
Overview
Background
Associate Professor Steyn is a leading expert in neurodegenerative disease research, specializing in the metabolic and physiological aspects of Motor Neurone Disease (MND). He currently directs a comprehensive translational research program at the University of Queensland, focusing on the interplay between metabolism and disease progression in MND, and leads key projects investigating the impact of metabolic dysfunction, appetite dysregulation, and hypermetabolism on patient outcomes. His work prioritizes the integration of pre-clinical models, clinical studies, and innovative digital health technologies to advance understanding of the heterogeneity in MND, patient care and therapeutic development.
Associate Professor Steyn’s career began with detailed investigations into the hypothalamic regulation of energy homeostasis, growth, and reproduction. He developed industry-standard methodologies for evaluating hormone release patterns in rodent models, particularly concerning growth hormone regulation. In 2015, he transitioned to focus on neurodegenerative diseases, establishing a research platform at UQ that has significantly advanced the analysis of metabolic phenotypes in MND.
His current research projects include the MEND-MND study, which explores how altered energy metabolism influences disease progression, and the EATT4MND study, which examines the consequences of appetite loss and impaired body weight regulation on disease outcomes. Through collaboration with industry partners, he is also developing novel therapeutic strategies and refining wearable digital health technologies for precise, real-time monitoring of disease progression, including the validation of actigraphy-based measures as clinical trial biomarkers.
Availability
- Associate Professor Frederik Steyn is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma, University of Otago
Works
Search Professor Frederik Steyn’s works on UQ eSpace
2022
Journal Article
Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T
Chang, Jeryn, Steyn, Frederik, Ngo, Shyuan, Henderson, Robert, Guo, Christine, Bollmann, Steffen, Fripp, Jurgen, Barth, Markus and Shaw, Thomas (2022). Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T. Journal of Open Source Software, 7 (76), 4368. doi: 10.21105/joss.04368
2022
Journal Article
Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey
Helleman, Jochem, Johnson, Barbara, Holdom, Cory, Hobson, Esther, Murray, Deirdre, Steyn, Frederik J., Ngo, Shyuan T., Henders, Anjali, Lokeshappa, Madhura B., Visser-Meily, Johanna M. A., van den Berg, Leonard H., Hardiman, Orla, Beelen, Anita, McDermott, Chris and van Eijk, Ruben P. A. (2022). Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey. Journal of Neurology, 269 (11), 1-11. doi: 10.1007/s00415-022-11273-x
2022
Journal Article
A longitudinal descriptive assessment of US college COVID-19 dashboards
Jones, Katerina A., Steyn, Frank D. and Wallace, Lorraine S (2022). A longitudinal descriptive assessment of US college COVID-19 dashboards. Journal of American College Health, 72 (3), 1-7. doi: 10.1080/07448481.2022.2061861
2022
Journal Article
Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5
2022
Journal Article
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
Hop, Paul J., Zwamborn, Ramona A.J., Hannon, Eilis, Shireby, Gemma L., Nabais, Marta F., Walker, Emma M., van Rheenen, Wouter, van Vugt, Joke J.F.A., Dekker, Annelot M., Westeneng, Henk-Jan, Tazelaar, Gijs H.P., van Eijk, Kristel R., Moisse, Matthieu, Baird, Denis, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Ticozzi, Nicola, Ratti, Antonia, Cooper-Knock, Jonathan, Morrison, Karen E., Shaw, Pamela J., Basak, A. Nazli, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Brunetti, Maura, Grassano, Maurizio, Gotkine, Marc ... Brain MEND Consortium (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14 (633) eabj0264, 1-15. doi: 10.1126/scitranslmed.abj0264
2022
Journal Article
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola ... SLAP Consortium (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nature Genetics, 54 (3), 361-361. doi: 10.1038/s41588-022-01020-3
2022
Journal Article
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
Restuadi, Restuadi, Steyn, Frederik J., Kabashi, Edor, Ngo, Shyuan T., Cheng, Fei-Fei, Nabais, Marta F., Thompson, Mike J., Qi, Ting, Wu, Yang, Henders, Anjali K., Wallace, Leanne, Bye, Chris R., Turner, Bradley J., Ziser, Laura, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Schultz, David, Kiernan, Matthew C., van Rheenen, Wouter, van den Berg, Leonard H., Veldink, Jan H., Ophoff, Roel, Gusev, Alexander, Zaitlen, Noah, McRae, Allan F., Henderson, Robert D., Wray, Naomi R., Giacomotto, Jean and Garton, Fleur C. (2022). Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Medicine, 14 (1) 7, 7. doi: 10.1186/s13073-021-01006-6
2022
Book Chapter
Biofluid biomarkers of amyotrophic lateral sclerosis
