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Dr David Klyne
Dr

David Klyne

Email: 
Phone: 
+61 7 336 54569

Overview

Background

David M. Klyne PhD, MSc (MolBiol), DPhty, BAppSc) is a NHMRC Emerging Leadership Fellow and Fulbright Scholar within the Centre for Clinical Research Excellence in Spinal Pain, Injury and Health. There he leads an international team that probe the bio-psycho-social mechanisms that underlie physiological and pathological pain. His niche is in understanding the neuro-immune pathways involved and how they can be targeted with interventions using a blend of basic and clinical sciences and his skills and knowledge gained through his four degrees – neuro-immunology (PhD), molecular biology (Master), physiotherapy (Doctorate) and applied sciences (Bachelor).

David has received numerous national and international research awards that span basic and clinical sciences. These include the premier international award for spine research (ISSLS Prize) on two occasions – in Basic Science (2019) and Clinical Science (2018). In 2019, he was awarded a postdoctoral Fulbright Fellowship to continue his work elucidating the role of sleep in chronic pain at the Lewis Katz School of Medicine (Temple University), in the USA. He was also one of ten Australian scientists to attend the Lindau Nobel Laureate Meeting in 2019 and again in 2023, and has received more than $100K in research prize money and $17.5M in research funding.

Availability

Dr David Klyne is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Applied Science, Institution to be confirmed
  • Doctor of Philosophy of Physiotherapy Studies, Bond University
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Acute to chronic pain

  • Neuro-immunology

  • Sleep

  • Chronic pain prevention and rehabilitation

Research impacts

Klyne's research has attracted 17.5M ($8.5M as CIA/PI) from local, national and international funding bodies, been adopted by the world’s leading forum on pain (IASP) in the form of an online Fact Sheet (2021; >50K online visits), informed clinical guidelines and policies relating to the management of pain (e.g., American Academy of Orthopaedic Manual Physical Therapists), and formed the basis of a chapter in one of the world’s leading physiotherapy textbooks – Grieve's (2024). His reputation is exemplified by his >40 national/international presentations (>20 funded invited and/or Keynote) and invitations to provide expertise on global matters such as at the 2019 Opioid Epidemic Consortium in Kentucky, USA. The significance of Klyne's program of research to the broader public is evidenced by features in the media, including 9 News Australia (interview), the Sydney Morning Herald and Australian Academy of Science. In 2021, 9 News released a mini-documentary about Klyne's work on sleep and pain, which ranked in the top 5 stories nationally on NineMSN. From this program of work, Klyne is consitently ranked in the top 1% of experts globally in back pain (Expertscape).

Works

Search Professor David Klyne’s works on UQ eSpace

44 works between 2012 and 2025

21 - 40 of 44 works

2022

Journal Article

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2022). Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis. PLoS One, 17 (5) e0268381, 1-14. doi: 10.1371/journal.pone.0268381

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

2022

Journal Article

Risk factors for low back pain outcome: Does it matter when they are measured?

Klyne, David Murray, Hall, Leanne Marie, Nicholas, Michael K. and Hodges, Paul William (2022). Risk factors for low back pain outcome: Does it matter when they are measured?. European Journal of Pain, 26 (4), 835-854. doi: 10.1002/ejp.1911

Risk factors for low back pain outcome: Does it matter when they are measured?

2022

Journal Article

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain

Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2022). Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain. The Spine Journal, 22 (2), 214-225. doi: 10.1016/j.spinee.2021.09.006

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain

2021

Conference Publication

Uncovering the role of sleep and exercise in the transition from acute to persistent pain

Klyne, D.M., Hilliard, B., Harris, M., Amin, M., Testa, C., Hobson, L., Cruz, G., Hodges, P.W. and Barbe, M.F. (2021). Uncovering the role of sleep and exercise in the transition from acute to persistent pain. Psychoneuroimmunology Research Society's 27th Annual Meeting, Online, 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.bbi.2021.08.099

Uncovering the role of sleep and exercise in the transition from acute to persistent pain

2021

Other Outputs

Environmental contributors to back pain

McPhee, Megan, Klyne, David and Graven-Nielsen, Thomas (2021). Environmental contributors to back pain. Washington, DC, USA: International Association for the Study of Pain.

Environmental contributors to back pain

2021

Journal Article

Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?

