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2025

Journal Article

The role and treatment potential of the complement pathway in chronic pain

Vygonskaya, Marina, Wu, Youzhi, Price, Theodore J., Chen, Zhuo, Smith, Maree T., Klyne, David M. and Han, Felicity Y. (2025). The role and treatment potential of the complement pathway in chronic pain. The Journal of Pain, 27 104689, 1-15. doi: 10.1016/j.jpain.2024.104689

The role and treatment potential of the complement pathway in chronic pain

2025

Journal Article

Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial

Hall, Michelle, Allison, Kim, Knox, Gabrielle, McManus, Fiona, Hinman, Rana S, Bennell, Kim L, Spiers, Libby, De Silva, Anurika P, Klyne, David M, Plinsinga, Melanie L, Costa, Ricardo J S, Murphy, Nicholas J, Wu, Wen and Dobson, Fiona L (2025). Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial. The Lancet Rheumatology. doi: 10.1016/s2665-9913(24)00373-4

Addition of aerobic physical activity to resistance exercise for hip osteoarthritis (PHOENIX): a randomised comparative effectiveness trial

2024

Journal Article

Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? 

Klyne, David M., Smith, Simon S. and Hall, Michelle (2024). Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? . Sleep, 47 (10) zsae177. doi: 10.1093/sleep/zsae177

Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? 

2024

Journal Article

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M., van Dieën, Jaap H., Cholewicki, Jacek and Hodges, Paul W. (2024). Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability. European Spine Journal, 33 (6), 2380-2394. doi: 10.1007/s00586-024-08205-w

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

2024

Journal Article

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

Barbe, Mary F., Chen, Frank Liu, Loomis, Regina H., Harris, Michele Y., Kim, Brandon M., Xie, Kevin, Hilliard, Brendan A., McGonagle, Elizabeth R., Bailey, Taylor D., Gares, Ryan P., Van Der Bas, Megan, Kalicharan, Betsy A., Holt-Bright, Lewis, Stone, Laura S., Hodges, Paul W. and Klyne, David M. (2024). Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury. Frontiers in Pain Research, 5 1394017, 1-23. doi: 10.3389/fpain.2024.1394017

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

2024

Journal Article

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2024). Coordination of hip and spine in individuals with acute low back pain during unstable sitting. The Spine Journal, 24 (5), 768-782. doi: 10.1016/j.spinee.2023.12.001

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

2024

Journal Article

Is sleep the new treatment for pain? Two issues need resolving before deciding

Klyne, David M and Hall, Michelle (2024). Is sleep the new treatment for pain? Two issues need resolving before deciding. SLEEP, 47 (6) zsae089. doi: 10.1093/sleep/zsae089

Is sleep the new treatment for pain? Two issues need resolving before deciding

2024

Journal Article

Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury

Klyne, David M., Hilliard, Brendan A., Harris, Michele Y., Amin, Mamta, Hall, Michelle, Besomi, Manuela, Mustafa, Sanam, Farrell, Scott F., Rawashdeh, Oliver, Han, Felicity Y., Hodges, Paul W., Frara, Nagat and Barbe, Mary F. (2024). Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury. Brain, Behavior, and Immunity - Health, 35 100714. doi: 10.1016/j.bbih.2023.100714

Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury

2024

Journal Article

Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis

Alshehri, Mansour Abdullah, Alzahrani, Hosam, van den Hoorn, Wolbert, Klyne, David M., Vette, Albert H., Hendershot, Brad D., Roberts, Brad W. R., Larivière, Christian, Barbado, David, Vera-Garcia, Francisco J., van Dieen, Jaap H., Cholewicki, Jacek, Nussbaum, Maury A., Madigan, Michael L., Reeves, Norman Peter, Silfies, Sheri P., Brown, Stephen H. M. and Hodges, Paul W. (2024). Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis. PLoS One, 19 (1) e0296968, 1-42. doi: 10.1371/journal.pone.0296968

Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis

2023

Journal Article

Low back pain and osteoarthritis pain: a perspective of estrogen

Pang, Huiwen, Chen, Shihui, Klyne, David M., Harrich, David, Ding, Wenyuan, Yang, Sidong and Han, Felicity Y. (2023). Low back pain and osteoarthritis pain: a perspective of estrogen. Bone Research, 11 (1) 42, 42. doi: 10.1038/s41413-023-00280-x

Low back pain and osteoarthritis pain: a perspective of estrogen

2023

Journal Article

Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis

Hall, Michelle, Dobson, Fiona, Klyne, David Murray, Zheng, Carmen Jiamin, Lima, Yuri Lopes and Egorova-Brumley, Natalia (2023). Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis. Scientific Reports, 13 (1) 12442, 12442. doi: 10.1038/s41598-023-39245-9

Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis

2023

Journal Article

Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain

Plinsinga, Melanie Louise, Vuvan, Viana, Maclachlan, Liam, Klyne, David, Graven-Nielsen, Thomas, Vicenzino, Bill, Hodges, Paul and Bjarke Vaegter, Henrik (2023). Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain. Pain, 164 (7), 1593-1599. doi: 10.1097/j.pain.0000000000002864

Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain

2023

Journal Article

Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain

Farrell, Scott F., Sterling, Michele, Klyne, David M., Mustafa, Sanam, Campos, Adrián I., Kho, Pik-Fang, Lundberg, Mischa, Rentería, Miguel E., Ngo, Trung Thanh and Cuéllar-Partida, Gabriel (2023). Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain. European Spine Journal, 32 (6), 2078-2085. doi: 10.1007/s00586-023-07711-7

Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain

2023

Journal Article

How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies

Lima, Yuri Lopes, Lee, Hopin, Klyne, David M., Dobson, Fiona L., Hinman, Rana S., Bennell, Kim L. and Hall, Michelle (2023). How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies. Arthritis Care and Research, 75 (3), 467-481. doi: 10.1002/acr.24983

How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies

2022

Journal Article

Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial

Hall, Michelle, Allison, Kim, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, Knox, Gabrielle, Plinsinga, Melanie, Klyne, David M., McManus, Fiona, Lamb, Karen E., Da Costa, Ricardo, Murphy, Nicholas J. and Dobson, Fiona L. (2022). Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial. BMC Musculoskeletal Disorders, 23 (1) 361. doi: 10.1186/s12891-022-05282-0

Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial

2022

Journal Article

Balance control in unstable sitting in individuals with an acute episode of low back pain

van den Hoorn, Wolbert, Meroni, Roberto, Klyne, David M., Alshehri, Mansour Abdullah and Hodges, Paul W. (2022). Balance control in unstable sitting in individuals with an acute episode of low back pain. Gait and Posture, 95, 15-21. doi: 10.1016/j.gaitpost.2022.03.014

Balance control in unstable sitting in individuals with an acute episode of low back pain

2022

Journal Article

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2022). Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis. PLoS One, 17 (5) e0268381, 1-14. doi: 10.1371/journal.pone.0268381

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

2022

Journal Article

Risk factors for low back pain outcome: Does it matter when they are measured?

Klyne, David Murray, Hall, Leanne Marie, Nicholas, Michael K. and Hodges, Paul William (2022). Risk factors for low back pain outcome: Does it matter when they are measured?. European Journal of Pain, 26 (4), 835-854. doi: 10.1002/ejp.1911

Risk factors for low back pain outcome: Does it matter when they are measured?

2022

Journal Article

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain

Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2022). Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain. The Spine Journal, 22 (2), 214-225. doi: 10.1016/j.spinee.2021.09.006

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain

2021

Journal Article

Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?

Klyne, David M., Barbe, Mary F., James, Greg and Hodges, Paul W. (2021). Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?. International Journal of Molecular Sciences, 22 (14) 7299, 1-21. doi: 10.3390/ijms22147299

Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?