Professor Timothy Mahony
Professor

Timothy Mahony

Email: 
Phone: 
+61 7 334 66505

Background

Prof Tim Mahony joined QAAFI’s Centre for Animal Science in October 2010, after 15 years of conducting research projects with the Queensland Government. He obtained his PhD from James Cook University in the area of molecular microbiology. During 2001 and 2002, Prof Mahony was a visiting professor at the University of Saskatchewan.

Research interests

Dr Mahony’s research interests are in the area of molecular virology revolving around improving viral disease control in production animals such as cattle and poultry. His group is characterising the molecular interactions between invading pathogens and the subsequent host responses with the goal of developing new vaccines and diagnostic technologies. A key component of this work includes improving the basic understanding of the molecular mechanisms that underpin and drive viral virulence and evolution. Next-generation sequencing has been used to sequence the genomes of herpesviruses and adenoviruses from a variety of species including, cattle, chickens, marsupials, horses, and crocodiles. Prof Mahony’s team is also investigating the role of virally encoded microRNAs in virulence, replication, and disease development. His group was one of the first in the world to apply bacterial artificial chromosome infectious clone technology for the efficient manipulation of herpesviruses that have large DNA genomes. These strategies are also being exploited to understand viral gene function and the development of vaccines.

Currently, Prof Mahony is researching risk factors that protect and predispose feedlot cattle to developing bovine respiratory disease (BRD). He is also leading the development of new vaccines for BRD and cattle tick infestations. Prof Mahony has also led the development of new vaccine delivery technologies for the poultry industry targeting the application of in ovo strategies. Prof Mahony research into improving animal health is increasing industry productivity, food safety, and consumer confidence in food products and he is keen to explore collaborations with other scientists in this area.

Prof Mahony has a strong interest to work with post-graduate students and has supervised a number of post-graduate students from Australia and overseas. These projects have covered research areas in molecular virology, animal health, vaccine development, and pathogen-host interactions.

Availability

Professor Timothy Mahony is:
Available for supervision
Media expert

Fields of research

Agricultural, Veterinary and Food Sciences Biological Sciences Host-parasite interactions Infectious agents Microbiology Veterinary immunology Veterinary sciences Veterinary virology

Qualifications

  • Doctor of Philosophy, James Cook University

Search Professor Timothy Mahony’s works on UQ eSpace

114 works between 1990 and 2025
All (114) Journal Article (101) Book Chapter (4) Conference Publication (9)

81 - 100 of 114 works

2010

Journal Article

Polyvalent Alphaherpesvirus vectors in veterinary vaccine research

Robinson, K. E., Meers, J. and Mahony, T. J. (2010). Polyvalent Alphaherpesvirus vectors in veterinary vaccine research. Current Topics in Virology, 8, 71-88.

Polyvalent Alphaherpesvirus vectors in veterinary vaccine research

2010

Journal Article

Bovine herpesvirus: What is missing from our understanding of the relationship between BoHV-1 and BoHV-5?

Mahony, Timothy J. (2010). Bovine herpesvirus: What is missing from our understanding of the relationship between BoHV-1 and BoHV-5?. Veterinary Journal, 184 (2), 124-125. doi: 10.1016/j.tvjl.2009.06.020

Bovine herpesvirus: What is missing from our understanding of the relationship between BoHV-1 and BoHV-5?

2010

Journal Article

Characterisation of the H5 and N1 genes of an Indonesian highly pathogenic avian influenza virus isolate by sequencing of multiple clone approach

Hartawan, Risza, Robinson, Karl, Mahony, Timothy and Meers, Joanne (2010). Characterisation of the H5 and N1 genes of an Indonesian highly pathogenic avian influenza virus isolate by sequencing of multiple clone approach. Indonesian Journal of Animal and Veterinary Sciences, 15 (3), 240-251. doi: 10.14334/jitv.v15i3.663

Characterisation of the H5 and N1 genes of an Indonesian highly pathogenic avian influenza virus isolate by sequencing of multiple clone approach

2010

Conference Publication

Vectoring of avian influenza antigens using a recombinant avian herpes virus vector

Hartawan, Risza, Meers, Joanne, Mahony, Tim and Robinson, Karl (2010). Vectoring of avian influenza antigens using a recombinant avian herpes virus vector. Global Biosecurity 2010, Brisbane, QLD, Australia, 28 February-3 March 2010.

