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2020 Journal Article The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosisTracey, T. J., Kirk, S. E., Steyn, F. J. and Ngo, S. T. (2020). The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis. Seminars in Cell and Developmental Biology, 112, 69-81. doi: 10.1016/j.semcdb.2020.08.012 |
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2020 Journal Article Prognostic value of weight loss in patients with amyotrophic lateral sclerosisSteyn, Frederik J and Ngo, Shyuan T (2020). Prognostic value of weight loss in patients with amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 91 (8), 813-813. doi: 10.1136/jnnp-2020-323440 |
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2020 Journal Article Response to Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction"Joustra, Sjoerd D., Roelfsema, Ferdinand, van Trotsenburg, A. S. Paul, Schneider, Harald J., Kosilek, Robert P., Kroon, Herman M., Logan, John G., Butterfield, Natalie C., Zhou, Xiang, Toufaily, Chirine, Bak, Beata, Turgeon, Marc-Olivier, Brule, Emilie, Steyn, Frederik J., Gurnell, Mark, Koulouri, Olympia, Le Tissier, Paul, Fontanaud, Pierre, Bassett, J. H. Duncan, Williams, Graham R., Oostdijk, Wilma, Wit, Jan M., Pereira, Alberto M., Biermasz, Nienke R., Bernard, Daniel J. and Schoenmakers, Nadia (2020). Response to Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction". Journal of Clinical Endocrinology and Metabolism, 105 (6), E2315-E2316. doi: 10.1210/clinem/dgaa147 |
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2020 Journal Article Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic TargetScaricamazza, Silvia, Salvatori, Illari, Giacovazzo, Giacomo, Loeffler, Jean Philippe, Renè, Frederique, Rosina, Marco, Quessada, Cyril, Proietti, Daisy, Heil, Constantin, Rossi, Simona, Battistini, Stefania, Giannini, Fabio, Volpi, Nila, Steyn, Frederik J., Ngo, Shyuan T., Ferraro, Elisabetta, Madaro, Luca, Coccurello, Roberto, Valle, Cristiana and Ferri, Alberto (2020). Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target. iScience, 23 (5) 101087, 101087. doi: 10.1016/j.isci.2020.101087 |
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2020 Journal Article Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosisNabais, Marta F., Lin, Tian, Benyamin, Beben, Williams, Kelly L., Garton, Fleur C., Vinkhuyzen, Anna A. E., Zhang, Futao, Vallerga, Costanza L., Restuadi, Restuadi, Freydenzon, Anna, Zwamborn, Ramona A. J., Hop, Paul J., Robinson, Matthew R., Gratten, Jacob, Visscher, Peter M., Hannon, Eilis, Mill, Jonathan, Brown, Matthew A., Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Needham, Merrilee, Veldink, Jan H., Mathers, Susan, Nicholson, Garth ... Wray, Naomi R. (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5 (1) 10, 1-9. doi: 10.1038/s41525-020-0118-3 |
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2020 Journal Article Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosisMcGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013 |
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2020 Journal Article Progression and survival of patients with motor neuron disease relative to their fecal microbiotaNgo, Shyuan T., Restuadi, Restuadi, McCrea, Allan F., Van Eijk, Ruben P., Garton, Fleur, Henderson, Robert D., Wray, Naomi R., McCombe, Pamela A. and Steyn, Frederik J. (2020). Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21 (7-8), 1-14. doi: 10.1080/21678421.2020.1772825 |
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2019 Journal Article IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory HyperfunctionJoustra, Sjoerd D., Roelfsema, Ferdinand, van Trotsenburg, A. S. Paul, Schneider, Harald J., Kosilek, Robert P., Kroon, Herman M., Logan, John G., Butterfield, Natalie C., Zhou, Xiang, Toufaily, Chirine, Bak, Beata, Turgeon, Marc-Olivier, Brûlé, Emilie, Steyn, Frederik J., Gurnell, Mark, Koulouri, Olympia, Le Tissier, Paul, Fontanaud, Pierre, Duncan Bassett, J. H., Williams, Graham R., Oostdijk, Wilma, Wit, Jan M., Pereira, Alberto M., Biermasz, Nienke R., Bernard, Daniel J. and Schoenmakers, Nadia (2019). IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. The Journal of Clinical Endocrinology & Metabolism, 105 (3) dgz093, e70-e84. doi: 10.1210/clinem/dgz093 |
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2019 Journal Article C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanomaNabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., Akhir, Fazrena N. M., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. FASEB Journal, 33 (10), fj201800980RR-11071. doi: 10.1096/fj.201800980rr |
