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2017 Conference Publication Combined C5aR1 and CD14 inhibition significantly reduced cytokine release induced by both viable and heat inactivated bacteria in human whole bloodChristiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Fure, Hilde, Ludviksen, Judith K., Stenvik, Jurgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2017). Combined C5aR1 and CD14 inhibition significantly reduced cytokine release induced by both viable and heat inactivated bacteria in human whole blood. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, Sep 08-12, 2017. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2017.06.147 |
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2017 Book Chapter Neuroinflammation as a therapeutic target in neurodegenerative diseasesGordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders. (pp. 43-64) edited by Veerle Baekelandt and Evy Lobbestael. Boston, MA, United States: Academic Press (Elsevier Press). |
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2017 Conference Publication Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in miceMagalhaes, Ricardo J. Soares, Giacomin, Paul, Sarnyay, Zoltan, Kraeuter, Ann, Urich, Tim, Bengtsson, Mia, Jin, Shuting, Albornoz, Eduardo A., Gordon, Richard and Woodruff, Trent (2017). Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in mice. 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta, GA, United States, 13-16 November 2016. Deerfield, United States: American Society of Tropical Medicine and Hygiene. |
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2017 Conference Publication Motor neuron disease proteins activate complement and generate C5aDeora, Vandana, Mantovani, Susanna, Yerbury, Justin, Clark, Richard, Atkin, Julie, Lee, John, Gordon, Richard and Woodruff, Trent M. (2017). Motor neuron disease proteins activate complement and generate C5a. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen, Denmark, 8-12 September 2017. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.144 |
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2017 Book Chapter Neuroinflammation as a therapeutic target in neurodegenerative diseasesGordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders: paving the way for disease-modifying therapies. (pp. 49-80) edited by Veerle Baekelandt and Evy Lobbestael. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-805120-7.00003-8 |
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2017 Conference Publication Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brainWoodruff, Trent M., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Leel, John D., Sepehrband', Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Coulthard, Liam G. (2017). Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, 8-12 September 2017. Kidlington, Oxford United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.178 |
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2016 Journal Article Complement in the fundamental processes of the cellHawksworth, Owen A., Coulthard, Liam G. and Woodruff, Trent M. (2016). Complement in the fundamental processes of the cell. Molecular Immunology, 84, 17-25. doi: 10.1016/j.molimm.2016.11.010 |
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2016 Journal Article Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degenerationGordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 7 (1) 12932, 12932.1-12932.18. doi: 10.1038/ncomms12932 |
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2016 Journal Article Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signallingCroker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43 |
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2016 Journal Article Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer compositionZhang, Jing, Woodruff, Trent M., Clark, Richard J., Martin, Darren J. and Minchin, Rodney F. (2016). Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition. Acta Biomaterialia, 41, 264-272. doi: 10.1016/j.actbio.2016.05.034 |
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2016 Journal Article C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupusMahajan, Supriya D., Tutino, Vincent M., Redae, Yonas, Meng, Hui, Siddiqui, Adnan, Woodruff, Trent M., Jarvis, James N., Hennon, Teresa, Schwartz, Stanley, Quigg, Richard J. and Alexander, Jessy J. (2016). C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology, 148 (4), 407-419. doi: 10.1111/imm.12619 |
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2016 Journal Article Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosisGu, Hongmei, Fisher, Amanda J., Mickler, Elizabeth A., Duerson, Frank, III, Cummings, Oscar W., Peters-Golden, Marc, Twigg, Homer L., III, Woodruff, Trent M., Wilkes, David S. and Vittal, Ragini (2016). Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis. FASEB Journal, 30 (6), 2336-2350. doi: 10.1096/fj.201500044 |
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2016 Journal Article The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1Shutov, Leonid P., Warwick, Charles A., Shi, Xiaoyu, Gnanasekaran, Aswini, Shepherd, Andrew J., Mohapatra, Durga P., Woodruff, Trent M., David Clark, J. and Usachev, Yuriy M. (2016). The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1. Journal of Neuroscience, 36 (18), 5055-5070. doi: 10.1523/JNEUROSCI.3249-15.2016 |
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2016 Conference Publication Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cellsWest, Erin E., Arbore, Giuseppina, Robertson, Avril A.B., Klos, Andreas, Woodruff, Trent M., O’Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cells. Immunology 2016™ Meeting, Seattle, WA United States, 13 - 17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.58.6 |
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2016 Journal Article The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responsesNabizadeh, Jamileh A., Manthey, Helga D., Steyn, Frederik J., Chen, Weiyu, Widiapradja, Alexander, Akhir, Fazrena N. Md, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2016). The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. Journal of Immunology, 196 (11), 4783-4792. doi: 10.4049/jimmunol.1600210 |
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2016 Journal Article Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defectsDenny, Kerina J., Kelly, Christina F., Kumar, Vinod, Witham, Katey L., Cabrera, Robert M., Fennell, Richard H., Taylor, Stephen M., Jeanes, Angela and Woodruff, Trent M. (2016). Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (3), 201-207. doi: 10.1002/bdra.23483 |
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2016 Journal Article EPHA4-FC treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeabilityWoodruff, Trent M., Wu, Mike C.-L., Morgan, Michael, Bain, Nathan T., Jeanes, Angela, Lipman, Jeffrey, Ting, Michael J., Boyd, Andrew W., Taylor, Stephen M. and Coulthard, Mark G. (2016). EPHA4-FC treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeability. Shock, 45 (2), 184-191. doi: 10.1097/SHK.0000000000000494 |
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2016 Conference Publication The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole bloodChristiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Mathisen, Monica Dammen, Fure, Hilde, Stenvik, Jorgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2016). The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole blood. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.212 |
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2016 Conference Publication A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's diseaseLi, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.186 |
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2016 Journal Article Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditionsBrennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016). Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 (3), 292-308. doi: 10.1016/j.smim.2016.03.015 |
