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Emerita Professor Mary Fletcher
Emerita Professor

Mary Fletcher

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Overview

Background

Professor Mary Fletcher is a natural product organic chemist, and led the Natural Toxin group within the Centre for Animal Science, Queensland Alliance for Agricultural and Food Innovation (QAAFI) 2010-2024,before being appointed Emeritus Professor in 2024. She previously worked as a research chemist at both The University Queensland and Queensland Primary Industries (Biosecurity Queensland), before joining the Queensland Alliance for Agricultural and Food Innovation in 2010. Prof Fletcher's current interest focuses on bioactives that reduce enteric methane and the application of slow release delivery systems appropriate to rangeland grazing systems. Prof Fletcher has an industry recognised expertise as an applied organic chemist with a specialist interest in the identification and analysis of natural toxins and other bioactives in a range of plants, fungi and agricultural products. Such toxins and bioactives can affect both human and animal health posing risks to livestock production, food safety and market access.

Prof Fletcher is also an Affiliate Professor in the School of Chemistry and Molecular Biosciences (http://www.scmb.uq.edu.au/index.html), and an Affiliated Scientist at the Biosciences eastern & central Africa-International Livestock Research Institute (BecA-ILRI) Hub in Nairobi, Kenya (http://hub.africabiosciences.org/).

Prof Fletcher is a Fellow of the Royal Australian Chemical Institute and in 2016 was elected President of the Queensland Branch of the Royal Australian Chemical Institute (http://www.raci.org.au/branches/qld-branch).

Availability

Emerita Professor Mary Fletcher is:
Not available for supervision

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Chemistry, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Slow release inserts to deliver bioactive compounds that reduce enteric methane

    Methane emissions from the beef cattle sector accounts for ~7% of Australia’s greenhouse gas emissions. This collaborative UQ-DAF project brings together a team of interdisciplinary scientists and applies novel technologies to progress the industry goal of achieving a carbon neutral beef industry by 2030. The synthetic feed additive 3 nitrooxypropanol (3-NOP) has shown promise in enteric methane mitigation. This compound targets the nickel enzyme methyl-coenzyme M reductase (MCR) in rumen archea, thereby inhibiting the last step of CH4 formation by reversibly oxidizing the nickel cofactor from Ni(I) to Ni(II). Applications to date have necessitated daily dosing regimes relevant mostly for intensive cattle systems, and this project seeks to provide alternate delivery mechanisms to enable application in extensive systems. In extensive grazing systems, most supplements are normally delivered through licks, with little or no control of intake by individual animals. Many methane mitigating active-agents including 3-NOP are required to be delivered consistently to the rumen to be effective. This project seeks to deliver a novel rumen insert for controlled release of active-agents to provide a sustained slow-release dose. Such technology avoids any process issues associated with traditional bolus capsule systems, where the capsule itself presents problems at abattoir. It is envisaged that the novel insert by comparison would be completely biodegraded with no problematic remains at abattoir.

  • Beneficial Sugars in Stingless Bee Honey

    Stingless bees (Meliponini) occur in all tropical and sub-tropical regions, and honey from these native bees has a long history of traditional indigenous use with a range of purported therapeutic properties. Prof Fletcher's research has identified the unusual low GI disaccharide trehalulose as a predominant sugar and distinctive marker of stingless bee honey in five species across three continents Australia, Malaysia and Brazil. The presence of this beneficial sugar has added support to the health claims of these native Meliponini honeys and provided impetus to this emerging industry. This is the first report of this unusual disaccharide as a major component of honey, and indeed the first significant natural occurrence in any food. Prof Fletcher's research team has further demonstrated that this rare sugar is produced by the bees themselves via an enzymatic isomerisation of nectar sucrose - further evidence of the unique characteristics of these stingless bees and the honey they produce.