Klyne, David M., Barbe, Mary F., James, Greg and Hodges, Paul W. (2021). Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?. International Journal of Molecular Sciences, 22 (14) 7299, 1-21. doi: 10.3390/ijms22147299

Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?

2021

Journal Article

Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2021). Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis. Journal of Neurophysiology, 125 (5), 1814-1824. doi: 10.1152/jn.00555.2020

Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis

2021

Other Outputs

Supplemental Data for "Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis" paper

Alshehri, Mansour Abdullah , van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2021). Supplemental Data for "Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis" paper. The University of Queensland. (Dataset) doi: 10.14264/c3f49b3

Supplemental Data for "Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis" paper

2020

Journal Article

Cohort profile: why do people keep hurting their back?

Klyne, David M., van den Hoorn, Wolbert, Barbe, Mary F., Cholewicki, Jacek, M. Hall, Leanne, Khan, Asaduzzaman, Meroni, Roberto, Moseley, G. Lorimer, Nicholas, Michael, O’Sullivan, Lee, Park, Rachel, Russell, Glen, Sterling, Michele and Hodges, Paul W. (2020). Cohort profile: why do people keep hurting their back?. BMC Research Notes, 13 (1) 538, 538. doi: 10.1186/s13104-020-05356-z

Cohort profile: why do people keep hurting their back?

2020

Journal Article

Trunk stiffness decreases and trunk damping increases with experimental low back pain

van den Hoorn, Wolbert, Cholewicki, Jacek, Coppieters, Michel W., Klyne, David M. and Hodges, Paul W. (2020). Trunk stiffness decreases and trunk damping increases with experimental low back pain. Journal of Biomechanics, 112 110053, 110053. doi: 10.1016/j.jbiomech.2020.110053

Trunk stiffness decreases and trunk damping increases with experimental low back pain

2020

Journal Article

Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy

Barbe, Mary F., Hilliard, Brendan A., Amin, Mamta, Harris, Michele Y., Hobson, Lucas J., Cruz, Geneva E., Dorotan, Jocelynne T., Paul, Ryan W., Klyne, David M. and Popoff, Steven N. (2020). Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy. Journal of Orthopaedic Research, 38 (11) jor.24709, 2396-2408. doi: 10.1002/jor.24709

Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy

2020

Journal Article

Circulating adipokines in predicting the transition from acute to persistent low back pain

Klyne, David M. and Hodges, Paul W. (2020). Circulating adipokines in predicting the transition from acute to persistent low back pain. Pain Medicine, 21 (11), 2975-2985. doi: 10.1093/pm/pnaa052

Circulating adipokines in predicting the transition from acute to persistent low back pain

2020

Journal Article

Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders

Smith, Tianqi Tenchi Gao, Barr-Gillespie, Ann E, Klyne, David M, Harris, Michelle Y, Amin, Mamta, Paul, Ryan W, Cruz, Geneva E, Zhao, Huaqing, Gallagher, Sean and Barbe, Mary F (2020). Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders. BMC Musculoskeletal Disorders, 21 (1) 57, 57. doi: 10.1186/s12891-020-3085-z

Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders

2019

Journal Article

Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al

Klyne, David M. and Hodges, Paul W. (2019). Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al. Spine Journal, 19 (11), 1899-1900. doi: 10.1016/j.spinee.2019.06.011

Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al

2019

Journal Article

Are signs of central sensitisation in acute low back pain a precursor to poor outcome?

Klyne, David M., Moseley, G. Lorimer, Sterling, Michele, Barbe, Mary F. and Hodges, Paul W. (2019). Are signs of central sensitisation in acute low back pain a precursor to poor outcome?. The Journal of Pain, 20 (8), 994-1009. doi: 10.1016/j.jpain.2019.03.001

Are signs of central sensitisation in acute low back pain a precursor to poor outcome?