Vectoring of avian influenza antigens using a recombinant avian herpes virus vector

2010

Journal Article

Characterization of microRNAs encoded by the bovine herpesvirus 1 genome

Glazov, Evgeny A., Horwood, Paul F., Assavalapsakul, Wanchai, Kongsuwan, Kritaya, Mitchell, Roger W., Mitter, Neena and Mahony, Timothy J. (2010). Characterization of microRNAs encoded by the bovine herpesvirus 1 genome. Journal of General Virology, 91 (1), 32-41. doi: 10.1099/vir.0.014290-0

Characterization of microRNAs encoded by the bovine herpesvirus 1 genome

2009

Journal Article

Molecular detection and phylogenetic analysis of betanodavirus isolates from Australian finfish

Moody, N. J. G., Horwood, P. F., Reynolds, A., Mahony, T. J., Anderson, I. G. and Oakey, H. J. (2009). Molecular detection and phylogenetic analysis of betanodavirus isolates from Australian finfish. Diseases of Aquatic Organisms, 87 (3), 151-160. doi: 10.3354/dao02130

Molecular detection and phylogenetic analysis of betanodavirus isolates from Australian finfish

2009

Journal Article

A Lucilia cuprina excretory-secretory protein inhibits the early phase of lymphocyte activation and subsequent proliferation

Elkington, R. A., Humphries, M., Commins, M., Maugeri, N., Tierney, T. and Mahony, T. J. (2009). A Lucilia cuprina excretory-secretory protein inhibits the early phase of lymphocyte activation and subsequent proliferation. Parasite Immunology, 31 (12), 750-765. doi: 10.1111/j.1365-3024.2009.01154.x

A Lucilia cuprina excretory-secretory protein inhibits the early phase of lymphocyte activation and subsequent proliferation

2009

Journal Article

Repertoire of bovine miRNA and miRNA-like small regulatory RNAs expressed upon viral infection

Glazov, Evgeny A., Kongsuwan, Kritaya, Assavalapsakul, Wanchai, Horwood, Paul F., Mitter, Neena and Mahony, Timothy J. (2009). Repertoire of bovine miRNA and miRNA-like small regulatory RNAs expressed upon viral infection. PLoS One, 4 (7) e6349, e6349-1-e6349-6. doi: 10.1371/journal.pone.0006349

Repertoire of bovine miRNA and miRNA-like small regulatory RNAs expressed upon viral infection

2009

Journal Article

Understanding animal viruses using the Gene Ontology

McCarthy, Fiona M., Mahony, Timothy J., Mark S. Parcells and Shane C. Burgess (2009). Understanding animal viruses using the Gene Ontology. Trends in Microbiology, 17 (7), 328-335. doi: 10.1016/j.tim.2009.04.006

Understanding animal viruses using the Gene Ontology

2008

Journal Article

The essential and non-essential genes of Bovine herpesvirus 1

Robinson, Karl E., Meers, Joanne, Gravel, Jennifer L., McCarthy, Fiona M. and Mahony, Timothy J. (2008). The essential and non-essential genes of Bovine herpesvirus 1. Journal of General Virology, 89 (11), 2851-2863. doi: 10.1099/vir.0.2008/002501-0

The essential and non-essential genes of Bovine herpesvirus 1

2008

Journal Article

Identification of two distinct bovine parainfluenza virus type 3 genotypes

Horwood, Paul Francis, Gravel, Jennifer Lillian and Mahony, Timothy John (2008). Identification of two distinct bovine parainfluenza virus type 3 genotypes. Journal of General Virology, 89 (7), 1643-1648. doi: 10.1099/vir.0.2008/000026-0

Identification of two distinct bovine parainfluenza virus type 3 genotypes

2007

Journal Article

A blowfly strike vaccine requires an understanding of host-pathogen interactions

Elkington, Rebecca A. and Mahony, Timothy J. (2007). A blowfly strike vaccine requires an understanding of host-pathogen interactions. Vaccine, 25 (28), 5133-5145. doi: 10.1016/j.vaccine.2007.04.074

A blowfly strike vaccine requires an understanding of host-pathogen interactions

2006

Conference Publication

Using immunology and resistant sheep to beat the fly

Colditz, Ian G., Mahony, T. and Elkington, R. (2006). Using immunology and resistant sheep to beat the fly.

Using immunology and resistant sheep to beat the fly

2006

Journal Article

Absolute quantitation of Marek's disease virus and Herpesvirus of turkeys in chicken lymphocyte, feather tip and dust samples using real-time PCR

Islam, Aminul, Cheetham, Brian F., Mahony, Timothy J., Young, Peter L. and Walkden-Brown, Stephen W. (2006). Absolute quantitation of Marek's disease virus and Herpesvirus of turkeys in chicken lymphocyte, feather tip and dust samples using real-time PCR. Journal of Virological Methods, 132 (1-2), 127-134. doi: 10.1016/j.jviromet.2005.10.009

Absolute quantitation of Marek's disease virus and Herpesvirus of turkeys in chicken lymphocyte, feather tip and dust samples using real-time PCR

2005

Journal Article

Genetic analysis of bovine viral diarrhoea viruses from Australia

Mahony, Timothy J., McCarthy, Fiona M., Gravel, Jennifer L., Corney, Bruce, Young, Peter L. and Vilcek, Stefan (2005). Genetic analysis of bovine viral diarrhoea viruses from Australia. Veterinary Microbiology, 106 (1-2), 1-6. doi: 10.1016/j.vetmic.2004.10.024

Genetic analysis of bovine viral diarrhoea viruses from Australia

2005

Journal Article

Construction of a gene inactivation library for Bovine herpesvirus 1 using infectious clone technology

Mahony, Timothy J, McCarthy, Fiona M, Gravel, Jennifer L and Young, Peter L (2005). Construction of a gene inactivation library for Bovine herpesvirus 1 using infectious clone technology. Methods in molecular biology (Clifton, N.J.), 292, 387-400.

Construction of a gene inactivation library for Bovine herpesvirus 1 using infectious clone technology

2005

Book Chapter

Construction of a gene inactivation library for Bovine herpesvirus 1 using infectious clone technology

Mahony, Timothy J., McCarthy, Fiona M., Gravel, Jennifer L. and Young, Peter L. (2005). Construction of a gene inactivation library for Bovine herpesvirus 1 using infectious clone technology. DNA viruses: Methods and protocols. (pp. 387-400) edited by Paul M. Lieberman. Totowa, NJ, United States: Humana Press. doi: 10.1385/1-59259-848-X:387

Construction of a gene inactivation library for Bovine herpesvirus 1 using infectious clone technology

2004

Journal Article

Differential amplification and quantification of Marek’s Disease viruses using real-time polymerase chain reaction

Islam, Aminul, Harrison, Bruce, Cheetham, Brian F., Mahony, Timothy J., Young, Peter L. and Walkden-Brown, Stephen W. (2004). Differential amplification and quantification of Marek’s Disease viruses using real-time polymerase chain reaction. Journal of Virological Methods, 119 (2), 103-113. doi: 10.1016/j.jviromet.2004.03.006

Differential amplification and quantification of Marek’s Disease viruses using real-time polymerase chain reaction

2003

Journal Article

Rapid and efficient construction of recombinant bovine herpesvirus 1 genomes

Mahony, T. J., McCarthy, F. M., Gravel, J. L. and Young, P. L. (2003). Rapid and efficient construction of recombinant bovine herpesvirus 1 genomes. Journal of Virological Methods, 107 (2), 269-274. doi: 10.1016/S0166-0934(02)00226-4

Rapid and efficient construction of recombinant bovine herpesvirus 1 genomes

2002

Journal Article

Construction and manipulation of an infectious clone of the bovine herpesvirus 1 genome maintained as a bacterial artificial chromosome

Mahony, Timothy J., McCarthy, Fiona M., Gravel, Jennifer L., West, Lani and Young, Peter L. (2002). Construction and manipulation of an infectious clone of the bovine herpesvirus 1 genome maintained as a bacterial artificial chromosome. Journal of Virology, 76 (13), 6660-6668. doi: 10.1128/JVI.76.13.6660-6668.2002

Construction and manipulation of an infectious clone of the bovine herpesvirus 1 genome maintained as a bacterial artificial chromosome

Current funding

  • 2023 - 2025
    Saving the endangered Spectacled flying fox from annual tick paralysis mortality events:
    Threatened Species Research Grants
    Open grant
  • 2023 - 2025
    Evaluation of a prototype vaccine for rattles in foals
    Agrifutures Australia
    Open grant
  • 2023 - 2025
    Harnessing the synbio potential of Australia's stingless bees, the first step
    Sugar Research Australia Limited
    Open grant
  • 2022 - 2026
    On-farm genomics: genomic solutions for Northern beef cattle management and breeding
    Meat & Livestock Australia
    Open grant
  • 2021 - 2026
    NB2: Assessing practical interventions to reduce calf wastage and herd mortality in northern systems
    Meat & Livestock Australia
    Open grant

Past funding

  • 2023
    Development of a novel assay for the detection of the bovine SRY transcript
    NBRYO PTY LTD
    Open grant
  • 2022 - 2024
    Use of an inhibin vaccine to increase litter size in pigs (University of Adelaide administered APRIL grant)
    University of Adelaide
    Open grant
  • 2020 - 2021
    Evaluation of anti-tick vaccines for tick immunological control in cattle
    Meat & Livestock Australia
    Open grant
  • 2019
    Advanced Nanoparticle, Colloid and Microparticle Characterisation and Precision Engineering Nanosystems Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2024
    Development of a single shot immunocontraceptive vaccine for cattle
    Meat & Livestock Australia
    Open grant
  • 2017 - 2023
    Improving bovine respiratory disease control through the characterisation of pathogen genomics and host interactions
    Meat & Livestock Australia
    Open grant
  • 2016 - 2019
    Testing and verification of a single-dose cattle tick vaccine
    Meat & Livestock Australia
    Open grant
  • 2015
    Identification of new and effective antimicrobials for sustainable use in intensively finished cattle
    UQ Collaboration and Industry Engagement Fund - Seed Research Grant
    Open grant
  • 2012 - 2014
    BioClay - Managing biotic stresses from field to market
    Bill & Melinda Gates Foundation
    Open grant
  • 2012 - 2016
    Live viral vaccines for bovine respiratory disease: BVDV efficacy
    Meat & Livestock Australia
    Open grant
  • 2012 - 2014
    Changing the vaccination paradigm: A single-dose cattle-tick vaccine for Queensland's extensive beef cattle enterprises using biopolymer platform
    Queensland Government Smart Futures Research Partnerships Program
    Open grant
  • 2011 - 2014
    Application of herpes viral vectors for in ovo delivery
    Queensland Department of Employment, Economic Development and Innovation
    Open grant
  • 2011 - 2012
    The function of microRNAs encoded within the Bovine herpesvirus 1 origin of replication
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2010 - 2015
    Epidemiology and management of bovine respiratory disease in feedlot cattle (Meat and Livestock Australia project novated from DEEDI)
    Meat & Livestock Australia
    Open grant

Availability

Professor Timothy Mahony is:
Available for supervision

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Available projects

  • The development of strand-specific sequencing methodologies double-stranded DNA viral genomes

    The herpesviruses are a large family of viruses that infected a broad range of hosts, such as mammals, reptiles, and molluscs. These viruses have a large double stranded DNA (dsDNA) genome. While the herpesviruses are considered to be genetically stable, variants with increased capacity to cause disease have emerged. The molecular basis underpinning the emergence of these virulent subtypes/genotypes for several herpesviruses of importance to veterinary medicine remains poorly understood. This project will utilise Oxford Nanopore sequencing technology to develop strategies to enable the strand-specific sequencing of herpesvirus genomes. The availability of strand-specific sequence data will be used to determine if the emergence of new genotypes of herpesviruses is a result of spontaneous mutation or the selection of existing genetic diversity within a viral isolate. This new knowledge will improve our understanding of this important virus family.

  • The application of gene editing to improve animal resistance to infections

    Gene editing technologies have enabled the rapid and specific modification of the genomes of complex organisms. Projects are available that will focus on the application of gene editing to increase the resilience of livestock cells to pathogens which reduce productivity. These projects will enable the candidate to gain experience in mammalian cell culture, transfection, growth and titration of viruses, molecular cloning, Western blotting, quantitative real-time PCR, genomic analyses, and fluorescence microscopy. These studies will improve our understanding of host/pathogen interactions towards the development of more resilient livestock.