  • Natural Toxins

    Prof Fletcher's research interests also encompass the identification and analysis of natural toxins and bioactives in a range of plants, fungi and agricultural products. Such toxins have the potential to form residues in agricultural products and pose a risk to both livestock and human consumers. Toxins of particular interest include mycotoxins, pyrrolizidine alkaloids, indospicine and simplexin. Her natural toxin research focusses on minimising the impacts of plant toxins on Australian livestock production. Plant toxins can have wide ranging animal impacts, depending on their chemical structure and have the potential to contribute to ill thrift through specific toxicoses such as Pimelea poisoning and pyrrolizidine alkaloid associated liver disease, and reproductive losses through abortion and teratogenic effects, or calf losses associated with premature births, weak calves, or failure to suckle. Devising strategies to deal with diverse plant toxins is not easy, as the chemical action and target organ varies considerably, and the best line of action is prevention rather than remedial treatment. In pasture systems, it is difficult to prevent consumption of poisonous plants, other than by total removal from the pasture which is generally not possible. However, plant consumption does not necessarily equal uptake of the toxin, and the approach of the proposed research is to devise strategies to enable toxin breakdown within the rumen before absorption into the animals circulatory systems. Our research approach is to capitalise on natural rumen response by isolating microbes capable of degrading toxins (for use as preventative probiotics), and investigating toxin absorbents and/or biopolymers to foster toxin-degrading microbe populations. Initially this research will be applied to the Pimelea toxin, simplexin, which causes frequently fatal poisoning in cattle grazing inland pastures of Australia with productivity losses estimated to be up to $50 million in bad years. Further interests include the presence of pyrrolizidine alkaloids in Australian honey and identification of diverse floral sources of these alkaloids using LCMS technologies to confirm alkaloid profiles. A collaborative project with Queensland Health is also investigating authenticity, adulteration and providence of these honeys using stable isotope MS techniques.

Research impacts

Throughout her career Prof Fletcher has applied her chemical skills to address diverse problems that pose threats to agricultural industries, from the identification of fruit fly pheromones to the determination of plant toxins responsible for livestock deaths, to the identification of bone volatiles attractive to phosphorous deficient cattle and more recently the identification of unusual beneficial sugars in stingless bee honey and the application of slow release devices for the release of bioactives to control enteric methane production in rangeland cattle. Her work has particular application in the areas of food safety and food security, both in Australia and overseas, including projects addressing the impacts of carcinogenic mycotoxin contamination of staple foods in sub-saharan Africa.

Current research funded by Meat and Livestock Australia (MLA) aims to develop a rumen insert that is applicable in extensive production systems to reduce methane emissions from northern Australia beef herds and applies novel biopolmyer technologies to progress the industry goal of achieving a carbon neutral beef industry by 2030. This collaborative UQ-DAF project aims to produce a rumen insert that slowly releases active-agents (such as 3-NOP) into the rumen over an extended period of time. The use of a rumen insert will mean that each animal will receive the treatment and should establish a more consistent reduced methane emission, when compared to other methods.

Works

Search Professor Mary Fletcher’s works on UQ eSpace

281 works between 1983 and 2025

61 - 80 of 281 works

2020

Conference Publication

Stingless bee honey as a unique source of trehalulose

Hungerford, Natasha L., Zhang, Jiali, Carpinelli de Jesus, Matheus, Yates, Hans, Webber, Dennis, Stone Isolbella S. J., Blanchfield, Joanne T., Zawawi, Norhasnida and Fletcher, Mary T. (2020). Stingless bee honey as a unique source of trehalulose. 5th Queensland Annual Chemistry Symposium, QACS 2020, Brisbane, QLD Australia, 27 November 2020.

Stingless bee honey as a unique source of trehalulose

2020

Conference Publication

Identification of volatile plant compounds in Pimelea trichostachya responsible for livestock aversion

Loh, Z. H., Hungerford, N. L., Ouwerkerk, D., Klieve, A. V. and Fletcher, M. T. (2020). Identification of volatile plant compounds in Pimelea trichostachya responsible for livestock aversion. 5th Queensland Annual Chemistry Symposium, QACS 2020, Brisbane, QLD, Australia, 27 November 2020.

Identification of volatile plant compounds in Pimelea trichostachya responsible for livestock aversion

2020

Conference Publication

A new test and guidelines for the authentication of new-world honeys

Chowdhury, Sadia A. , Carter, James F. , Anuj, Shalona R. , Cozzolino, Daniel , Hungerford, Natasha L. and Fletcher, Mary T. (2020). A new test and guidelines for the authentication of new-world honeys. 5th Queensland Annual Chemistry Symposium, QACS 2020, Brisbane, QLD, Australia, 27 November 2020.

