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2015 Journal Article Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the mythCoulthard, Liam G. and Woodruff, Trent M. (2015). Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth. Journal of Immunology, 194 (8), 3542-3548. doi: 10.4049/jimmunol.1403068 |
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2015 Journal Article A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy modelsBenson, Melissa J, Thomas, Nicola K, Talwar, Sahil, Hodson, Mark P, Lynch, Joseph W, Woodruff, Trent M and Borges, Karin (2015). A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models. Neurobiology of Disease, 76, 87-97. doi: 10.1016/j.nbd.2015.02.004 |
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2015 Journal Article Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent mannerJain, Umang, Cao, Qi, Thomas, Nikhil A, Woodruff, Trent M, Schwaeble, Wilhelm J, Stover, Cordula M and Stadnyk, Andrew W (2015). Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner. Journal of Immunology, 194 (7), 3414-3421. doi: 10.4049/jimmunol.1401814 |
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2015 Conference Publication Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegenerationKumar, Vinod, Lee, John, Noakes, Peter and Woodruff, Trent (2015). Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration. 8th International Conference on Complement Therapeutics, Chania, Crete, Greece, 1-6 January 2015. |
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2015 Conference Publication Peripheral immune complement activation in neurodegenerative diseaseMantovani, S., Gordon, R., Ngo, S., Pfluger, C., O'Sullivan, J., Noakes, P., Henderson, R., McCombe, P. and Woodruff, T. (2015). Peripheral immune complement activation in neurodegenerative disease. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188 |
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2015 Conference Publication Investigating the role of C5a-CD88 signalling axis in diabetic nephropathyTan, S. M., Nguyen, T. V., Woodruff, T. M. and Coughlan, M. T. (2015). Investigating the role of C5a-CD88 signalling axis in diabetic nephropathy. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September, 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543 |
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2015 Conference Publication Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathwayAlbornoz, E., Deora, V., Robertson, B. A., Cooper, M. A., Schroder, K., Woodruff, T. M. and Gordon, R. (2015). Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathway. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley-Blackwell. |
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2015 Conference Publication Unexpected activities of the complement pathway in migrating neuronsReiner, O., Gorelik, A., Sapir, T., Bialas, A. R., Stevens, B., Woodruff, T. M. and Haffner-Krausz, R. (2015). Unexpected activities of the complement pathway in migrating neurons. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185 |
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2014 Journal Article Derivation of ligands for the complement C3a receptor from the C-terminus of C5aHalai, Reena, Bellows-Peterson, Meghan L., Branchett, Will, Smadbeck, James, Kieslich, Chris A., Croker, Daniel E., Cooper, Matthew A., Morikis, Dimitrios, Woodruff, Trent M., Floudas, Christodoulos A. and Monk, Peter N. (2014). Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. European Journal of Pharmacology, 745, 176-181. doi: 10.1016/j.ejphar.2014.10.041 |
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2014 Journal Article Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014). Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 (12), 3278-3284. doi: 10.1002/stem.1801 |
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2014 Journal Article Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methodsKhan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003 |
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2014 Journal Article Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosisGu H., Mickler E.A., Cummings O.W., Sandusky G.E., Weber D.J., Gracon A., Woodruff T., Wilkes D.S. and Vittal R. (2014). Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis. FASEB Journal, 28 (10), 4223-4234. doi: 10.1096/fj.13-247650 |
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2014 Journal Article Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient bloodMantovani, S., Gordon, R., Macmaw, J. K., Plfluger, C. M., Henderson, R. D., Noakes, P. G., McCombe, P. A. and Woodruff, T. M. (2014). Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood. Journal of Neuroimmunology, 276 (1-2), 213-218. doi: 10.1016/j.jneuroim.2014.09.005 |
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2014 Journal Article Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and dockingTamamis, Phanourios, Kieslich, Chris A., Nikiforovich, Gregory V., Woodruff, Trent M., Morikis, Dimitrios and Archontis, Georgios (2014). Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and docking. BMC Biophysics, 7 (1) 5, 1-16. doi: 10.1186/2046-1682-7-5 |
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2014 Journal Article Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)Barrett, Helen L., Kubala, Marta H., Scholz Romero, Katherin, Denny, Kerina J., Woodruff, Trent M., McIntyre, H. David, Callaway, Leonie K. and Nitert, Marloes Dekker (2014). Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM). PLoS One, 9 (8) e104826, e104826.1-e104826.8. doi: 10.1371/journal.pone.0104826 |
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2014 Conference Publication Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord InjuryRuitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. 11th Symposium of the International-Neurotrauma-Society, Budapest, Hungary, 19-23 March 2014. New Rochelle, NY United States: Mary Ann Liebert. |
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2014 Conference Publication C3a and C5a homeostasis in health and diseaseWoodruff, Trent M. (2014). C3a and C5a homeostasis in health and disease. 25th International Complement Workshop, Rio de Janeiro Brazil, 14-18 September 2014. Kidlington, Oxford, United Kingdom: Pergamon Press. |
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2014 Journal Article Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injuryDe Hoog, Vince C., Timmers, Leo, Van Duijvenvoorde, Amerik, De Jager, Saskia C. A., Van Middelaar, Ben J., Smeets, Mirjam B., Woodruff, Trent M., Doevendans, Pieter A., Pasterkamp, Gerard, Hack, C. Erik and De Kleijn, Dominique P. V. (2014). Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury. Cardiovascular Research, 103 (4), 521-529. doi: 10.1093/cvr/cvu153 |
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2014 Journal Article Increased placental expression of fibroblast growth factor 21 in gestational diabetes mellitusDekker Nitert, Marloes, Barrett, Helen L., Kubala, Marta H., Scholz Romero, Katherin, Denny, Kerina J., Woodruff, Trent M., David McIntyre, H. David and Callaway, Leonie K. (2014). Increased placental expression of fibroblast growth factor 21 in gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 99 (4), E591.1-E591.8. doi: 10.1210/jc.2013-2581 |
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2014 Conference Publication Discovery of novel selective C5a2 ligands that can modulate IL-6 releAse from macrophagesCroker, Daniel E., Halai, Reena, Kaeslin, Geraldine, Morikis, Dimitrios, Woodruff, Trent, Floudas, Christodoulos A., Monk, Peter N. and Cooper, Matthew A. (2014). Discovery of novel selective C5a2 ligands that can modulate IL-6 releAse from macrophages. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, Oct 26-29, 2014. London United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.039 |
