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2017 Conference Publication Targeting the C5a-C5aR1 signalling axis in diabetic kidney diseaseCoughlan, M. T., Tan, S. M., Ekinci, E. I., Snelson, M., Penfold, S. A., Higgins, G. C., Lindblom, R. S., Sourris, K. C., Thallas-Bonke, V., Jerums, G., Skene, A., Power, D. A., MacIsaac, R. J., Cooper, M. E. and Woodruff, T. M. (2017). Targeting the C5a-C5aR1 signalling axis in diabetic kidney disease. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, Sep 11-15, 2017. NEW YORK: SPRINGER. |
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2017 Journal Article New concepts on the therapeutic control of complement anaphylatoxin receptorsHawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015 |
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2017 Journal Article Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammationChen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4 |
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2017 Journal Article The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microgliaDeora, Vandana, Albornoz, Eduardo A., Zhu, Kevin, Woodruff, Trent M. and Gordon, Richard (2017). The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia. Journal of Neuroimmune Pharmacology, 12 (4), 1-7. doi: 10.1007/s11481-017-9754-5 |
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2017 Journal Article Serping1/C1 inhibitor affects cortical development in a cell autonomous and non-cell autonomous mannerGorelik, Anna, Sapir, Tamar, Woodruff, Trent M. and Reiner, Orly (2017). Serping1/C1 inhibitor affects cortical development in a cell autonomous and non-cell autonomous manner. Frontiers in Cellular Neuroscience, 11 169. doi: 10.3389/fncel.2017.00169 |
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2017 Journal Article Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosisWang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M. and Noakes, Peter G. (2017). Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Skeletal Muscle, 7 (1) 10, 10. doi: 10.1186/s13395-017-0128-8 |
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2017 Journal Article Developmental activities of the complement pathway in migrating neuronsGorelik, Anna , Sapir, Tamar , Haffner-Krausz, Rebecca , Olender, Tsviya , Woodruff, Trent M. and Reiner, Orly (2017). Developmental activities of the complement pathway in migrating neurons. Nature Communications, 8 (1) 15096, 15096 .1-15096 .12. doi: 10.1038/ncomms15096 |
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2017 Journal Article The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injuryBiggins, Patrick, Brennan, Faith, Taylor, Stephen, Woodruff, Trent and Ruitenberg, Marc (2017). The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injury. Journal of Neurotrauma, 34 (12), 2075-2085. doi: 10.1089/neu.2016.4701 |
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2017 Journal Article Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanismJain, U., Midgen, C. A., Woodruff, T. M., Schwaeble, W. J., Stover, C. M. and Stadnyk, A. W. (2017). Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism. Clinical and Experimental Immunology, 188 (1), 36-44. doi: 10.1111/cei.12922 |
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2017 Journal Article Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring systemSpiers, Jereme G., Chen, Hsiao-Jou Cortina, Steyn, Frederik J., Lavidis, Nickolas A., Woodruff, Trent M. and Lee, John D. (2017). Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system. Stress, 20 (1), 59-67. doi: 10.1080/10253890.2016.1276898 |
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2017 Conference Publication Combined C5aR1 and CD14 inhibition significantly reduced cytokine release induced by both viable and heat inactivated bacteria in human whole bloodChristiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Fure, Hilde, Ludviksen, Judith K., Stenvik, Jurgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2017). Combined C5aR1 and CD14 inhibition significantly reduced cytokine release induced by both viable and heat inactivated bacteria in human whole blood. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, Sep 08-12, 2017. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2017.06.147 |
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2017 Book Chapter Neuroinflammation as a therapeutic target in neurodegenerative diseasesGordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders. (pp. 43-64) edited by Veerle Baekelandt and Evy Lobbestael. Boston, MA, United States: Academic Press (Elsevier Press). |
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2017 Conference Publication Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in miceMagalhaes, Ricardo J. Soares, Giacomin, Paul, Sarnyay, Zoltan, Kraeuter, Ann, Urich, Tim, Bengtsson, Mia, Jin, Shuting, Albornoz, Eduardo A., Gordon, Richard and Woodruff, Trent (2017). Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in mice. 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta, GA, United States, 13-16 November 2016. Deerfield, United States: American Society of Tropical Medicine and Hygiene. |
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2017 Conference Publication Motor neuron disease proteins activate complement and generate C5aDeora, Vandana, Mantovani, Susanna, Yerbury, Justin, Clark, Richard, Atkin, Julie, Lee, John, Gordon, Richard and Woodruff, Trent M. (2017). Motor neuron disease proteins activate complement and generate C5a. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen, Denmark, 8-12 September 2017. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.144 |
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2017 Book Chapter Neuroinflammation as a therapeutic target in neurodegenerative diseasesGordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders: paving the way for disease-modifying therapies. (pp. 49-80) edited by Veerle Baekelandt and Evy Lobbestael. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-805120-7.00003-8 |
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2017 Conference Publication Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brainWoodruff, Trent M., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Leel, John D., Sepehrband', Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Coulthard, Liam G. (2017). Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, 8-12 September 2017. Kidlington, Oxford United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.178 |
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2016 Journal Article Complement in the fundamental processes of the cellHawksworth, Owen A., Coulthard, Liam G. and Woodruff, Trent M. (2016). Complement in the fundamental processes of the cell. Molecular Immunology, 84, 17-25. doi: 10.1016/j.molimm.2016.11.010 |
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2016 Journal Article Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degenerationGordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 7 (1) 12932, 12932.1-12932.18. doi: 10.1038/ncomms12932 |
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2016 Journal Article Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signallingCroker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43 |
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2016 Journal Article Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer compositionZhang, Jing, Woodruff, Trent M., Clark, Richard J., Martin, Darren J. and Minchin, Rodney F. (2016). Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition. Acta Biomaterialia, 41, 264-272. doi: 10.1016/j.actbio.2016.05.034 |
