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Dr Adam Hagg
Dr

Adam Hagg

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Overview

Background

Dr. Adam Hagg is a post-doctoral fellow whose research centres on the biology of skeletal muscle, particularly investigating the cellular mechanisms that regulate skeletal muscle mass and function. Adam’s expertise involves utilising molecular tools to characterise skeletal muscle in pre-clinical models, providing insights into the pathophysiology of skeletal muscle wasting associated with cancer, frailty, metabolic disorders and neuromuscular diseases.

Working in Dr. Kelly Walton’s laboratory at the School of Biomedical Sciences, Adam is part of a research team focused on the role of growth factors in maintaining physiological balance in metabolic tissues, including skeletal muscle and adipose tissue, as well as their functions within reproductive tissues. Adam’s research aims to better understand the integrated nature by which skeletal muscle contributes to whole-body function and health, ultimately contributing to therapeutic solutions for muscle wasting diseases.

Before joining UQ in 2022, Dr. Hagg received his PhD in physiology from Monash University in 2021. His doctoral research was conducted across the Baker Heart and Diabetes Institute, Monash University, and the University of Melbourne. His PhD work focused on identifying novel mechanisms underlying skeletal muscle wasting and neuromuscular remodelling in the context of advanced cancer, an area of research that remains a passion and core interest for Adam.

Availability

Dr Adam Hagg is:
Available for supervision

Works

Search Professor Adam Hagg’s works on UQ eSpace

16 works between 2013 and 2025

1 - 16 of 16 works

2025

Journal Article

Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

Ongaro, Luisina, Zhou, Xiang, Wang, Ying, Schultz, Hailey, Zhou, Ziyue, Buddle, Evan R. S., Brûlé, Emilie, Lin, Yeu-Farn, Schang, Gauthier, Hagg, Adam, Castonguay, Roselyne, Liu, Yewei, Su, Gloria H., Seidah, Nabil G., Ray, Kevin C., Karp, Seth J., Boehm, Ulrich, Ruf-Zamojski, Frederique, Sealfon, Stuart C., Walton, Kelly L., Lee, Se-Jin and Bernard, Daniel J. (2025). Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science, 387 (6731), 329-336. doi: 10.1126/science.adi4736

Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

2023

Journal Article

Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

Hagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1) e220290, 1-15. doi: 10.1530/joe-22-0290

Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

2021

Journal Article

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

Sartori, Roberta, Hagg, Adam, Zampieri, Sandra, Armani, Andrea, Winbanks, Catherine E., Viana, Lais R., Haidar, Mouna, Watt, Kevin, Qian, Hongwei, Pezzini, Camilla, Zanganeh, Pardis, Turner, Bradley J., Larsson, Anna, Zanchettin, Gianpietro, Pierobon, Elisa S., Moletta, Lucia, Valmasoni, Michele, Ponzoni, Alberto, Attar, Shady, Da Dalt, Gianfranco, Sperti, Cosimo, Kustermann, Monika, Thomson, Rachel E., Larsson, Lars, Loveland, Kate L., Costelli, Paola, Megighian, Aram, Merigliano, Stefano, Penna, Fabio ... Sandri, Marco (2021). Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Science Translational Medicine, 13 (605) eaay9592. doi: 10.1126/scitranslmed.aay9592

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

2021

Journal Article

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

Watt, K., Henstridge, D. C., Ziemann, M., Sim, C. B., Montgomery, M. K., Samocha-Bonet, D., Parker, B. L., Dodd, G. T., Bond, S. T., Salmi, T. M., Lee, R. S., Thomson, R. E., Hagg, A., Davey, J. R., Qian, H., Koopman, R., El-Osta, A., Greenfield, J. R., Watt, M. J., Febbraio, M. A., Drew, B. G., Cox, A. G., Porrello, E. R., Harvey, K. F. and Gregorevic, P. (2021). Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nature Communications, 12 (1) 2887. doi: 10.1038/s41467-021-23240-7

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

2021

Journal Article

Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β

Goodman, Craig A., Davey, Jonathan R., Hagg, Adam, Parker, Benjamin L. and Gregorevic, Paul (2021). Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β. Molecular and Cellular Proteomics, 20 100050, 100050. doi: 10.1016/j.mcpro.2021.100050

Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β

2020

Journal Article

TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass

Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225

TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass

2020

Journal Article

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Davey, Jonathan R., Estevez, Emma, Thomson, Rachel E., Whitham, Martin, Watt, Kevin I., Hagg, Adam, Qian, Hongwei, Henstridge, Darren C., Ludlow, Helen, Hedger, Mark P., McGee, Sean L., Coughlan, Melinda T., Febbraio, Mark A. and Gregorevic, Paul (2020). Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes. The FASEB Journal, 34 (4), 5697-5714. doi: 10.1096/fj.201802059rrr

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

2019

Journal Article

Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice

Walton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257

Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice

2018

Journal Article

Molecular characterization of latent GDF8 reveals mechanisms of activation

Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115

Molecular characterization of latent GDF8 reveals mechanisms of activation

2017

Journal Article

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

2016

Journal Article

Differential effects of IL6 and activin A in the development of cancer-associated cachexia

Chen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152

Differential effects of IL6 and activin A in the development of cancer-associated cachexia

2016

Journal Article

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348) 348ra98. doi: 10.1126/scitranslmed.aac4976

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

2016

Journal Article

Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size

Hagg, Adam, Colgan, Timothy D., Thomson, Rachel E., Qian, Hongwei, Lynch, Gordon S. and Gregorevic, Paul (2016). Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size. Scientific Reports, 6 (1) 23042, 23042. doi: 10.1038/srep23042

Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size

2015

Journal Article

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

Sepulveda, Patricio V., Lamon, Severine, Hagg, Adam, Thomson, Rachel E., Winbanks, Catherine E., Qian, Hongwei, Bruce, Clinton R., Russell, Aaron P. and Gregorevic, Paul (2015). Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy. Scientific Reports, 5 (1) 17535, 17535. doi: 10.1038/srep17535

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

2015

Journal Article

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F. and Gregorevic, P. (2015). The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size. Nature Communications, 6 (1) 6048, 6048. doi: 10.1038/ncomms7048

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

2013

Journal Article

miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4

Winbanks, Catherine E., Beyer, Claudia, Hagg, Adam, Qian, Hongwei, Sepulveda, Patricio V. and Gregorevic, Paul (2013). miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4. PLoS One, 8 (9) e73589, e73589. doi: 10.1371/journal.pone.0073589

miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4

Supervision

Availability

Dr Adam Hagg is:
Available for supervision

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Supervision history

Current supervision

Media

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