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2026

Journal Article

Systemic C-reactive protein and vitamin D are not associated with development of chronic musculoskeletal pain over a 2–7 year follow-up period

Collyer, Martin R., Sterling, Michele, Armfield, Nigel R., Xie, Yanfei, Cabot, Peter J., Elphinston, Rachel A., Klyne, David M. and Farrell, Scott F. (2026). Systemic C-reactive protein and vitamin D are not associated with development of chronic musculoskeletal pain over a 2–7 year follow-up period. The Journal of Pain, 44 106297, 1-12. doi: 10.1016/j.jpain.2026.106297

Systemic C-reactive protein and vitamin D are not associated with development of chronic musculoskeletal pain over a 2–7 year follow-up period

2026

Journal Article

Time to wake up to the potential benefits of targeting sleep in osteoarthritis management

Hall, Michelle, Ferreira, Paulo, Eyles, Jillian, Hawker, Gillian, Smith, Simon S., Egorova-Brumley, Natalia, McCurry, Susan M., Thorlund, Jonas B. and Klyne, David M (2026). Time to wake up to the potential benefits of targeting sleep in osteoarthritis management. Osteoarthritis and Cartilage, 34 (6), 776-783. doi: 10.1016/j.joca.2026.03.122

Time to wake up to the potential benefits of targeting sleep in osteoarthritis management

2026

Journal Article

Biomimetic MCC950-loaded cerium-layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin-induced mice

Pang, Huiwen, Chen, Zhuo, Wu, Youzhi, Nguyen, Thanh-Truc, Wang, Jingjing, Klyne, David M., Xu, Zhi Ping, Chen, Chen, Rowan, Alan and Han, Felicity Y. (2026). Biomimetic MCC950-loaded cerium-layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin-induced mice. British Journal of Pharmacology bph.70451. doi: 10.1111/bph.70451

Biomimetic MCC950-loaded cerium-layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin-induced mice

2026

Journal Article

Changes in sleep and clinical outcomes in hip osteoarthritis: a longitudinal secondary analysis of a randomised controlled trial

Zhang, Hanzhi, Dobson, Fiona, Allison, Kim, Knox, Gabrielle, Spiers, Libby, Egorova-Brumley, Natalia, Klyne, David M., Ferreira, Paulo and Hall, Michelle (2026). Changes in sleep and clinical outcomes in hip osteoarthritis: a longitudinal secondary analysis of a randomised controlled trial. Osteoarthritis and Cartilage Open, 8 (3) 100813, 100813. doi: 10.1016/j.ocarto.2026.100813

Changes in sleep and clinical outcomes in hip osteoarthritis: a longitudinal secondary analysis of a randomised controlled trial

2026

Journal Article

Neuroimmune pathways linking sleep disturbance to persistent pain after injury are mitigated by exercise

Klyne, David M., Van Der Bas, Megan, Harris, Michele Y., Hilliard, Brendan A., Patel, Parth R., Kegg, Abby, Rajpal, Astha, Ceasar, Khyleisha, Kalicharan, Betsy A., Hodges, Paul W. and Barbe, Mary F. (2026). Neuroimmune pathways linking sleep disturbance to persistent pain after injury are mitigated by exercise. Pain. doi: 10.1097/j.pain.0000000000003978

Neuroimmune pathways linking sleep disturbance to persistent pain after injury are mitigated by exercise

2026

Journal Article

Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective

Klyne, David M., Hall, Michelle, Smith, Simon S., Barbe, Mary F., Egorova-Brumley, Natalia, Serafimovska, Anastasia, Hodges, Paul W. and Suraev, Anastasia (2026). Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective. Musculoskeletal Science and Practice, 82 103509, 1-12. doi: 10.1016/j.msksp.2026.103509

Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective

2026

Journal Article

ASSOCIATIONS BETWEEN INSOMNIA AND TOTAL JOINT REPLACEMENT IN ADULTS WITH HIP (41,737) OR KNEE PAIN (81,958): A UK BIOBANK STUDY

