
Overview
Background
Dr. Adam Hagg is a post-doctoral fellow whose research centres on the biology of skeletal muscle, particularly investigating the cellular mechanisms that regulate skeletal muscle mass and function. Adam’s expertise involves utilising molecular tools to characterise skeletal muscle in pre-clinical models, providing insights into the pathophysiology of skeletal muscle wasting associated with cancer, frailty, metabolic disorders and neuromuscular diseases.
Working in Dr. Kelly Walton’s laboratory at the School of Biomedical Sciences, Adam is part of a research team focused on the role of growth factors in maintaining physiological balance in metabolic tissues, including skeletal muscle and adipose tissue, as well as their functions within reproductive tissues. Adam’s research aims to better understand the integrated nature by which skeletal muscle contributes to whole-body function and health, ultimately contributing to therapeutic solutions for muscle wasting diseases.
Before joining UQ in 2022, Dr. Hagg received his PhD in physiology from Monash University in 2021. His doctoral research was conducted across the Baker Heart and Diabetes Institute, Monash University, and the University of Melbourne. His PhD work focused on identifying novel mechanisms underlying skeletal muscle wasting and neuromuscular remodelling in the context of advanced cancer, an area of research that remains a passion and core interest for Adam.
Availability
- Dr Adam Hagg is:
- Available for supervision
Works
Search Professor Adam Hagg’s works on UQ eSpace
2025
Journal Article
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Ongaro, Luisina, Zhou, Xiang, Wang, Ying, Schultz, Hailey, Zhou, Ziyue, Buddle, Evan R. S., Brûlé, Emilie, Lin, Yeu-Farn, Schang, Gauthier, Hagg, Adam, Castonguay, Roselyne, Liu, Yewei, Su, Gloria H., Seidah, Nabil G., Ray, Kevin C., Karp, Seth J., Boehm, Ulrich, Ruf-Zamojski, Frederique, Sealfon, Stuart C., Walton, Kelly L., Lee, Se-Jin and Bernard, Daniel J. (2025). Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science, 387 (6731), 329-336. doi: 10.1126/science.adi4736
2023
Journal Article
Targeting activins and inhibins to treat reproductive disorders and cancer cachexia
Hagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1) e220290, 1-15. doi: 10.1530/joe-22-0290
2021
Journal Article
Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia
Sartori, Roberta, Hagg, Adam, Zampieri, Sandra, Armani, Andrea, Winbanks, Catherine E., Viana, Lais R., Haidar, Mouna, Watt, Kevin, Qian, Hongwei, Pezzini, Camilla, Zanganeh, Pardis, Turner, Bradley J., Larsson, Anna, Zanchettin, Gianpietro, Pierobon, Elisa S., Moletta, Lucia, Valmasoni, Michele, Ponzoni, Alberto, Attar, Shady, Da Dalt, Gianfranco, Sperti, Cosimo, Kustermann, Monika, Thomson, Rachel E., Larsson, Lars, Loveland, Kate L., Costelli, Paola, Megighian, Aram, Merigliano, Stefano, Penna, Fabio ... Sandri, Marco (2021). Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Science Translational Medicine, 13 (605) eaay9592. doi: 10.1126/scitranslmed.aay9592
2021
Journal Article
Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
Watt, K., Henstridge, D. C., Ziemann, M., Sim, C. B., Montgomery, M. K., Samocha-Bonet, D., Parker, B. L., Dodd, G. T., Bond, S. T., Salmi, T. M., Lee, R. S., Thomson, R. E., Hagg, A., Davey, J. R., Qian, H., Koopman, R., El-Osta, A., Greenfield, J. R., Watt, M. J., Febbraio, M. A., Drew, B. G., Cox, A. G., Porrello, E. R., Harvey, K. F. and Gregorevic, P. (2021). Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nature Communications, 12 (1) 2887. doi: 10.1038/s41467-021-23240-7
2021
Journal Article
Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β
Goodman, Craig A., Davey, Jonathan R., Hagg, Adam, Parker, Benjamin L. and Gregorevic, Paul (2021). Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β. Molecular and Cellular Proteomics, 20 100050, 100050. doi: 10.1016/j.mcpro.2021.100050
2020
Journal Article
TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass
Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225
2020
Journal Article
Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes
Davey, Jonathan R., Estevez, Emma, Thomson, Rachel E., Whitham, Martin, Watt, Kevin I., Hagg, Adam, Qian, Hongwei, Henstridge, Darren C., Ludlow, Helen, Hedger, Mark P., McGee, Sean L., Coughlan, Melinda T., Febbraio, Mark A. and Gregorevic, Paul (2020). Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes. The FASEB Journal, 34 (4), 5697-5714. doi: 10.1096/fj.201802059rrr
2019
Journal Article
Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice
Walton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257
2018
Journal Article
Molecular characterization of latent GDF8 reveals mechanisms of activation
Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115
2017
Journal Article
Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease
Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114
2016
Journal Article
Differential effects of IL6 and activin A in the development of cancer-associated cachexia
Chen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152
2016
Journal Article
Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice
Winbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348) 348ra98. doi: 10.1126/scitranslmed.aac4976
2016
Journal Article
Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size
Hagg, Adam, Colgan, Timothy D., Thomson, Rachel E., Qian, Hongwei, Lynch, Gordon S. and Gregorevic, Paul (2016). Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size. Scientific Reports, 6 (1) 23042, 23042. doi: 10.1038/srep23042
2015
Journal Article
Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy
Sepulveda, Patricio V., Lamon, Severine, Hagg, Adam, Thomson, Rachel E., Winbanks, Catherine E., Qian, Hongwei, Bruce, Clinton R., Russell, Aaron P. and Gregorevic, Paul (2015). Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy. Scientific Reports, 5 (1) 17535, 17535. doi: 10.1038/srep17535
2015
Journal Article
The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size
Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F. and Gregorevic, P. (2015). The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size. Nature Communications, 6 (1) 6048, 6048. doi: 10.1038/ncomms7048
2013
Journal Article
miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4
Winbanks, Catherine E., Beyer, Claudia, Hagg, Adam, Qian, Hongwei, Sepulveda, Patricio V. and Gregorevic, Paul (2013). miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4. PLoS One, 8 (9) e73589, e73589. doi: 10.1371/journal.pone.0073589
Supervision
Availability
- Dr Adam Hagg is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Transforming growth factors to alter metabolic and functional physiology in health and disease.
Associate Advisor
Other advisors: Associate Professor Frederik Steyn, Dr Kelly Walton
Media
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