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2026

Journal Article

Pain and the immune system

Hodges, Paul W., Fiore, Nathan T., Watkins, Linda R., Klyne, David M., Coppieters, Michel W. and Grace, Peter M. (2026). Pain and the immune system. Musculoskeletal Science and Practice, 82 103484, 1-14. doi: 10.1016/j.msksp.2025.103484

Pain and the immune system

2026

Journal Article

Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective

Klyne, David M., Hall, Michelle, Smith, Simon S., Barbe, Mary F., Egorova-Brumley, Natalia, Serafimovska, Anastasia, Hodges, Paul W. and Suraev, Anastasia (2026). Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective. Musculoskeletal Science and Practice, 82 103509, 1-12. doi: 10.1016/j.msksp.2026.103509

Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective

2026

Journal Article

A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}

Sterling, Michele, Farrell, Scott F., Ferguson, Lisa, Mitchell, Geoffrey, Schug, Stephan, Ware, Robert S., Dinh, Michael, Celenza, Antonio, Connelly, Luke, Hodges, Paul W., Klyne, David M., Elphinston, Rachel, Nikles, Jane, McAuley, James and Lin, Chung-Wei Christine (2026). A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}. Trials, 27 (1) 186, 1-13. doi: 10.1186/s13063-026-09479-9

A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}

2026

Journal Article

Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians

Lutke Schipholt, Ivo J., Coppieters, Michel W., Scholten-Peeters, Gwendolyne G.M., Hutchinson, Mark R. and Klyne, David M. (2026). Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians. Musculoskeletal Science and Practice, 81 103469. doi: 10.1016/j.msksp.2025.103469

Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians

2026

Journal Article

Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study

Haber, Travis, Dyer, Brett, Klyne, David M., Ferreira, Paulo H., Nicolson, Philippa J A, Lawford, Belinda J., McCurry, Susan M. and Hall, Michelle (2026). Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study. RMD Open, 12 (1) e006357, 1-12. doi: 10.1136/rmdopen-2025-006357

Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study

2025

Journal Article

Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures

Alshehri, Mansour Abdullah, Riddick, Ryan, Besomi, Manuela, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2025). Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures. Journal of Clinical Medicine, 14 (21) 7518, 1-17. doi: 10.3390/jcm14217518

Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures

2025

Conference Publication

O035 Sleep status informs exercise prescription in hip osteoarthritis

Klyne, D, Chan, S, Dobson, F, Allison, K, Knox, G, Spiers, L and Hall, M (2025). O035 Sleep status informs exercise prescription in hip osteoarthritis. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.035

O035 Sleep status informs exercise prescription in hip osteoarthritis

2025

Conference Publication

O037 Improved sleep is associated with improved hip osteoarthritis symptoms

Zhang, H, Dobson, F, Allison, K, Klyne, D, Ferreira, P, Venkatesha, V and Hall, M (2025). O037 Improved sleep is associated with improved hip osteoarthritis symptoms. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.037

O037 Improved sleep is associated with improved hip osteoarthritis symptoms

2025

Conference Publication

O036 Sleep moderates but does not mediate aerobic benefits in osteoarthritis

Wang, M, Dobson, F, Klyne, D, Ferreira, P, Allison, K, Knox, G, Hinman, R, Bennell, K, Spiers, L and Hall, M (2025). O036 Sleep moderates but does not mediate aerobic benefits in osteoarthritis. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.036

O036 Sleep moderates but does not mediate aerobic benefits in osteoarthritis

2025

Conference Publication

O021 Associations between signs of insomnia and incident joint replacement

Haber, T, Dyer, B, Klyne, D, Ferreira, P, Nicolson, P, Lawford, B, McCurry, S and Hall, M (2025). O021 Associations between signs of insomnia and incident joint replacement. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.021

