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2018

Journal Article

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease

Tracey, Timothy J., Steyn, Frederik J., Wolvetang, Ernst J. and Ngo, Shyuan T. (2018). Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience, 11 10, 10. doi: 10.3389/fnmol.2018.00010

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease

2018

Journal Article

Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction

McCombe, Pamela A., Ngo, Shyuan T., Guo, Christine Cong, Fazlollahi, Amir, Bollmann, Saskia, Wang, Liting, Hu, Xintao, Barth, Markus, Salvado, Olivier, Davis, Mark, Ceslis, Amelia, Robinson, Gail, Henderson, Robert D. and Steyn, Frederik J. (2018). Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction. Journal of Neurology, Neurosurgery and Psychiatry, 90 (8), 952-954. doi: 10.1136/jnnp-2018-318823

Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction

2017

Journal Article

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Steyn, Frederik J., Ngo, Shyuan T., Chen, Vicky Ping, Bailey-Downs, Lora C., Xie, Teresa Y., Ghadami, Martin, Brimijoin, Stephen, Freeman, Willard M., Rubinstein, Marcelo, Low, Malcolm J. and Stout, Michael B. (2017). 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell, 17 (1) e12703, 1-6. doi: 10.1111/acel.12703

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

2017

Journal Article

Endocrine rhythms of growth hormone release: insights from animal studies

Steyn, Frederik J. and Ngo, Shyuan T. (2017). Endocrine rhythms of growth hormone release: insights from animal studies. Best Practice and Research: Clinical Endocrinology and Metabolism, 31 (6), 521-533. doi: 10.1016/j.beem.2017.10.009

Endocrine rhythms of growth hormone release: insights from animal studies

2017

Journal Article

Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity

Varamini, Pegah, Rafiee, Amirreza, Giddam, Ashwini Kumar, Mansfeld, Friederike M., Steyn, Frederik and Toth, Istvan (2017). Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity. Journal of Medicinal Chemistry, 60 (20), 8309-8320. doi: 10.1021/acs.jmedchem.6b01771

Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity

2017

Journal Article

Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions

Ngo, Shyuan T., Mi, Jia D., Henderson, Robert D., McCombe, Pamela A. and Steyn, Frederik J. (2017). Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degenerative Neurological and Neuromuscular Disease, 7, 95-108. doi: 10.2147/DNND.S120607

Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions

2017

Journal Article

Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass

Ioannides, Z. A., Steyn, F. J., Henderson, R. D., McCombe, P. A. and Ngo, S. T. (2017). Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass. Cogent Medicine, 4 (1), 1343000. doi: 10.1080/2331205X.2017.1343000

Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass

2017

Journal Article

Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse

Kirk, S. E., Xie, T. Y., Steyn, F. J., Grattan, D. R. and Bunn, S. J. (2017). Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse. Journal of Neuroendocrinology, 29 (6) JNE12477. doi: 10.1111/jne.12477

Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse

2017

Journal Article

New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency

Varamini, Pegah, Mansfeld, Friederike M., Giddam, Ashwini Kumar, Steyn, Frederik and Toth, Istvan (2017). New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency. International Journal of Pharmaceutics, 521 (1-2), 327-336. doi: 10.1016/j.ijpharm.2017.02.054

New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency

2017

Journal Article

Anthropometric measures are not accurate predictors of fat mass in ALS

Ioannides, Zara A., Steyn, Frederik J., Henderson, Robert D., Mccombe, Pamela A. and Ngo, Shyuan T. (2017). Anthropometric measures are not accurate predictors of fat mass in ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18 (7-8), 486-491. doi: 10.1080/21678421.2017.1317811

Anthropometric measures are not accurate predictors of fat mass in ALS

2017

Journal Article

Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system

Spiers, Jereme G., Chen, Hsiao-Jou Cortina, Steyn, Frederik J., Lavidis, Nickolas A., Woodruff, Trent M. and Lee, John D. (2017). Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system. Stress, 20 (1), 59-67. doi: 10.1080/10253890.2016.1276898

Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system

2017

Journal Article

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, Michael B. , Steyn, Frederik J. , Jurczak, Michael J. , Camporez, Joao-Paulo G., Zhu, Yi , Hawse, John R., Jurk, Diana, Palmer, Allyson K. , Xu, Ming, Pirtskhalava, Tamar, Evans, Glenda L., De Souza Santos, Roberta, Frank, Aaron P. , White, Thomas A., Monroe, David G. , Singh, Ravinder J., Casaclang-Verzosa, Grace, Miller, Jordan D. , Clegg, Deborah J., LeBrasseur, Nathan K., Von Zglinicki, Thomas, Shulman, Gerald I. , Tchkonia, Tamara and Kirkland, James L. (2017). 17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization. Journals of Gerontology, Series A, 72 (1), 3-15. doi: 10.1093/gerona/glv309

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

2016

Journal Article

Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone

Tan, H. Y., Steyn, F. J., Huang, L., Cowley, M., Veldhuis, J. D. and Chen, C. (2016). Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone. Journal of Physiology, 594 (24), 7309-7326. doi: 10.1113/JP272770

Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone

2016

Journal Article

Pulse and surge profiles of luteinizing hormone secretion in the mouse

Czieselsky, Katja, Prescott, Mel, Porteous, Robert, Campos, Pauline, Clarkson, Jenny, Steyn, Frederik J., Campbell, Rebecca E. and Herbison, Allan E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157 (12), 4794-4802. doi: 10.1210/en.2016-1351

Pulse and surge profiles of luteinizing hormone secretion in the mouse

2016

Journal Article

Transgenic adipose-specific expression of the nuclear receptor RORα drives a striking shift in fat distribution and impairs glycemic control

Tuong, Zewen Kelvin, Fitzsimmons, Rebecca, Wang, Shu-Ching Mary, Oh, Tae Gyu, Lau, Patrick, Steyn, Frederik, Thomas, Gethin and Muscat, George E. O. (2016). Transgenic adipose-specific expression of the nuclear receptor RORα drives a striking shift in fat distribution and impairs glycemic control. EBioMedicine, 11, 101-117. doi: 10.1016/j.ebiom.2016.08.027

Transgenic adipose-specific expression of the nuclear receptor RORα drives a striking shift in fat distribution and impairs glycemic control

2016

Journal Article

Altered metabolic homeostasis in amyotrophic lateral sclerosis: mechanisms of energy imbalance and contribution to disease progression

Ioannides, Z. A., Ngo, S. T., Henderson, R. D., McCombe, P. A. and Steyn, F. J. (2016). Altered metabolic homeostasis in amyotrophic lateral sclerosis: mechanisms of energy imbalance and contribution to disease progression. Neurodegenerative Diseases, 15 (5-6), 382-397. doi: 10.1159/000446502

Altered metabolic homeostasis in amyotrophic lateral sclerosis: mechanisms of energy imbalance and contribution to disease progression

2016

Journal Article

The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses

Nabizadeh, Jamileh A., Manthey, Helga D., Steyn, Frederik J., Chen, Weiyu, Widiapradja, Alexander, Akhir, Fazrena N. Md, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2016). The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. Journal of Immunology, 196 (11), 4783-4792. doi: 10.4049/jimmunol.1600210

The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses

2016

Journal Article

Neuroendocrine regulation of growth hormone secretion

Steyn, Frederik J., Tolle, Virginie, Chen, Chen and Epelbaum, Jacques (2016). Neuroendocrine regulation of growth hormone secretion. Comprehensive Physiology, 6 (2), 687-735. doi: 10.1002/cphy.c150002

Neuroendocrine regulation of growth hormone secretion

2016

Journal Article

Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles

Li, Rui, Steyn, Frederik J., Stout, Michael B., Lee, Kevin, Cully, Tanya R., Calderon, Juan C. and Ngo, Shuyan T. (2016). Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles. The Journal of Physiology, 594 (24), 7197-7213. doi: 10.1113/JP272988

Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles

2015

Journal Article

Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice

Xie, T. Y., Ngo, S. T., Veldhuis, J. D., Jeffery, P. L., Chopin, L. K., Tschop, M., Waters, M. J., Tolle, V., Epelbaum, J., Chen, C. and Steyn, F. J. (2015). Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice. Journal of Neuroendocrinology, 27 (12), 872-886. doi: 10.1111/jne.12327

Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice