-Tole, Emma (2024). The use of digital devices to monitor physical behaviour in motor neuron disease: a systematic review . Journal of Medical Internet Research, 27 e68479, e68479. doi: 10.2196/68479 |
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2024 Journal Article Generation of human induced pluripotent stem cell lines from sporadic, sporadic frontotemporal dementia, familial SOD1, and familial C9orf72 amyotrophic lateral sclerosis (ALS) patientsJiang, Leanne, Tracey, Timothy J., Gill, Melinder K., Howe, Stephanie L., Power, Dominique T., Bharti, Vanda, McCombe, Pamela A., Henderson, Robert D., Steyn, Frederik J. and Ngo, Shyuan T. (2024). Generation of human induced pluripotent stem cell lines from sporadic, sporadic frontotemporal dementia, familial SOD1, and familial C9orf72 amyotrophic lateral sclerosis (ALS) patients. Stem Cell Research, 78 103447, 1-6. doi: 10.1016/j.scr.2024.103447 |
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2024 Journal Article Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosisWong, Julian P. H., Blazev, Ronnie, Ng, Yaan‐Kit, Goodman, Craig A., Montgomery, Magdalene K., Watt, Kevin I., Carl, Christian S., Watt, Matthew J., Voldstedlund, Christian T., Richter, Erik A., Crouch, Peter J., Steyn, Frederik J., Ngo, Shyuan T. and Parker, Benjamin L. (2024). Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosis. The FASEB Journal, 38 (10) e23647, 1-19. doi: 10.1096/fj.202400045r |
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2024 Journal Article Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitisSajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 1-13. doi: 10.1038/s41467-024-48317-x |
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2024 Journal Article The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunctionChoudhury, Chandra, Gill, Melinder K., McAleese, Courtney E., Butcher, Neville J., Ngo, Shyuan T., Steyn, Frederik J. and Minchin, Rodney F. (2024). The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunction. Pharmacological Reviews, 76 (2), 300-320. doi: 10.1124/pharmrev.123.000835 |
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2024 Journal Article Variation in resting metabolic rate affects identification of metabolic change in geographically distinct cohorts of patients with ALSHoldom, Cory J., Janse van Mantgem, Mark R., He, Ji, Howe, Stephanie L., McCombe, Pamela A., Fan, Dongsheng, van den Berg, Leonard H., Henderson, Robert D., van Eijk, Ruben, Steyn, Frederik J. and Ngo, Shyuan T. (2024). Variation in resting metabolic rate affects identification of metabolic change in geographically distinct cohorts of patients with ALS. Neurology, 102 (5) e208117, 1-11. doi: 10.1212/wnl.0000000000208117 |
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2024 Journal Article TSH pulses finely tune thyroid hormone release and TSH receptor transductionGuillou, Anne, Kemkem, Yasmine, Lafont, Chrystel, Fontanaud, Pierre, Calebiro, Davide, Campos, Pauline, Bonnefont, Xavier, Fiordelisio-Coll, Tatiana, Wang, Ying, Brûlé, Emilie, Bernard, Daniel J, Le Tissier, Paul, Steyn, Frederik and Mollard, Patrice (2024). TSH pulses finely tune thyroid hormone release and TSH receptor transduction. Endocrinology, 165 (1) 1, 1-9. doi: 10.1210/endocr/bqad164 |
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2024 Journal Article Associations of postprandial ghrelin, liver‐expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosisHowe, Stephanie L., Holdom, Cory J., McCombe, Pamela A., Henderson, Robert D., Zigman, Jeffrey M., Ngo, Shyuan T. and Steyn, Frederik J. (2024). Associations of postprandial ghrelin, liver‐expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosis. European Journal of Neurology, 31 (1) e16052, e16052. doi: 10.1111/ene.16052 |
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2023 Journal Article Skeletal muscle in amyotrophic lateral sclerosisShefner, Jeremy M., Musaro, Antonio, Ngo, Shyuan T., Lunetta, Christian, Steyn, Frederik J., Robitaille, Richard, De Carvalho, Mamede, Rutkove, Seward, Ludolph, Albert C. and Dupuis, Luc (2023). Skeletal muscle in amyotrophic lateral sclerosis. Brain, 146 (11), 4425-4436. doi: 10.1093/brain/awad202 |
