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2019 Journal Article Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibodyGulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B., Shaughnessy, Jutamas, Nowak, Nancy A., Taylor, Ronald P., Botto, Marina, He, Xianbao, Ingalls, Robin R., Woodruff, Trent M., Song, Wen-Chao, Schuurman, Janine, Rice, Peter A. and Ram, Sanjay (2019). Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody. PLoS Biology, 17 (6) e3000323, e3000323. doi: 10.1371/journal.pbio.3000323 |
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2019 Journal Article The complement receptor C5aR2: a powerful modulator of innate and adaptive immunityLi, Xaria X., Lee, John D., Kemper, Claudia and Woodruff, Trent M. (2019). The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity. Journal of Immunology, 202 (12), 3339-3348. doi: 10.4049/jimmunol.1900371 |
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2019 Journal Article Gut microbiota in ALS: possible role in pathogenesis?McCombe, Pamela A., Henderson, Robert D., Lee, Aven, Lee, John D., Woodruff, Trent M., Restuadi, Restuadi, McRae, Allan, Wray, Naomi R., Ngo, Shyuan and Steyn, Frederik J. (2019). Gut microbiota in ALS: possible role in pathogenesis?. Expert Review of Neurotherapeutics, 19 (9), 1-21. doi: 10.1080/14737175.2019.1623026 |
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2019 Journal Article Deletion of biliverdin reductase A in myeloid cells promotes chemokine expression and chemotaxis in part via a complement C5a–C5aR1 pathwayBisht, Kavita, Canesin, Giacomo, Cheytan, Tasneem, Li, Mailin, Nemeth, Zsuzsanna, Csizmadia, Eva, Woodruff, Trent M., Stec, David E., Bulmer, Andrew C., Otterbein, Leo E. and Wegiel, Barbara (2019). Deletion of biliverdin reductase A in myeloid cells promotes chemokine expression and chemotaxis in part via a complement C5a–C5aR1 pathway. The Journal of Immunology, 202 (10), ji1701443-2990. doi: 10.4049/jimmunol.1701443 |
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2019 Journal Article Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254 |
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2019 Journal Article Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1Pandey, Shubhi, Li, Xaria X., Srivastava, Ashish, Baidya, Mithu, Kumari, Punita, Dwivedi, Hemlata, Chaturvedi, Madhu, Ghosh, Eshan, Woodruff, Trent M. and Shukla, Arun K. (2019). Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1. Journal of Biological Chemistry, 294 (24), jbc.RA119.007485-9429. doi: 10.1074/jbc.ra119.007485 |
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2019 Journal Article Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4Landsem, A., Fure, H., Krey Ludviksen, J., Christiansen, D., Lau, C., Mathisen, M., Bergseth, G., Nymo, S., Lappegård, K. T., Woodruff, T. M., Espevik, T., Mollnes, T. E. and Brekke, O. L. (2019). Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4. Clinical and Experimental Immunology, 196 (1), 97-110. doi: 10.1111/cei.13240 |
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2019 Journal Article Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Liu, Ning, Levin, Samantha C., Ottosson, Lars, Andersson, Ulf, Harris, Helena E. and Woodruff, Trent M. (2019). Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 16 (1) 45, 45. doi: 10.1186/s12974-019-1435-2 |
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2019 Conference Publication Complement Inhibition: A Possible Therapeutic Strategy For Controlling Cobra EnvenomationSilva-de-Franca, Felipe, Villas-Boas, Isadora, Cogliati, Bruno, Woodruff, Trent, da-Silva-Reis, Edimara, Lambris, John and Tambourgi, Denise (2019). Complement Inhibition: A Possible Therapeutic Strategy For Controlling Cobra Envenomation. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom: Elsevier . |
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2019 Conference Publication Bacterial-induced il-8 release is dependent on c5a-05ar1 and thrombin-dependent activation of platelets in human whole bloodQuang Huy Quach,, Johnson, Christina, Lau, Corinna, Woodruff, Trent M., Pischke, Soren E., Mollnes, Tom Eirik and Nilsson, Per H. (2019). Bacterial-induced il-8 release is dependent on c5a-05ar1 and thrombin-dependent activation of platelets in human whole blood. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom: Elsevier . |
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2019 Conference Publication Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibodyBeurskens, Frank, de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane, Shaughnessy, Jutamas, Taylors, Ronald, Botto, Marina, He, Xianbao, Ingalls, Robin, Woodruff, Trent, Song, Wen-Chao, Schuurman, Janine, Rice, Peter and Ram, Sanjay (2019). Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibody. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom: Elsevier . |
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2019 Conference Publication Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanomaNabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany: Wiley. |
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2019 Conference Publication Deciphering key roles for complement peptide receptors in brain developmentWoodruff, T., Hawksworth, O., Lee, J. and Coulthard, L. (2019). Deciphering key roles for complement peptide receptors in brain development. Joint Meeting of the International Society for Neurochemistry and American Society for Neurochemistry (ISN-ASN), Montreal, Canada, 4-8 August 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. |
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2019 Conference Publication Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogrammingCoughlan, M. T., Tan, S., Ziemann, M., Snelson, M., El-Osta, A., MacIsaac, R. J., Meikle, P. J., Forbes, J. M., Cooper, M. E., Ekinci, E. I. and Woodruff, T. M. (2019). Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming. 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona Spain, 16-20 September 2019. Heidelberg, Germany: Springer. |
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2018 Journal Article C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliteransVerghese, Divya A., Chun, Nicholas, Paz, Katelyn, Fribourg, Miguel, Woodruff, Trent M., Flynn, Ryan, Hu, Yuan, Xiong, Huabao, Zhang, Weijia, Yi, Zhengzi, Du, Jing, Blazar, Bruce R. and Heeger, Peter S. (2018). C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans. JCI Insight, 3 (24). doi: 10.1172/jci.insight.124646 |
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2018 Journal Article Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signallingSchofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M. and Cooper, Matthew A. (2018). Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Scientific Reports, 8 (1) 17819, 17819. doi: 10.1038/s41598-018-36242-1 |
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2018 Conference Publication The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal diseaseMuenstermann, Marcel, Herrmann, Johannes, Strobel, Lea, Woodruff, Trent, Klos, Andreas, Wetsel, Rick, Gerard, Craig, Koehl, Joerg and Johswich, Kay Ole (2018). The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal disease. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.109 |
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2018 Conference Publication Complement activation contributes to the pathogenesis of African cobra envenomationSilva-de-Franca, Felipe, Villas-Boas, Isadora, Cogliati, Bruno, Woodruff, Trent and Tambourgi, Denise (2018). Complement activation contributes to the pathogenesis of African cobra envenomation. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.220 |
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2018 Conference Publication Mass cytometry analysis detects dysregulated T cell complement responses in scleroderma patientsOng, Voon, Arbore, Giuseppina, Costantini, Benedetta, Abrahams, David, Denton, Christopher, Placais, Leo, Mitchell, Lynne, Ellis, Richard, Heck, Susanne, Woodruff, Trent, Kordasti, Shahram, Kemper, Claudia and Hourcade, Dennis (2018). Mass cytometry analysis detects dysregulated T cell complement responses in scleroderma patients. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.098 |
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2018 Journal Article Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performanceCoulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271 |