A new test and guidelines for the authentication of new-world honeys

2020

Journal Article

Toxin degradation by rumen microorganisms: a review

Loh, Zhi Hung, Ouwerkerk, Diane, Klieve, Athol V., Hungerford, Natasha L. and Fletcher, Mary T. (2020). Toxin degradation by rumen microorganisms: a review. Toxins, 12 (10) 664, 1-37. doi: 10.3390/toxins12100664

Toxin degradation by rumen microorganisms: a review

2020

Journal Article

Mineral and Trace Element Analysis of Australian/Queensland Apis mellifera Honey

Hungerford, Natasha L., Tinggi, Ujang, Tan, Benjamin L. L., Farrell, Madeleine and Fletcher, Mary T. (2020). Mineral and Trace Element Analysis of Australian/Queensland Apis mellifera Honey. International Journal of Environmental Research and Public Health, 17 (17) 6304, 6304-14. doi: 10.3390/ijerph17176304

Mineral and Trace Element Analysis of Australian/Queensland Apis mellifera Honey

2020

Journal Article

A review on Pimelea poisoning of livestock

Gordon, Russell J., Hungerford, Natasha L., Laycock, Bronwyn and Fletcher, Mary T. (2020). A review on Pimelea poisoning of livestock. Toxicon, 186, 46-57. doi: 10.1016/j.toxicon.2020.07.023

A review on Pimelea poisoning of livestock

2020

Journal Article

Stingless bee honey, a novel source of trehalulose: a biologically active disaccharide with health benefits

Fletcher, Mary T., Hungerford, Natasha L., Webber, Dennis, Carpinelli de Jesus, Matheus, Zhang, Jiali, Stone, Isobella S. J., Blanchfield, Joanne T. and Zawawi, Norhasnida (2020). Stingless bee honey, a novel source of trehalulose: a biologically active disaccharide with health benefits. Scientific Reports, 10 (1) 12128, 1-8. doi: 10.1038/s41598-020-68940-0

Stingless bee honey, a novel source of trehalulose: a biologically active disaccharide with health benefits

2020

Journal Article

Emerging food safety risk of hepatotoxic indospicine in feral Australian camel meat

Tan, Eddie T. T., Ng, Jack C., Al Jassim, Rafat, D’Arcy, Bruce R., Netzel, Gabriele and Fletcher, Mary T. (2020). Emerging food safety risk of hepatotoxic indospicine in feral Australian camel meat. Food Control, 113 107205, 107205. doi: 10.1016/j.foodcont.2020.107205

Emerging food safety risk of hepatotoxic indospicine in feral Australian camel meat

2020

Journal Article

Management of phosphorus nutrition of beef cattle grazing seasonally dry rangelands: a review

Dixon, R. M., Anderson, S. T., Kidd, L. J. and Fletcher, M. T. (2020). Management of phosphorus nutrition of beef cattle grazing seasonally dry rangelands: a review. Animal Production Science, 60 (7), 863-879. doi: 10.1071/an19344

Management of phosphorus nutrition of beef cattle grazing seasonally dry rangelands: a review

2020

Journal Article

Food safety and natural toxins

Fletcher, Mary T. and Netzel, Gabriele (2020). Food safety and natural toxins. Toxins, 12 (4) 236, 236. doi: 10.3390/toxins12040236

Food safety and natural toxins

2020

Conference Publication

Phosphorus nutrition in ruminants grazing tropical rangelands

Dixon, Rob, Anderson, Stephen, Kidd, Lisa and Fletcher, Mary (2020). Phosphorus nutrition in ruminants grazing tropical rangelands. Third International Tropical Agriculture Conference (TROPAG 2019), , Brisbane, QLD Australia, 11-13 November 2019. Basel, Switzerland: MDPI . doi: 10.3390/proceedings2019036200

Phosphorus nutrition in ruminants grazing tropical rangelands

2020

Journal Article

Dual-locus DNA metabarcoding reveals southern hairy-nosed wombats (Lasiorhinus latifrons Owen) have a summer diet dominated by toxic invasive plants