2019

Journal Article

ISSLS Prize in Basic science 2019: physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration

James, G., Klyne, D. M., Millecamps, M., Stone, L. S. and Hodges, P. W. (2019). ISSLS Prize in Basic science 2019: physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. European Spine Journal, 28 (5), 893-904. doi: 10.1007/s00586-019-05902-9

ISSLS Prize in Basic science 2019: physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration

2019

Conference Publication

Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly

Klyne, D. M. (2019). Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly. PsychoNeuroImmunology Research Society's 25th Annual Scientific Meeting, Miami Beach, FL, United States, 6-9 June 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.bbi.2018.11.244

Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly

2018

Other Outputs

Biological factors in the transition from acute to persistent low back pain

Klyne, David Murray (2018). Biological factors in the transition from acute to persistent low back pain. PhD Thesis, School of Health and Rehabilitation Sciences, The University of Queensland. doi: 10.14264/uql.2018.468

Biological factors in the transition from acute to persistent low back pain

2018

Journal Article

Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: impact of stimulus type, sleep, psychological and lifestyle factors

Klyne, David M., Moseley, G. Lorimer, Sterling, Michele, Barbe, Mary F. and Hodges, Paul W. (2018). Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: impact of stimulus type, sleep, psychological and lifestyle factors. The Journal of Pain, 19 (8), 942.e1-942.e18. doi: 10.1016/j.jpain.2018.02.017

Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: impact of stimulus type, sleep, psychological and lifestyle factors

2018

Journal Article

ISSLS Prize in clinical science 2018: Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly

Klyne, David M., Barbe, Mary F, van den Hoorn, Wolbert and Hodges, Paul W. (2018). ISSLS Prize in clinical science 2018: Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly. European Spine Journal, 27 (4), 763-777. doi: 10.1007/s00586-018-5490-7

ISSLS Prize in clinical science 2018: Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly

Funding

Current funding

  • 2025
    Does poor sleep drive chronic pain and can this be accurately measured in the real world?
    UQ Foundation Research Excellence Awards
    Open grant
  • 2024 - 2028
    Comparative effectiveness of exercise, cognitive behavioural therapy, and their combination for people with chronic musculoskeletal pain and poor sleep
    United States Congressionally Directed Medical Research Programs - Chronic Pain Management Research Program
    Open grant
  • 2024 - 2028
    The role of sleep, physical activity and central sensitisation in chronic back pain development
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2028
    PRioRTI: PReventing chronic pain after whiplash Road Traffic Injury
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2022 - 2027
    What causes low back pain to flare: Has a major opportunity to understand back pain been missed?
    United States National Institutes of Health
    Open grant
  • 2021 - 2026
    Biomarkers of Tissue Tolerance and Behaviour in a Rat Model (NIH Grant administered by Temple University)
    Temple University
    Open grant

Past funding

  • 2020 - 2024
    Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions
    United States Congressionally Directed Medical Research Programs - Chronic Pain Management Research Program
    Open grant

Supervision

Availability

Dr David Klyne is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Disentangling the relationship between sleep and pain

    We are seeking PhD students with a background in biomedical and/or rehabilitative sciences to join our team to contribute to a body of work that aims to identify if and how sleep influences pain. Projects will involve the measurement and analysis of sleep in the “real world” to understand how daily variations in sleep – one of the most important, yet modifiable health behaviors – drive the day-to-day “waxing and waning” of back pain. The work will involve a multidisciplinary team to address this challenging issue.

    Essential criteria: An undergraduate degree with first or second class division 1 Honours in biomedical science, physiotherapy or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English.

  • Unravelling the molecular mechanisms that explain how exercise programs improve chronic pain

    Physical activity and sleep are two of the most modifiable “every day” behaviours that we are learning to target with interventions to prevent and manage chronic diseases. This fully funded PhD will focus on unravelling the molecular mechanisms that explain how physical activity/exercise programs benefit people with chronic hip pain, and how sleep may influence this relationship. Outcomes will guide the refinement and development of new exercise and sleep interventions for improved chronic pain management and prevention. The successful PhD candidate will join Dr Klyne’s team at The University of Queensland and be co-supervised by A/Prof Michelle Hall at The University of Sydney.

    Essential criteria: An undergraduate degree in biomedical science, physiotherapy, human movement or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English. Previous research experience and/or coursework in molecular biology is highly desirable.

    Interested applicants should email Dr David Klyne with the subject line “PhD student application”. In your email, please briefly describe your research interests, career ambitions, qualifications and career groups. Please also include a PDF of your CV. Applications will be reviewed as soon as they are received and will continue to be accepted until the position is filled.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Dr David Klyne directly for media enquiries about:

  • Chronic Pain
  • Pain
  • Physical Activity
  • Sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au