Haber, Travis S., Dyer, Brett, Klyne, David, Ferreira, Paulo, Nicolson, Philippa J., Lawford, Belinda, McCurry, Susan and Hall, Michelle (2026). ASSOCIATIONS BETWEEN INSOMNIA AND TOTAL JOINT REPLACEMENT IN ADULTS WITH HIP (41,737) OR KNEE PAIN (81,958): A UK BIOBANK STUDY. Osteoarthritis and Cartilage, 34, S105-S106. doi: 10.1016/j.joca.2026.01.121

ASSOCIATIONS BETWEEN INSOMNIA AND TOTAL JOINT REPLACEMENT IN ADULTS WITH HIP (41,737) OR KNEE PAIN (81,958): A UK BIOBANK STUDY

2026

Journal Article

EFFECTS OF ADDING AEROBIC PHYSICAL ACTIVITY TO RESISTANCE EXERCISE ON EXPLORATORY OUTCOMES AND THEIR MEDIATING ROLE IN PEOPLE WITH HIP OSTEOARTHRITIS

Wang, Michelle, Dobson, Fiona, Klyne, David, Ferreira, Paulo, Allison, Kim, Knox, Gabrielle, Hinman, Rana, Bennell, Kim, Spiers, Libby and Hall, Michelle (2026). EFFECTS OF ADDING AEROBIC PHYSICAL ACTIVITY TO RESISTANCE EXERCISE ON EXPLORATORY OUTCOMES AND THEIR MEDIATING ROLE IN PEOPLE WITH HIP OSTEOARTHRITIS. Osteoarthritis and Cartilage, 34, S399-S400. doi: 10.1016/j.joca.2026.01.583

EFFECTS OF ADDING AEROBIC PHYSICAL ACTIVITY TO RESISTANCE EXERCISE ON EXPLORATORY OUTCOMES AND THEIR MEDIATING ROLE IN PEOPLE WITH HIP OSTEOARTHRITIS

2026

Journal Article

Pain and the immune system

Hodges, Paul W., Fiore, Nathan T., Watkins, Linda R., Klyne, David M., Coppieters, Michel W. and Grace, Peter M. (2026). Pain and the immune system. Musculoskeletal Science and Practice, 82 103484, 1-14. doi: 10.1016/j.msksp.2025.103484

Pain and the immune system

2026

Journal Article

PHYSIOTHERAPISTS’ PERCEPTIONS AND ATTITUDES TOWARD TRAINING IN COGNITIVE BEHAVIOURAL THERAPY FOR INSOMNIA (CBT-I)

Wang, Michelle, Eyles, Jillian P., Bunzli, Samantha, Klyne, David, McCurry, Susan, Lawford, Belinda, Dinh, Amanda, Schütze, Rob, Nguyen, Alan, Rhon, Daniel I., Hinman, Rana, Smith, Simon, Window, Peter, Grealis, Stacey and Hall, Michelle (2026). PHYSIOTHERAPISTS’ PERCEPTIONS AND ATTITUDES TOWARD TRAINING IN COGNITIVE BEHAVIOURAL THERAPY FOR INSOMNIA (CBT-I). Osteoarthritis and Cartilage, 34, S177. doi: 10.1016/j.joca.2026.01.234

PHYSIOTHERAPISTS’ PERCEPTIONS AND ATTITUDES TOWARD TRAINING IN COGNITIVE BEHAVIOURAL THERAPY FOR INSOMNIA (CBT-I)

2026

Journal Article

Improved sleep is associated with improved hip osteoarthritis symptoms: a longitudinal study

Zhang, Hanzhi, Dobson, Fiona, Allison, Kim, Knox, Gabrielle, Spiers, Libby, Brumley, Natalia E., Klyne, David, Ferreira, Paulo and Hall, Michelle (2026). Improved sleep is associated with improved hip osteoarthritis symptoms: a longitudinal study. Osteoarthritis and Cartilage, 34, S390. doi: 10.1016/j.joca.2026.01.565