Camp, Amanda, Croxford, Adam E., Ford, Caroline S., Baumann, Ute, Clements, Peter R., Hiendleder, Stefan, Woolford, Lucy, Netzel, Gabrielle, Boardman, Wayne S. J., Fletcher, Mary T. and Wilkinson, Mike J. (2020). Dual-locus DNA metabarcoding reveals southern hairy-nosed wombats (Lasiorhinus latifrons Owen) have a summer diet dominated by toxic invasive plants. PLoS One, 15 (3) e0229390, e0229390. doi: 10.1371/journal.pone.0229390

Dual-locus DNA metabarcoding reveals southern hairy-nosed wombats (Lasiorhinus latifrons Owen) have a summer diet dominated by toxic invasive plants

2020

Journal Article

Indospicine combined with arginine deprivation triggers cancer cell death via caspase-dependent apoptosis

Shuvayeva, Galyna Y., Bobak, Yaroslav P., Vovk, Olena I., Kunz-Schughart, Leoni A., Fletcher, Mary T. and Stasyk, Oleh V. (2020). Indospicine combined with arginine deprivation triggers cancer cell death via caspase-dependent apoptosis. Cell Biology International, 45 (3) cbin.11321, 518-527. doi: 10.1002/cbin.11321

Indospicine combined with arginine deprivation triggers cancer cell death via caspase-dependent apoptosis

2020

Conference Publication

Analysis of environmental contaminants in Australian honey and comparison to stingless bee honey from Queensland and Malaysia

Hungerford, Natasha L., Tan, Benjamin L.L., Tinggi, Ujang, Zawawi, Norhasmida, Farrell, Madeleine, Tsai, Heng Hang, Hnatko, Darina, Swann, Lorinda J., Kelly, Cassandra L., Anuj, Shalona R., Webber, Dennis C., Were, Stephen T. and Fletcher, Mary T. (2020). Analysis of environmental contaminants in Australian honey and comparison to stingless bee honey from Queensland and Malaysia. The Third International Tropical Agriculture Conference TropAg 2019 , Brisbane, QLD Australia, 11-13 November 2019. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2019036101

Analysis of environmental contaminants in Australian honey and comparison to stingless bee honey from Queensland and Malaysia

2020

Conference Publication

Adsorbents for the sequestration of the Pimelea toxin, simplexin

Gordon, Russell, Hungerford, Natasha L., Laycock, Bronwyn, Ouwerkerk, Diane and Fletcher, Mary T. (2020). Adsorbents for the sequestration of the Pimelea toxin, simplexin. The Third International Tropical Agriculture Conference TropAg 2019 , Brisbane, QLD Australia, 11-13 November 2019. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2019036090

Adsorbents for the sequestration of the Pimelea toxin, simplexin

2020

Conference Publication

Modelling the controlled release of toxins in a rumen environment

Yuan, Yue, Gauthier, Emilie, Hungerford, Natasha L., Ouwerkerk, Diane , Fletcher, Mary T. and Laycock, Bronwyn (2020). Modelling the controlled release of toxins in a rumen environment. The Third International Tropical Agriculture Conference TropAg 2019 , Brisbane, QLD Australia, 11-13 November 2019. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2019036089

Modelling the controlled release of toxins in a rumen environment

2020

Other Outputs

Improved management of cattle phosphorus status through applied physiology

Dixon, Rob, Fletcher, Mary, Anderson, Stephen, Kidd, Lisa, Benvenutti, Marcelo, Mayer, Bob, McNeill, David and Goodwin, Kerry (2020). Improved management of cattle phosphorus status through applied physiology. North Sydney, NSW Australia: Meat and Livestock Australia.

