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2026 Journal Article Systemic C-reactive protein and vitamin D are not associated with development of chronic musculoskeletal pain over a 2–7 year follow-up periodCollyer, Martin R., Sterling, Michele, Armfield, Nigel R., Xie, Yanfei, Cabot, Peter J., Elphinston, Rachel A., Klyne, David M. and Farrell, Scott F. (2026). Systemic C-reactive protein and vitamin D are not associated with development of chronic musculoskeletal pain over a 2–7 year follow-up period. The Journal of Pain, 44 106297, 1-12. doi: 10.1016/j.jpain.2026.106297 |
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2026 Journal Article Neuroimmune pathways linking sleep disturbance to persistent pain after injury are mitigated by exerciseKlyne, David M., Van Der Bas, Megan, Harris, Michele Y., Hilliard, Brendan A., Patel, Parth R., Kegg, Abby, Rajpal, Astha, Ceasar, Khyleisha, Kalicharan, Betsy A., Hodges, Paul W. and Barbe, Mary F. (2026). Neuroimmune pathways linking sleep disturbance to persistent pain after injury are mitigated by exercise. Pain. doi: 10.1097/j.pain.0000000000003978 |
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2026 Journal Article Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspectiveKlyne, David M., Hall, Michelle, Smith, Simon S., Barbe, Mary F., Egorova-Brumley, Natalia, Serafimovska, Anastasia, Hodges, Paul W. and Suraev, Anastasia (2026). Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective. Musculoskeletal Science and Practice, 82 103509, 1-12. doi: 10.1016/j.msksp.2026.103509 |
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2026 Journal Article Pain and the immune systemHodges, Paul W., Fiore, Nathan T., Watkins, Linda R., Klyne, David M., Coppieters, Michel W. and Grace, Peter M. (2026). Pain and the immune system. Musculoskeletal Science and Practice, 82 103484, 1-14. doi: 10.1016/j.msksp.2025.103484 |
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2026 Journal Article Time to wake up to the potential benefits of targeting sleep in osteoarthritis managementHall, Michelle, Ferreira, Paulo, Eyles, Jillian, Hawker, Gillian, Smith, Simon S., Egorova-Brumley, Natalia, McCurry, Susan M., Thorlund, Jonas B. and Klyne, David M (2026). Time to wake up to the potential benefits of targeting sleep in osteoarthritis management. Osteoarthritis and Cartilage. doi: 10.1016/j.joca.2026.03.122 |
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2026 Journal Article A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}Sterling, Michele, Farrell, Scott F., Ferguson, Lisa, Mitchell, Geoffrey, Schug, Stephan, Ware, Robert S., Dinh, Michael, Celenza, Antonio, Connelly, Luke, Hodges, Paul W., Klyne, David M., Elphinston, Rachel, Nikles, Jane, McAuley, James and Lin, Chung-Wei Christine (2026). A Phase III triple-blind randomised placebo-controlled trial to evaluate effectiveness of early treatment with pregabalin to reduce pain severity after whiplash road traffic injury: study protocol for the PRioRTI Trial {1}. Trials, 27 (1) 186, 1-13. doi: 10.1186/s13063-026-09479-9 |
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2026 Journal Article Neuroimmune interactions in musculoskeletal conditions. An introduction for cliniciansLutke Schipholt, Ivo J., Coppieters, Michel W., Scholten-Peeters, Gwendolyne G.M., Hutchinson, Mark R. and Klyne, David M. (2026). Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians. Musculoskeletal Science and Practice, 81 103469. doi: 10.1016/j.msksp.2025.103469 |
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2026 Journal Article Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort studyHaber, Travis, Dyer, Brett, Klyne, David M., Ferreira, Paulo H., Nicolson, Philippa J A, Lawford, Belinda J., McCurry, Susan M. and Hall, Michelle (2026). Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study. RMD Open, 12 (1) e006357, 1-12. doi: 10.1136/rmdopen-2025-006357 |
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2025 Journal Article Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measuresAlshehri, Mansour Abdullah, Riddick, Ryan, Besomi, Manuela, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2025). Exploring lumbar spine posture and movement in sitting: a comparison between laboratory and real-world measures. Journal of Clinical Medicine, 14 (21) 7518, 1-17. doi: 10.3390/jcm14217518 |
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2025 Journal Article Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brainBarbe, Mary F., Lambi, Alex G., Harris, Michele Y., Patel, Parth R., Tamas, Istvan P., McGonagle, Elizabeth R., Van Der Bas, Megan, Kalicharan, Betsy A., Bright-Rowe, Lewis, Popoff, Steven N. and Klyne, David M. (2025). Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain. Frontiers in Physiology, 16 1500795, 1-25. doi: 10.3389/fphys.2025.1500795 |