O021 Associations between signs of insomnia and incident joint replacement

2025

Journal Article

Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain

Barbe, Mary F., Lambi, Alex G., Harris, Michele Y., Patel, Parth R., Tamas, Istvan P., McGonagle, Elizabeth R., Van Der Bas, Megan, Kalicharan, Betsy A., Bright-Rowe, Lewis, Popoff, Steven N. and Klyne, David M. (2025). Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain. Frontiers in Physiology, 16 1500795, 1-25. doi: 10.3389/fphys.2025.1500795

Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain

2025

Journal Article

Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial

Hall, Michelle, Allison, Kim, Knox, Gabrielle, McManus, Fiona, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, De Silva, Anurika P., Klyne, David M., Plinsinga, Melanie L., Costa, Ricardo J. S., Murphy, Nicholas J., Wu, Wen and Dobson, Fiona L. (2025). Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial. The Lancet Rheumatology, 7 (5), e343-e354. doi: 10.1016/s2665-9913(24)00373-4

Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial

2025

Journal Article

The role and treatment potential of the complement pathway in chronic pain

Vygonskaya, Marina, Wu, Youzhi, Price, Theodore J., Chen, Zhuo, Smith, Maree T., Klyne, David M. and Han, Felicity Y. (2025). The role and treatment potential of the complement pathway in chronic pain. The Journal of Pain, 27 104689, 1-15. doi: 10.1016/j.jpain.2024.104689

The role and treatment potential of the complement pathway in chronic pain

2024

Journal Article

Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? 

Klyne, David M., Smith, Simon S. and Hall, Michelle (2024). Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? . Sleep, 47 (10) zsae177. doi: 10.1093/sleep/zsae177

Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? 

2024

Book Chapter

Biological Contributors to Musculoskeletal Pain and Disability

Farrell, Scott F., deZoete, Rutger M.J., Klyne, David M., Schmid, Annina B., Polli, Andrea, Nijs, Jo and Sterling, Michele (2024). Biological Contributors to Musculoskeletal Pain and Disability. Grieve's Modern Musculoskeletal Physiotherapy. (pp. 22-35) edited by Deborah Falla, Jeremy Lewis, Christopher McCarthy, Chad E. Cook and Michele Sterling. London, United Kingdom: Elsevier. doi: 10.1016/B978-0-7020-8089-0.00005-7

Biological Contributors to Musculoskeletal Pain and Disability

2024

Journal Article

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M., van Dieën, Jaap H., Cholewicki, Jacek and Hodges, Paul W. (2024). Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability. European Spine Journal, 33 (6), 2380-2394. doi: 10.1007/s00586-024-08205-w

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

2024

Conference Publication

The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial

Hall, Michelle, Allison, Kim, Knox, Gabrielle, Hinman, Rana S., Bennell, Kim, Spiers, Libby, Plinsinga, Melanie, Klyne, David, McManus, Fiona, De Silva, Anurika, Da Costa, Ricardo, Murphy, Nicholas and Dobson, Fiona (2024). The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.03.098

The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial

2024

Journal Article

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

Barbe, Mary F., Chen, Frank Liu, Loomis, Regina H., Harris, Michele Y., Kim, Brandon M., Xie, Kevin, Hilliard, Brendan A., McGonagle, Elizabeth R., Bailey, Taylor D., Gares, Ryan P., Van Der Bas, Megan, Kalicharan, Betsy A., Holt-Bright, Lewis, Stone, Laura S., Hodges, Paul W. and Klyne, David M. (2024). Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury. Frontiers in Pain Research, 5 1394017, 1-23. doi: 10.3389/fpain.2024.1394017

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

2024

Journal Article

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2024). Coordination of hip and spine in individuals with acute low back pain during unstable sitting. The Spine Journal, 24 (5), 768-782. doi: 10.1016/j.spinee.2023.12.001

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

2024

Journal Article

Is sleep the new treatment for pain? Two issues need resolving before deciding

Klyne, David M and Hall, Michelle (2024). Is sleep the new treatment for pain? Two issues need resolving before deciding. SLEEP, 47 (6) zsae089. doi: 10.1093/sleep/zsae089

Is sleep the new treatment for pain? Two issues need resolving before deciding