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2019 Journal Article Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosisNgo, Shyuan T., Van Eijk, Ruben P. A., Chachay, V. , Van Den Berg, Leonard H., Mccombe, Pamela A., Henderson, Robert D. and Steyn, Frederik J. (2019). Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 20 (7-8), 1-9. doi: 10.1080/21678421.2019.1621346 |
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2019 Journal Article Gut microbiota in ALS: possible role in pathogenesis?McCombe, Pamela A., Henderson, Robert D., Lee, Aven, Lee, John D., Woodruff, Trent M., Restuadi, Restuadi, McRae, Allan, Wray, Naomi R., Ngo, Shyuan and Steyn, Frederik J. (2019). Gut microbiota in ALS: possible role in pathogenesis?. Expert Review of Neurotherapeutics, 19 (9), 1-21. doi: 10.1080/14737175.2019.1623026 |
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2019 Journal Article Biomarkers of metabolism in amyotrophic lateral sclerosisKirk, Siobhan E., Tracey, Timothy J., Steyn, Frederik J. and Ngo, Shyuan T. (2019). Biomarkers of metabolism in amyotrophic lateral sclerosis. Frontiers in Neurology, 10 191, 191. doi: 10.3389/fneur.2019.00191 |
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2018 Journal Article Hypermetabolism in ALS is associated with greater functional decline and shorter survivalSteyn, Frederik J., Ioannides, Zara A., van Eijk, Ruben P. A., Heggie, Susan, Thorpe, Kathryn A., Ceslis, Amelia, Heshmat, Saman, Henders, Anjali K., Wray, Naomi R., van den Berg, Leonard H., Henderson, Robert D., McCombe, Pamela A. and Ngo, Shyuan T. (2018). Hypermetabolism in ALS is associated with greater functional decline and shorter survival. Journal of Neurology, Neurosurgery, and Psychiatry, 89 (10), jnnp-2017. doi: 10.1136/jnnp-2017-317887 |
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2018 Journal Article Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and DiseaseTracey, Timothy J., Steyn, Frederik J., Wolvetang, Ernst J. and Ngo, Shyuan T. (2018). Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience, 11 10, 10. doi: 10.3389/fnmol.2018.00010 |
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2018 Journal Article Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunctionMcCombe, Pamela A., Ngo, Shyuan T., Guo, Christine Cong, Fazlollahi, Amir, Bollmann, Saskia, Wang, Liting, Hu, Xintao, Barth, Markus, Salvado, Olivier, Davis, Mark, Ceslis, Amelia, Robinson, Gail, Henderson, Robert D. and Steyn, Frederik J. (2018). Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction. Journal of Neurology, Neurosurgery and Psychiatry, 90 (8), 952-954. doi: 10.1136/jnnp-2018-318823 |
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2017 Journal Article 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behaviorSteyn, Frederik J., Ngo, Shyuan T., Chen, Vicky Ping, Bailey-Downs, Lora C., Xie, Teresa Y., Ghadami, Martin, Brimijoin, Stephen, Freeman, Willard M., Rubinstein, Marcelo, Low, Malcolm J. and Stout, Michael B. (2017). 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell, 17 (1) e12703, 1-6. doi: 10.1111/acel.12703 |
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2017 Journal Article Endocrine rhythms of growth hormone release: insights from animal studiesSteyn, Frederik J. and Ngo, Shyuan T. (2017). Endocrine rhythms of growth hormone release: insights from animal studies. Best Practice and Research: Clinical Endocrinology and Metabolism, 31 (6), 521-533. doi: 10.1016/j.beem.2017.10.009 |
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2017 Journal Article Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activityVaramini, Pegah, Rafiee, Amirreza, Giddam, Ashwini Kumar, Mansfeld, Friederike M., Steyn, Frederik and Toth, Istvan (2017). Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity. Journal of Medicinal Chemistry, 60 (20), 8309-8320. doi: 10.1021/acs.jmedchem.6b01771 |
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2017 Journal Article Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventionsNgo, Shyuan T., Mi, Jia D., Henderson, Robert D., McCombe, Pamela A. and Steyn, Frederik J. (2017). Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degenerative Neurological and Neuromuscular Disease, 7, 95-108. doi: 10.2147/DNND.S120607 |
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2017 Journal Article Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free massIoannides, Z. A., Steyn, F. J., Henderson, R. D., McCombe, P. A. and Ngo, S. T. (2017). Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass. Cogent Medicine, 4 (1), 1343000. doi: 10.1080/2331205X.2017.1343000 |
