Honorary Professor

Kum Kum Khanna

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Availability

Honorary Professor Kum Kum Khanna is:
Available for supervision

Fields of research

Biological Sciences Oncology and carcinogenesis

Search Professor Kum Kum Khanna’s works on UQ eSpace

197 works between 1995 and 2025
All (197) Journal Article (184) Conference Publication (11) Other Outputs (2)

21 - 40 of 197 works

2020

Journal Article

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer

Raninga, Prahlad V., Lee, Andy C., Sinha, Debottam, Shih, Yu-Yin, Mittal, Deepak, Makhale, Ashwini, Bain, Amanda L., Nanayakarra, Devathri, Tonissen, Kathryn F., Kalimutho, Murugan and Khanna, Kum Kum (2020). Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer. International Journal of Cancer, 146 (1), 123-136. doi: 10.1002/ijc.32410

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer

2020

Journal Article

Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma

Sze, Jun Hui, Raninga, Prahlad V., Nakamura, Kyohei, Casey, Mika, Khanna, Kum Kum, Berners-Price, Susan J., Di Trapani, Giovanna and Tonissen, Kathryn F. (2020). Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma. Redox Biology, 28 101310, 1-12. doi: 10.1016/j.redox.2019.101310

Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma

2019

Journal Article

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018)

Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2019). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018). Scientific Reports, 9 18771. doi: 10.1038/s41598-019-55020-1

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018)

2019

Conference Publication

Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer

Raninga, P., Lee, A., Sinha, D., Shin, Y-Y., Mittal, D., Kalimutho, M. and Khanna, K. K. (2019). Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer. 44th Congress of the European-Society-for-Medical-Oncology (ESMO), Barcelona, Spain, 27 September - 1 October 2019. Oxford, United Kingdom: Oxford University Press.

Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer

2019

Journal Article

First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation

Zhou, Chenxi, Hancock, Janelle L., Khanna, Kum Kum and Homer, Hayden A. (2019). First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation. Journal of Cell Science, 132 (18) jcs233379, jcs233379. doi: 10.1242/jcs.233379

First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation

2019

Journal Article

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

Cabrera, Elisa, Raninga, Prahlad, Khanna, Kum Kum and Freire, Raimundo (2019). GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival. Cancers, 11 (8), 1073. doi: 10.3390/cancers11081073

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

2019

Journal Article

Mechanisms of genomic instability in breast cancer

Duijf, Pascal H.G., Nanayakkara, Devathri, Nones, K., Srihari, Sriganesh, Kalimutho, Murugan and Khanna, Kum Kum (2019). Mechanisms of genomic instability in breast cancer. Trends in Molecular Medicine, 25 (7), 595-611. doi: 10.1016/j.molmed.2019.04.004

Mechanisms of genomic instability in breast cancer

2019

Journal Article

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

Nones, K., Johnson, J., Newell, F., Patch, A. M., Thorne, H., Kazakoff, S. H., de Luca, X. M., Parsons, M. T., Ferguson, K., Reid, L. E., McCart Reed, A. E., Srihari, S., Lakis, V., Davidson, A. L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., The Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), The Australian Breast Cancer Tissue Bank (ABCTB), The Brisbane Breast Bank (BBB), Beesley, J., Harris, J. M., Barnes, D., Degasperi, A., Ragan, M. A., Spurdle, A. B., Khanna, K. K. ... Simpson, P. T. (2019). Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. Annals of Oncology, 30 (7) mdz132, 1071-1079. doi: 10.1093/annonc/mdz132

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

2019

Other Outputs

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Sanij, Elaine, Hannan, Katherine M., Yan, Shunfei, Xuan, Jiachen, Ahern, Jessica E., Chan, Keefe T., Son, Jinbae, Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Trigos, Anna S., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M.J.J., Hannan, Ross D, Scott, Clare L., Sheppard, Karen E and Pearson, Richard B (2019). Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer. doi: 10.1101/621623

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

2019

Journal Article

Patterns of genomic instability in breast cancer

Kalimutho, Murugan, Nones, Katia, Srihari, Sriganesh, Duijf, Pascal H.G., Waddell, Nicola and Khanna, Kum Kum (2019). Patterns of genomic instability in breast cancer. Trends in Pharmacological Sciences, 40 (3), 198-211. doi: 10.1016/j.tips.2019.01.005

Patterns of genomic instability in breast cancer

2019

Journal Article

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Kalimutho, Murugan, Sinha, Debottam, Mittal, Deepak, Srihari, Sriganesh, Nanayakkara, Devathri, Shafique, Shagufta, Raninga, Prahlad, Nag, Purba, Parsons, Kate and Khanna, Kum Kum (2019). Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. Journal of Experimental and Clinical Cancer Research, 38 (1) 85, 1-18. doi: 10.1186/s13046-019-1075-5