Holdom, Cory J., Steyn, Frederik J., Henderson, Robert D., McCombe, Pamela A., Rogers, Mary-Louise and Ngo, Shyuan T. (2022). Biofluid biomarkers of amyotrophic lateral sclerosis. Neurodegenerative diseases biomarkers: towards translating research to clinical practice. (pp. 263-306) edited by Philip V. Peplow, Bridget Martinez and Thomas A. Gennarelli. New York, United States: Springer . doi: 10.1007/978-1-0716-1712-0_11
2022
Journal Article
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: a study in SOD1 mice
Scaricamazza, Silvia, Salvatori, Illari, Amadio, Susanna, Nesci, Valentina, Torcinaro, Alessio, Giacovazzo, Giacomo, Primiano, Aniello, Gloriani, Michela, Candelise, Niccolò, Pieroni, Luisa, Loeffler, Jean-Philippe, Renè, Frederique, Quessada, Cyril, Tefera, Tesfaye W, Wang, Hao, Steyn, Frederik J, Ngo, Shyuan T, Dobrowolny, Gabriella, Lepore, Elisa, Urbani, Andrea, Musarò, Antonio, Volonté, Cinzia, Ferraro, Elisabetta, Coccurello, Roberto, Valle, Cristiana and Ferri, Alberto (2022). Repurposing of Trimetazidine for amyotrophic lateral sclerosis: a study in SOD1 mice. British Journal of Pharmacology, 179 (8), 1732-1752. doi: 10.1111/bph.15738
2022
Other Outputs
snrRNA-seq_muscle_dataset
Ngo, Shyuan, Power, Dominique, Andersen, Stacey, Taherian Fard, Atefeh, Chang, Jeryn and Steyn, Frederik (2022). snrRNA-seq_muscle_dataset. The University of Queensland. (Dataset) doi: 10.48610/0106c8e
2021
Journal Article
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola ... SLAP Consortium (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nature Genetics, 53 (12), 1636-1648. doi: 10.1038/s41588-021-00973-1
2021
Journal Article
Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice
Toufaily, Chirine, Fortin, Jérôme, Alonso, Carlos A. I., Lapointe, Evelyn, Zhou, Xiang, Santiago-Andres, Yorgui, Lin, Yeu-Farn, Cui, Yimming, Wang, Ying, Devost, Dominic, Roelfsema, Ferdinand, Steyn, Frederik, Hanyaloglu, Aylin C., Hébert, Terence E., Fiordelisio, Tatiana, Boerboom, Derek and Bernard, Daniel J. (2021). Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice. eLife, 10 e72937. doi: 10.7554/eLife.72937
2021
Journal Article
An exercise ‘sweet spot’ reverses cognitive deficits of ageing by growth hormone-induced neurogenesis
Blackmore, Daniel G., Steyn, Frederik J., Carlisle, Alison, O’Keeffe, Imogen, Vien, King-Year, Zhou, Xiaoqing, Leiter, Odette, Jhaveri, Dhanisha, Vukovic, Jana, Waters, Michael J. and Bartlett, Perry F. (2021). An exercise ‘sweet spot’ reverses cognitive deficits of ageing by growth hormone-induced neurogenesis. iScience, 24 (11) 103275, 1-25. doi: 10.1016/j.isci.2021.103275
2021
Journal Article
Venous creatinine as a biomarker for loss of fat‐free mass and disease progression in patients with Amyotrophic Lateral Sclerosis
Holdom, Cory J., Janse van Mantgem, Mark R., van Eijk, Ruben P.A., Howe, Stephanie L., van den Berg, Leonard H., McCombe, Pamela A., Henderson, Robert D., Ngo, Shyuan T. and Steyn, Frederik J. (2021). Venous creatinine as a biomarker for loss of fat‐free mass and disease progression in patients with Amyotrophic Lateral Sclerosis. European Journal of Neurology, 28 (11) ene.15003, 3615-3625. doi: 10.1111/ene.15003
2021
Journal Article
Low plasma hyaluronan is associated with faster functional decline in patients with amyotrophic lateral sclerosis
Holdom, Cory J., Ngo, Shyuan T., McCombe, Pamela A., Henderson, Robert D. and Steyn, Frederik J. (2021). Low plasma hyaluronan is associated with faster functional decline in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 23 (1-2), 1-7. doi: 10.1080/21678421.2021.1918721
2021
Journal Article
A road map for remote digital health technology for motor neuron disease
van Eijk, Ruben P A, Beelen, Anita, Kruitwagen, Esther T, Murray, Deirdre, Radakovic, Ratko, Hobson, Esther, Knox, Liam, Helleman, Jochem, Burke, Tom, Rubio Pérez, Miguel Ángel, Reviers, Evy, Genge, Angela, Steyn, Frederik J, Ngo, Shyuan, Eaglesham, John, Roes, Kit C B, van den Berg, Leonard H, Hardiman, Orla and McDermott, Christopher J (2021). A road map for remote digital health technology for motor neuron disease. Journal of Medical Internet Research, 23 (9) e28766, e28766. doi: 10.2196/28766
2021
Journal Article
Monocyte CD14 and HLA-DR expression increases with disease duration and severity in amyotrophic lateral sclerosis
McGill, R.B., Steyn, F.J., Ngo, S.T., Thorpe, K.A., Heggie, S., Henderson, R.D., Mccombe, P.A. and Woodruff, T.M. (2021). Monocyte CD14 and HLA-DR expression increases with disease duration and severity in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 23 (5-6), 1-8. doi: 10.1080/21678421.2021.1964531
2021
Journal Article
17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner
Sidhom, Silvana, Schneider, Augusto, Fang, Yimin, McFadden, Samuel, Darcy, Justin, Sathiaseelan, Roshini, Palmer, Allyson K, Steyn, Frederik J, Grillari, Johannes, Kopchick, John J, Bartke, Andrzej, Siddiqi, Shadab, Masternak, Michal M and Stout, Michael B (2021). 17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 76 (5), 778-785. doi: 10.1093/gerona/glaa215