Improved sleep is associated with improved hip osteoarthritis symptoms: a longitudinal study

2026

Journal Article

A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}

Sterling, Michele, Farrell, Scott F., Ferguson, Lisa, Mitchell, Geoffrey, Schug, Stephan, Ware, Robert S., Dinh, Michael, Celenza, Antonio, Connelly, Luke, Hodges, Paul W., Klyne, David M., Elphinston, Rachel, Nikles, Jane, McAuley, James and Lin, Chung-Wei Christine (2026). A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}. Trials, 27 (1) 186, 1-13. doi: 10.1186/s13063-026-09479-9

A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}

2026

Journal Article

Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians

Lutke Schipholt, Ivo J., Coppieters, Michel W., Scholten-Peeters, Gwendolyne G.M., Hutchinson, Mark R. and Klyne, David M. (2026). Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians. Musculoskeletal Science and Practice, 81 103469. doi: 10.1016/j.msksp.2025.103469

Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians

2026

Journal Article

Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study

Haber, Travis, Dyer, Brett, Klyne, David M., Ferreira, Paulo H., Nicolson, Philippa J A, Lawford, Belinda J., McCurry, Susan M. and Hall, Michelle (2026). Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study. RMD Open, 12 (1) e006357, 1-12. doi: 10.1136/rmdopen-2025-006357

Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study

2025

Journal Article

Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures

Alshehri, Mansour Abdullah, Riddick, Ryan, Besomi, Manuela, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2025). Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures. Journal of Clinical Medicine, 14 (21) 7518, 1-17. doi: 10.3390/jcm14217518

Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures

2025

Conference Publication

O036 Sleep moderates but does not mediate aerobic benefits in osteoarthritis

Wang, M, Dobson, F, Klyne, D, Ferreira, P, Allison, K, Knox, G, Hinman, R, Bennell, K, Spiers, L and Hall, M (2025). O036 Sleep moderates but does not mediate aerobic benefits in osteoarthritis. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.036

O036 Sleep moderates but does not mediate aerobic benefits in osteoarthritis

2025

Conference Publication

O021 Associations between signs of insomnia and incident joint replacement

Haber, T, Dyer, B, Klyne, D, Ferreira, P, Nicolson, P, Lawford, B, McCurry, S and Hall, M (2025). O021 Associations between signs of insomnia and incident joint replacement. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.021

O021 Associations between signs of insomnia and incident joint replacement

2025

Conference Publication

O035 Sleep status informs exercise prescription in hip osteoarthritis

Klyne, D, Chan, S, Dobson, F, Allison, K, Knox, G, Spiers, L and Hall, M (2025). O035 Sleep status informs exercise prescription in hip osteoarthritis. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.035

O035 Sleep status informs exercise prescription in hip osteoarthritis

2025

Conference Publication

O037 Improved sleep is associated with improved hip osteoarthritis symptoms

Zhang, H, Dobson, F, Allison, K, Klyne, D, Ferreira, P, Venkatesha, V and Hall, M (2025). O037 Improved sleep is associated with improved hip osteoarthritis symptoms. Oxford University Press (OUP). doi: 10.1093/sleepadvances/zpaf053.037

O037 Improved sleep is associated with improved hip osteoarthritis symptoms

2025

Journal Article

Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain

Barbe, Mary F., Lambi, Alex G., Harris, Michele Y., Patel, Parth R., Tamas, Istvan P., McGonagle, Elizabeth R., Van Der Bas, Megan, Kalicharan, Betsy A., Bright-Rowe, Lewis, Popoff, Steven N. and Klyne, David M. (2025). Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain. Frontiers in Physiology, 16 1500795, 1-25. doi: 10.3389/fphys.2025.1500795

Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain