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2020

Journal Article

Tissue-type plasminogen activator and tenecteplase-mediated increase in blood brain barrier permeability involves cell intrinsic complement

Keragala, Charithani B., Woodruff, Trent M., Liu, Zikou, Niego, Be'eri, Ho, Heidi, McQuilten, Zoe and Medcalf, Robert L. (2020). Tissue-type plasminogen activator and tenecteplase-mediated increase in blood brain barrier permeability involves cell intrinsic complement. Frontiers in Neurology, 11 577272, 1-12. doi: 10.3389/fneur.2020.577272

Tissue-type plasminogen activator and tenecteplase-mediated increase in blood brain barrier permeability involves cell intrinsic complement

2020

Journal Article

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xiang X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2020). Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). doi: 10.2218/gtopdb/f5/2020.5

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

2020

Journal Article

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?

Lee, John D., Taylor, Stephen M. and Woodruff, Trent M. (2020). Is the C3a receptor antagonist SB290157 a useful pharmacological tool?. British Journal of Pharmacology, 177 (24) bph.15264, 5677-5678. doi: 10.1111/bph.15264

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?

2020

Journal Article

Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor

Schofield, Zoe, Wu, Mike C. L., Hansbro, Philip M., Cooper, Matthew A. and Woodruff, Trent M. (2020). Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor. The FASEB Journal, 34 (8), 10418-10430. doi: 10.1096/fj.202000960R

Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor

2020

Journal Article

A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry, 158 (3) jnc.15119, 807-817. doi: 10.1111/jnc.15119

A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

2020

Journal Article

COVID-19: Complement, coagulation, and collateral damage

Lo, Martin W., Kemper, Claudia and Woodruff, Trent M. (2020). COVID-19: Complement, coagulation, and collateral damage. The Journal of Immunology, 205 (6), ji2000644-1495. doi: 10.4049/jimmunol.2000644

COVID-19: Complement, coagulation, and collateral damage

2020

Journal Article

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Lee, John D., McDonald, Tanya S., Fung, Jenny N. T. and Woodruff, Trent M. (2020). Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 57 (10), 4143-4155. doi: 10.1007/s12035-020-02019-9

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis

2020

Journal Article

Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation

Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291

Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation

2020

Journal Article

Emerging insights into the structure and function of complement C5a receptors

Pandey, Shubhi, Maharana, Jagannath, Li, Xaria X., Woodruff, Trent M. and Shukla, Arun K. (2020). Emerging insights into the structure and function of complement C5a receptors. Trends in Biochemical Sciences, 45 (8), 693-705. doi: 10.1016/j.tibs.2020.04.004

Emerging insights into the structure and function of complement C5a receptors

2020

Conference Publication

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

West, Erin E., Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Mogensen, Trine Hyrup, Woodruff, Trent M., Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollnes, Tom Eirik, Christiansen, Mette and Kemper, Claudia (2020). T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.150.23

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

2020

Journal Article

The peripheral immune system and amyotrophic lateral sclerosis

McCombe, Pamela A., Lee, John D., Woodruff, Trent M. and Henderson, Robert D. (2020). The peripheral immune system and amyotrophic lateral sclerosis. Frontiers in Neurology, 11 279, 279. doi: 10.3389/fneur.2020.00279

The peripheral immune system and amyotrophic lateral sclerosis

2020

Journal Article

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

McDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

2020

Journal Article

Complement: bridging the innate and adaptive immune systems in sterile inflammation

Lo, Martin W. and Woodruff, Trent M. (2020). Complement: bridging the innate and adaptive immune systems in sterile inflammation. Journal of Leukocyte Biology, 108 (1) JLB.3MIR0220-270R, 339-351. doi: 10.1002/jlb.3mir0220-270r

Complement: bridging the innate and adaptive immune systems in sterile inflammation

2020

Journal Article

Low-fouling fluoropolymers for bioconjugation and in vivo tracking

Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah, Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent, Kent, Stephen, Searles, Debra and Whittaker, Andrew (2020). Low-fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie International Edition, 59 (12), 4729-4735. doi: 10.1002/anie.201914119

Low-fouling fluoropolymers for bioconjugation and in vivo tracking

2020

Journal Article

Editorial: The Role of Complement in Tumors

Rolfe, Barbara E., Pio, Ruben, Woodruff, Trent M., Markiewski, Maciej M. and Manthey, Helga D. (2020). Editorial: The Role of Complement in Tumors. Frontiers in Immunology, 11 139, 139. doi: 10.3389/fimmu.2020.00139

Editorial: The Role of Complement in Tumors

2020

Journal Article

Low‐fouling fluoropolymers for bioconjugation and in vivo tracking

Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah G., Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent M., Kent, Stephen J., Searles, Debra J. and Whittaker, Andrew K. (2020). Low‐fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie, 132 (12), 4759-4765. doi: 10.1002/ange.201914119

Low‐fouling fluoropolymers for bioconjugation and in vivo tracking

2020

Journal Article

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Deora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

2020

Journal Article

Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice

Kumar, Vinod, Lee, John D., Clark, Richard J., Noakes, Peter G., Taylor, Stephen M. and Woodruff, Trent M. (2020). Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice. ACS Omega, 5 (5) acsomega.9b03735, 2345-2354. doi: 10.1021/acsomega.9b03735

Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice

2020

Journal Article

Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

Arbore, Giuseppina, Ong, Voon H., Costantini, Benedetta, Denton, Christopher P., Abraham, David, Placais, Leo, Blighe, Kevin, Mitchell, Lynne, Ellis, Richard, Heck, Susanne, Nocerino, Paola, Woodruff, Trent M., Kordasti, Shahram, Kemper, Claudia and Hourcade, Dennis E. (2020). Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis. Cellular & Molecular Immunology, 17 (9), 1010-1013. doi: 10.1038/s41423-019-0360-8

Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

2020

Conference Publication

Increased complement component 5a signalling drives severe asthma pathogenesis

Kim, R., Brown, A., Carroll, O., Hsu, A., Baines, K., Pathinayake, P., Kemper, C., Woodruff, T., Adcock,, Gibson, P., Wark, P., Horvat, J. and Hansbro, P. (2020). Increased complement component 5a signalling drives severe asthma pathogenesis. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health and Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777

Increased complement component 5a signalling drives severe asthma pathogenesis