Overview
Availability
- Honorary Professor Kum Kum Khanna is:
- Available for supervision
Fields of research
Works
Search Professor Kum Kum Khanna’s works on UQ eSpace
2019
Journal Article
First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation
Zhou, Chenxi, Hancock, Janelle L., Khanna, Kum Kum and Homer, Hayden A. (2019). First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation. Journal of Cell Science, 132 (18) jcs233379, jcs233379. doi: 10.1242/jcs.233379
2019
Journal Article
GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival
Cabrera, Elisa, Raninga, Prahlad, Khanna, Kum Kum and Freire, Raimundo (2019). GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival. Cancers, 11 (8), 1073. doi: 10.3390/cancers11081073
2019
Journal Article
Mechanisms of genomic instability in breast cancer
Duijf, Pascal H.G., Nanayakkara, Devathri, Nones, K., Srihari, Sriganesh, Kalimutho, Murugan and Khanna, Kum Kum (2019). Mechanisms of genomic instability in breast cancer. Trends in Molecular Medicine, 25 (7), 595-611. doi: 10.1016/j.molmed.2019.04.004
2019
Journal Article
Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers
Nones, K., Johnson, J., Newell, F., Patch, A. M., Thorne, H., Kazakoff, S. H., de Luca, X. M., Parsons, M. T., Ferguson, K., Reid, L. E., McCart Reed, A. E., Srihari, S., Lakis, V., Davidson, A. L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., The Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), The Australian Breast Cancer Tissue Bank (ABCTB), The Brisbane Breast Bank (BBB), Beesley, J., Harris, J. M., Barnes, D., Degasperi, A., Ragan, M. A., Spurdle, A. B., Khanna, K. K. ... Simpson, P. T. (2019). Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. Annals of Oncology, 30 (7) mdz132, 1071-1079. doi: 10.1093/annonc/mdz132
2019
Journal Article
Patterns of genomic instability in breast cancer
Kalimutho, Murugan, Nones, Katia, Srihari, Sriganesh, Duijf, Pascal H.G., Waddell, Nicola and Khanna, Kum Kum (2019). Patterns of genomic instability in breast cancer. Trends in Pharmacological Sciences, 40 (3), 198-211. doi: 10.1016/j.tips.2019.01.005
2019
Journal Article
Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer
Kalimutho, Murugan, Sinha, Debottam, Mittal, Deepak, Srihari, Sriganesh, Nanayakkara, Devathri, Shafique, Shagufta, Raninga, Prahlad, Nag, Purba, Parsons, Kate and Khanna, Kum Kum (2019). Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. Journal of Experimental and Clinical Cancer Research, 38 (1) 85, 1-18. doi: 10.1186/s13046-019-1075-5
2018
Journal Article
RNA interference to enhance radiation therapy: targeting the DNA damage response
Ratnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018). RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439, 14-23. doi: 10.1016/j.canlet.2018.09.011
2018
Journal Article
RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination
Harris, Janelle Louise, Rabellino, Andrea and Khanna, Kum Kum (2018). RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination. Annals of Translational Medicine, 6 ARTN S122. doi: 10.21037/atm.2018.12.30
2018
Journal Article
Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy
Prasanna, Thiru, Wu, Fan, Khanna, Kum Kum, Yip, Desmond, Malik, Laeeq, Dahlstrom, Jane E. and Rao, Sudha (2018). Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy. Cancer Science, 109 (11), 3383-3392. doi: 10.1111/cas.13799
2018
Journal Article
CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer
Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566. doi: 10.15252/emmm.201708566
2018
Conference Publication
CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo
Sinha, D., Kalimutho, M., Bain, A.L. and Khanna, K.K. (2018). CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo. 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, Netherlands, 30 June – 3 July 2018. London, United Kingdom: Elsevier. doi: 10.1136/esmoopen-2018-eacr25.730
2018
Journal Article
The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking
Harris, Janelle L., Dave, Keyur, Gorman, Jeffrey and Khanna, Kum Kum (2018). The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. International Journal of Biochemistry & Cell Biology, 99, 28-37. doi: 10.1016/j.biocel.2018.03.002
2018
Journal Article
Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling
Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M., O'Bryan, Moira K. and Khanna, Kum Kum (2018). Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 (9), 4984-4999. doi: 10.1096/fj.201701096RR
2018
Journal Article
Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient
Johnson, Julie, Bessette, Darrell C., Saunus, Jodi M., Smart, Chanel E., Song, Sarah, Johnston, Rebecca L., Cocciardi, Sibylle, Rozali, Esdy N., Johnstone, Cameron N., Vargas, Ana Christina, Kazakoff, Stephen H., BioBank, Victorian Cancer, Khanna, Kum Kum, Lakhani, Sunil R., Chenevix-Trench, Georgia, Simpson, Peter T., Nones, Katia, Waddell, Nicola and Al-Ejeh, Fares (2018). Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Research and Treatment, 170 (1), 179-188. doi: 10.1007/s10549-018-4719-9