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2025 Journal Article Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trialHall, Michelle, Allison, Kim, Knox, Gabrielle, McManus, Fiona, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, De Silva, Anurika P., Klyne, David M., Plinsinga, Melanie L., Costa, Ricardo J. S., Murphy, Nicholas J., Wu, Wen and Dobson, Fiona L. (2025). Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial. The Lancet Rheumatology, 7 (5), e343-e354. doi: 10.1016/s2665-9913(24)00373-4 |
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2025 Journal Article The role and treatment potential of the complement pathway in chronic painVygonskaya, Marina, Wu, Youzhi, Price, Theodore J., Chen, Zhuo, Smith, Maree T., Klyne, David M. and Han, Felicity Y. (2025). The role and treatment potential of the complement pathway in chronic pain. The Journal of Pain, 27 104689, 1-15. doi: 10.1016/j.jpain.2024.104689 |
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2024 Journal Article Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? Klyne, David M., Smith, Simon S. and Hall, Michelle (2024). Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? . Sleep, 47 (10) zsae177. doi: 10.1093/sleep/zsae177 |
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2024 Journal Article Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disabilityAlshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M., van Dieën, Jaap H., Cholewicki, Jacek and Hodges, Paul W. (2024). Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability. European Spine Journal, 33 (6), 2380-2394. doi: 10.1007/s00586-024-08205-w |
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2024 Journal Article Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injuryBarbe, Mary F., Chen, Frank Liu, Loomis, Regina H., Harris, Michele Y., Kim, Brandon M., Xie, Kevin, Hilliard, Brendan A., McGonagle, Elizabeth R., Bailey, Taylor D., Gares, Ryan P., Van Der Bas, Megan, Kalicharan, Betsy A., Holt-Bright, Lewis, Stone, Laura S., Hodges, Paul W. and Klyne, David M. (2024). Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury. Frontiers in Pain Research, 5 1394017, 1-23. doi: 10.3389/fpain.2024.1394017 |
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2024 Journal Article Coordination of hip and spine in individuals with acute low back pain during unstable sittingAlshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2024). Coordination of hip and spine in individuals with acute low back pain during unstable sitting. The Spine Journal, 24 (5), 768-782. doi: 10.1016/j.spinee.2023.12.001 |
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2024 Journal Article Is sleep the new treatment for pain? Two issues need resolving before decidingKlyne, David M and Hall, Michelle (2024). Is sleep the new treatment for pain? Two issues need resolving before deciding. SLEEP, 47 (6) zsae089. doi: 10.1093/sleep/zsae089 |
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2024 Journal Article Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injuryKlyne, David M., Hilliard, Brendan A., Harris, Michele Y., Amin, Mamta, Hall, Michelle, Besomi, Manuela, Mustafa, Sanam, Farrell, Scott F., Rawashdeh, Oliver, Han, Felicity Y., Hodges, Paul W., Frara, Nagat and Barbe, Mary F. (2024). Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury. Brain, Behavior, and Immunity - Health, 35 100714, 100714. doi: 10.1016/j.bbih.2023.100714 |
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2024 Journal Article Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysisAlshehri, Mansour Abdullah, Alzahrani, Hosam, van den Hoorn, Wolbert, Klyne, David M., Vette, Albert H., Hendershot, Brad D., Roberts, Brad W. R., Larivière, Christian, Barbado, David, Vera-Garcia, Francisco J., van Dieen, Jaap H., Cholewicki, Jacek, Nussbaum, Maury A., Madigan, Michael L., Reeves, Norman Peter, Silfies, Sheri P., Brown, Stephen H. M. and Hodges, Paul W. (2024). Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis. PLoS One, 19 (1) e0296968, 1-42. doi: 10.1371/journal.pone.0296968 |
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2023 Journal Article Low back pain and osteoarthritis pain: a perspective of estrogenPang, Huiwen, Chen, Shihui, Klyne, David M., Harrich, David, Ding, Wenyuan, Yang, Sidong and Han, Felicity Y. (2023). Low back pain and osteoarthritis pain: a perspective of estrogen. Bone Research, 11 (1) 42, 42. doi: 10.1038/s41413-023-00280-x |