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

2018

Journal Article

RNA interference to enhance radiation therapy: targeting the DNA damage response

Ratnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018). RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439, 14-23. doi: 10.1016/j.canlet.2018.09.011

RNA interference to enhance radiation therapy: targeting the DNA damage response

2018

Journal Article

RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination

Harris, Janelle Louise, Rabellino, Andrea and Khanna, Kum Kum (2018). RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination. Annals of Translational Medicine, 6 S122. doi: 10.21037/atm.2018.12.30

RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination

2018

Journal Article

Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy

Prasanna, Thiru, Wu, Fan, Khanna, Kum Kum, Yip, Desmond, Malik, Laeeq, Dahlstrom, Jane E. and Rao, Sudha (2018). Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy. Cancer Science, 109 (11), 3383-3392. doi: 10.1111/cas.13799

Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy

2018

Journal Article

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566. doi: 10.15252/emmm.201708566

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

2018

Conference Publication

CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo

Sinha, D., Kalimutho, M., Bain, A.L. and Khanna, K.K. (2018). CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo. 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, Netherlands, 30 June – 3 July 2018. London, United Kingdom: Elsevier. doi: 10.1136/esmoopen-2018-eacr25.730

CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo

2018

Journal Article

The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking

Harris, Janelle L., Dave, Keyur, Gorman, Jeffrey and Khanna, Kum Kum (2018). The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. International Journal of Biochemistry & Cell Biology, 99, 28-37. doi: 10.1016/j.biocel.2018.03.002

The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking

2018

Journal Article

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M., O'Bryan, Moira K. and Khanna, Kum Kum (2018). Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 (9), 4984-4999. doi: 10.1096/fj.201701096RR

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

2018

Journal Article

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

Johnson, Julie, Bessette, Darrell C., Saunus, Jodi M., Smart, Chanel E., Song, Sarah, Johnston, Rebecca L., Cocciardi, Sibylle, Rozali, Esdy N., Johnstone, Cameron N., Vargas, Ana Christina, Kazakoff, Stephen H., BioBank, Victorian Cancer, Khanna, Kum Kum, Lakhani, Sunil R., Chenevix-Trench, Georgia, Simpson, Peter T., Nones, Katia, Waddell, Nicola and Al-Ejeh, Fares (2018). Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Research and Treatment, 170 (1), 179-188. doi: 10.1007/s10549-018-4719-9

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

2018

Journal Article

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2018). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Scientific Reports, 8 (1) 73. doi: 10.1038/s41598-017-17913-x

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

Current funding

  • 2024 - 2025
    Targeting the redox niche in triple-negative breast cancer to treat brain metastases
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant
  • 2024 - 2027
    Targeting metstatic breast cancer by oligonucleotide therapeutics with the FDA lipid nanoparticles (LNP) delivery system.
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant
  • 2022 - 2025
    Targeting CEP55 in Triple-Negative Breast Cancer (US DoD CDMRP grant administered by QIMR)
    Queensland Institute of Medical Research
    Open grant

Past funding

  • 2024
    Exploitation of immunogenicity of Cep 55 to enhance efficacy of therapy for triple-negative breast cancer
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant

Availability

Honorary Professor Kum Kum Khanna is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Optimising systemic therapies of metastatic and recurrent triple-negative breast cancer using next generation 3D models

    Principal Advisor

  • Doctor Philosophy

    Understanding novel regulators of mitosis and their implication in cancer

    Principal Advisor

  • Doctor Philosophy

    Understanding novel regulators of mitosis and their implication in cancer

    Principal Advisor

  • Doctor Philosophy

    Functional validation of therapeutic targets for basal breast cancer

    Principal Advisor

  • Doctor Philosophy

    Optimising systemic therapies of metastatic and recurrent triple-negative breast cancer using next generation 3D models

    Principal Advisor

  • Doctor Philosophy

    Investigating the diagnostic and functional significance of specific epigenomic features in triple-negative breast cancer (TNBC)

    Associate Advisor

    Other advisors: Dr Jodi Saunus

  • Doctor Philosophy

    Breaking barriers: unlocking the potential of cytomegalovirus-specific T cells in allogeneic CAR T cell therapies

    Associate Advisor

  • Doctor Philosophy

    Designing Therapeutic Strategies Targeting KRAS

    Associate Advisor

Completed supervision

Enquiries

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