2018
Journal Article
LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2018). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Scientific Reports, 8 (1) ARTN 73. doi: 10.1038/s41598-017-17913-x
2017
Journal Article
Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families
Li, Jun, Li, Hongyan, Makunin, Igor, Thompson, Bryony A., Tao, Kayoko, Young, Erin L., Lopez, Jacqueline, Camp, Nicola J., Tavtigian, Sean V., John, Esther M., Andrulis, Irene L., Khanna, Kum Kum, Goldgar, David and Chenevix-Trench, Georgia (2017). Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families. Breast Cancer Research and Treatment, 166 (3), 937-949. doi: 10.1007/s10549-017-4469-0
2017
Journal Article
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research
Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017). Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, 167 (1), 1-13. doi: 10.1007/s10549-017-4496-x
2017
Conference Publication
Targeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer
Raninga, P., Kalimutho, M., Sinha, D., Bain, A., Tonissen, K. and Khanna, K. K. (2017). Targeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer. 42nd European Society for Medical Oncology Congress (ESMO), Madrid, Spain, 8-12 September 2017. Oxford, United Kingdom: Oxford University Press.
2017
Conference Publication
Synergistic inhibition of CEP55 induces mitotic catastrophe and specifically targets aggressive breast cancer
Sinha, D., Kalimutho, M., Lopez, A. J. and Khanna, K. K. (2017). Synergistic inhibition of CEP55 induces mitotic catastrophe and specifically targets aggressive breast cancer. 42nd European-Society-for-Medical-Oncology Congress (ESMO), Madrid, Spain, 8-12 September 2017. Oxford, United Kingdom: OXFORD UNIV.
2017
Journal Article
Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage
Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropee, Romain, Patch, Ann.-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen Shu W., Day, Bryan, Moller, Andreas, Cloonan, Nicole, Pearson,John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E. ... French, Juliet D. (2017). Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage. American Journal of Human Genetics, 101 (2), 255-266. doi: 10.1016/j.ajhg.2017.07.007
Funding
Current funding
Supervision
Availability
- Honorary Professor Kum Kum Khanna is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Functional validation of therapeutic targets for basal breast cancer
Principal Advisor
-
Doctor Philosophy
Understanding novel regulators of mitosis and their implication in cancer
Principal Advisor
-
Doctor Philosophy
Designing Therapeutic Strategies Targeting KRAS
Associate Advisor
Completed supervision
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2016
Doctor Philosophy
Novel therapeutic targets in breast cancer: From functional validation to therapeutic application
Principal Advisor
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2013
Doctor Philosophy
Understanding the roles of CEP55 and alphaB-Crystallin in Oncogenesis
Principal Advisor
-
-
2010
Doctor Philosophy
Tousled like kinases: phosphorylation and function during the cell cycle
Principal Advisor
-
2008
Doctor Philosophy
The Functional Characterisation of Centrobin in Endocytic Trafficking and Microtubule Dynamics
Principal Advisor
Other advisors: Honorary Professor Nathan Subramaniam, Professor Robert Parton
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2006
Doctor Philosophy
FUNTIONAL CHARACTERISATION OF BCOR-L1, A NOVEL COREPRESSOR PROTEIN
Principal Advisor
-
2024
Doctor Philosophy
Understanding the role and regulation of the FBXL4-BNIP3/NIX pathway in mitophagy
Associate Advisor
Other advisors: Dr Mathew Jones, Dr Melissa Reichelt, Dr Julia Pagan
-
2020
Doctor Philosophy
Role of nucleic acid binding proteins in oocyte development and female fertility
Associate Advisor
Other advisors: Professor Hayden Homer
-
2020
Doctor Philosophy
The Role of Glycan-related Genes Expression in Triple-negative Breast Cancer Pathogenesis
Associate Advisor
-
2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Dr Nick Fletcher, Dr Christopher Howard, Professor Kristofer Thurecht
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2016
Doctor Philosophy
Computational analysis of DNA repair pathways in breast cancer
Associate Advisor
Other advisors: Associate Professor Peter Simpson
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2012
Doctor Philosophy
Various approaches to identify breast cancer susceptibility genes.
Associate Advisor
Other advisors: Professor Grant Montgomery
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2008
Doctor Philosophy
BRCA1 interactors and cancer
Associate Advisor
Other advisors: Honorary Professor Amanda Spurdle
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