Overview
Availability
- Honorary Professor Kum Kum Khanna is:
- Available for supervision
Fields of research
Works
Search Professor Kum Kum Khanna’s works on UQ eSpace
2015
Conference Publication
The adaptor protein ASC controls transplantation outcomes independently of the inflammasome
Cheong, Melody, Gartlan, Kate, Tey, Siok-Keen, Kuns, Rachel, Lor, Mary, Lineburg, Katie, Tea, Bianca, Shi, Wei, Raju, Jyothy, Zhang, Ping, Varelias, Antiopi, Leveque-El Mouttie, Lucie, Olver, Stuart, Bunting, Mark, Lane, Steven, Boyle, Glen, Ting, Jenny, Schroder, Kate, Engwerda, Christian, Khanna, Kum Kum, Smyth, Mark, MacDonald, Kelli, Koyama, Motoko and Hill, Geoffrey (2015). The adaptor protein ASC controls transplantation outcomes independently of the inflammasome. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), New Orleans La, May 08-12, 2015. BETHESDA: AMER ASSOC IMMUNOLOGISTS.
2015
Journal Article
Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis
Jeffery, J., Sinha, D., Srihari, S., Kalimutho, M. and Khanna, K. K. (2015). Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene, 35 (6), 683-690. doi: 10.1038/onc.2015.128
2015
Journal Article
The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin
Kalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G. and Soutoglou, Evi (2015). The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin. Cell Reports, 11 (1), 149-163. doi: 10.1016/j.celrep.2015.03.005
2015
Journal Article
The Integrator complex controls the termination of transcription at diverse classes of gene targets
Skaar, Jeffrey R., Ferris, Andrea L., Wu, Xiaolin, Saraf, Anita, Khanna, Kum Kum, Florens, Laurence, Washburn, Michael P., Hughes, Stephen H. and Pagano, Michele (2015). The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Research, 25 (3), 288-305. doi: 10.1038/cr.2015.19
2015
Journal Article
Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
Pandita, Raj K., Chow, Tracy T., Udayakumar, Durga, Bain, Amanda L., Cubeddu, Liza, Hunt, Clayton R., Shi, Wei, Horikoshi, Nobuo, Zhao, Yong, Wright, Woodring E., Khanna, Kum Kum, Shay, Jerry W. and Pandita, Tej K. (2015). Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research, 75 (5), 858-869. doi: 10.1158/0008-5472.CAN-14-2289
2015
Journal Article
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines
Momeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846
2015
Conference Publication
Genomic and transcriptomic landscapes of human brain metastases
Saunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Cloonan, N., Nones, K., Miller, D., Mariasegaram, M., Lau, Q., Jeffree, L., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. and Lakhani, S. R. (2015). Genomic and transcriptomic landscapes of human brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3
2015
Journal Article
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1
Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754
2014
Journal Article
Complex-based analysis of dysregulated cellular processes in cancer
Srihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014). Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 (Supplement 4) S1. doi: 10.1186/1752-0509-8-S4-S1
2014
Journal Article
SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replication
Johansson, Pegah, Jeffery, Jessie, Al-Ejeh, Fares, Schulz, Renèe B., Callen, David F., Kumar, Raman and Khanna, Kum Kum (2014). SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replication. Journal of Biological Chemistry, 289 (26), 18514-18525. doi: 10.1074/jbc.M114.559930
2014
Journal Article
Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma
Al-Ejeh, Fares, Pajic, Marina, Shi, Wei, Kalimutho, Murugan, Miranda, Mariska, Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Grimmond, Sean M., Brown, Michael P. and Khanna, Kum Kum (2014). Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma. Clinical Cancer Research, 20 (12), 3187-3197. doi: 10.1158/1078-0432.CCR-14-0048
2014
Journal Article
Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
Bolderson, Emma, Petermann, Eva, Croft, Laura, Suraweera, Amila, Pandita, Raj K., Pandita, Tej K., Helleday, Thomas, Khanna, Kum Kum and Richard, Derek J. (2014). Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42 (10), 6326-6336. doi: 10.1093/nar/gku276
2014
Journal Article
A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy
Liu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014). A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 (10), 6106-6127. doi: 10.1093/nar/gku284
2014
Journal Article
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer
Al-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. and Khanna, K. K. (2014). Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 (4) e100, 1-12. doi: 10.1038/oncsis.2014.14