2021
Journal Article
Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia
Restuadi, Restuadi, Garton, Fleur C., Benyamin, Beben, Lin, Tian, Williams, Kelly L., Vinkhuyzen, Anna, van Rheenen, Wouter, Zhu, Zhihong, Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Visscher, Peter M., Needham, Merrilee, Mathers, Susan, Nicholson, Garth, Rowe, Dominic B., Henderson, Robert D., McCombe, Pamela A., Pamphlett, Roger, Blair, Ian P., Wray, Naomi R. and McRae, Allan F. (2021). Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia. European Journal of Human Genetics, 30 (5), 1-8. doi: 10.1038/s41431-021-00885-y
2021
Journal Article
Development of a highly sensitive ELISA for measurement of FSH in serum, plasma, and whole blood in mice
Ongaro, Luisina, Alonso, Carlos Agustin Isidro, Zhou, Xiang, Brûlé, Emilie, Li, Yining, Schang, Gauthier, Parlow, Albert F., Steyn, Frederik and Bernard, Daniel J. (2021). Development of a highly sensitive ELISA for measurement of FSH in serum, plasma, and whole blood in mice. Endocrinology, 162 (4) bqab014, 1-11. doi: 10.1210/endocr/bqab014
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Frederik Steyn is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
MINDE: A patient-centred study on Metabolism, Individualised Nutrition & Daily Eating
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo
-
Doctor Philosophy
NAT1 as a regulator of the metabolic response to disease
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo
-
Doctor Philosophy
Use of bioinformatics to decode disease heterogeneity in motor neuron disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo, Dr Thomas Shaw
-
Doctor Philosophy
Redefining digital technology to provide patient centric platform to meet the need of patients with Motor Neuron Disease
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo, Dr Rebecca Packer, Associate Professor Taylor Dick
-
Doctor Philosophy
Non-traditional biomarkers for motor neuron disease
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Non-traditional biomarkers for motor neuron disease
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Deciphering the spatio-temporal landscape of cell-autonomous and non-cell-autonomous drivers of motor neuron death in MND
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for amyotrophic lateral sclerosis (METALS)
Associate Advisor
Other advisors: Associate Professor Adam Walker, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Fine tuning metabolic flux: Modulating substrate oxidation as a therapeutic strategy in motor neuron disease (MND)
Associate Advisor
Other advisors: Associate Professor Peter Noakes, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Fine tuning metabolic flux: Modulating substrate oxidation as a therapeutic strategy in motor neuron disease (MND)
Associate Advisor
Other advisors: Associate Professor Peter Noakes, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for ALS (METALS)
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Targeting metabolic flexibility as a therapeutic approach for amyotrophic lateral sclerosis (METALS)
Associate Advisor
Other advisors: Associate Professor Adam Walker, Associate Professor Shyuan Ngo
-
Doctor Philosophy
Transforming growth factors to alter metabolic and functional physiology in health and disease.
Associate Advisor
Other advisors: Dr Adam Hagg, Dr Kelly Walton
-
Doctor Philosophy
Fine tuning metabolic flux: Modulating substrate oxidation as a therapeutic strategy in motor neuron disease (MND)
Associate Advisor
Other advisors: Associate Professor Peter Noakes, Associate Professor Shyuan Ngo
Completed supervision
-
2025
Doctor Philosophy
Non-traditional biomarkers for motor neuron disease
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo
-
2022
Master Philosophy
Validating a candidate ALS gene in Drosophila
Associate Advisor
Other advisors: Associate Professor Sean Millard
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2018
Doctor Philosophy
Effects of adiposity, age and deletion of ghrelin o-acyltransferase on pulsatile growth hormone secretion in male mice
Associate Advisor
-
2017
Doctor Philosophy
The role of the Growth Hormone/Insulin-like Growth Factor-1 axis in Neuromuscular Degeneration in a mouse model of Amyotrophic Lateral Sclerosis
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo
-
2017
Master Philosophy
Energy metabolism in amyotrophic lateral sclerosis: Assessment of body composition and energy expenditure
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo, Professor Pamela McCombe
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2014
Doctor Philosophy
Investigating the Role of Melanocortin System in Regulating Linear Growth and Growth Hormone Secretion
Associate Advisor
-
2014
Doctor Philosophy
Modulation of Pulsatile Growth Hormone (GH) Secretion in Positive and Negative Energy Balance in the Mouse
Associate Advisor
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