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2016 Journal Article C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupusMahajan, Supriya D., Tutino, Vincent M., Redae, Yonas, Meng, Hui, Siddiqui, Adnan, Woodruff, Trent M., Jarvis, James N., Hennon, Teresa, Schwartz, Stanley, Quigg, Richard J. and Alexander, Jessy J. (2016). C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology, 148 (4), 407-419. doi: 10.1111/imm.12619 |
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2016 Journal Article Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosisGu, Hongmei, Fisher, Amanda J., Mickler, Elizabeth A., Duerson, Frank, III, Cummings, Oscar W., Peters-Golden, Marc, Twigg, Homer L., III, Woodruff, Trent M., Wilkes, David S. and Vittal, Ragini (2016). Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis. FASEB Journal, 30 (6), 2336-2350. doi: 10.1096/fj.201500044 |
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2016 Journal Article The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1Shutov, Leonid P., Warwick, Charles A., Shi, Xiaoyu, Gnanasekaran, Aswini, Shepherd, Andrew J., Mohapatra, Durga P., Woodruff, Trent M., David Clark, J. and Usachev, Yuriy M. (2016). The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1. Journal of Neuroscience, 36 (18), 5055-5070. doi: 10.1523/JNEUROSCI.3249-15.2016 |
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2016 Conference Publication Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cellsWest, Erin E., Arbore, Giuseppina, Robertson, Avril A.B., Klos, Andreas, Woodruff, Trent M., O’Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cells. Immunology 2016™ Meeting, Seattle, WA United States, 13 - 17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.58.6 |
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2016 Journal Article The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responsesNabizadeh, Jamileh A., Manthey, Helga D., Steyn, Frederik J., Chen, Weiyu, Widiapradja, Alexander, Akhir, Fazrena N. Md, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2016). The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. Journal of Immunology, 196 (11), 4783-4792. doi: 10.4049/jimmunol.1600210 |
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2016 Journal Article Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defectsDenny, Kerina J., Kelly, Christina F., Kumar, Vinod, Witham, Katey L., Cabrera, Robert M., Fennell, Richard H., Taylor, Stephen M., Jeanes, Angela and Woodruff, Trent M. (2016). Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (3), 201-207. doi: 10.1002/bdra.23483 |
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2016 Journal Article EPHA4-FC treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeabilityWoodruff, Trent M., Wu, Mike C.-L., Morgan, Michael, Bain, Nathan T., Jeanes, Angela, Lipman, Jeffrey, Ting, Michael J., Boyd, Andrew W., Taylor, Stephen M. and Coulthard, Mark G. (2016). EPHA4-FC treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeability. Shock, 45 (2), 184-191. doi: 10.1097/SHK.0000000000000494 |
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2016 Conference Publication EphA2KO mice survive longer in a mouse model of sepsisKumar, V., Woodruff, T., Ting, M., Boyd, A., Coulthard, M., Souza-Fonseca-Guimaraes, F. and Smyth, M. (2016). EphA2KO mice survive longer in a mouse model of sepsis. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200 |
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2016 Journal Article Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic miceMantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050 |
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2016 Conference Publication Investigating the role of complement component C5a receptor 2 (C5aR2/C5L2) in spinal cord injuryBiggins, P. J. C., Brennan, F. H., Taylor, S. M., Woodruff, T. M. and Ruitenberg, M. J. (2016). Investigating the role of complement component C5a receptor 2 (C5aR2/C5L2) in spinal cord injury. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.058 |
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2016 Conference Publication The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole bloodChristiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Mathisen, Monica Dammen, Fure, Hilde, Stenvik, Jorgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2016). The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole blood. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.212 |
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2016 Conference Publication A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's diseaseLi, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.186 |
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2016 Journal Article Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditionsBrennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016). Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 (3), 292-308. doi: 10.1016/j.smim.2016.03.015 |
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2016 Conference Publication Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArgFreeley, Simon, Le Friec, Gaelle, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Pete and Kemper, Claudia (2016). Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.120 |
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2016 Conference Publication The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's diseaseLi, R., Levin, S., Lee, J., Gordon, R. and Woodruff, T. (2016). The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200 |
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2016 Conference Publication Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.146 |
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2016 Conference Publication Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cellsWest, Erin E., Arbore, Giuseppina, Robertson, Avril A. B., Klos, Andreas, Woodruff, Trent M., O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Joerg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cells. Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, United States, 13-17 May 2016. Bethesda, MD, United States: American Association of Immunologists. |
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2015 Journal Article The receptor for advanced glycation endproducts does not contribute to pathology in a mouse mesenteric ischemia/reperfusion-induced injury modelWu, Mike C. L., Gilmour, Timothy D., Mantovani, Susanna and Woodruff, Trent M. (2015). The receptor for advanced glycation endproducts does not contribute to pathology in a mouse mesenteric ischemia/reperfusion-induced injury model. Frontiers in Immunology, 6 (DEC) 614, 1-7. doi: 10.3389/fimmu.2015.00614 |
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2015 Journal Article Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosisNgo, S. T., Steyn, F. J., Huang, L., Mantovani, S., Pfluger, C. M. M., Woodruff, T. M., O'Sullivan, J. D., Henderson, R. D. and McCombe, P. A. (2015). Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 357 (1-2), 22-27. doi: 10.1016/j.jns.2015.06.053 |
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2015 Journal Article Co-ordinated expression of innate immune molecules during mouse neurulationJeanes, Angela, Coulthard, Liam G., Mantovani, Susanna, Markham, Kathryn and Woodruff, Trent M. (2015). Co-ordinated expression of innate immune molecules during mouse neurulation. Molecular Immunology, 68 (2), 253-260. doi: 10.1016/j.molimm.2015.09.004 |
