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2018 Journal Article Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performanceCoulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271 |
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2018 Journal Article New tricks for an ancient system: physiological and pathological roles of complement in the CNSTenner, Andrea J., Stevens, Beth and Woodruff, Trent M. (2018). New tricks for an ancient system: physiological and pathological roles of complement in the CNS. Molecular Immunology, 102, 3-13. doi: 10.1016/j.molimm.2018.06.264 |
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Featured 2018 Journal Article Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosisLee, John D., Levin, Samantha C., Willis, Emily F., Li, Rui, Woodruff, Trent M. and Noakes, Peter G. (2018). Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 15 (1) 171, 171. doi: 10.1186/s12974-018-1217-2 |
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2018 Journal Article Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4 |
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2018 Journal Article Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitisMichailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen P., Georgakopoulou, Theodosia, de Wissel, Marit B., Wolterman, Ruud A., Ruizendaal, Patrick, Klar-Mohamad, Ngaisah, Grootemaat, Anita E., Picavet, Daisy I., Kumar, Vinod, van Kooten, Cees, Woodruff, Trent M., Morgan, B. Paul, van der Wel, Nicole N., Ramaglia, Valeria, Fluiter, Kees and Baas, Frank (2018). Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications, 6 (1) 36, 36. doi: 10.1186/s40478-018-0536-y |
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2018 Journal Article T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survivalA. Verghese, Divya, Demir, Markus, Chun, Nicholas, Fribourg, Miguel, Cravedi, Paolo, Llaudo, Ines, Woodruff, Trent M., Yadav, Pragya, Lira, Sergio A., Medof, M. Edward and Heeger, Peter S. (2018). T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survival. Journal of Immunology, 200 (6), 2186-2198. doi: 10.4049/jimmunol.1701638 |
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2018 Journal Article Complement in stem cells and developmentHawksworth, Owen A., Coulthard, Liam G., Mantovani, Susanna and Woodruff, Trent M (2018). Complement in stem cells and development. Seminars in Immunology, 37 (C), 74-84. doi: 10.1016/j.smim.2018.02.009 |
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2018 Journal Article Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviourGiacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092 |
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2018 Journal Article Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulationSkjeflo, E. W., Christiansen, D., Fure, H., Ludviksen, J. K., Woodruff, T. M., Espevik, Terje, Nielsen, E. W., Brekke, O. L. and Mollnes, T. E. (2018). Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation. Journal of Thrombosis and Haemostasis, 16 (5), 905-918. doi: 10.1111/jth.13979 |
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2018 Journal Article Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced painMorgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016 |
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2018 Journal Article Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease TreatmentHerrmann, Johannes B., Muenstermann, Marcel, Strobel, Lea, Schubert-Unkmeir, Alexandra, Woodruff, Trent M., Gray-Owen, Scott D., Klos, Andreas and Johswich, Kay O. (2018). Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment. mBio, 9 (1) e01755-17, 1-17. doi: 10.1128/mBio.01755-17 |
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2018 Book Chapter C3aR1Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C3aR1. The complement FactsBook. (pp. 385-396) edited by Scott Barnum and Theresa Schein. London, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-810420-0.00036-5 |
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2018 Book Chapter C5aR2Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C5aR2. The complement FactsBook. (pp. 407-414) edited by Scott Barnum and Theresa Schein. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810420-0.00038-9 |
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2018 Conference Publication C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activationGordon, Richard, Albornoz, Eduardo, Kanthasamy, Anumantha and Woodruff, Trent (2018). C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, Sep 16-20, 2018. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2018.06.247 |
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2018 Book Chapter Inflammasomes in CNS diseasesAlbornoz, Eduardo A., Woodruff, Trent M. and Gordon, Richard (2018). Inflammasomes in CNS diseases. Inflammasomes: clinical and therapeutic implications. (pp. 41-60) edited by Mario D. Cordero and Elisabet Alcocer-Gómez. Cham, Switzerland: Springer International. doi: 10.1007/978-3-319-89390-7_3 |
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2018 Conference Publication Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulationWest, Erin E., Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Peter N. and Kemper, Claudia (2018). Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, 16-20 September 2018. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2018.06.246 |
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2018 Book Chapter C5aR1Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C5aR1. The Complement FactsBook. (pp. 397-405) edited by Scott Barnum and Theresa Schein. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810420-0.00037-7 |
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2017 Journal Article C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritisDick, Jonathan, Gan, Poh-Yi, Ford, Sharon L., Odobasic, Dragana, Alikhan, Maliha A., Loosen, Sven H., Hall, Pam, Westhorpe, Clare L., Li, Anqi, Ooi, Joshua D., Woodruff, Trent M., Mackay, Charles R., Kitching, A Richard, Hickey, Michael J. and Holdsworth, Stephen R. (2017). C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis. Kidney International, 93 (3), 615-625. doi: 10.1016/j.kint.2017.09.018 |
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2017 Journal Article The concise guide to pharmacology 2017/18: OverviewAlexander, Stephen P. H., Kelly, Eamonn, Marrion, Neil V., Peters, John A., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Buneman, O. Peter, Cidlowski, John A., Christopoulos, Arthur, Davenport, Anthony P., Fabbro, Doriano, Spedding, Michael, Striessnig, Jorg, Davies, Jamie A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K., Arumugam, T., V, Attali, B., Back, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M. ... Woodruff, Trent (2017). The concise guide to pharmacology 2017/18: Overview. British Journal of Pharmacology, 174, S1-S16. doi: 10.1111/bph.13882/full |
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2017 Journal Article Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouseKarsten, Christian M., Wiese, Anna V., Mey, Fabian, Figge, Julia, Woodruff, Trent M., Reuter, Tom, Scurtu, Olga, Kordowski, Anna, Almeida, Larissa N., Briukhovetska, Daria, Quell, Katharina M., Sun, Jing, Ender, Fanny, Schmudde, Inken, Vollbrandt, Tillman, Laumonnier, Yves and Köhl, Jörg (2017). Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouse. Journal of Immunology, 199 (9), 3234-3248. doi: 10.4049/jimmunol.1700710 |