2014
Journal Article
Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice
Tomimatsu, Nozomi, Mukherjee, Bipasha, Catherine Hardebeck, Molly, Ilcheva, Mariya, Vanessa Camacho, Cristel, Louise Harris, Janelle, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum K.um and Burma, Sandeep (2014). Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nature communications, 5 3561. doi: 10.1038/ncomms4561
2014
Journal Article
Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells
Speckmann, Bodo, Gerloff, Kirsten, Simms, Lisa, Oancea, Iulia, Shi, Wei, McGuckin, Michael A., Radford-Smith, Graham and Khanna, Kum Kum (2014). Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radical Biology and Medicine, 67, 265-277. doi: 10.1016/j.freeradbiomed.2013.11.001
2014
Journal Article
Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer
Al-Ejeh, Fares, Miranda, Mariska, Shi,Wei, Simpson, Peter T., Song, Sarah, Vargas, Ana Cristina, Saunus, Jodi M., Smart, Chanel E., Mariasegaram, Mythily, Wiegmans, Adrian P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2014). Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget, 5 (10), 3145-3158. doi: 10.18632/oncotarget.1865
2014
Journal Article
Rad51 supports triple negative breast cancer metastasis
Wiegmans, Adrian P., Al-Ejeh, Fares, Chee, Nicole, Yap, Pei-Yi, Gorski, Julia J., Da Silva, Leonard, Bolderson, Emma, Chenevix-Trench, Georgia, Anderson, Robin, Simpson, Peter T., Lakhani, Sunil R. and Khanna, Kum Kum (2014). Rad51 supports triple negative breast cancer metastasis. Oncotarget, 5 (10), 3261-3272. doi: 10.18632/oncotarget.1923
2013
Journal Article
Tumor protein D52 represents a negative regulator of ATM protein levels
Chen, Yuyan, Kamili, Alvin, Hardy, Jayne R., Groblewski, Guy E., Khanna, Kum Kum and Byrne, Jennifer A. (2013). Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle, 12 (18), 3083-3097. doi: 10.4161/cc.26146
2013
Journal Article
Mouse models uncap novel roles of SSBs
Bain, Amanda L., Shi, Wei and Khanna, Kum Kum (2013). Mouse models uncap novel roles of SSBs. Cell Research, 23 (6), 744-745. doi: 10.1038/cr.2013.63
Funding
Current funding
Supervision
Availability
- Honorary Professor Kum Kum Khanna is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Functional validation of therapeutic targets for basal breast cancer
Principal Advisor
-
Doctor Philosophy
Understanding novel regulators of mitosis and their implication in cancer
Principal Advisor
-
Doctor Philosophy
Designing Therapeutic Strategies Targeting KRAS
Associate Advisor
Completed supervision
-
2016
Doctor Philosophy
Novel therapeutic targets in breast cancer: From functional validation to therapeutic application
Principal Advisor
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2013
Doctor Philosophy
Understanding the roles of CEP55 and alphaB-Crystallin in Oncogenesis
Principal Advisor
-
-
2010
Doctor Philosophy
Tousled like kinases: phosphorylation and function during the cell cycle
Principal Advisor
-
2008
Doctor Philosophy
The Functional Characterisation of Centrobin in Endocytic Trafficking and Microtubule Dynamics
Principal Advisor
Other advisors: Honorary Professor Nathan Subramaniam, Professor Robert Parton
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2006
Doctor Philosophy
FUNTIONAL CHARACTERISATION OF BCOR-L1, A NOVEL COREPRESSOR PROTEIN
Principal Advisor
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2024
Doctor Philosophy
Understanding the role and regulation of the FBXL4-BNIP3/NIX pathway in mitophagy
Associate Advisor
Other advisors: Dr Mathew Jones, Dr Melissa Reichelt, Dr Julia Pagan
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2020
Doctor Philosophy
Role of nucleic acid binding proteins in oocyte development and female fertility
Associate Advisor
Other advisors: Professor Hayden Homer
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2020
Doctor Philosophy
The Role of Glycan-related Genes Expression in Triple-negative Breast Cancer Pathogenesis
Associate Advisor
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2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Dr Nick Fletcher, Dr Christopher Howard, Professor Kristofer Thurecht
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2016
Doctor Philosophy
Computational analysis of DNA repair pathways in breast cancer
Associate Advisor
Other advisors: Associate Professor Peter Simpson
-
2012
Doctor Philosophy
Various approaches to identify breast cancer susceptibility genes.
Associate Advisor
Other advisors: Professor Grant Montgomery
-
2008
Doctor Philosophy
BRCA1 interactors and cancer
Associate Advisor
Other advisors: Honorary Professor Amanda Spurdle
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