  • The application of synthetic biology to large DNA viral genomes

    The capacity to manipulate the genomes of viruses in the laboratory remains dependent on their in vitro replication efficiency. This limitation has hindered our attempts better understand many of these viruses. This project will address this issue by applying long range PCR and DNA fragment assembly to construction copies of selected herpesviral genomes. The capacity of these genomes to facilitate rescue of infectious virus will also be determined. The availability of these infectious genome copies will aide in the development of improved diagnostics and control methods for these currently difficult to work with viruses.

  • Characterisation of bovine herpesvirus 2 genome

    Bovine herpesvirus 2 (BoHV-2) is associated with mastitis in cattle. Of all of the herpesviruses which infect cattle, BoHV-2 is by far the most poorly characterised. This project will address this knowledge gap by using next generation sequencing and conventional PCR and sequencing technologies to completely sequence the BoHV-2 genome. The results of this project will enable the genome-wide comparisons of the BoHV-2 genome to other bovine and mammalian herpesviruses. These comparisons will improve our understanding of host/virus interactions at the molecular level for important viral properties such as tissue tropism and virulence.

  • Construction of bovine herpesvirus 5 infectious clone

    Bovine herpesvirus 1 (BoHV-5) is a neurotrophic which is associated with severe and fatal disease in young cattle. Unlike bovine herpesvirus 1, BoHV-5 occurs sporadically in the world’s cattle population, except in South America. In this project, you will utilise genome edit tools, such as CRISPR/Cas9, to manipulate the BoHV-5 genome to construct an infectious clone of the virus. The results of this project will provide a better understanding of gene function in BoHV-5, particularly in respect to virulence. This information will improve our understand of how BoHV-5 interacts with its host at the molecular level and lead to the development of improved control strategies.

Supervision history

Current supervision

  • Doctor Philosophy

    Modelling superior phenotypes through the identification and exploitation of genomic safe harbours in cattle.

    Principal Advisor

    Other advisors: Dr Karl Robinson

  • Doctor Philosophy

    Modelling superior phenotypes through the identification and exploitation of genomic safe harbours in cattle.

    Principal Advisor

    Other advisors: Dr Karl Robinson

  • Doctor Philosophy

    The application of genome editing to improve the disease resilience of livestock species

    Principal Advisor

    Other advisors: Dr Karishma Mody

  • Doctor Philosophy

    Modelling superior phenotypes through the identification and exploitation of genomic safe harbours in cattle.

    Principal Advisor

    Other advisors: Dr Karl Robinson

  • Doctor Philosophy

    Development of a viral vector vaccine for Australian flying foxes

    Principal Advisor

    Other advisors: Professor Joanne Meers

  • Doctor Philosophy

    Sustainable Control of the Australian Blowfly Using Topical RNA Interference

    Associate Advisor

    Other advisors: Dr Karishma Mody

  • Doctor Philosophy

    Sustainable Control of the Australian Blowfly Using Topical RNA Interference

    Associate Advisor

    Other advisors: Dr Karishma Mody

  • Doctor Philosophy

    Sustainable Control of the Australian Blowfly Using Topical RNA Interference

    Associate Advisor

    Other advisors: Dr Karishma Mody

  • Doctor Philosophy

    Innovative RNAi for ectoparasites of livestock

    Associate Advisor

    Other advisors: Dr Karl Robinson, Dr Karishma Mody

  • Doctor Philosophy

    Sustainable Control of the Australian Blowfly Using Topical RNA Interference

    Associate Advisor

    Other advisors: Dr Karishma Mody

  • Doctor Philosophy

    Sustainable Control of the Australian Blowfly Using Topical RNA Interference

    Associate Advisor

    Other advisors: Dr Karishma Mody

  • Doctor Philosophy

    Characterisation of a novel flying fox retrovirus

    Associate Advisor

    Other advisors: Professor Joanne Meers, Dr Lee McMichael

Completed supervision

Enquiries

Contact Professor Timothy Mahony directly for media enquiries about:

  • Animal vaccines
  • Animals - viral diseases
  • Vaccines - animals
  • Viral diseases - animals

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