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2024 Conference Publication Temporal characterisation of renal immunophenotype with mitochondrial kinetic profile in a preclinical model of diabetic kidney diseaseTrambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Woodruff, Trent, Coughlan, Melinda and Tan, Sih Min (2024). Temporal characterisation of renal immunophenotype with mitochondrial kinetic profile in a preclinical model of diabetic kidney disease. 59th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Adelaide, SA, Australia, 31 August–4 September 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14360 |
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2024 Conference Publication Dual inhibition of complement C5a receptor 1 and 2 in diabetic kidney diseaseTan, Sih Min, Trambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Woodruff, Trent and Coughlan, Melinda (2024). Dual inhibition of complement C5a receptor 1 and 2 in diabetic kidney disease. 59th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Adelaide, SA, Australia, 31 August–4 September 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14361 |
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2024 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Gorman, Declan, Li, Xaria, Dent, Joshua, Cui, Cedric, Lee, Han Siean, Fung, Jenny, Lee, John, Rosengren, K. Johan and Woodruff, Trent (2024). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Journal Article Sex differences in Huntington's disease from a neuroinflammation perspectiveRisby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480 |
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2024 Journal Article Complement(ing) long-COVID thromboinflammation and pathogenesisLee, John D. and Woodruff, Trent M. (2024). Complement(ing) long-COVID thromboinflammation and pathogenesis. Trends in Immunology, 45 (6), 397-399. doi: 10.1016/j.it.2024.04.001 |
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2024 Conference Publication C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environmentAhmari, Niousha, Perrino, Melissa, Pundavela, Jay, Szabo, Sara, Woodruff, Trent, Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment. ASPET 2024 Annual Meeting, Arlington, VA United States, 16-19 May 2024. Rockville, MD United States: American Society for Pharmacology and Experimental Therapeutics. doi: 10.1124/jpet.249.988670 |
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2024 Conference Publication Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironmentsBeach, Callum, MacLean, David, Majorova, Dominika, Valbuena, Gabriel N., Damavandi, Mahnaz Darvish, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Moon, Eui Jung, Guglietta, Silvia, Krieg, Carsten, Woodruff, Trent M., Maughan, Tim, Buczacki, Simon J.A., Leedham, Simon J., Giaccia, Amato J., Clark, Heather and Olcina, Monica M. (2024). Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments. ESTRO meets Asia 2024, Kuala Lumpur, Malaysia, 23-25 August 2024. Shannon, Ireland: Elsevier. doi: 10.1016/s0167-8140(24)01225-8 |
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2024 Journal Article Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposureChen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306 |
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2024 Conference Publication Dysregulation of T cell intrinsic C5aR2 activation causes uncontrolled inflammatory Th responses and autoinflammatory syndromeWest, Erin, Merle, Nicolas, Bibby, Jack, Singh, Parul, Rahman, Jubayer, Morgensen, Trine Hyrup, Woodruff, Trent, Monk, Peter, Christiansen, Mette and Kemper, Claudia (2024). Dysregulation of T cell intrinsic C5aR2 activation causes uncontrolled inflammatory Th responses and autoinflammatory syndrome. Annual Meeting of the American Association of Immunologists (IMMUNOLOGY), Chicago, IL, United States, 3-7 May 2024. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.212.supp.0526.5407 |
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2024 Journal Article C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosisPerrino, Melissa R., Ahmari, Niousha, Hall, Ashley, Jackson, Mark, Na, Youjin, Pundavela, Jay, Szabo, Sara, Woodruff, Trent M., Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. Life Science Alliance, 7 (5) e202302229, 1-16. doi: 10.26508/lsa.202302229 |
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2024 Journal Article A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosisVassileff, Natasha, Spiers, Jereme G., Lee, John D., Woodruff, Trent M., Ebrahimie, Esmaeil, Mohammadi Dehcheshmeh, Manijeh, Hill, Andrew F. and Cheng, Lesley (2024). A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 61 (8), 5901-5915. doi: 10.1007/s12035-023-03857-z |
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2024 Book Chapter The role of the complement system in cancer etiology and managementSonderegger, Stefan E., Manzanero, Silvia, Woodruff, Trent M., Farouqa, Jad, Nabizadeh, Jamileh, Panagides, Nadya and Rolfe, Barbara E. (2024). The role of the complement system in cancer etiology and management. Clinical immuno-oncology. (pp. 41-60.e10) edited by John E. Niederhuber. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-87763-3.00012-5 |
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2023 Journal Article Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activationLi, Xaria X. and Woodruff, Trent M. (2023). Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation. STAR Protocols, 4 (4) 102758, 1-20. doi: 10.1016/j.xpro.2023.102758 |
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2023 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2023). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23) e168277, 1-19. doi: 10.1172/jci168277 |
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2023 Journal Article The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptorsAlexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180 (S2), S23-S144. doi: 10.1111/bph.16177 |
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2023 Journal Article Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse ModelChen, Min, Edwards, Stephen R., Maskey, Dhiraj, Woodruff, Trent M., Tomlinson, Stephen and Reutens, David (2023). Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model. Neurotrauma Reports, 4 (1) neur.2023.0024, 663-681. doi: 10.1089/neur.2023.0024 |
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2023 Journal Article 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptorsAlbornoz, Eduardo and Woodruff, Trent (2023). 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptors. Immunobiology, 228 (5) 152650, 1-1. doi: 10.1016/j.imbio.2023.152650 |
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2023 Conference Publication T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunityMerle, Nicolas S., Freeley, Simon, Bibby, Jack, Singh, Parul, Rahman, Jubayer, Kolev, Martin, Niyonzima, Nathalie, Morgensen, Trine Hyrup, Woodruff, Trent M., Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollness, Tom Eirik, Christiansen, Mette, West, Erin E. and Kemper, Claudia (2023). T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.64.15 |
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2023 Journal Article Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivoAlthobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964, e4964. doi: 10.1002/nbm.4964 |
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2023 Journal Article Complement peptide receptors in GtoPdb v.2023.1Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2023). Complement peptide receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f5/2023.1 |
