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Dr David Klyne
Dr

David Klyne

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+61 7 336 54569

Overview

Background

David M. Klyne PhD, MSc (MolBiol), DPhty, BAppSc) is a NHMRC Emerging Leadership Fellow and Fulbright Scholar within the Centre for Clinical Research Excellence in Spinal Pain, Injury and Health. There he leads an international team that probe the bio-psycho-social mechanisms that underlie physiological and pathological pain. His niche is in understanding the neuro-immune pathways involved and how they can be targeted with interventions using a blend of basic and clinical sciences and his skills and knowledge gained through his four degrees – neuro-immunology (PhD), molecular biology (Master), physiotherapy (Doctorate) and applied sciences (Bachelor).

David has received numerous national and international research awards that span basic and clinical sciences. These include the premier international award for spine research (ISSLS Prize) on two occasions – in Basic Science (2019) and Clinical Science (2018). In 2019, he was awarded a postdoctoral Fulbright Fellowship to continue his work elucidating the role of sleep in chronic pain at the Lewis Katz School of Medicine (Temple University), in the USA. He was also one of ten Australian scientists to attend the Lindau Nobel Laureate Meeting in 2019 and again in 2023, and has received more than $100K in research prize money and $17.5M in research funding.

Availability

Dr David Klyne is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Applied Science, Institution to be confirmed
  • Doctor of Philosophy of Physiotherapy Studies, Bond University
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Acute to chronic pain

  • Neuro-immunology

  • Sleep

  • Chronic pain prevention and rehabilitation

Research impacts

Klyne's research has attracted 17.5M ($8.5M as CIA/PI) from local, national and international funding bodies, been adopted by the world’s leading forum on pain (IASP) in the form of an online Fact Sheet (2021; >50K online visits), informed clinical guidelines and policies relating to the management of pain (e.g., American Academy of Orthopaedic Manual Physical Therapists), and formed the basis of a chapter in one of the world’s leading physiotherapy textbooks – Grieve's (2024). His reputation is exemplified by his >40 national/international presentations (>20 funded invited and/or Keynote) and invitations to provide expertise on global matters such as at the 2019 Opioid Epidemic Consortium in Kentucky, USA. The significance of Klyne's program of research to the broader public is evidenced by features in the media, including 9 News Australia (interview), the Sydney Morning Herald and Australian Academy of Science. In 2021, 9 News released a mini-documentary about Klyne's work on sleep and pain, which ranked in the top 5 stories nationally on NineMSN. From this program of work, Klyne is consitently ranked in the top 1% of experts globally in back pain (Expertscape).

Works

Search Professor David Klyne’s works on UQ eSpace

44 works between 2012 and 2025

41 - 44 of 44 works

2018

Conference Publication

Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: a potential factor in tissue effects in low back pain

Klyne, David, Barbe, Mary, Van Den Hoorn, Wolbert and Hodges, Paul (2018). Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: a potential factor in tissue effects in low back pain. 5th International Fascia Research Congress, Berlin, Germany, 14-15 November 2018. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jbmt.2018.09.056

Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: a potential factor in tissue effects in low back pain

2017

Journal Article

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2017). Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Brain, Behavior, and Immunity, 60, 84-92. doi: 10.1016/j.bbi.2016.10.003

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

2015

Journal Article

Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation

Klyne, David M., Schmid, Annina B., Moseley, G. Lorimer, Sterling, Michele and Hodges Paul W. (2015). Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation. Journal of Pain, 16 (2), 176-185. doi: 10.1016/j.jpain.2014.11.005

Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation

2012

Journal Article

The effect of anterior cruciate ligament rupture on the timing and amplitude of gastrocnemius muscle activation: A study of alterations in EMG measures and their relationship to knee joint stability

Klyne, David M., Keays, Susan L., Bullock-Saxton, Joanne E. and Newcombe, Peter A. (2012). The effect of anterior cruciate ligament rupture on the timing and amplitude of gastrocnemius muscle activation: A study of alterations in EMG measures and their relationship to knee joint stability. Journal of Electromyography and Kinesiology, 22 (3), 446-455. doi: 10.1016/j.jelekin.2012.01.013

The effect of anterior cruciate ligament rupture on the timing and amplitude of gastrocnemius muscle activation: A study of alterations in EMG measures and their relationship to knee joint stability

Funding

Current funding

  • 2025
    Does poor sleep drive chronic pain and can this be accurately measured in the real world?
    UQ Foundation Research Excellence Awards
    Open grant
  • 2024 - 2028
    Comparative effectiveness of exercise, cognitive behavioural therapy, and their combination for people with chronic musculoskeletal pain and poor sleep
    United States Congressionally Directed Medical Research Programs - Chronic Pain Management Research Program
    Open grant
  • 2024 - 2028
    The role of sleep, physical activity and central sensitisation in chronic back pain development
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2028
    PRioRTI: PReventing chronic pain after whiplash Road Traffic Injury
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2022 - 2027
    What causes low back pain to flare: Has a major opportunity to understand back pain been missed?
    United States National Institutes of Health
    Open grant
  • 2021 - 2026
    Biomarkers of Tissue Tolerance and Behaviour in a Rat Model (NIH Grant administered by Temple University)
    Temple University
    Open grant

Past funding

  • 2020 - 2024
    Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions
    United States Congressionally Directed Medical Research Programs - Chronic Pain Management Research Program
    Open grant

Supervision

Availability

Dr David Klyne is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Disentangling the relationship between sleep and pain

    We are seeking PhD students with a background in biomedical and/or rehabilitative sciences to join our team to contribute to a body of work that aims to identify if and how sleep influences pain. Projects will involve the measurement and analysis of sleep in the “real world” to understand how daily variations in sleep – one of the most important, yet modifiable health behaviors – drive the day-to-day “waxing and waning” of back pain. The work will involve a multidisciplinary team to address this challenging issue.

    Essential criteria: An undergraduate degree with first or second class division 1 Honours in biomedical science, physiotherapy or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English.

  • Unravelling the molecular mechanisms that explain how exercise programs improve chronic pain

    Physical activity and sleep are two of the most modifiable “every day” behaviours that we are learning to target with interventions to prevent and manage chronic diseases. This fully funded PhD will focus on unravelling the molecular mechanisms that explain how physical activity/exercise programs benefit people with chronic hip pain, and how sleep may influence this relationship. Outcomes will guide the refinement and development of new exercise and sleep interventions for improved chronic pain management and prevention. The successful PhD candidate will join Dr Klyne’s team at The University of Queensland and be co-supervised by A/Prof Michelle Hall at The University of Sydney.

    Essential criteria: An undergraduate degree in biomedical science, physiotherapy, human movement or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English. Previous research experience and/or coursework in molecular biology is highly desirable.

    Interested applicants should email Dr David Klyne with the subject line “PhD student application”. In your email, please briefly describe your research interests, career ambitions, qualifications and career groups. Please also include a PDF of your CV. Applications will be reviewed as soon as they are received and will continue to be accepted until the position is filled.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Dr David Klyne directly for media enquiries about:

  • Chronic Pain
  • Pain
  • Physical Activity
  • Sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au