Improved management of cattle phosphorus status through applied physiology

2020

Conference Publication

Blood phosphorus concentration as an indicator of phosphorus deficiency in growing cattle

Dixon, Rob, Anderson, Stephen, Kidd, Lisa and Fletcher, Mary (2020). Blood phosphorus concentration as an indicator of phosphorus deficiency in growing cattle. Third International Tropical Agriculture Conference (TROPAG 2019) , Brisbane, Australia, 11–13 November 2019. Basel, Switzerland: MDPI . doi: 10.3390/proceedings2019036136

Blood phosphorus concentration as an indicator of phosphorus deficiency in growing cattle

2020

Journal Article

The impact of commercial prebiotics on the growth, survival and nisin production by Lactococcus lactis 537 in milk

Almutairi, Batlah, Turner, Mark S., Fletcher, Mary T. and Sultanbawa, Yasmina (2020). The impact of commercial prebiotics on the growth, survival and nisin production by Lactococcus lactis 537 in milk. LWT- Food Science and Technology, 137 110356, 110356. doi: 10.1016/j.lwt.2020.110356

The impact of commercial prebiotics on the growth, survival and nisin production by Lactococcus lactis 537 in milk

2020

Conference Publication

A new method for the authentication of Australian honey

Chowdhury, Sadia A., Anuj, Shalona R., Carter, James F., Hungerford, Natasha L., Webber, Dennis, Sultanbawa, Yasmina and Fletcher, Mary T. (2020). A new method for the authentication of Australian honey. Third International Tropical Agriculture Conference (TROPAG 2019), Brisbane, Australia, 11-13 November 2019. Basel, Switzerland: MDPI . doi: 10.3390/proceedings2019036112

A new method for the authentication of Australian honey

Funding

Current funding

  • 2023 - 2025
    Harnessing the synbio potential of Australia's stingless bees, the first step
    Sugar Research Australia Limited
    Open grant
  • 2022 - 2025
    Developing cutting-edge capability for atypical saccharides in emerging and novel foods
    Queensland Health Forensic and Scientific Services
    Open grant
  • 2022 - 2027
    EAP - Biopolymers to deliver bioactive compounds that reduce enteric methane
    Meat & Livestock Australia
    Open grant

Past funding

  • 2023 - 2024
    Indospicine from the Australian plant Indigofera spicata as potential anticancer agent
    Ukraine-Australia Research Fund
    Open grant
  • 2021
    Rapid and Non-destructive Identification of Mycotoxins in Animal Feed Ingredients
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2020 - 2021
    Authentication of Australian stingless bee honey - proof of concept study
    Queensland Health
    Open grant
  • 2020 - 2021
    Optimising bioactive content of Australian stingless bee honey
    Agrifutures Australia
    Open grant
  • 2018 - 2019
    Improving nitrogen usage efficiency to reduce the environmental impact of beef cattle
    UQ-FAPESP Strategic Research Fund SPRINT
    Open grant
  • 2018 - 2023
    Nitrogen recycling as determinant for feed efficiency of Bos indicus cattle
    Meat & Livestock Australia
    Open grant
  • 2018 - 2022
    Improving beef production through management of plant toxins
    Meat & Livestock Australia
    Open grant
  • 2017 - 2018
    Analysis of environmental contaminants in Australian/Queensland honey
    Queensland Health Forensic and Scientific Services
    Open grant
  • 2017 - 2018
    Pimelea toxicity - finding potential solutions for managing cattle poisoning
    Meat & Livestock Australia
    Open grant
  • 2016 - 2018
    The risk of pyrollizidine alkaloids in Queensland honey
    Queensland Health Forensic and Scientific Services
    Open grant
  • 2016 - 2017
    Bio-actives: Value-adding to industrial hemp production
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2015 - 2017
    Indospicine - managing the risk of residues in Western Australia meat
    Western Australian Department of Primary Industries and Rural Development
    Open grant
  • 2014 - 2016
    Native plant extracts for extended shelf life in corn
    Rural Industries Research & Development Corporation
    Open grant
  • 2012 - 2017
    Improved management of cattle phosphorus status through applied physiology
    Meat & Livestock Australia
    Open grant
  • 2011 - 2015
    Capacity and Action for Aflatoxin Reduction in Eastern Africa
    CSIRO
    Open grant
  • 2003 - 2004
    Linking structure to activity: identification of fruit fly sex pheromones with potential for pest management
    UQ New Staff Research Start-Up Fund
    Open grant

Supervision

Availability

Emerita Professor Mary Fletcher is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Media

Enquiries

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